23,978 results match your criteria gallstone


A Predictive Model for the Risk of Cognitive Impairment in Patients with Gallstones.

Biomed Res Int 2021 17;2021:3792407. Epub 2021 Jul 17.

Department of General Surgery, The First Affiliated Hospital of USTC, China.

Objectives: Gallstones can cause malnutrition in patients and further lead to cognitive impairment. This study is aimed at constructing a validated clinical prediction model for evaluating the risk of developing cognitive impairment from gallstones.

Methods: The study was a single-centre crosssectional study. Read More

View Article and Full-Text PDF

A Case of Gallstones Causing Pelvic Pain.

Case Rep Surg 2021 19;2021:5553994. Epub 2021 Jul 19.

Department of Surgery, Tamworth Base Hospital, 2340 Tamworth, New South Wales, Australia.

Introduction: Assessing abdominal pain, particularly in women of reproductive age, requires thorough history taking, clinical examination, and investigations to obtain an accurate diagnosis. Both surgical and gynecological causes need to be considered, particularly previous relevant surgical history. We report a case of pelvic pain secondary to multiple gallstones found within the pelvic cavity postlaparoscopic cholecystectomy. Read More

View Article and Full-Text PDF

Mutational Characteristics of Causative Genes in Chinese Hereditary Spherocytosis Patients: a Report on Fourteen Cases and a Review of the Literature.

Front Pharmacol 2021 16;12:644352. Epub 2021 Jul 16.

Pediatric Research Institute, Qilu Children's Hospital of Shandong University, Jinan, China.

Hereditary spherocytosis (HS), characterized by the presence of spherocytic red cells in peripheral blood, hemolysis, splenomegaly, jaundice, and gallstones, is a common form of inherited hemolytic anemia (HA). To date, five causative genes associated with HS have been identified, including , and . Clinically suspected patients with HS or undiagnosed HA from 14 Chinese families were enrolled in this study. Read More

View Article and Full-Text PDF

Abscess of the Ligamentum Teres: a Rare Entity.

Indian J Surg 2021 Jul 26:1-2. Epub 2021 Jul 26.

Neotia Getwel Hospital, Siliguri, 734011 West Bengal India.

Abscess of the ligamentum teres is one of the rarest causes of acute abdomen and causes severe dilemma and real challenge in clinching the diagnosis. A 69-year-old lady with severe upper abdominal pain with history of gall stones underwent MRI upper abdomen and was diagnosed as abscess of the ligamentum teres. There are only very few reported cases of this entity in the literature. Read More

View Article and Full-Text PDF

Impact of early cholecystectomy on the readmission rate in patients with acute gallstone cholangitis: a retrospective single-centre study.

BMJ Open Gastroenterol 2021 Jul;8(1)

Gastroenterology, SUNY Upstate Medical University, Syracuse, New York, USA.

Background And Aims: The pathogenesis of acute cholangitis (AC) occurs with biliary obstruction followed by bacterial growth in the bile duct. The leading cause of AC is obstructing gallstones. There have been conflicting theories about the optimal timing for cholecystectomy following AC. Read More

View Article and Full-Text PDF

Abdominal and gastrointestinal manifestations in COVID-19 patients: Is imaging useful?

World J Gastroenterol 2021 Jul;27(26):4143-4159

Diagnostic and Interventional Radiology, Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Pisa 56126, Italy.

Coronavirus disease 2019 (COVID-19) can be considered a systemic disease with a specific tropism for the vascular system, in which the alterations of the microcirculation have an important pathogenetic role. The lungs are the main organ involved in COVID-19, and severe progressive respiratory failure is the leading cause of death in the affected patients; however, many other organs can be involved with variable clinical manifestations. Concerning abdominal manifestations, the gastrointestinal tract and the hepatobiliary system are mainly affected, although the pancreas, urinary tract and spleen may also be involved. Read More

View Article and Full-Text PDF

Impact of Early Cholecystectomy on the Cost of Treating Mild Gallstone Pancreatitis: Gallstone PANC Trial.

