7,375 results match your criteria gabapentin r2>0999


Percutaneous transplantation of allogenic bone marrow-derived mesenchymal stem cells for the management of paraplegia secondary to Hansen type I intervertebral disc herniation in a Beagle dog.

Iran J Vet Res 2021 ;22(2):161-166

Division of Physiology and Climatology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, India.

Background: Intervertebral disc herniation (IVDH) is one of the common causes of spinal cord injury (SCI) in dogs. It is commonly treated by performing surgical decompression that involves the removal of the extruded disc material. However, the recovery rates after surgical interventions are variable and many times unsatisfactory. Read More

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January 2021

Compounding Pearls -- Wound Care: Drugs and Formulations for Dermal Healing, Part 2.

Authors:
Mike Riepl

Int J Pharm Compd 2021 Jul-Aug;25(4):282-287

Retired Compounding Pharmacist, Bismarck, North Dakota.

Diseases of and injuries to the human skin have been recognized since antiquity as health hazards that can increase morbidity and mortality and greatly compromise quality of life. The earliest effective treatments for such conditions and disorders were compounded, as were all ancient medicaments, to accommodate individual patient sensitivities and responses to therapy. That tradition continues today in precision pharmaceutical compounding, which is an essential component in a triad of medical and pharmaceutical care that actively involves physicians, pharmacists, and patients. Read More

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Gabapentin-Induced Angioedema of Tongue.

J Acute Med 2021 Jun;11(2):72-73

National Taiwan University Hospital Hualien Tzu Chi Hospital Hualien Taiwan.

Angioedema of tongue can be a truly emergency situation and needs rapid evaluation and intervention if airway compromise happens. It is also crucial to recognize the causality of the allergic reaction. Mostly the culprit can be identified if detailed medical regimen and exposure history have been reviewed. Read More

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α2δ-1 switches the phenotype of synaptic AMPA receptors by physically disrupting heteromeric subunit assembly.

Cell Rep 2021 Jul;36(3):109396

Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

Many neurological disorders show an increased prevalence of GluA2-lacking, Ca-permeable AMPA receptors (CP-AMPARs), which dramatically alters synaptic function. However, the molecular mechanism underlying this distinct synaptic plasticity remains enigmatic. Here, we show that nerve injury potentiates postsynaptic, but not presynaptic, CP-AMPARs in the spinal dorsal horn via α2δ-1. Read More

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Oncologic causes of oculopalatal tremors: neurophysiology and treatment.

Acta Neurol Belg 2021 Jul 20. Epub 2021 Jul 20.

College of Osteopathic Medicine, Michigan State University, East Lansing, MI, USA.

Oculopalatal tremor (OPT) is an acquired pathology characterized by continuous and rhythmical soft palatal movements combined with pendular nystagmus. Aside from vascular lesions, oncological masses affecting the dentatorubro-olivary pathway can impair brainstem and/or cerebellar pathways, manifesting as dyssynchronous movement. In this review, we delve into the neurophysiology of OPT along with oncological causes and treatment options based on the most recent clinical trial data. Read More

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Expert review and recommendations for the management of acute, chronic, and neuropathic pain in Qatar.

Qatar Med J 2021 7;2021(2):19. Epub 2021 Jul 7.

Neuromuscular Division, Hamad Medical Corporation, Doha, Qatar; Neurology Division, Department of Medicine, Al Khor Hospital, Doha, Qatar.

Background: Pain management is an evolving area of expertise in Qatar. Gaps in knowledge, inadequate training for physicians and nurses, and the absence of policies/guidelines are the main barriers to effective pain management in Qatar. In addition, the use of certain pain medication, especially opioids, is highly regulated, limiting their availability in outpatient pain management. Read More

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Postinjury stimulation triggers a transition to nociplastic pain in mice.

Pain 2021 Jun 14. Epub 2021 Jun 14.

Department of Neuroscience, Cell Biology, and Anatomy, University of Texas Medical Branch, Galveston, TX, United States.

