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Conversion of AML-blasts to leukemia-derived dendritic cells (DCleu) in 'DC-culture-media' shifts correlations of released chemokines with antileukemic T-cell reactions.

Immunobiology 2021 Mar 20;226(3):152088. Epub 2021 Mar 20.

Department for Hematopoietic Transplantations, Med III, University Hospital of Munich, Germany; Helmholtz Center, Munich, Clinical Cooperative Group Human Cell Transplantation (CCG-HCT), Germany. Electronic address:

Dendritic cells (DC) and T-cells are mediators of CTL-responses. Autologous (from patients with acute myeloid leukaemia (AML) or myelodysplasia (MDS)) or allogeneic (donor)-T-cells stimulated by DC, gain an efficient lysis of naive blasts, although not in every case. CXCL8, -9, -10, CCL2, -5 and Interleukin (IL-12) were quantified by Cytometric Bead Array (CBA) in supernatants from 5 DC-generating methods and correlated with AML-/MDS-patients' serum-values, DC-/T-cell-interactions/antileukemic T-cell-reactions after mixed lymphocyte culture (MLC) and patients' clinical course. Read More

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Anti-GPR56 monoclonal antibody potentiates GPR56-mediated Src-Fak signaling to modulate cell adhesion.

J Biol Chem 2021 Jan 8;296:100261. Epub 2021 Jan 8.

The Brown Foundation Institute of Molecular Medicine and Center for Translational Cancer Research, University of Texas Health Science Center at Houston, Houston, Texas, USA. Electronic address:

GPR56 is a member of the adhesion G-protein-coupled receptor family shown to play important roles in cell adhesion, brain development, immune function, and tumorigenesis. GPR56 is highly upregulated in colorectal cancer and correlates with poor prognosis. Several studies have shown GPR56 couples to the Gα class of heterotrimeric G-proteins to promote RhoA activation. Read More

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January 2021

Atherogenic Dyslipidemia After Liver Transplantation: Mechanisms and Clinical Implications.

Liver Transpl 2021 Apr 10. Epub 2021 Apr 10.

Department of Gastroenterology, Nutrition and Hepatology, Virginia Commonwealth University, Richmond, VA, United States.

Cardiovascular disease (CVD), particularly atherosclerosis-associated CVD, is a major cause of long-term mortality after liver transplantation (LT). The liver is central in lipid homeostasis and changes associated with insulin resistance, weight gain, adipose tissue inflammation, and development of nonalcoholic fatty liver disease after LT promote atherogenesis. These factors synergistically alter lipid homeostasis, thereby leading to production of pro-atherogenic lipoproteins, which contribute to heighted risk of CVD associated events observed in LT recipients. Read More

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WBP2 negatively regulates the Hippo pathway by competitively binding to WWC3 with LATS1 to promote non-small cell lung cancer progression.

Cell Death Dis 2021 Apr 9;12(4):384. Epub 2021 Apr 9.

Department of Pathology, College of Basic Medical Sciences and the First Affiliated Hospital of China Medical University, Shenyang, China.

WW domain binding protein-2 (WBP2) can function as a Yes-associated protein/transcriptional co-activator with PDZ-binding motif (YAP/TAZ) co-activator and has a crucial role in promoting breast cancer progression. However, the expression and potential molecular mechanisms of WBP2 in the context of lung cancer are not fully understood. We determined that WBP2 was highly expressed in lung cancer specimens and cell lines and that this expression was closely related to the advanced pTNM stage, lymph node metastasis, and poor prognosis of patients. Read More

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The Hsp70 chaperone system: distinct roles in erythrocyte formation and maintenance.

Haematologica 2021 Apr 8. Epub 2021 Apr 8.

Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria.

Erythropoiesis is a tightly regulated cell differentiation process in which specialized oxygen- and carbon dioxide-carrying red blood cells are generated in vertebrates. Extensive reorganization and depletion of the erythroblast proteome leading to the deterioration of general cellular protein quality control pathways and rapid hemoglobin biogenesis rates could generate misfolded/aggregated proteins and trigger proteotoxic stresses during erythropoiesis. Such cytotoxic conditions could prevent proper cell differentiation resulting in premature apoptosis of erythroblasts (ineffective erythropoiesis). Read More

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Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosis.

Atherosclerosis 2021 Mar 25;324:58-68. Epub 2021 Mar 25.