J Am Coll Surg 2021 Jul 22. Epub 2021 Jul 22.

Department of Surgery, McGovern Medical School at the University of Texas Health Science Center, Houston, Texas; Center for Surgical Trials and Evidence-based Practice (CSTEP), McGovern Medical School at the University of Texas Health Science Center, Houston, Texas; Center for Clinical Research and Evidence-Based Medicine, McGovern Medical School at the University of Texas Health Science Center, Houston, Texas. Electronic address:

Background: The Gallstone Pancreatitis: Admission versus Normal Cholecystectomy (Gallstone PANC) Trial demonstrated that cholecystectomy within 24 hours of admission (early) compared to after clinical resolution (control) for mild gallstone pancreatitis significantly reduced 30-day length-of-stay (LOS) without increasing major postoperative complications. We assessed whether early cholecystectomy decreased 90-day healthcare utilization and costs.

Study Design: A secondary economic evaluation of the Gallstone PANC Trial was performed from the healthcare system perspective. Read More

View Article and Full-Text PDF

Association of Helicobacter pylori infection with colorectal adenoma in the Chinese urban population: A cross-sectional study.

Microb Pathog 2021 Jul 26;158:105111. Epub 2021 Jul 26.

Department of Gastroenterology, Geriatric Hospital of Nanjing Medical University, Nanjing, 210024, China. Electronic address:

Objection: Helicobacter pylori (H. pylori) infection is considered to increase the risk of colorectal adenoma (CRA) and remains controversial. In this study, we aimed to evaluate the association between H. Read More

View Article and Full-Text PDF

Mucosal Schwann Cell Hamartoma of the Gall Bladder.

J Indian Assoc Pediatr Surg 2021 May-Jun;26(3):182-183. Epub 2021 May 17.

Department of Paediatric Surgery and Pathology, AIIMS, Delhi, India.

Mucosal Schwann cell hamartoma (M-SCH) of the intestinal mucosa is a rare entity and incidental finding in histological examination. Histological characteristics are Schwannonian cell proliferation in lamina propria with S100-positivity. M-SCH-like lesion in the gall bladder is even rarer and is a recently reported entity. Read More

View Article and Full-Text PDF

Causal relationship from coffee consumption to diseases and mortality: a review of observational and Mendelian randomization studies including cardiometabolic diseases, cancer, gallstones and other diseases.

Eur J Nutr 2021 Jul 28. Epub 2021 Jul 28.

Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Borgmester Ib Juuls Vej 1, 2730, Herlev, Denmark.

Purpose: High coffee consumption is associated with low risk of mortality and morbidity, but the causality remains unclear. This review aims to discuss findings from observational studies on coffee consumption in context of Mendelian randomization studies.

Methods: The PubMed database was searched for all Mendelian randomization studies on coffee consumption and corresponding observational studies. Read More

View Article and Full-Text PDF

Gallstone extraction from a back abscess resulting from spilled gallstones during laparoscopic cholecystectomy: a case report.

J Surg Case Rep 2021 Jul 23;2021(7):rjab293. Epub 2021 Jul 23.

General Surgery, Croydon University Hospital, London, CR77YE, UK.

Laparoscopic cholecystectomy is a routinely performed surgery nowadays. However, it is associated with certain complications. Gall bladder perforation during the procedure can result in spilled and lost gallstones. Read More

View Article and Full-Text PDF

Bronchobiliary fistula: a rare postoperative complication of spilled gallstones from laparoscopic cholecystectomy.

BMJ Case Rep 2021 Jul 27;14(7). Epub 2021 Jul 27.

Radiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA

Bronchobiliary fistula (BBF) is defined as the abnormal connection between the biliary system and the bronchial tree, which presents clinically as an irritant cough with bilioptysis. Many conditions can lead to its development. We present a case of an acquired BBF in a 61-year-old man with a significant history of spilled gallstones from a prior laparoscopic cholecystectomy and subsequent presentation of intermittent right upper quadrant pain and recurrent pneumonia. Read More

View Article and Full-Text PDF

Acute oesophageal necrosis: an important differential in the elderly population with haematemesis.

BMJ Case Rep 2021 Jul 27;14(7). Epub 2021 Jul 27.

Gastroenterology, Southend University Hospital NHS Foundation Trust, Westcliff-on-Sea, UK.

Acute oesophageal necrosis is a rare cause of haematemesis associated with high mortality and morbidity in elderly patients with multiple comorbidities. Acute oesophageal necrosis is thought to be caused by a combination of hypoperfusion, vascular disease and duodenal disease causing transient gastric outlet obstruction and therefore reflux of gastric contents. The subsequent necrosis is associated with significant morbidity and mortality. Read More

View Article and Full-Text PDF

Magnetic Resonance Cholangiopancreatography (MRCP) in the Setting of Acute Pancreaticobiliary Disease: Can Certain Clinical Factors Guide Appropriate Utilization?

Can Assoc Radiol J 2021 Jul 27:8465371211025527. Epub 2021 Jul 27.

Radiology, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.

View Article and Full-Text PDF

Comparison of intraoperative endoscopic retrograde cholangiopancreatography and laparoscopic common bile duct exploration combined with laparoscopic cholecystectomy for treating gallstones and common bile duct stones: a systematic review and meta-analysis.

Surg Endosc 2021 Jul 26. Epub 2021 Jul 26.

The First Clinical Medicine College, Gansu University of Chinese Medicine, Lanzhou, 730000, China.

Background: This study aimed to compare the efficacy and safety of laparoscopic cholecystectomy combined with intraoperative endoscopic retrograde cholangiopancreatography (LC-IntraERCP) and laparoscopic cholecystectomy combined with laparoscopic common bile duct exploration (LC-LCBDE) to determine which one-stage therapeutic strategy provides better outcomes for patients with gallstones and common bile duct stones.

Methods: Cochrane Library, EMBASE, PubMed, and Web of Science databases were searched to identify eligible articles from the database inception to September 2020. The revised Cochrane risk of bias tools for randomized trials (RoB-2) and non-randomized interventions (ROBINS-I) was used to assess the quality of the included studies. Read More

View Article and Full-Text PDF

Management of gallstone-induced severe acute cholecystitis and pancreatitis in the second trimester of pregnancy during covid-19 pandemic: A case report.

Ann Med Surg (Lond) 2021 Aug 15;68:102563. Epub 2021 Jul 15.

Faculty of Medicine, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, 55281, Indonesia.

Introduction: Gallstone-induced severe acute cholecystitis with acute pancreatitis during pregnancy can be life-threatening both for the mother and fetus. Surgical approach is recommended in this complicated disease to prevent morbidity and mortality. During COVID-19 pandemic, additional precautions are needed when dealing with abdominal complaints. Read More

View Article and Full-Text PDF

Recent advances, novel targets and treatments for cholelithiasis; a narrative review.

Eur J Pharmacol 2021 Jul 22:174376. Epub 2021 Jul 22.

Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, 570 015, Karnataka, India. Electronic address:

Cholelithiasis is a common and frequent condition all over the world with a high prevalence rate in western countries. Individuals with cholesterol gallstone disease experience intense gastrointestinal symptoms and have a high risk of developing comorbidities like cholecystitis, Gall bladder (GB) cancer and pancreatitis. Multiple risk factors associated with cholesterol gallstones include but not limited to genetics, dietary habits, lifestyle changes, comorbid conditions and various drugs. Read More

View Article and Full-Text PDF

Gallstone Ileus with COVID-19 Infection: An Unintended Sequela of Non-Operative Management of Acute Cholecystitis During the COVID-19 Pandemic.

Clin Case Rep 2021 Jul 19;9(7):e04275. Epub 2021 Jul 19.