Abstract: Acute injury-induced pain can transition to chronic nociplastic pain, which predominantly affects women. To facilitate studies on the underlying mechanisms of nociplastic pain, we developed a mouse model in which postinjury thermal stimulation (intermittent 40°C water immersion for 10 minutes at 2 hours postcapsaicin) prolongs capsaicin (ie, experimental injury)-induced transient mechanical hypersensitivity outside of the injury area. Although capsaicin injection alone induced mechanical and thermal hypersensitivity that resolved in ∼7 days (slower recovery in females), the postinjury stimulation prolonged capsaicin-induced mechanical, but not thermal, hypersensitivity up to 3 weeks in both sexes. Read More

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Evaluation of discharge prescribing after rescheduling of gabapentin as a controlled substance.

Am J Health Syst Pharm 2021 Jul 20. Epub 2021 Jul 20.

Department of Pharmacy, Sentara Norfolk General Hospital, Norfolk, VA, USA.

Purpose: Gabapentin has increasingly been identified as a drug of abuse, especially when used concurrently with opioids. Rescheduling gabapentin as a schedule V controlled substance may strengthen monitoring and prescribing restrictions. The purpose of this study was to characterize the impact of rescheduling gabapentin from a nonscheduled to a schedule V substance in Virginia on discharge prescribing patterns in a health system. Read More

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Increasing the use of multimodal analgesia during adult surgery in a tertiary academic anaesthesia department.

BMJ Open Qual 2021 Jul;10(3)

Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, USA

Objective: Multimodal analgesia pathways have been shown to reduce opioid use and side effects in surgical patients. A quality improvement initiative was implemented to increase the use of multimodal analgesia in adult patients presenting for general anaesthesia at an academic tertiary care centre. The aim of this study was to increase adoption of a perioperative multimodal analgesia protocol across a broad population of surgical patients. Read More

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Impact of a Multimodal Analgesia Protocol on Inpatient and Outpatient Opioid Use in Acute Trauma.

J Surg Res 2021 Jul 16;268:9-16. Epub 2021 Jul 16.

Department of General Surgery, University of Cincinnati, Cincinnati, Ohio.

Background: Multimodal analgesia protocols have been implemented after elective surgery to reduce opioid use, however there is limited data on utility after polytrauma. Therefore, we investigated the impact of a multimodal analgesia protocol on inpatient and post-discharge outpatient opioid use after polytrauma.

Methods: A retrospective review of patients admitted to a Level I trauma center between September 2017-February 2018 (prior to multimodal protocol; "pre-cohort") and October 2018-April 2019 (after multimodal protocol; "post-cohort") was performed. Read More

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The Use of Botulinum Toxin in a Case of Acquired Periodic Alternating Nystagmus.

Br Ir Orthopt J 2021 15;17(1):85-90. Epub 2021 Apr 15.

Moorfields Eye Hospital, GB.

Aim: To describe a case of acquired Periodic Alternating Nystagmus (PAN) with oscillopsia treated with botulinum toxin injections into four horizontal rectus muscles.

Method: A 22-year-old woman presented with sudden onset PAN. The only abnormality found following extensive investigations was bilateral superior cerebellar peduncle atrophy on MRI. Read More

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Drug-induced Urinary Retention: An Analysis of a National Spontaneous Adverse Drug Reaction Reporting Database.

Eur Urol Focus 2021 Jul 15. Epub 2021 Jul 15.

Department of Diagnostics and Public Health, University of Verona, Verona, Italy. Electronic address:

Background: Numerous drugs have been associated with urinary retention (UR), but updated information on drugs that may induce UR is limited.

Objective: To evaluate drug-induced UR using the Italian spontaneous adverse drug reactions (ADRs) reporting database.

Design, Setting, And Participants: We selected all suspected spontaneous reports of drug-induced UR collected into the Italian spontaneous reporting system (SRS) database from its inception to June 30, 2019. Read More

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Evaluation of prescribing practices for gabapentin as an analgesic among veterinary professionals.

Vet Anaesth Analg 2021 Jun 21. Epub 2021 Jun 21.

