Protein Pept Lett 2010 Sep;17(9):1155-62
Department of Protein Science & Engineering, Institute of Microbial Technology (IMTECH), Chandigarh 160036, India.
The lens protein, gamma B-crystallin, precipitates during cataract formation. As a recombinant protein, in aqueous solution, gamma B aggregates and precipitates upon heating, cooling, exposure to ultraviolet light, or refolding from a denatured state. We have studied soluble gamma B crystallin, as well as each of the above aggregated forms, to determine whether gamma B's polypeptide chain is differently organized in each form. Read More