Department of Surgery Howard University Hospital and College of Medicine Washington DC USA.

Appropriate risk stratification and careful follow-up are mandated in elderly patients with comorbidities. Herein, we report a case presenting 5 months after the nonoperative management of acute cholecystitis during the height of the COVID-19 pandemic. Read More

View Article and Full-Text PDF

Cannabis-Induced Pancreatitis in a Young Adult Male.

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211035238

Kern Medical, Bakersfield, CA, USA.

Drugs account for 2% of all the causes of acute pancreatitis. To date, there are approximately 26 reported cases of acute pancreatitis associated with the use of cannabis. We report the case of a 20-year-old male who presented with intractable nausea, vomiting, and epigastric pain and a lipase level of 1541 with reportedly no alcohol use, and no evidence of medication, biliary, or autoimmune etiology. Read More

View Article and Full-Text PDF

Comparison of clinical characteristics and outcomes between alcohol-induced and gallstone-induced acute pancreatitis: An Australian retrospective observational study.

SAGE Open Med 2021 10;9:20503121211030837. Epub 2021 Jul 10.

Department of Intensive Care Medicine, Frankston Hospital, Frankston, VIC, Australia.

Objectives: To compare the characteristics and outcomes of patients presenting to hospital with alcohol-induced and gallstone-induced acute pancreatitis.

Methods: Retrospective study of all patients with alcohol-induced or gallstone-induced pancreatitis during the period 1 June 2012 to 31 May 2016. The primary outcome measure was hospital mortality. Read More

View Article and Full-Text PDF

Budget Impact of Restrictive Strategy Versus Usual Care for Cholecystectomy (SECURE-trial).

J Surg Res 2021 Jul 17;268:59-70. Epub 2021 Jul 17.

Department of Surgery, Radboud University Medical Centre, Nijmegen, the Netherlands. Electronic address:

Objectives: A cost-effectiveness analysis of a multicenter randomized-controlled trial comparing restrictive strategy versus usual care in patients with gallstones showed that savings by restrictive strategy could not compensate for the lower proportion of pain-free patients. However, four subgroups based on combined stratification factors resulted in less cholecystectomies and more pain-free patients in restrictive strategy (female-low volume-BMI > 30, female-low volume-BMI25-30, female-high volume-BMI25-30, and male-low volume-BMI < 25). The aim of this study was to explore the budget impact from a hospital healthcare perspective of implementation of restrictive strategy in these subgroups. Read More

View Article and Full-Text PDF

Association of Microbial Dysbiosis with Gallbladder Diseases Identified by Bile Microbiome Profiling.

J Korean Med Sci 2021 Jul 19;36(28):e189. Epub 2021 Jul 19.

Department of Surgery, Hanyang University College of Medicine, Seoul, Korea.

Background: Cholecystitis is an important risk factor for gallbladder cancer, but the bile microbiome and its association with gallbladder disease has not been investigated fully. We aimed to analyze the bile microbiome in normal conditions, chronic cholecystitis, and gallbladder cancer, and to identify candidate bacteria that play an important role in gallbladder carcinogenesis.

Methods: We performed metagenome sequencing on bile samples of 10 healthy individuals, 10 patients with chronic cholecystitis, and 5 patients with gallbladder cancer, and compared the clinical, radiological, and pathological characteristics of the participants. Read More

View Article and Full-Text PDF

Commentary on "Determining the optimal time interval for cholecystectomy in moderate to severe gallstone pancreatitis: A systematic review of published evidence" (Int J Surg 2020; 84:171-179).

Int J Surg 2021 Jul 16:106027. Epub 2021 Jul 16.

Department of Gastroenterology Gansu Provincial Hospital, Lanzhou, 730000, Gansu, China. Electronic address:

View Article and Full-Text PDF

[Acute and chronic pancreatitis-summary of the most common types of pancreatitis].

Pathologe 2021 Jul 19. Epub 2021 Jul 19.