School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551. Electronic address:

Background And Aims: Aging is the primary risk factor for cardiovascular disease (CVD), but the mechanisms underlying age-linked atherosclerosis remain unclear. We previously observed that long-lived vascular matrix proteins can acquire 'gain-of-function' isoDGR motifs that might play a role in atherosclerotic pathology.

Methods: IsoDGR-specific mAb were generated and used for ELISA-based measurement of motif levels in plasma samples from patients with coronary artery diseases (CAD) and non-CAD controls. Read More

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Effect of self-care intervention for controlling interdialytic weight gain among patients on haemodialysis: A systematic review and meta-analysis.

J Clin Nurs 2021 Apr 7. Epub 2021 Apr 7.

College of Nursing Science, East-West Nursing Research Institute, Kyung Hee University, Seoul, Korea.

Aims And Objectives: This study aims to identify the combined effects of self-care or self-management nursing interventions on primary (interdialytic weight gain) and secondary (potassium, phosphorous, self-care and self-efficacy) outcomes in haemodialysis patients with chronic kidney disease.

Background: Prior systematic reviews and meta-analyses revealed inconclusive evidence regarding the effects of self-care or self-management nursing interventions among the patients on haemodialysis. Also, insufficient or unclear descriptions of methods resulted in weak empirical evidence of such effects. Read More

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Longitudinal associations of fruit juice intake in infancy with DXA-measured abdominal adiposity in mid-childhood and early adolescence.

Am J Clin Nutr 2021 Apr 7. Epub 2021 Apr 7.

Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.

Background: Excessive abdominal adiposity is associated with health risks in children and adults. Higher consumption of fruit juice and other sources of fructose has been shown to promote weight gain and specifically visceral adiposity in adulthood.

Objectives: We aimed to examine the longitudinal associations of fruit juice intake in infancy with visceral adiposity in mid-childhood and early adolescence. Read More

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Knowledge and behavior of consumers towards the non-prescription purchase of antibiotics: An insight from a qualitative study from New Delhi, India.

Pharm Pract (Granada) 2021 Jan-Mar;19(1):2206. Epub 2021 Mar 22.

MTech. (Biotechnol). Junior Research Fellow. Pharmacology Department, Vallabhbhai Patel Chest Institute (VPCI), University of Delhi. Delhi (India).

Background: In Low-and Middle-Income Countries, including India, consumers often purchase antibiotics over-the-counter (OTC) from retail pharmacies. This practice leads to the inappropriate use of antibiotics in the community which is an important driver for the development of antimicrobial resistance. A better understanding of consumers' views towards this grave public health concern is critical to developing evidence-based intervention programs for awareness among the general population. Read More

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Long Non-Coding RNA LINC00313 Accelerates Cervical Carcinoma Progression by miR-4677-3p/CDK6 Axis.

Onco Targets Ther 2021 29;14:2213-2226. Epub 2021 Mar 29.

Department of Radiological Intervention, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu Province, People's Republic of China.

Background: Cervical cancer is one of the most common gynecologic tumors. Evidence is accumulating that long non-coding RNAs participate in the pathogenesis of cancers, but the expression and role of lncRNA LINC00313 in cervical carcinoma is not reported.

Methods: We measured the expression levels of LINC00313 in clinical samples of cervical carcinoma and investigated the function of LINC00313 in the regulation of proliferation, metastasis, and EMT. Read More

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The miR396-GRFs Module Mediates the Prevention of Photo-oxidative Damage by Brassinosteroids during Seedling De-Etiolation in Arabidopsis.

Plant Cell 2020 Aug;32(8):2525-2542

The Key Laboratory of Plant Development and Environmental Adaptation Biology, Ministry of Education, School of Life Science, Shandong University, 266237 Qingdao, China.

The switch from dark- to light-mediated development is critical for the survival and growth of seedlings, but the underlying regulatory mechanisms are incomplete. Here, we show that the steroids phytohormone brassinosteroids play crucial roles during this developmental transition by regulating chlorophyll biosynthesis to promote greening of etiolated seedlings upon light exposure. Etiolated seedlings of the brassinosteroids-deficient det2-1 (de-etiolated2) mutant accumulated excess protochlorophyllide, resulting in photo-oxidative damage upon exposure to light. Read More

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ATF3 Suppresses Growth and Metastasis of Clear Cell Renal Cell Carcinoma by Deactivating EGFR/AKT/GSK3β/β-Catenin Signaling Pathway.

Front Cell Dev Biol 2021 19;9:618987. Epub 2021 Mar 19.

Department of General Surgery, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, China.

