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Education and screening for obesity, hypertension, and diabetes (including gestational diabetes) "at the doorstep" of women from nine underprivileged urban areas in Delhi National Capital Region.

Diabetes Metab Syndr 2021 Jul 12;15(5):102209. Epub 2021 Jul 12.

National-Diabetes, Obesity and Cholesterol Foundation (N-DOC), SDA, New Delhi, 110016, India; Diabetes Foundation (India), New Delhi, 110016, India; Fortis C-DOC Center of Excellence for Diabetes, Metabolic Diseases, and Endocrinology, B 16, Chirag Enclave, New Delhi, India. Electronic address:

Background And Aims: Women in underprivileged urban areas have poor access to health and education, making them vulnerable to non-communicable diseases (NCDs), specifically diabetes. The current project has sought to focus on this group, to educate and screen this population to prevent and manage obesity and diabetes.

Methods: The project was conducted in 9 underprivileged areas of Delhi NCR using a mobile van unit. Read More

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Adolescents' Exposure to and Experiences of Weight Stigma During the COVID-19 Pandemic.

J Pediatr Psychol 2021 Jul 27. Epub 2021 Jul 27.

Rudd Center for Food Policy and Obesity, University of Connecticut.

Objective: The COVID-19 pandemic has increased attention to the proliferation of pediatric obesity amidst significant changes in weight-related health functioning (e.g., compromised physical activity, limited food access, increased stress). Read More

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Community-Driven Methods for Open and Reproducible Software Tools for Analyzing Datasets from Atom Probe Microscopy.

Microsc Microanal 2021 Jul 27:1-16. Epub 2021 Jul 27.

Australian Centre for Microscopy & Microanalysis, School of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, Sydney, NSW2006, Australia.

Atom probe tomography, and related methods, probe the composition and the three-dimensional architecture of materials. The software tools which microscopists use, and how these tools are connected into workflows, make a substantial contribution to the accuracy and precision of such material characterization experiments. Typically, we adapt methods from other communities like mathematics, data science, computational geometry, artificial intelligence, or scientific computing. Read More

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Food Safety, Health Management, and Biosecurity Characteristics of Poultry Farms in Arusha City, Northern Tanzania, Along a Gradient of Intensification.

East Afr Health Res J 2018 23;2(2):168-180. Epub 2018 Nov 23.

Institute of Biodiversity, Animal Health & Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

Background: With the growth, urbanisation, and changing consumption patterns of Tanzania's human population, new livestock production systems are emerging. Intensification of poultry production may result in opportunities and threats for food safety, such as improved awareness of biosecurity or increasing prevalence of foodborne pathogens including nontyphoidal or spp. We conducted a semiquantitative analysis of poultry production systems in northern Tanzania, with emphasis on biosecurity, health management practices, and prevalence of foodborne pathogens, to gain insight into potential associations between intensification and food safety. Read More

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November 2018

Weight loss, hypertension and mental well-being improvements during COVID-19 with a multicomponent health promotion programme on Zoom: a service evaluation in primary care.

BMJ Nutr Prev Health 2021 15;4(1):102-110. Epub 2021 Feb 15.

Independent Researcher, London, UK.

Background: Obesity is a risk factor for complications from SARS-CoV-2 infection, increasing the need for effective weight management measures in primary care. However, in the UK, COVID-19 restrictions have hampered primary care weight management referral and delivery, and COVID-19 related weight gain has been reported. The present study evaluated outcomes from a multicomponent weight loss and health promotion programme in UK primary care, delivered remotely due to COVID-19 restrictions. Read More

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February 2021

Influence of Loss Aversion and Income Effect on Consumer Food Choice for Food Safety and Quality Labels.

Front Psychol 2021 8;12:711671. Epub 2021 Jul 8.

College of Economics and Management, Nanjing Agricultural University, Nanjing, China.

Food safety and food quality are two closely related aspects of the food management system. The difference between the two is that one keeps consumers safe while the other keeps consumers satisfied. This study examined the differences in how consumers value food safety and food quality with a focus on the influence of loss aversion on one's psychological level and of income effect on one's socio-demographic level. Read More

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A Practical Tool for Family Assessment Based on the Social Relations Model.

