Am J Psychiatry 2021 Jul 14:appiajp202120121757. Epub 2021 Jul 14.
Department of Psychiatry and Behavioral Sciences, Addiction Sciences Division (Prisciandaro, Hoffman, Voronin, Book, Bristol, Anton), and Department of Radiology (Brown), Medical University of South Carolina, Charleston.
Objective: Although gabapentin has demonstrated efficacy in mitigating alcohol withdrawal symptoms and preventing relapse drinking in individuals with alcohol use disorder (AUD), the neurobiological mechanisms of action underlying these therapeutic effects remain unknown. The present study evaluated changes in GABA and glutamate levels in the dorsal anterior cingulate cortex (dACC) as candidate mechanisms of action.
Methods: In a 16-week randomized clinical trial, 68 adults with AUD, including a history of alcohol withdrawal syndrome, received 1,200 mg/day of gabapentin (N=37) or placebo (N=31) and nine medical management visits after ≥72 hours of abstinence. Read More