Department of Clinical Sciences, Cummings Veterinary Medical Center at Tufts University, North Grafton, MA, USA.

Objective: To describe the prescribing practices for gabapentin as an analgesic within the veterinary community.

Study Design: Anonymous online voluntary survey.

Population: A total of 718 veterinarians within the United States and Canada, including general practitioners and diplomates of the American Colleges of Veterinary Anesthesia and Analgesia, Emergency and Critical Care, Surgery and Internal Medicine. Read More

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Pharmacological characterization of the chronic phase of the monoiodoacetate-induced rat model of osteoarthritis pain in the knee joint.

Clin Exp Pharmacol Physiol 2021 Jul 18. Epub 2021 Jul 18.

School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, QLD, Australia.

For patients with osteoarthritis (OA) of the knee, pain is the most debilitating symptom. Although it has been proposed that the chronic phase of the monoiodoacetate (MIA)-induced rodent model of knee joint pain may be superior to other chronic or acute OA models for assessing the analgesic efficacy of novel molecules, relatively few pharmacological studies have been conducted in the chronic phase of this model. Hence this study was designed to use pharmacological methods to characterize the chronic phase of the MIA-induced rat model of knee joint OA pain. Read More

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Severe cutaneous adverse reactions in Asians: Trends observed in culprit anti-seizure medicines using VigiBase®.

Seizure 2021 Jul 13;91:332-338. Epub 2021 Jul 13.

Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India.

Purpose: Diverse ethnic genetic populations display variability in the risk regarding anti-seizure medicine (ASM)-induced severe cutaneous adverse reactions (SCARs). However, clinical and epidemiological data on ASM-induced SCARs in Asians is limited.

Methods: We conducted a retrospective, post-market study until April 30, 2020 using VigiBase® for demographic characteristics, causative ASMs, complications and mortality. Read More

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Evaluation of discharge prescribing after rescheduling of gabapentin as a controlled substance.

Am J Health Syst Pharm 2021 Jul 14. Epub 2021 Jul 14.

Department of Pharmacy, Sentara Norfolk General Hospital, Norfolk, VA, USA.

Disclaimer: In an effort to expedite the publication of articles related to the COVID-19 pandemic, AJHP is posting these manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. Read More

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Peripheral neuropathy from use of linezolid and metronidazole in a pediatric patient.

IDCases 2021 29;25:e01210. Epub 2021 Jun 29.

Department of Pediatrics, University of Saskatchewan, Saskatoon, Canada.

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Trends in Gabapentin and Pregabalin Prescribing in a Tertiary Pediatric Medical Center.

Hosp Pediatr 2021 Jul 13. Epub 2021 Jul 13.

Department of Anesthesiology, Critical Care and Pain Medicine and.

Objectives: Analgesic medications are commonly prescribed in pediatrics, with prescribing practices frequently extrapolated from adult trials. Gabapentinoids (gabapentin and pregabalin) are widely used as analgesics but are labeled in pediatrics only for epilepsy. We aim to (1) define trends in pediatric gabapentinoid prescribing (label and off-label) over 7 years, and (2) evaluate use in chronic pain clinic (CPC) patients during 2018. Read More

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Effects of Gabapentin on Dorsal Anterior Cingulate Cortex GABA and Glutamate Levels and Their Associations With Abstinence in Alcohol Use Disorder: A Randomized Clinical Trial.

Am J Psychiatry 2021 Jul 14:appiajp202120121757. Epub 2021 Jul 14.

Department of Psychiatry and Behavioral Sciences, Addiction Sciences Division (Prisciandaro, Hoffman, Voronin, Book, Bristol, Anton), and Department of Radiology (Brown), Medical University of South Carolina, Charleston.

Objective: Although gabapentin has demonstrated efficacy in mitigating alcohol withdrawal symptoms and preventing relapse drinking in individuals with alcohol use disorder (AUD), the neurobiological mechanisms of action underlying these therapeutic effects remain unknown. The present study evaluated changes in GABA and glutamate levels in the dorsal anterior cingulate cortex (dACC) as candidate mechanisms of action.