Front Psychol 2021 7;12:699831. Epub 2021 Jul 7.

Department of Data Analysis, Ghent University, Ghent, Belgium.

An empirically based family assessment can help family therapists understand how a family functions. In systemic therapy a family is seen as a dynamic system in which the family members form interdependent subsystems. The Social Relations Model (SRM) is a useful tool to study such interdependence within a family. Read More

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Genetic Modeling of the Neurodegenerative Disease Spinocerebellar Ataxia Type 1 in Zebrafish.

Int J Mol Sci 2021 Jul 8;22(14). Epub 2021 Jul 8.

Division of Cellular & Molecular Neurobiology, Zoological Institute, Technische Universität Braunschweig, Spielmannstraße 7, 38106 Braunschweig, Germany.

Dominant spinocerebellar ataxias (SCAs) are progredient neurodegenerative diseases commonly affecting the survival of Purkinje cells (PCs) in the human cerebellum. Spinocerebellar ataxia type 1 (SCA1) is caused by the mutated () gene product, in which a polyglutamine stretch encoded by CAG repeats is extended in affected SCA1 patients. As a monogenetic disease with the Atx1-polyQ protein exerting a gain of function, SCA1 can be genetically modelled in animals by cell type-specific overexpression. Read More

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Exploring the Concept of Dimerization-Induced Intersystem Crossing: At the Origins of Spin-Orbit Coupling Selection Rules.

J Phys Chem B 2021 Jul 22. Epub 2021 Jul 22.

Univ Lyon, ENS de Lyon, CNRS UMR 5182, Université Claude Bernard Lyon 1, F-69342 Lyon, France.

Singlet-triplet interconversions (intersystem crossing, ISC) in organic molecules are at the basis of many important processes in cutting-edge photonic applications (organic light-emitting devices, photodynamic therapy, etc.). Selection rules for these transitions are mainly governed by the spin-orbit coupling (SOC) phenomenon. Read More

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Expression of the ACE2 Virus Entry Protein in the Nervus Terminalis Reveals the Potential for an Alternative Route to Brain Infection in COVID-19.

Front Cell Neurosci 2021 5;15:674123. Epub 2021 Jul 5.

L. Rydygier Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.

Previous studies suggested that the SARS-CoV-2 virus may gain access to the brain by using a route along the olfactory nerve. However, there is a general consensus that the obligatory virus entry receptor, angiotensin converting enzyme 2 (ACE2), is not expressed in olfactory receptor neurons, and the timing of arrival of the virus in brain targets is inconsistent with a neuronal transfer along olfactory projections. We determined whether nervus terminalis neurons and their peripheral and central projections should be considered as a potential alternative route from the nose to the brain. Read More

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Understanding Open Access Data Using Visuals: Integrating Prospective Studies of Children's Responses to Natural Disasters.

Child Youth Care Forum 2019 Aug 1;48(4):563-583. Epub 2019 Mar 1.

Lynch School of Education and Human Development, Boston College, 316A Campion Hall, 140 Commonwealth Ave, Chestnut Hill, MA 02467, USA.

Background: As access to open data is increasing, researchers gain the opportunity to build integrated datasets and to conduct more powerful statistical analyses. However, using open access data presents challenges for researchers in understanding the data. Visuals allow researchers to address these challenges by facilitating a greater understanding of the information available. Read More

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Ear-EEG-based binaural speech enhancement (ee-BSE) using auditory attention detection and audiometric characteristics of hearing-impaired subjects.

J Neural Eng 2021 Jul 21. Epub 2021 Jul 21.

Faculty of Electrical and Computer Eng., Dept. of Biomedical Eng., University of Tabriz, University of Tabriz, 29 Bahman Blvd., Faculty of Electrical and Computer Eng., Tabriz, East Azerbaijan, 51666-15813, Iran (the Islamic Republic of).

Objective: Speech perception in cocktail party scenarios has been the concern of a group of researchers who are involved with the design of hearing-aid devices.