Background: Clear cell renal cell carcinoma (ccRCC) is one of the most common malignant cancers in East Asia, with high incidence and mortality. Accumulating evidence has shown that ATF3 is associated with tumor progression.

Methods: Using qPCR, the expression of ATF3 was detected in 93 patients with ccRCC, including 24 paired normal and tumor tissues, which were used to further compare ATF3 expression through western blotting and immunohistochemistry. Read More

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TMPRSS4 Promotes Cell Proliferation and Inhibits Apoptosis in Pancreatic Ductal Adenocarcinoma by Activating ERK1/2 Signaling Pathway.

Front Oncol 2021 18;11:628353. Epub 2021 Mar 18.

Department of Hepatobiliary Surgery I, Zhujiang Hospital, Southern Medical University, Guangzhou, China.

Transmembrane protease serine 4 (TMPRSS4) is upregulated in various kinds of human cancers, including pancreatic cancer. However, its biological function in pancreatic ductal adenocarcinoma (PDAC) remains unclear. In the current study, real-time qPCR, immunohistochemical staining, Western blotting, and database (Cancer Genome Atlas and Gene Expression) analysis revealed remarkable overexpression of TMPRSS4 in PDAC tissue as compared to non-tumor tissue. Read More

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LINC00176 facilitates CD4T cell adhesion in systemic lupus erythematosus via the WNT5a signaling pathway by regulating WIF1.

Mol Immunol 2021 Apr 2;134:202-209. Epub 2021 Apr 2.

Department of Anesthesiology, The Second Hospital of Jilin University, Changchun, 130041, PR China. Electronic address:

Accruing research shows the implications of long non-coding RNAs (lncRNAs) in the progression of various autoimmune diseases including systemic lupus erythematosus (SLE). The present study aimed to identify the expression pattern of LINC00176 in SLE and to explore its effects on CD4T cell adhesion in this context. The biological functions of LINC00176, WIF1 and WNT5a on CD4T cells in SLE were evaluated via gain- and loss-of-function experiments, following delivery of pcDNA3-LINC00176, siRNA-LINC00176, pcDNA3-WIF1 and WNT-sFRP5 (an inhibitor for the WNT5a signaling pathway). Read More

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A novel auxiliary agarolytic pathway expands metabolic versatility in agar-degrading marine bacterium A3.

Appl Environ Microbiol 2021 Apr 2. Epub 2021 Apr 2.

Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Korea

Marine microorganisms encode a complex repertoire of carbohydrate-active enzymes (CAZymes) for the catabolism of algal cell wall polysaccharides. While the core enzyme cascade for degrading agar is conserved across agarolytic marine bacteria, gain of novel metabolic functions can lead to the evolutionary expansion of the gene repertoire. Here, we describe how two less abundant GH96 α-agarases harbored in the agar specific polysaccharide utilization locus (PUL) of A3 facilitate the versatility of the agarolytic pathway. Read More

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Implications of Tributyrin on Gut Microbiota Shifts Related to Performances of Weaning Piglets.

Microorganisms 2021 Mar 12;9(3). Epub 2021 Mar 12.

Department for Sustainable Food Process (DiSTAS), Università Cattolica del Sacro Cuore, via E. Parmense 84, 29122 Piacenza, Italy.

Alternatives to antibiotic treatments are required owing to the ban on the use of these drugs as growth promoters in food animal production. Tributyrin appears to play a role in improving growth performance in pigs, albeit with varying degrees of effectiveness. So far, very little is known about its effects on gut microbiota composition. Read More

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Impacts of the New Worldwide Light-Duty Test Procedure on Technology Effectiveness and China's Passenger Vehicle Fuel Consumption Regulations.

Int J Environ Res Public Health 2021 Mar 19;18(6). Epub 2021 Mar 19.

State Key Laboratory of Automotive Safety and Energy, Tsinghua University, Beijing 100084, China.

As a main measure to promote the development of China's energy-saving and new energy vehicles, the Phase V fuel consumption regulation is dramatically different from the past four phases, especially in the test procedure, moving from the New European Driving Cycle (NEDC) to the worldwide harmonized light duty test cycle (WLTC) and corresponding test procedure (WLTP). The switch of test procedure will not only affect the effectiveness of technologies but also change the fuel consumption target of the industry. However, few studies have systematically investigated the impacts of the new WLTP on the Chinese market. Read More

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Epithelial Mutant p53 Promotes Resistance to Anti-PD-1-Mediated Oral Cancer Immunoprevention in Carcinogen-Induced Mouse Models.

