215 results match your criteria gains 149

Assessment of Isochromosome 12p & 12p Abnormalities in Germ Cell Tumors Using FISH, SNP-Arrays & NGS/ Mate-Pair Sequencing.

Hum Pathol 2021 Mar 30. Epub 2021 Mar 30.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA;. Electronic address:

The identification of isochromosome 12p [i(12p)] and 12p gains have significant clinical utility in the diagnosis of germ cell tumors (GCT). We have summarized the results of FISH assays to identify i(12p), performed in a Clinical Laboratory Improvement Amendments (CLIA)-validated setting for 536 specimens. In addition, the American Association for Cancer Research (AACR) Project GENIE registry & The Cancer Genome Atlas (TCGA) datasets were evaluated for chromosome 12p gains, and a limited number of cases were concurrently evaluated using FISH, SNP-arrays and NGS (including mate-pair sequencing). Read More

View Article and Full-Text PDF

Does resistance training promote enough muscular strength increases to move weak older women to better strength categories?

Exp Gerontol 2021 Mar 22;149:111322. Epub 2021 Mar 22.

Metabolism, Nutrition and Exercise Laboratory, Physical Education and Sport Center, State University of Londrina, Londrina, Brazil.

We compared the magnitude of muscular strength changes among older women occupants of different strength tertiles in response to progressive resistance-training (RT). Additionally, we examined the possibility of older women initially characterized as weak (occupants of the lower tertile of strength status) can achieve a higher muscular strength level to be inserted into a better category (middle or upper tertiles). The present investigation was attended by 113 physically independent older women (>60 years old). Read More

View Article and Full-Text PDF

Immersive virtual reality is effective in the rehabilitation of older adults with balance disorders: A randomized clinical trial.

Exp Gerontol 2021 Mar 18;149:111308. Epub 2021 Mar 18.

Health Sciences, Physiology Department, Health Sciences Graduate Program (PPGCS), Federal University of Sergipe, Aracaju, SE, Brazil.

Question: What are the effects of immersive virtual reality (IVR) training compared to conventional physiotherapy on body balance and risk of falls in older adults with balance disorders?

Design: A randomized controlled trial with two intervention arms, concealed allocation, per-protocol analysis, and blinded assessment.

Participants: Thirty-seven older adults with balance disorders and risk of falling.

Intervention: Participants were randomized into two groups: a control group, which received balance training with conventional physiotherapy using multimodal circuit exercises, and an experimental group, which received balance training using immersive virtual reality. Read More

View Article and Full-Text PDF

Anteromedial versus posterolateral hip musculature strengthening with dose-controlled in women with patellofemoral pain: A randomized controlled trial.

Phys Ther Sport 2021 Mar 2;49:149-156. Epub 2021 Mar 2.

Knee and Sports Research Group, Physical Therapy Department, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil; Master Program in Physical Therapy and Functioning, Physical Therapy Department, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.

Objective: To compare the effectiveness of adding anteromedial versus posterolateral hip musculature strengthening to knee strengthening in women with patellofemoral pain (PFP).

Design: Randomized controlled trial.

Setting: University physiotherapy clinic. Read More

View Article and Full-Text PDF

The FamilyTalk randomized controlled trial: patient-reported outcomes in clinical genetic sequencing for colorectal cancer.

Cancer Causes Control 2021 May 16;32(5):483-492. Epub 2021 Feb 16.

Departments of Medicine (Medical Genetics) and Genome Sciences, University of Washington Medical Center, Seattle, WA, USA.

As genetics gains favor in clinical oncology, it is important to address patient concerns around confidentiality, privacy, and security of genetic information that might otherwise limit its utilization. We designed a randomized controlled trial to assess the social impact of an online educational tool (FamilyTalk) to increase family communication about colorectal cancer (CRC) risk and screening. Of 208 randomized participants, 149 (71. Read More

View Article and Full-Text PDF

Repetitive Negative Thinking outperforms loneliness and lack of social connectedness as a predictor of prospective depressive symptoms in adolescents.

Scand J Child Adolesc Psychiatr Psychol 2020 3;8:149-156. Epub 2020 Oct 3.

Department of Developmental, Personality and Social Psychology, Ghent University, Belgium.

