417,832 results match your criteria gastric


Dual activation of Hedgehog and Wnt/β-catenin signaling pathway caused by downregulation of SUFU targeted by miRNA-150 in human gastric cancer.

Aging (Albany NY) 2021 Apr 12;13. Epub 2021 Apr 12.

Guangdong Key Laboratory for Genome Stability and Disease Prevention, Department of Pathology, Shenzhen University School of Medicine, Shenzhen 518060, Guangdong, P.R. China.

Mounting evidence has shown that miRNA-150 expression is upregulated in gastric cancer (GC) and is associated with gastric carcinogenesis, but the underlying oncogenic mechanism remains elusive. Here, we discovered that miRNA-150 targets the tumor suppressor SUFU to promote cell proliferation, migration, and the epithelial-mesenchymal transition (EMT) via the dual activation of Hedgehog (Hh) and Wnt signaling. MiRNA-150 was highly expressed in GC tissues and cell lines, and the level of this miRNA was negatively related to that of SUFU. Read More

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Combined effect of microplastics and global warming factors on early growth and development of the sea urchin (Paracentrotus lividus).

Sci Total Environ 2021 Apr 1;782:146888. Epub 2021 Apr 1.

Centro Oceanográfico de Vigo, Instituto Español de Oceanografía, IEO, Subida a Radio Faro, 50, 36390 Vigo, Pontevedra, Spain.

The aim of this work was to estimate the potential risk of the combined effect of global change factors (acidification, temperature increase) and microplastic (MP) pollution on the growth and development of the sea urchin P. lividus. Embryo-larval bioassays were conducted to determine growth and morphology after 48 h of incubation with MP (1000 and 3000 particles/mL); with filtered sea water at pH = 7. Read More

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Women with advanced maternal age have gastric volume similar to that of non-pregnant women: A prospective pilot study using preoperative gastric ultrasound.

J Clin Anesth 2021 Apr 10;72:110270. Epub 2021 Apr 10.

Department of Anesthesiology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330008, China. Electronic address:

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Outcomes of endoscopic submucosal dissection for early esophageal and gastric cardia adenocarcinomas.

Clin Res Hepatol Gastroenterol 2021 Apr 10:101700. Epub 2021 Apr 10.

Department of Gastroenterology and Digestive Oncology, Cochin Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France; Université de Paris, France. Electronic address:

Objectives: Adenocarcinomas of the esophagus and of the gastric cardia are regarded as a same clinical entity in oncology. For endoscopic resection however, endoscopic mucosal resection is recommended for esophageal adenocarcinoma, while endoscopic submucosal dissection (ESD) is advocated for gastric adenocarcinomas. Our aim was to compare the outcomes of ESD in both types of esophagogastric junction adenocarcinomas. Read More

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Palliation of malignant esophageal obstruction using an anti-migration self-expandable metal stent: results of a prospective multicenter study.

Clin Res Hepatol Gastroenterol 2021 Apr 10:101683. Epub 2021 Apr 10.

Department of Gastroenterology, General Hospital, Sanremo (IM), Italy.

Background: Self-expanding metal stents (SEMS) placement is primarily indicated to palliate dysphagia for patients with expected short-term survival. We aimed to assess the migration rate and other stent-related adverse events (AEs) of a fully covered SEMS with an anti-migration system (FCSEMS-AMS) for palliation of malignant dysphagia.

Methods: This is a prospective study including patients with inoperable esophageal cancer that received a FCSEMS-AMS (Taewoong, Niti-S Beta), in five tertiary-care endoscopic centers from January 2014 to February 2016. Read More

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Potassium bromate (KBrO3) Modulates Oxidative stress and inflammatory biomarkers in NaOH induced crohn's colitis in Wistar rats.

Can J Physiol Pharmacol 2021 Apr 13. Epub 2021 Apr 13.

University of Ibadan, Faculty of Basic Medical Sciences, Physiology, Ibadan, Oyo, Nigeria.

Potassium bromate (KBrO3) present in consumed ozonised water was recently documented to exacerbate experimental gastric ulcer. Report is however vague as regards its effects in the colon; where water reabsorption occurs. In this study, we observed the possible effects of KBrO3 on oxidative stress and inflammatory biomarkers in NaOH induced crohn's colitis. Read More

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Rare Case of Gastric Xanthoma in a 15-Year-Old Patient.

Pediatr Dev Pathol 2021 Apr 13:10935266211007246. Epub 2021 Apr 13.

PathWest Laboratory Medicine Western Australia, Perth Children's Hospital, Nedlands, Australia.