Cancers (Basel) 2021 Mar 23;13(6). Epub 2021 Mar 23.

Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Oral squamous cell carcinoma (OSCC) develops through the multistep malignant progression of squamous epithelium. This process can be prevented by PD-1 blockade in a mouse model for oral carcinogenesis. OSCCs exhibit a high incidence of mutations that confer oncogenic gain-of-function (GOF) activities that promote resistance to standard therapies and poor clinical outcomes. Read More

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Optimal Preclinical Conditions for Using Adult Human Multipotent Neural Cells in the Treatment of Spinal Cord Injury.

Int J Mol Sci 2021 Mar 4;22(5). Epub 2021 Mar 4.

Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul 06351, Korea.

Stem cell-based therapeutics are amongst the most promising next-generation therapeutic approaches for the treatment of spinal cord injury (SCI), as they may promote the repair or regeneration of damaged spinal cord tissues. However, preclinical optimization should be performed before clinical application to guarantee safety and therapeutic effect. Here, we investigated the optimal injection route and dose for adult human multipotent neural cells (ahMNCs) from patients with hemorrhagic stroke using an SCI animal model. Read More

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Relation among Perceived Weight Change, Sedentary Activities and Sleep Quality during COVID-19 Lockdown: A Study in an Academic Community in Northern Italy.

Int J Environ Res Public Health 2021 03 13;18(6). Epub 2021 Mar 13.

Department of Psychology, University of Torino, Via Verdi, 10, 10124 Torino, Italy.

In Italy, COVID-19 lockdown was imposed from 8 March until 3 May 2020 with negative consequences on the lifestyles and health of people. Within this context, the paper aims: (i) to analyse the impact of COVID-19 lockdown on perceived weight changes; (ii) to evaluate factors associated with the perception of weight changes (Body Mass Index (BMI), sleep quality, time spent in sedentary activities), in an Italian academic community of students and workers. A total of 3666 participants took part in this cross-sectional study (2838 students and 828 workers, of whom 73. Read More

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[Gorgeous Colorful Rainbow: The Beauty and Sorrow of Indigenous People`s Health].

Authors:
Yi-Maun Subeq

Hu Li Za Zhi 2021 Apr;68(2):4-5

PhD, RN, NP, Associate Professor, Department of Nursing, National Taichung University of Science and Technology, Taiwan, ROC.

Residing across this island for over 8,000 years, Taiwan`s indigenous people represent the world`s northernmost population of Austronesian islanders. Although Taiwan`s more than 500,000 indigenous citizens today account for only 0.11% of the 300 million Austronesians worldwide, Taiwan and Taiwan`s long-thriving Austronesian culture played an indispensable role in the historical migrations of ancient Austronesian peoples from Mainland Asia and their proliferation throughout the Pacific (Council on Indigenous Peoples, n. Read More

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RIP3 mediates TCN-induced necroptosis through activating mitochondrial metabolism and ROS production in chemotherapy-resistant cancers.

Am J Cancer Res 2021 1;11(3):729-745. Epub 2021 Mar 1.

Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University Changsha 410078, Hunan, PR China.

Resisting cell death is one of the hallmarks of cancer. Necroptosis is a form of non-caspase dependent necrotic cell death mediated by receptor-interacting protein kinase-1/3 (RIP1/3), which represents another mode of programmed cell death besides apoptosis. RIP3 also acts as an energy metabolism regulator associated with switching cell death from apoptosis to necroptosis. Read More

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Natural Bioactive Compounds as Potential Browning Agents in White Adipose Tissue.

Pharm Res 2021 Mar 30. Epub 2021 Mar 30.

Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, 670 West Baltimore St, Baltimore, MD, 21201, USA.

The epidemic of overweight and obesity underlies many common metabolic diseases. Approaches aimed to reduce energy intake and/or stimulate energy expenditure represent potential strategies to control weight gain. Adipose tissue is a major energy balancing organ. Read More

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A Review of the NANN Research Summit Experience: Continuing to Promote a Platform for Research and Clinical Inquiry.

Adv Neonatal Care 2021 Mar 25. Epub 2021 Mar 25.

Children's Wisconsin, Milwaukee (Dr Esser); JoAnn McGrath School of Nursing and Health Professions, Alverno College, Milwaukee, Wisconsin (Dr Esser); National Association of Neonatal Nurses (Ms Shelley); and College of Nursing, University of Nebraska Medical Center, Omaha, Nebraska (Dr Moore).

