Immunobiology 2021 Mar 20;226(3):152088. Epub 2021 Mar 20.
Department for Hematopoietic Transplantations, Med III, University Hospital of Munich, Germany; Helmholtz Center, Munich, Clinical Cooperative Group Human Cell Transplantation (CCG-HCT), Germany. Electronic address:
Dendritic cells (DC) and T-cells are mediators of CTL-responses. Autologous (from patients with acute myeloid leukaemia (AML) or myelodysplasia (MDS)) or allogeneic (donor)-T-cells stimulated by DC, gain an efficient lysis of naive blasts, although not in every case. CXCL8, -9, -10, CCL2, -5 and Interleukin (IL-12) were quantified by Cytometric Bead Array (CBA) in supernatants from 5 DC-generating methods and correlated with AML-/MDS-patients' serum-values, DC-/T-cell-interactions/antileukemic T-cell-reactions after mixed lymphocyte culture (MLC) and patients' clinical course. Read More