Approach: In this paper, a new unified ear-EEG-based binaural speech enhancement (ee-BSE) system is introduced for HI listeners. The proposed model, which is based on auditory attention detection (AAD) and individual hearing threshold (HT) characteristics, has four main processing stages. Read More

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Chemistry or Service? Sugar Daddies' (Re)quest for Mutuality within the Confines of Commercial Exchange.

J Sex Res 2021 Jul 21:1-12. Epub 2021 Jul 21.

School of Humanities, Education and Social Sciences, Örebro University.

With the emergence and global proliferation of "sugar dating" websites, the phenomenon of sugar dating is gaining increased attention. Sugar dating is described by these websites as arrangements based on an exchange of financial or other forms of support for intimacy and companionship. The framing of sugar dating as something in between a business transaction and mutually enjoyable dating serves as the point of departure of this article, which draws on semi-structured interviews and a survey questionnaire with "sugar daddies" engaged in heterosexual sugar dating in Sweden. Read More

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Oncology Expanded Access and FDA's Project Facilitate.

Oncologist 2021 Jul 19. Epub 2021 Jul 19.

Oncology Center of Excellence, U.S. Food and Drug Administration.

The Oncology Center of Excellence at the Food and Drug Administration (FDA) launched Project Facilitate on May 31, 2019, to assist oncology healthcare providers with Expanded Access requests for investigational drugs. Expanded Access, sometimes called "compassionate use" is a regulatory pathway for physicians caring for patients who have a life-threatening condition or a serious disease to gain access to an investigational drug for treatment when no comparable or satisfactory alternative treatment options are available [1]. Herein we describe the Project Facilitate program and the process for requesting Expanded Access to an investigational drug. Read More

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High levels of standardized ileal digestible amino acids improve feed efficiency in slow-growing pigs at late grower-finisher stage.

J Anim Physiol Anim Nutr (Berl) 2021 Jul 20. Epub 2021 Jul 20.

Pig Development Department, Animal and Grassland Research and Innovation Centre, Teagasc, Fermoy, Cork, Ireland.

Slow-growing pigs negatively affect production efficiency in conventional pig farms by increasing the occupation time of the facilities and being a limiting factor for the All-In/All-Out swine production systems. This subset of pigs is usually managed with the rest of the pigs, and their nutrient requirements may not be fulfilled. The purpose of the present study was to compare the productive performance of slow- and fast-growing pigs to different standardized ileal digestible (SID) amino acids (AA) dietary levels at late grower-finisher stage. Read More

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RNA Helicase DDX17 inhibits Hepatitis B Virus Replication by Blocking Viral Pregenomic RNA Encapsidation.

J Virol 2021 Jul 21:JVI0044421. Epub 2021 Jul 21.

Department of Microbiology and Immunology, Indiana University School of Medicine Indianapolis, IN, USA.

DDX17 is a member of the DEAD-Box helicase family proteins involved in cellular RNA folding, splicing, and translation. It has been reported that DDX17 serves as a co-factor of host zinc finger antiviral protein (ZAP)-mediated retroviral RNA degradation and exerts direct antiviral function against Raft Valley Fever Virus though binding to specific stem-loop structures of viral RNA. Intriguingly, we have previously shown that ZAP inhibits Hepatitis B virus (HBV) replication through promoting viral RNA decay, and the ZAP-responsive element (ZRE) of HBV pregenomic RNA (pgRNA) contains a stem-loop structure, specifically epsilon, which serves as the packaging signal for pgRNA encapsidation. Read More

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A andomisd, controlled, double blind tudy to assess mechanstic effects of combination therapy of dapagflozin with xenatide QW versus dapagliflozin alone i obese patients with ype 2 diabetes mellitus (RESILIENT): study protocol.

BMJ Open 2021 Jul 20;11(7):e045663. Epub 2021 Jul 20.

Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.