Background: The NANN Research Summit has been providing a platform for neonatal scholarship and clinical inquiry for 15 years. As the discipline of nursing and nursing research continue to evolve, it is important to gain perspective on current trends and needs for areas of strength and growth.

Purpose: To evaluate participant outcomes of the NANN Research Summit and determine opportunities for improvement. Read More

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Recurrent ganglioneuroma in PTPN11-associated Noonan syndrome: A case report and literature review.

Am J Med Genet A 2021 Mar 29. Epub 2021 Mar 29.

Department of Clinical Genomics, Mayo Clinic, Phoenix, Arizona, USA.

Noonan syndrome (NS) is an autosomal dominant condition with variable expressivity most commonly due to a germline pathogenic variant in PTPN11, which encodes the protein tyrosine phosphatase SHP-2. Gain-of-function variants in PTPN11 are known to promote oncogenic behavior in affected tissues. We report the clinical description of a young adult male presenting with relapsing ganglioneuromas, dysmorphic features, cardiac abnormalities, and multiple lentigines, strongly suspicious for NS. Read More

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Activating Mutation of SHP2 Establishes a Tumorigenic Phonotype Through Cell-Autonomous and Non-Cell-Autonomous Mechanisms.

Front Cell Dev Biol 2021 11;9:630712. Epub 2021 Mar 11.

School of Life Sciences, Beijing Institute of Technology, Beijing, China.

Gain-of-function mutation of SHP2 is a central regulator in tumorigenesis and cancer progression through cell-autonomous mechanisms. Activating mutation of SHP2 in microenvironment was identified to promote cancerous transformation of hematopoietic stem cell in non-autonomous mechanisms. It is interesting to see whether therapies directed against SHP2 in tumor or microenvironmental cells augment antitumor efficacy. Read More

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E3 Ubiquitin Ligase UBR5 Promotes the Metastasis of Pancreatic Cancer Destabilizing F-Actin Capping Protein CAPZA1.

Front Oncol 2021 12;11:634167. Epub 2021 Mar 12.

State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

The ubiquitin-proteasome system (UPS) is a regulated mechanism of intracellular protein degradation and turnover, and its dysfunction is associated with various diseases including cancer. UBR5, an E3 ubiquitin ligase, is emerging as an important regulator of the UPS in cancers, but its role in pancreatic cancer is poorly understood. Here, we show that UBR5 is significantly upregulated in pancreatic cancer tissues. Read More

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Shared Decision-Making: An Autoethnography About Service User Perspectives in Making Choices About Mental Health Care and Treatment.

Authors:
Joanna Fox

Front Psychiatry 2021 10;12:637560. Epub 2021 Mar 10.

School of Education and Social Care, Anglia Ruskin University, Cambridge, United Kingdom.

Shared decision-making (SDM) between mental health medication prescribers and service users is a central pillar in the recovery approach, because it supports people experiencing mental ill-health to explore their care and treatment options to promote their well-being and to enable clinicians to gain knowledge of the choices the service user prefers. SDM is receiving increasing recognition both in the delivery of physical and mental health services; and as such, is of significance to current practice. As an expert-by-experience with over 30 years of receiving mental health treatment, I have made many choices about taking medication and accessing other forms of support. Read More

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The Binary Classification of Protein Kinases.

Authors:
Zeev Elkoshi

J Inflamm Res 2021 18;14:929-947. Epub 2021 Mar 18.

Research and Development Department, Taro Pharmaceutical Industries Ltd, Haifa, Israel.

In an earlier publication a binary model for chronic diseases classification has been proposed. According to the model, chronic diseases were classified as "high Treg" or "low Treg" diseases, depending on whether the immune response is anti- or pro-inflammatory and assuming that regulatory T cells are major determinants of the response. It turned out that most cancers are "high Treg" diseases, while autoimmune diseases are "low Treg". Read More

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Poor Weight Recovery Between Stage 1 Palliation and Hospital Discharge for Infants with Single Ventricle Physiology: An Analysis of the NPC-QIC Phase II Dataset.

J Pediatr 2021 Mar 24. Epub 2021 Mar 24.

Department of Pediatrics, Division of Cardiology, University of Utah and Primary Children's Hospital, Salt Lake City, UT, USA.

Objective: To investigate change in weight-for-age z-scores (WAZ) and risk factors for impaired weight gain between stage 1 palliation (S1P) for single ventricle physiology and discharge.

Study Design: Secondary analysis of the National Pediatric Cardiology Quality Improvement Collaborative Phase II database. The primary outcome was change in WAZ between S1P and discharge. Read More

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