Methods: In a 16-week randomized clinical trial, 68 adults with AUD, including a history of alcohol withdrawal syndrome, received 1,200 mg/day of gabapentin (N=37) or placebo (N=31) and nine medical management visits after ≥72 hours of abstinence. Read More

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Pharmacological evaluation of the gabapentin salicylaldehyde derivative, gabapentsal, against tonic and phasic pain models, inflammation, and pyrexia.

Naunyn Schmiedebergs Arch Pharmacol 2021 Jul 12. Epub 2021 Jul 12.

Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, CF10 3NB, UK.

Gabapentinoids are effective drugs in most animal models of pain and inflammation with variable effects in humans. The current study evaluated the pharmacological activity of gabapentin (GBP) and its salicylaldehyde derivative (gabapentsal; [2-(1-(((2-hydroxybenzylidene) amino) methyl) cyclohexyl) acetic acid]; GPS) in well-established mouse models of nociceptive pain, inflammatory edema, and pyrexia at doses of 25-100 mg/kg. GPS allayed tonic visceral pain as reflected by acetic acid-induced nociception and it also diminished thermally induced nociception as a mimic of phasic thermal pain. Read More

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Nonsurgical Approaches to Neuroma Management.

Hand Clin 2021 Aug;37(3):323-333

Department of Surgery, University of Washington, 325 9th Avenue, 7 CT 70, MS 359796, Seattle, WA 98104, USA. Electronic address:

Symptomatic neuromas and chronic neuropathic pain are significant problems affecting patients' quality of life and independence that are challenging to treat. These symptoms are due to structural and functional changes that occur peripherally within neuromas, as well as alterations that occur centrally within the brain and spinal cord. A multimodal approach is most effective, with goals to minimize opioid use, to capitalize on the synergistic effects of nonopioid medications and to explore potential benefits of novel adjunctive treatments. Read More

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α2δ-1 Upregulation in Primary Sensory Neurons Promotes NMDA Receptor-Mediated Glutamatergic Input in Resiniferatoxin-Induced Neuropathy.

J Neurosci 2021 Jul 17;41(27):5963-5978. Epub 2021 Jun 17.

Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas 77030

Systemic treatment with resiniferatoxin (RTX) induces small-fiber sensory neuropathy by damaging TRPV1-expressing primary sensory neurons and causes distinct thermal sensory impairment and tactile allodynia, which resemble the unique clinical features of postherpetic neuralgia. However, the synaptic plasticity associated with RTX-induced tactile allodynia remains unknown. In this study, we found that RTX-induced neuropathy is associated with α2δ-1 upregulation in the dorsal root ganglion (DRG) and increased physical interaction between α2δ-1 and GluN1 in the spinal cord synaptosomes. Read More

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American Rhinologic Society expert practice statement: Postoperative pain management and opioid use after sinonasal surgery.

Int Forum Allergy Rhinol 2021 Jul 11. Epub 2021 Jul 11.

Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, SC.

The goal of this American Rhinologic Society expert practice statement (EPS) is to provide clinically applicable, evidence-based recommendations regarding pain management in sinonasal surgery. This EPS was developed following the recommended methodology and approval process as previously outlined. The topics of interest included preoperative counseling, local anesthesia, use of opioids for postoperative pain, use of nonopioid medication for postoperative pain, nonsteroidal anti-inflammatory drugs and bleeding, and use of gabapentin for pain control. Read More

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Eagle syndrome: toward a clinical delimitation.

Neurologia (Engl Ed) 2021 Jul-Aug;36(6):412-417. Epub 2020 Feb 13.

Hospital Clínico Universitario de Valladolid, Valladolid, Spain.

Introduction: Orofacial and cervical pain are a frequent reason for neurology consultations and may be due to multiple pathological processes. These include Eagle syndrome (ES), a very rare entity whose origin is attributed to calcification of the stylohyoid ligament or elongation of the temporal styloid process. We present a series of five patients diagnosed with ES. Read More

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February 2020

The Treatment of Painful Diabetic Neuropathy.