Institut für Pathologie, Universitätsmedizin der JGU Mainz, Langenbeckstraße 1, 55131, Mainz, Deutschland.

Pancreatitis harbors a spectrum of different inflammatory changes of the pancreas of variable etiology and histopathology. In this context, common variants have to be distinguished from rare variants to optimize therapy. Each type of pancreatitis has characteristic features such as the age of patients and clinical presentation as well as the composition of the inflammatory infiltrates and histological changes. Read More

View Article and Full-Text PDF

Persistent Cannabis Abuse and Risk for Hospitalization for Acute Pancreatitis: A Cross-Sectional Study in United States Hospitals.

Cureus 2021 Jun 11;13(6):e15601. Epub 2021 Jun 11.

Psychiatry, Government Medical College, Amritsar, IND.

Objectives To explore the independent association between cannabis abuse and subsequent hospitalizations for acute pancreatitis (AP) and delineate the demographic differences among AP in patients with and without persistent cannabis abuse. Methods We conducted a retrospective cross-sectional study using the nationwide inpatient sample and included 50,444,133 patients (age 18-50 years) with a primary discharge diagnosis for medical illnesses and further grouped by presence of AP (N = 666,248). We used the logistic regression model to measure the odds ratio (OR) of the association between cannabis abuse and hospitalization for AP and adjusted it for demographic confounders and comorbid risk factors. Read More

View Article and Full-Text PDF

Polysaccharides Ameliorate Diet-Induced Gallstone Formation by Modulating Synthesis of Bile Acids and the Gut Microbiota.

Front Pharmacol 2021 1;12:701003. Epub 2021 Jul 1.

Digestive Endoscopic Center, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Cholesterol gallstone (CG) disease has relationships with several metabolic abnormalities. polysaccharides (APS) have been shown to have multiple benefits against metabolic disorders. We attempted to uncover the effect and mechanism of action of APS on diet-induced CG formation in mice. Read More

View Article and Full-Text PDF

Sodium butyrate alleviates cholesterol gallstones by regulating bile acid metabolism.

Eur J Pharmacol 2021 Jul 14;908:174341. Epub 2021 Jul 14.

Shanghai Jiao Tong University Affiliated Sixth People's Hospital, School of Medicine, Shanghai, China; Digestive Endoscopic Center, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, China. Electronic address:

Cholesterol overloading and bile acid metabolic disorders play an important role in the onset of cholesterol gallstone (CGS). Short-chain fatty acids (SCFAs) can regulate bile acid metabolism by modulating the gut microbiota. However, the role and mechanism by which sodium butyrate (NaB) targets bile acids to attenuate CGS are still unknown. Read More

View Article and Full-Text PDF

Abdominal distention and vomiting in 57-year-old man.

Am J Med 2021 Jul 14. Epub 2021 Jul 14.

Division of Gastroenterology and Hepatology, Taichung Armed Forces General Hospital, Taichung, Taiwan. Electronic address:

View Article and Full-Text PDF

Abscess of ligamentum teres hepatis: A case report.

Asian J Surg 2021 Jul 13. Epub 2021 Jul 13.

Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan Province, China. Electronic address:

View Article and Full-Text PDF

Clinical Characteristics and Prognosis of Idiopathic Acute Pancreatitis.

Rambam Maimonides Med J 2021 Jul 20;12(3). Epub 2021 Jul 20.

Internal Medicine Division F, Soroka University Medical Center, Beer-Sheva, Israel.

Objective: Acute pancreatitis is a serious diagnosis with an increasing incidence in the Western world. In this study we sought to investigate the incidence of idiopathic AP and to compare clinical and prognostic characteristics of idiopathic cases with cases of AP with known etiology.

Methods: In this retrospective study of adult hospitalized patients diagnosed with acute pancreatitis between 2012 and 2015, a comparison was made between admissions of patients with known etiology and those for whom no cause was found. Read More

View Article and Full-Text PDF