Introduction: The newer glucose-lowering therapies for type 2 diabetes (T2D), the glucagon-like peptide-1 receptor agonists (GLP1-RAs) and the sodium-glucose co-transporter 2 inhibitors (SGLT2i), have additional clinical benefits beyond improving glycaemic control; promoting weight loss, addressing associated cardiovascular risk factors and reducing macrovascular and microvascular complications. Considering their independent mechanisms of actions, there is a potential for significant synergy with combination therapy, yet limited data exist. This 32-week randomised, double-blind, placebo-controlled trial will gain mechanistic insight into the effects of coadministration of exenatide QW, a weekly subcutaneous GLP1-RA, with dapagliflozin, a once daily oral SGLT2i, on the dynamic, adaptive changes in energy balance, total, regional and organ-specific fat mass and multiorgan insulin sensitivity. Read More

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ESTRO vision 2030: the young Italian Association of Radiotherapy and Clinical Oncology (yAIRO) commitment statement.

Radiol Med 2021 Jul 20. Epub 2021 Jul 20.

Radiation Oncology, Azienda Ospedaliero-Universitaria Careggi, University of Florence, Florence, Italy.

The aim of this document is to share the action plan from the young Italian Association of Radiotherapy and Clinical Oncology (yAIRO). We believe it is important to enhance a constructive dialog between societies. The hope is to offer to young radiation oncologists a wealth of opportunities to refine their skills and gain access to the latest developments, according to a shared European vision. Read More

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Healthcare workers' perceptions and experiences of communicating with people over 50 years of age about vaccination: a qualitative evidence synthesis.

Cochrane Database Syst Rev 2021 07 20;7:CD013706. Epub 2021 Jul 20.

Universitair Medisch Centrum Utrecht, Utrecht, Netherlands.

Background: Infectious diseases are a major cause of illness and death among older adults. Vaccines can prevent infectious diseases, including against seasonal influenza, pneumococcal diseases, herpes zoster and COVID-19. However, the uptake of vaccination among older adults varies across settings and groups. Read More

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Femtosecond Laser Assisted Intraocular Lens (IOL) Exchange.

J Cataract Refract Surg 2021 Jul 19. Epub 2021 Jul 19.

Private Practice, Advanced Vision Care, Los Angeles, CA and Clinical Instructor, Stein Eye Institute, UCLA Private Practice, Advanced Vision Care, Los Angeles, CA and Clinical Professor, Stein Eye Institute, David Geffen School of Medicine, UCLA Private Practice, Advanced Vision Care, Los Angeles, CA Private Practice, Advanced Vision Care, Los Angeles, CA.

Abstract: Intraocular Lens (IOL) exchange in patients with anterior capsule contraction resulting from phimosis can complicate IOL exchange as the fibrotic anterior capsule must be cut to gain access to the IOL. Maintaining a curvilinear capsulotomy is particularly important when the desired outcome is bag to bag IOL exchange. Similarly, when the posterior capsule is open a properly sized curvilinear anterior capsulotomy will allow for optic capture and further stability of the exchanged IOL. Read More

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Access to intervene. An ethnographic study of public health practices targeting health inequalities.

Health (London) 2021 Jul 19:13634593211032869. Epub 2021 Jul 19.

University of Southern Denmark, Denmark.

Much public health research has devoted attention to the question of how interventions aimed at reducing health inequalities can access so-called "hard-to-reach" populations. This work has generally reflected an instrumentalist approach, which implies the preexistence of particular target groups characterized by specific public health problems. The key research interests are to find ways to effectively alleviate health inequalities and to identify the best ways to intervene to address disparate health problems among certain groups of people. Read More

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Meeting the Needs of Families Involved in the Child Welfare System for Parental Substance Abuse: Outcomes From an Effectiveness Trial of the Families Actively Improving Relationships Program.

Front Psychol 2021 2;12:689483. Epub 2021 Jul 2.

Oregon Social Learning Center, Eugene, OR, United States.

Limited evidence-based practices exist to address the unique treatment needs of families involved in the child welfare system with parental substance abuse. Specifically, parental opioid and methamphetamine abuse have increased over the last decade, with associated increases of families reported to the child welfare system. The Families Actively Improving Relationships (FAIR) program was developed to address the complexities of these families. Read More

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Effects of delaying increase in milk allowance and type of gradual weaning program on performance and health of calves fed lower levels of milk.

J Dairy Sci 2021 Jul 15. Epub 2021 Jul 15.