Curr Diabetes Rev 2021 Jul 6. Epub 2021 Jul 6.

Diabetes Research Unit, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield. United Kingdom.

Painful diabetic peripheral neuropathy (painful-DPN) is a highly prevalent and disabling condition, affecting up to one-third of patients with diabetes. This condition can have a profound impact, resulting in a low quality of life, disruption of employment, impaired sleep, and poor mental health with an excess of depression and anxiety. The management of painful-DPN poses a great challenge. Read More

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Pharmacotherapy for the Prevention of Chronic Pain after Surgery in Adults: An Updated Systematic Review and Meta-analysis.

Anesthesiology 2021 Aug;135(2):304-325

Background: Chronic postsurgical pain can severely impair patient health and quality of life. This systematic review update evaluated the effectiveness of systemic drugs to prevent chronic postsurgical pain.

Methods: The authors included double-blind, placebo-controlled, randomized controlled trials including adults that evaluated perioperative systemic drugs. Read More

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HIV Neuropathy-a Review of Mechanisms, Diagnosis, and Treatment of Pain.

Curr Pain Headache Rep 2021 Jul 8;25(8):55. Epub 2021 Jul 8.

Department of Anesthesiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas, USA.

Purpose Of Review: This article is a systematic review of data from 2018 to 2020 regarding information from publications on epidemiologic, diagnostic, and therapeutic advancements in human immunodeficiency virus-associated peripheral neuropathy.

Recent Findings: The epidemiology/pathology of HIV neuropathy is discussed. Diagnostics includes skin wrinkling-eutectic mixture of local anesthetic test and neurologic examinations. Read More

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[Hepatotoxicity probably associated with gabapentin].

Rev Med Inst Mex Seguro Soc 2021 Jun 14;59(2):157-162. Epub 2021 Jun 14.

Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades "Dr. Bernardo Sepúlveda Gutiérrez", Departamento de Anestesiología. Ciudad de México, México.

Background: Gabapentin is an anticonvulsant medication used as an adjuvant in the treatment of neuropathic pain; few cases have been reported in which it causes acute liver injury.

Clinical Case: 56-year-old male patient with a history of chronic kidney disease on hemodialysis and narrowing of the spinal canal under treatment with gabapentin, who presented acute liver injury probably secondary to a dose of gabapentin; however, it remitted with the suspension of said drug.

Conclusion: Gabapentin lacks liver metabolism; the mechanism by which it produces liver injury is still unknown; however, there are reports of hepatotoxicity associated with its administration, so its use must be individualized for each patient. Read More

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Tetrahydrocannabinol and cannabidiol as an oromucosal spray in a 1:1 ratio: a therapeutic option for patients with central post-stroke pain syndrome?

Authors:
Ulrich Moser

BMJ Case Rep 2021 Jul 6;14(7). Epub 2021 Jul 6.

Bayerische Ärztekammer, Munich, Germany

Central pain after stroke due to brainstem infarction is very rare. Treatment is difficult and specific guidelines are lacking. This is the report of a 61-year-old female patient who, after a posterolateral left medulla oblongata insult with incomplete Wallenberg syndrome, subsequently developed a burning and tingling pain in the contralateral leg and a burning and shooting pain in the ipsilateral face in trigeminal branches 1 and 2. Read More

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Pain intensity and pain medication prescription patterns in Veterans with heart failure and back pain.

Heart Lung 2021 Jul 1;50(6):770-774. Epub 2021 Jul 1.

VA Connecticut Healthcare System, West Haven, CT, USA; Department of Emergency Medicine, Yale School of Medicine, New Haven, CT, USA.

Background: Pain and heart failure are highly comorbid.

Objectives: The purpose of this study was to examine differences in pain intensity and pain medication prescriptions among Veterans with comorbid heart failure and pain and those with pain alone.

Methods: The [Blinded for Review] cohort includes 5,237,763 Veterans diagnosed with a musculoskeletal disorder between 2000 and 2013. Read More

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