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The effect of visceral reception activation (water load test) on autonomic activity and gastric myoelectric activity in gastrointestinal malignancies.

Bratisl Lek Listy 2021 ;122(5):347-356

Objectives: The aim of this study was to analyze the effect of water load test (WLT) on heart rate variability (HRV), blood pressure variability (BPV), hemodynamic parameters and gastric myoelectric activity in gastrointestinal (GI) cancer patients.

Background: WLT activates gastrointestinal mechanoreception and osmoreception, and hence, can indirectly modulate autonomic activity.

Methods: Eighty patients (mean age 61. Read More

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January 2021

Investigation on potential biomarkers of hyperprogressive disease (HPD) triggered by immune checkpoint inhibitors (ICIs).

Authors:
J Liu Q Wu S Wu X Xie

Clin Transl Oncol 2021 Apr 13. Epub 2021 Apr 13.

Department of Oncology, Molecular Oncology Research Institute, the First Affiliated Hospital, Fujian Medical University, Chazhong Road No 20, Fuzhou 350005, Fujian, China.

Purpose: This project aimed to survey the clinical characteristics and survivals of hyperprogressive disease (HPD) mediated by immune checkpoint inhibitors (ICIs) in an attempt to explore the potential predictors.

Methods: After searching PubMed, MEDLINE, Google Scholar and Cochrane Library databases, 12 studies incorporating 1766 individuals were enrolled. The data were analyzed with Review manager 5. Read More

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Immunotactoid glomerulonephritis in a patient with cold agglutinins: causal association or mere coincidence?

CEN Case Rep 2021 Apr 13. Epub 2021 Apr 13.

Department of Nephrology, Yokosuka Kyosai Hospital, 1-16 Yonegahamadori, Yokosuka, Kanagawa, 238-8558, Japan.

We report a case of immunotactoid glomerulonephritis (ITG) in a patient with cold agglutinins. An 86-year-old Japanese male with a history of hypertension, dyslipidemia, and gastric malignancy presented to our hospital for the evaluation of proteinuria and hematuria. He had an elevated blood pressure of 200/77 mmHg and edema of the lower extremities. Read More

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The Activity of Crizotinib in Chemo-Refractory MET-Amplified Esophageal and Gastric Adenocarcinomas: Results from the AcSé-Crizotinib Program.

Target Oncol 2021 Apr 13. Epub 2021 Apr 13.

Gustave Roussy, Villejuif, France.

Background: The AcSé-crizotinib program provides extensive screening of crizotinib-targeted genomic alteration in several malignancies. We here report the results in patients with esogastric MET-amplified adenocarcinomas.

Objective: The objective of the study was to evaluate the efficacy and tolerability of crizotinib in patients with pretreated esogastric MET-amplified adenocarcinoma who have no alternative treatment options. Read More

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Investigating Intestinal Transporter Involvement in Rivaroxaban Disposition through Examination of Changes in Absorption.

Pharm Res 2021 Apr 13. Epub 2021 Apr 13.

Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco, San Francisco, California, 94143-0912, USA.

Purpose: The involvement of the intestinally expressed xenobiotic transporters P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP) have been implicated in rivaroxaban disposition based on in vitro studies, similar to what had previously been proposed for apixaban. We recently showed that these efflux transporters were not clinically relevant for apixaban disposition and examine here their relevance for this second Factor Xa inhibitor.

Methods: Using recently published methodologies to discern metabolic- from transporter- mediated drug interactions, a critical evaluation was undertaken of 9 rivaroxaban studies reporting 12 DDIs, one study of food effects and one study of hepatic function. Read More

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A pilot study on EORTC or PERCIST for the prediction of progression-free survival with nivolumab therapy in advanced or metastatic gastric cancers: A STROBE-compliant article.

Medicine (Baltimore) 2021 Apr;100(15):e25494

Department of Radiology, Kagoshima University, Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544.

Abstract: Recent breakthrough results from immune checkpoint inhibitors (ICIs) have paved the way to a new era of cancer immunotherapy, and have thus led to a paradigm shift of cancer treatment. In particular, inhibition of the antiprogrammed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) axis with ICI, including nivolumab and pembrolizumab, has been emerging as a novel treatment strategy for advanced gastric cancers. An accurate noninvasive assessment of the response to ICI is important for the management of patients with advanced or metastatic gastric cancer. Read More

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Comparison of nutrition and quality of life of esophagogastrostomy and the double-tract reconstruction after laparoscopic proximal gastrectomy.

Medicine (Baltimore) 2021 Apr;100(15):e25453

Center for Gastric Cancer, National Cancer Center, Goyang.