Background: Repetitive Negative Thinking (RNT) is a well-established predictor in adolescents of emotional problems, such as depression. Surprisingly little research, however, has looked at the relative importance of RNT vs. more interpersonally relevant variables in the context of depression, such as loneliness and lack of social connectedness. Read More

View Article and Full-Text PDF
October 2020

Results of the Behavioral Health Readiness Evaluation and Decision-Making Instrument Study.

Mil Med 2021 01;186(Suppl 1):142-152

Department of Military Psychiatry, Walter Reed Army Institute of Research, Silver Spring, MD, 20910, USA.

Introduction: Recent reports have demonstrated behavioral health (BH) system and individual provider challenges to BH readiness success. These pose a risk to winning on the battlefield and present a significant safety issue for the Army. One of the most promising areas for achieving better BH readiness results lies in improving readiness decision-making support for BH providers. Read More

View Article and Full-Text PDF
January 2021

The Quality of Infectious Disease Hospital Websites in Poland in Light of the COVID-19 Pandemic.

Int J Environ Res Public Health 2021 01 13;18(2). Epub 2021 Jan 13.

Department of Economics and Informatics, Faculty of Organization and Management, Silesian University of Technology in Gliwice, 2A AkademickaStreet, 44-100 Gliwice, Poland.

The quality of healthcare service websites gains particular importance in the time of the pandemic, asthe popularity of electronic services grows. This applies to infectious disease hospitals as well, often on the front line of the effort against COVID-19. The paper aims to assess the quality of infectious disease hospital websites in Poland in light of the COVID-19 pandemic. Read More

View Article and Full-Text PDF
January 2021

Matching action to need: an analysis of Global Burden of Disease 2017 and population health data to focus adolescent health policy and actions in Myanmar.

Glob Health Action 2021 Jan;14(1):1844976

Burnet Institute , Melbourne, Australia.

: Myanmar is a country undergoing rapid transitions in health. Its national strategic policy for young people's health is being revised but there is a paucity of population data to inform local priorities and needs. : In this paper we describe a comprehensive profile of adolescent health in Myanmar to focus policy and health actions. Read More

View Article and Full-Text PDF
January 2021

Cost-effectiveness analysis of robotic-assisted versus retropubic radical prostatectomy: a single cancer center experience.

J Robot Surg 2021 Jan 8. Epub 2021 Jan 8.

Head of Urology Division, ACCamargo Cancer Center, São Paulo, Brazil.

Prostate cancer (PCa) treatment has been greatly impacted by the robotic surgery. The economics literature about PCa is scarce. We aim to carry-out cost-effectiveness and cost-utility analyses of the robotic-assisted radical prostatectomy (RALP) using the "time-driven activity-based cost" methodology. Read More

View Article and Full-Text PDF
January 2021

Neural evidence of dysfunction of reward processing in women with premenstrual syndrome.

Neuropsychologia 2020 12 5;149:107669. Epub 2020 Nov 5.

Department of Psychology, Nanjing University, Nanjing, 210023, China. Electronic address:

Background: Most studies on the mechanism behind premenstrual syndrome (PMS) have focused on negative emotional overreaction, but little evidence exists regarding the weakening of positive emotions. Given the close relationship between positive emotions and reward processing, the aim of this study is to investigate the dysfunction of reward processing in women with PMS.

Method: Seventeen women with PMS and seventeen healthy women were scanned during a card guessing task in the late luteal phase. Read More

View Article and Full-Text PDF
December 2020

School as a Protective Setting for Excess Weight Gain and Child Obesity: A Meta-Analysis.

J Sch Health 2021 Jan 5;91(1):19-28. Epub 2020 Nov 5.

Loyola University Chicago, 1032 W. Sheridan Rd, Chicago, IL 60660.

Background: The structure provided by school settings even with no specific obesity-intervention may prevent weight gain. This meta-analytic study considered this premise by examining weight outcomes from control groups in published randomized controlled trials of school-year obesity-related interventions conducted in-school and out-of-school.

Methods: A systematic review and random-effects meta-analysis were conducted in accordance with Preferred Reporting Items of Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Read More

View Article and Full-Text PDF
January 2021

Evaluation of endocrine therapy and patients preferences in early breast cancer: results of Elena study.

Breast Cancer Res Treat 2020 Dec 14;184(3):783-795. Epub 2020 Sep 14.

Division of Senology, IEO, European Institute of Oncology IRCCS, Milan, Italy.