Department of Animal Biosciences, University of Guelph, Guelph, ON, N1G 2W1, Canada. Electronic address:

The objective of this study was to investigate the effects of delayed increase in milk allowance and type of gradual weaning program on the feed intake, health, and growth of male Holstein calves. Using a 2 × 2 factorial design, each male Holstein calf was randomly assigned to 1 of 2 milk level treatments and 1 of 2 weaning treatments upon arrival to a rearing facility. Calves were either assigned to a moderate (MM) or lower (LM) milk level treatment. Read More

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Assessing the perspective of well-being of older patients with multiple morbidities by using the LAVA tool - a person-centered approach.

BMC Geriatr 2021 Jul 16;21(1):427. Epub 2021 Jul 16.

Department of Internal Medicine, Univ Medical Center Groningen, University Groningen, Groningen, Netherlands.

Background: Older patients with multiple morbidities are a particularly vulnerable population that is likely to face complex medical decisions at some time in their lives. A patient-centered medical care fosters the inclusion of the patients' perspectives, priorities, and complaints into clinical decision making.

Methods: This article presents a short and non-normative assessment tool to capture the priorities and problems of older patients. Read More

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A Meal Replacement Program for the Treatment of Obesity: A Cost-Effectiveness Analysis from the Swiss Payer's Perspective.

Diabetes Metab Syndr Obes 2021 8;14:3147-3160. Epub 2021 Jul 8.

Global Market Access & Pricing, Nestlé Health Science, Vevey, Switzerland.

Background: Obesity is a disease associated with high direct medical costs and high indirect costs resulting from productivity loss. The high prevalence of obesity generates the need for payers to identify cost-effective weight loss approaches. Among various weight management techniques, the OPTI (Optifast) program is a clinically recognised total meal replacement diet that can lead to significant weight loss and reduction in complications. Read More

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Preparation of Samples for Large-Scale Automated Electron Microscopy of Tissue and Cell Ultrastructure.

Microsc Microanal 2021 Jul 16:1-13. Epub 2021 Jul 16.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Functional Anatomy, Charitéplatz 1, 10117Berlin, Germany.

Manual selection of targets in experimental or diagnostic samples by transmission electron microscopy (TEM), based on single overview and detail micrographs, has been time-consuming and susceptible to bias. Substantial information and throughput gain may now be achieved by the automated acquisition of virtually all structures in a given EM section. Resulting datasets allow the convenient pan-and-zoom examination of tissue ultrastructure with preserved microanatomical orientation. Read More

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Anti-obesity Medication Use Among Adults with Overweight and Obesity in the United States: 2015-2018.

Endocr Pract 2021 Jul 12. Epub 2021 Jul 12.

Eli Lilly & Company, Indianapolis, IN.

Objective: To estimate utilization of FDA-approved prescription anti-obesity medications (AOMs) and identify factors associated with AOM use in the United States.

Methods: Respondents >18 years-old meeting AOM eligibility criteria in 2015-2016 and 2017-2018 National Health and Nutrition Examination Survey (NHANES) and 2016 Medical Expenditure Panel Survey (MEPS) were included in the study. AOM eligibility was defined as having a body mass index (BMI) >30 kg/m, or a BMI between 27 to 29. Read More

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Jealousy and Electronic Intrusion Mediated by Relationship Uncertainty in Married and Cohabiting Couples During COVID-19.

Cyberpsychol Behav Soc Netw 2021 Jul;24(7):444-449

Department of Psychology, University of South Florida, Tampa, Florida, USA.

The COVID-19 pandemic poses unique threats to romantic relationships as couples were issued to stay at home by a mandatory order, limiting social interactions with others. Although technology allows for social interactions, the privacy of interactions through technology may be compromised. Electronic intrusion (EI) occurs when individuals covertly gain access of their partner's mobile device to go through content (e. Read More

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Experiences of patients with a disability in receiving primary health care: Using experience-based design for quality improvement.

Can Fam Physician 2021 Jul;67(7):517-524

Clinical social worker in the Department of Family Medicine at Mount Sinai Hospital.

Objective: To use patient-guided tours to gain insight into the experiences of patients with disabilities receiving primary care, with the goal of suggesting improvements.

Design: A qualitative experience-based design study, using patient-guided tours.

Setting: Multidisciplinary academic urban primary care practice. Read More

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