Abstract: This study aims to compare the nutritional outcomes and quality of life between patients who underwent esophagogastrostomy (EG) and those who underwent the double-tract reconstruction (DTR) after laparoscopic proximal gastrectomy for early gastric cancer.We retrospectively reviewed the prospectively established database of 45 patients who underwent EG with anti-reflux procedure and 58 patients who underwent the DTR after laparoscopic proximal gastrectomy between December 2013 and June 2017. Then, we compared the baseline characteristics, clinical outcomes, postoperative nutritional parameters, and quality of life (QOL) using European Organization for Research and Treatment of Cancer (EORTC) QLQ STO-22 between the EG and DTR groups. Read More

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Interface-Mediated Mechanism of Action-The Root of the Cytoprotective Effect of Immediate-Release Omeprazole.

J Med Chem 2021 Apr 13. Epub 2021 Apr 13.

LAQV, REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal.

Omeprazole is usually administered under an enteric coating. However, there is a Food and Drug Administration-approved strategy that enables its release in the stomach. When locally absorbed, omeprazole shows a higher efficacy and a cytoprotective effect, whose mechanism was still unknown. Read More

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Fusion imaging in the preoperative assessment of the extension of disease in patients with advanced ovarian cancer: feasibility and agreement with laparoscopic findings.

Ultrasound Obstet Gynecol 2021 Apr 13. Epub 2021 Apr 13.

Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Rome, Italy.

Objectives: Fusion imaging is an emerging technique that can fuse real time ultrasound examination with other imaging modalities such as computed tomography (CT), magnetic resonance, and positron emission tomography. The primary aim of the study was to evaluate the Fusion imaging feasibility in patients with advanced ovarian cancer. The secondary aims were: 1) to compare agreement laparoscopic findings with Fusion, CT scan alone and ultrasound alone in assessing the extension of intra-abdominal disease; 2) to evaluate the time required by the Fusion technique. Read More

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TYMSOS drives the proliferation, migration and invasion of gastric cancer cells by regulating ZNF703 via sponging miR-4739.

Cell Biol Int 2021 Apr 13. Epub 2021 Apr 13.

the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

Gastric cancer (GC) is a kind of malignancy originating from the epithelium of gastric mucosa. Long non-coding RNAs (lncRNAs) are tightly related to the GC progression. Herein, our research was meant to investigate a novel lncRNA thymidylate synthetase opposite strand (TYMSOS) in GC. Read More

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Drugs in Focus: Proton Pump Inhibitors.

J Pediatr Gastroenterol Nutr 2021 May;72(5):645-653

Neurogastroenterology and Motility Unit, Department of Paediatric Gastroenterology, Great Ormond Street Hospital NHS Foundation Trust.

Abstract: Proton pump inhibitors (PPIs) are amongst the most commonly prescribed drugs in infants and children with the last decades witnessing a dramatic rise in their utilization. Although PPIs are clearly effective when used appropriately and have been regarded as safe drugs, there is growing evidence regarding their potential adverse effects. Although, largely based on adult data it is clear that many of these are also relevant to pediatrics. Read More

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The anti-depressant effects of a novel PDE4 inhibitor derived from resveratrol.

Pharm Biol 2021 Dec;59(1):418-423

School of Pharmacy & School of Medicine, Changzhou University, Changzhou, PR China.

Context: Resveratrol has shown anti-stress and anti-depressant-like abilities involved in inhibiting phosphodiesterase-4 (PDE4) enzyme. However, its application is limited due to its low efficacy, bioavailability and selectivity.

Objective: This study synthesized a new resveratrol derivative RES003 and evaluated its PDE4 inhibitory and anti-depressant-like activities and , respectively. Read More

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December 2021

The POLR2E rs3787016 polymorphism is associated with susceptibility to and prognosis of gastric cancer.

Neoplasma 2021 Apr 13. Epub 2021 Apr 13.

Medical Functional Experiment Center, School of Medical Sciences, North Sichuan Medical College, Nanchong, China.

Long non-coding RNAs (lncRNAs) have been proposed as promising diagnostic and prognostic biomarkers for cancer. We investigated the associations of RNA polymerase II subunit E (POLR2E) rs3787016 polymorphism with the risk and prognosis of gastric cancer (GC). The study subjects included 368 GC patients who underwent surgical resection and 294 healthy volunteers, adjusted for age, gender, smoking status, alcohol status, and Helicobacter pylori infection status. Read More

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ARF3 inhibits proliferation and promotes apoptosis in gastric cancer by regulating AKT and ERK pathway.