Purpose: The development of the adjuvant therapy requires that clinicians and patients should discuss the magnitude of benefit of treatment for individual patient, estimating the pros and cons and the personal preferences. The aim of the present study was to determine the preferences of women treated with adjuvant hormonal therapy (HT) for breast cancer.

Methods: The analyses were conducted into three different groups of early breast cancer patients to evaluate the survival benefit needed to make treatment worthwhile before starting HT (A), after a few months from the beginning (B) and after several years of HT (C). Read More

View Article and Full-Text PDF
December 2020

Trauma-informed care training with HIV and related community service workers: Short and long term effects on attitudes.

Psychol Serv 2020 Jul 2. Epub 2020 Jul 2.

Traumatic Stress Institute of Klingberg Family Centers.

Although the experience of trauma is a widespread, global phenomenon, individuals living with HIV, who are two-spirit, lesbian, gay, bisexual, transgender, queer+ (2SLGBTQ+), who use injection drugs, and/or who have marginalized status, are disproportionately affected (Harris & Fallot, 2006; Hopper, Bassuk, & Olivet, 2009; Seedat, 2012). The need for trauma competent service provision, meaning integrating psychoeducation about trauma, and knowledge of its prevalence, impact, and outcomes, is clear. Numerous HIV service and affiliated agencies in Ontario requested a Trauma-Informed Care workshop for their staff and volunteers, and the current project reports on the outcomes of this workshop. Read More

View Article and Full-Text PDF

Physician preferences for non-metastatic castration-resistant prostate cancer treatment.

BMC Urol 2020 Jun 22;20(1):73. Epub 2020 Jun 22.

Bayer U.S. LLC, Whippany, NJ, USA.

Background: Recent approvals of second-generation androgen receptor inhibitors (SGARIs) have changed the treatment landscape for non-metastatic castration-resistant prostate cancer (nmCRPC). These SGARIs have similar efficacy but differ in safety profiles. We used a discrete choice experiment to explore how United States physicians make treatment decisions between adverse events (AEs) and survival gains in nmCRPC, a largely asymptomatic disease. Read More

View Article and Full-Text PDF

Cost-Utility Analysis of VEGF Inhibitors for Treating Neovascular Age-Related Macular Degeneration.

Am J Ophthalmol 2020 10 19;218:225-241. Epub 2020 Jun 19.

Retina-Vitreous Associates Medical Group, Los Angeles, California, USA.

Purpose: To perform 11- and 2-year health care sector (ophthalmic) and societal cost perspective reference case, cost-utility analyses comparing bevacizumab, ranibizumab, and aflibercept monotherapies for neovascular age-related macular degeneration (NVAMD).

Design: Cost-utility analysis.

Methods: The authors performed 11-year and 2-year ophthalmic and societal cost perspective, cost-utility analyses comparing bevacizumab, ranibizumab, and aflibercept monotherapies for neovascular age-related macular degeneration (NVAMD). Read More

View Article and Full-Text PDF
October 2020

Repeated episodes of pediatric constraint induced movement therapy with a gross motor training component: A prospective cohort study.

J Pediatr Rehabil Med 2020 ;13(2):149-159

Children's Minnesota Research Institute, Children's Minnesota, Minneapolis, MN, USA.

Purpose: To examine the results of repeated episodes of 21-day pediatric constraint induced movement therapy (PCIMT) paired with gross motor training (GMT).

Methods: Nineteen children, age 14 months - 6 years with unilateral upper extremity impairment enrolled in this cohort study to receive repeated episodes of 21 day PCIMT-GMT. Outcome measures included the Peabody Developmental Motor Scales-2 (PDMS-2), the Assisting Hand Assessment (AHA) and the Canadian Occupational Performance Measure (COPM). Read More

View Article and Full-Text PDF
January 2020

Controlled case series demonstrates how parents can be trained to treat paediatric feeding disorders at home.

Acta Paediatr 2021 01 3;110(1):149-157. Epub 2020 Jun 3.

Paediatric Feeding International, Sydney, NSW, Australia.

Aim: Paediatric feeding disorders are normally managed by specialist clinics. We examined whether treatment gains were maintained when trained parents continued the programme at home and during meals out.

Methods: This controlled consecutive case series recruited 26 children (22 boys) with avoidant/restrictive food intake disorder, from a private paediatric feeding disorders practice in New South Wales, Australia. Read More

View Article and Full-Text PDF
January 2021

Intercomparison of crop establishment methods for improving yield and profitability in the rice-wheat system of Eastern India.

Field Crops Res 2020 May;250:107776

International Maize and Wheat Improvement Centre, NASC Complex, New Delhi, India.

Conventionally managed rice-wheat systems of the eastern Indo-Gangetic Plains (E-IGP) that rely on soil puddling for rice and intensive tillage for wheat are low-yielding and resource-inefficient, leading to low profitability. While a host of alternative tillage and crop establishment (TCE) methods have been advocated as solutions for sustainably enhancing productivity and profitability, few systematic comparisons of these methods are reported. To address this gap, a three-year field study was conducted in Bihar, India with the goal of identifying TCE methods for rice-wheat systems that are high yielding, less resource-intensive, and more profitable. Read More

View Article and Full-Text PDF

Characterization of chickpea genotypes of Pakistani origin for genetic diversity and zinc grain biofortification.

J Sci Food Agric 2020 Aug 19;100(11):4139-4149. Epub 2020 May 19.

Department of Crop Sciences, College of Agricultural and Marine Sciences, Sultan Qaboos University, Al Khoudh, Oman.

Background: Intake of food low in essential minerals, like zinc (Zn), is one of the major reasons of malnutrition. Development of genotypes with grains enriched in essential minerals may help to solve the issue of malnutrition. In this study, 16 chickpea genotypes (eight each of desi and kabuli types) of Pakistani origin were evaluated for genetic diversity and grain Zn biofortification potential with and without Zn fertilization. Read More

View Article and Full-Text PDF

Children's exposure to spatial language promotes their spatial thinking.

J Exp Psychol Gen 2020 Jun 26;149(6):1116-1136. Epub 2020 Mar 26.

Department of Human Development.

Does spatial language contribute to the growth of preschool children's spatial skills? Four-year-old children (N = 50) were randomly assigned to a play-only (n = 24) or a spatial-language and play condition (n = 26). Their mental rotation and spatial vocabulary were assessed at baseline and several days after 5 play sessions. Children in the spatial-language condition scored higher at posttest on a mental rotation task than those in the play-only condition. Read More

View Article and Full-Text PDF

Patient Experience Captured by Quality-of-Life Measurement in Oncology Clinical Trials.

JAMA Netw Open 2020 03 2;3(3):e200363. Epub 2020 Mar 2.

Division of Hematology Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland.

Importance: Quality of life (QoL) is an important consideration in cancer medicine, especially because drugs are becoming more costly and may only result in modest gains in overall survival. However, there has been no descriptive analysis for the points at which QoL is measured in cancer trials.

Objective: To estimate the prevalence of studies that measure QoL at different points and see how many studies measure QoL for the entirety of a patient's life. Read More

View Article and Full-Text PDF

What influence does resistance exercise order have on muscular strength gains and muscle hypertrophy? A systematic review and meta-analysis.

Eur J Sport Sci 2021 Feb 28;21(2):149-157. Epub 2020 Feb 28.

Metabolism, Nutrition, and Exercise Laboratory, Physical Education and Sport Center, Londrina State University, Londrina, Brazil.

The objectives of this paper were to: (a) systematically review studies that explored the effects of exercise order (EO) on muscular strength and/or hypertrophy; (b) pool their results using a meta-analysis; and (c) provide recommendations for the prescription of EO in resistance training (RT) programmes. A literature search was performed in four databases. Studies were included if they explored the effects of EO on dynamic muscular strength and/or muscle hypertrophy. Read More

View Article and Full-Text PDF
February 2021

Examining Heterogeneity of Outcomes in a Weight Gain Prevention Program for Young Adults.

Obesity (Silver Spring) 2020 03 6;28(3):521-528. Epub 2020 Feb 6.

Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Miriam Hospital, Providence, Rhode Island, USA.

Objective: This study aimed to characterize young adults who experienced significant weight gains (> 10%) over 3 years in a weight gain prevention program.

Methods: Secondary data analysis from the Study of Novel Approaches to Weight Gain Prevention (SNAP), a randomized trial comparing two self-regulation interventions and a control arm in young adults (18-35 years; BMI 21-30.9 kg/m ), was used. Read More

View Article and Full-Text PDF

Age differences in risk attitude are shaped by option complexity.

J Exp Psychol Gen 2020 Sep 6;149(9):1644-1683. Epub 2020 Feb 6.

Center for Adaptive Rationality.