Acta Biochim Pol 2021 Apr 13. Epub 2021 Apr 13.

Department of Digestive Tumor Surgery, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, 210029, Chin.

ADP-ribosylation factor 3 (ARF3) has confirmed participate in diverse biological processes in many cancers. However, the expression patterns and roles of ARF3 in gastric cancer (GC) remains largely unknown. In our study, by using qRT-PCR and western blot, we found that, in In GC tissues and cells, the expression of ARF3 was significantly down-regulated. Read More

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Predictive Role of Endoscopic Surveillance after Total Gastrectomy with R0 Resection for Gastric Cancer.

J Korean Med Sci 2021 Apr 12;36(14):e88. Epub 2021 Apr 12.

Division of Gastroenterology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: Endoscopic surveillance after total gastrectomy (TG) for gastric cancer is routinely performed to detect tumor recurrence and postoperative adverse events. However, the reports on the clinical benefits of endoscopic surveillance are ambiguous. We investigated the clinical benefit of endoscopic surveillance after TG for gastric cancer. Read More

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Oral multivalent epitope vaccine, based on UreB, HpaA, CAT, and LTB, for prevention and treatment of Helicobacter pylori infection in C57BL / 6 mice.

Helicobacter 2021 Apr 12:e12807. Epub 2021 Apr 12.

Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, China.

Background: As the resistance of Helicobacter pylori to traditional triple therapy is gradually revealed, an increasing number of people are focusing on vaccine treatments for H. pylori infection. Epitope vaccines are a promising strategy for the treatment of H. Read More

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Lactobacillus plantarum HFY09 alleviates alcohol-induced gastric ulcers in mice via an anti-oxidative mechanism.

J Food Biochem 2021 Apr 13:e13726. Epub 2021 Apr 13.

Chongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education, Chongqing, China.

The protective effect of Lactobacillus plantarum HFY09 (LP-HFY09) on alcohol-induced gastric ulcers was investigated. Gastric morphology observation and pathological tissue sections showed that LP-HFY09 effectively relieved gastric tissue injury. The biochemical indicator detection showed that LP-HFY09 increased superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), glutathione (GSH), prostaglandin E2 (PGE2), and somatostatin (SS) levels, and decreased malondialdehyde (MDA) levels. Read More

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Gastric Bypass Compared with Sleeve Gastrectomy for Nonalcoholic Fatty Liver Disease: a Systematic Review and Meta-analysis.

Obes Surg 2021 Apr 13. Epub 2021 Apr 13.

Gastroenterology Department, University of Sao Paulo, Av. Dr. Enéas de Carvalho Aguiar 255, São Paulo, SP, 05403-000, Brazil.

The effects of bariatric procedures on nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) remain unclear. A systematic review and meta-analysis was performed to compare the impact of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) on NAFLD/NASH. Patients submitted to RYGB presented significant reduction of steatohepatitis (RD: 0. Read More

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Low prevalence of gastroesophageal reflux symptoms in vegetarians.

Indian J Gastroenterol 2021 Apr 12. Epub 2021 Apr 12.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria.

Background: Dietary modification could reduce the risk of gastroesophageal reflux disease. Circumstantial evidence suggests that gastroesophageal reflux is less prevalent in people adhering to a vegetarian diet. We aimed to study the relationship between vegetarianism and the occurrence of gastroesophageal reflux symptoms (GERS). Read More

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The Discordance of Clinical and Pathologic Staging in Locally Advanced Gastric Adenocarcinoma.

J Gastrointest Surg 2021 Apr 12. Epub 2021 Apr 12.

Department of Surgery, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA.

Background: Clinical staging guides decisions about optimal treatment sequence in patients with gastric cancer, although the preoperative accuracy is not strongly established. This study investigates concordance of clinical and pathologic stage as well as its impact on the survival of patients with gastric adenocarcinoma.

Methods: Patients with clinical stage T2-4, N0, M0 gastric adenocarcinoma who underwent surgery without neoadjuvant therapy were identified from the National Cancer Database (2010-2015). Read More

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Bioaccessibility of Cd and its Correlation with Divalent Mineral Nutrients in Locally Grown Rice from Two Provinces in China.

Biol Trace Elem Res 2021 Apr 13. Epub 2021 Apr 13.

College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China.

Rice and rice products are the main sources of Cd contamination in humans. The total and bioaccessible concentrations of Cd and three divalent nutrients, Mn, Cu, and Zn, in locally grown rice grains from Hunan and Guangdong Provinces in China were investigated. An in vitro physiologically based extraction test method was introduced to evaluate the bioaccessibility of the target metals in the rice grains. Read More

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