The canonical conclusion from research on age differences in risky choice is that older adults are more risk averse than younger adults, at least in choices involving gains. Most of the evidence for this conclusion derives from studies that used a specific type of choice problem: choices between a safe and a risky option. However, safe and risky options differ not only in the degree of risk but also in the amount of information to be processed-that is, in their complexity. Read More

View Article and Full-Text PDF
September 2020

Short-term exposure to ambient fine particulate matter and out-of-hospital cardiac arrest: a nationwide case-crossover study in Japan.

Lancet Planet Health 2020 01;4(1):e15-e23

Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia; Department of Cardiology, Graduate School of Medicine, Gunma University, Maebashi, Japan; Department of Cardiology, Sydney Medical School Nepean, Faculty of Medicine and Health, Charles Perkins Centre Nepean, The University of Sydney, Kingswood, NSW, Australia. Electronic address:

Background: PM is an important but modifiable environmental risk factor, not only for pulmonary diseases and cancers, but for cardiovascular health. However, the evidence regarding the association between air pollution and acute cardiac events, such as out-of-hospital cardiac arrest (OHCA), is inconsistent, especially at concentrations lower than the WHO daily guideline (25 μg/m). This study aimed to determine the associations between exposure to ambient air pollution and the incidence of OHCA. Read More

View Article and Full-Text PDF
January 2020

Guess who? Facial identity discrimination training improves face memory in typically developing children.

J Exp Psychol Gen 2020 May 3;149(5):901-913. Epub 2019 Oct 3.

College of Health and Life Sciences.

While vast individual differences in face recognition have been observed in adults, very little work has explored when these differences come online during development, their domain specificity, and their consistency across different aspects of face processing. These issues do not only have important theoretical implications for the cognitive and developmental psychological literatures, but may reveal critical windows of neuroplasticity for optimal remediation of face recognition impairments. Here, we describe the first formal remedial face training program that is suitable for children, modifying the popular game . Read More

View Article and Full-Text PDF

Resistance training-induced gains in knee extensor strength are related to increased neural cell adhesion molecule expression in older adults with knee osteoarthritis.

BMC Res Notes 2019 Sep 18;12(1):595. Epub 2019 Sep 18.

Department of Medicine, College of Medicine, University of Vermont, Burlington, VT, USA.

Objective: Resistance training (RT) can improve whole muscle strength without increasing muscle fiber size or contractility. Neural adaptations, which lead to greater neural activation of muscle, may mediate some of these improvements, particularly in older adults, where motor neuron denervation is common. The purpose of this study was to explore the relationship of neural adaptations, as reflected by neural cell adhesion molecule (NCAM) expression, to improvements in (1) whole muscle strength and (2) muscle fiber size following RT in older adults with knee osteoarthritis. Read More

View Article and Full-Text PDF
September 2019

Getting Addiction Into the Nursing Education "Water Supply": A U.K. Case Study.

J Addict Nurs 2019 Jul/Sep;30(3):149-158

Carmel Clancy, PhD, RGN, RMN, BSc (Hons), PG Cert HE, FPH, ICAPIII, Department of Mental Health and Social Work, School of Health and Education, Middlesex University, London, UK. Adenekan Oyefeso, PhD, MSc, BSc (Hons), CPsychol AFBPsS, Jeesal Group, Norwich, UK.

Evidence remains fundamentally unchanged over the last 30 years that nurses are not sufficiently prepared during their undergraduate education to work with alcohol and other drug (AOD) use. Employing a mixed-methods longitudinal panel design, our study objectives were to (a) explore perceptions among entry level nursing students regarding AOD work and (b) explore whether current alcohol and drug education efforts impact on the perception of AOD by nursing students over time. Two hundred forty-two students were recruited (94% response rate). Read More

View Article and Full-Text PDF
February 2020

Effects of assistive technology for students with reading and writing disabilities.

Disabil Rehabil Assist Technol 2021 Feb 16;16(2):196-208. Epub 2019 Aug 16.

Department of Mathematical Science, Chalmers University of Technology, Göteborg, Sweden.

Background: Assistive technology has been used to mitigate reading disabilities for almost three decades, and tablets with text-to-speech and speech-to-text apps have been introduced in recent years to scaffold reading and writing. Few scientifically rigorous studies, however, have investigated the benefits of this technology.

Purpose: The aim was to explore the effects of assistive technology for students with severe reading disabilities. Read More

View Article and Full-Text PDF
February 2021