48 results match your criteria gabapentin quantified

Pharmaceuticals and environmental risk assessment in municipal wastewater treatment plants and rivers from Peru.

Environ Int 2021 Oct 23;155:106674. Epub 2021 Jun 23.

Research Institute for Pesticides and Water (IUPA), University Jaume I, Castellón, Spain.

This is the first study dealing with removal of the pharmaceutical substances in municipal wastewater treatment plants (MWWTPs) from Peru and the impact of these compounds in surface waters receiving treated wastewater. To this aim, samples from MWWTP of Lima (Peruvian Coast), MWWTP of Cusco, Puno and Juliaca (Peruvian Highlands), as well surface water (confluence of Torococha and Coata rivers in Juliaca) were analyzed. A total of 38 target pharmaceuticals were included in this study and were determined by Liquid Chromatography coupled to tandem Mass Spectrometry (LC-MS/MS). Read More

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October 2021

Coprescription of Opioids With Other Medications and Risk of Opioid Overdose.

Clin Pharmacol Ther 2021 May 28. Epub 2021 May 28.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Polypharmacy is common among patients taking prescription opioids long-term, and the codispensing of interacting medications may further increase opioid overdose risk. To identify nonopioid medications that may increase opioid overdose risk in this population, we conducted a case-crossover-based screening of electronic claims data from IBM MarketScan and Optum Clinformatics Data Mart spanning 2003 through 2019. Eligible patients were 18 years of age or older and had at least 180 days of continuous enrollment and 90 days of prescription opioid use immediately before an opioid overdose resulting in an emergency room visit or hospitalization. Read More

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Pharmacokinetics of oral and compounded intravenous gabapentin in Duroc swine (Sus Scrofa).

J Vet Pharmacol Ther 2021 May 12. Epub 2021 May 12.

Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, California, USA.

The objective of this study was to determine the pharmacokinetics (PK) of oral (OS; 20 mg/kg) and compounded intravenous (IV; 5.5 mg/kg) gabapentin in 6 healthy, adult, Duroc pigs. Subjects were randomized to receive IV and OS gabapentin in a cross-over design, with at least 14 days of wash-out period between the two rounds of drug administrations. Read More

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High concentrations of illicit stimulants and cutting agents cause false positives on fentanyl test strips.

Harm Reduct J 2021 Mar 9;18(1):30. Epub 2021 Mar 9.

Department of Chemistry and Biochemistry, University of Notre Dame, 251 Stepan Hall of Chemistry, Notre Dame, IN, 46556, USA.

Background: The opioid epidemic has caused an increase in overdose deaths which can be attributed to fentanyl combined with various illicit substances. Drug checking programs have been started by many harm reduction groups to provide tools for users to determine the composition of their street drugs. Immunoassay fentanyl test strips (FTS) allow users to test drugs for fentanyl by either filling a baggie or cooker with water to dissolve the sample and test. Read More

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Characterization of Mechanical Allodynia and Skin Innervation in a Mouse Model of Type-2 Diabetes Induced by Cafeteria-Style Diet and Low-Doses of Streptozotocin.

Front Pharmacol 2020 3;11:628438. Epub 2021 Feb 3.

Unidad Académica Multidisciplinaria Reynosa Aztlán, Universidad Autónoma de Tamaulipas, Reynosa, México.

Painful distal symmetrical polyneuropathy (DPN) is a frequent complication of type-2 diabetes mellitus (T2DM) that commonly presents as neuropathic pain and loss of skin nerve fibers. However, there are limited therapies to effectively treat DPN and many of the current animal models of T2DM-induced DPN do not appear to mirror the human disease. Thus, we validated a DPN mouse model induced by a cafeteria-style diet plus low-doses of streptozotocin (STZ). Read More

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February 2021

Laboratory and pilot evaluation of aquaporin-based forward osmosis membranes for rejection of micropollutants.

Water Res 2021 Apr 12;194:116924. Epub 2021 Feb 12.

Department of Environmental Science, Aarhus University, Frederiksborgvej 399, 4000, Roskilde, Denmark; WATEC - Centre for Water Technology, Aarhus University, Ny Munkegade 120, Aarhus 8000, Denmark. Electronic address:

Aquaporin-based forward osmosis (AQP FO) membranes were applied both in laboratory- and pilot-scale for removing micropollutants from water. The effect of operating parameters (feed flow, draw flow, and transmembrane pressure) on the i) rejection of micropollutants, ii) water flux, iii) reverse salt flux, and iv) water recovery of the AQP FO membrane modules was studied. Among the 21 micropollutants spiked, only four compounds, atenolol, propranolol, metoprolol, and citalopram, permeated through the AQP FO membranes to an extent that they could be quantified in the draw solutions of both the laboratory and pilot systems. Read More

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Treatment of wastewater effluents from Bogotá - Colombia by the photo-electro-Fenton process: Elimination of bacteria and pharmaceutical.

Sci Total Environ 2021 Jun 29;772:144890. Epub 2021 Jan 29.

Grupo de Investigación en Ciencias Biológicas y Químicas (GIBIQS), Facultad de Ciencias, Universidad Antonio Nariño (UAN), Bogotá, Colombia. Electronic address:

In this work, the occurrences of bacteria families and relevant pharmaceuticals in municipal wastewater effluents from Bogotá (Colombia), and their treatment by the photo-electro-Fenton process were studied. Twenty-five representative pharmaceuticals (azithromycin, carbamazepine, ciprofloxacin, clarithromycin, diclofenac, enalapril, gabapentin, iopromide, metoprolol, sulfamethoxazole, trimethoprim, valsartan, clindamycin, erythromycin, levamisole, lincomycin, norfloxacin, oxolinic acid, phenazone, primidone, salbutamol, sulfadiazine, tetracycline, tramadol, and venlafaxine) were quantified in the effluent by LC-MS/MS analysis. Four of these target compounds (azithromycin, diclofenac, trimethoprim, norfloxacin) were found at concentrations that represent an environmental risk. Read More

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Use of valproate in pregnancy and in women of childbearing age between 2014 and 2018 in Switzerland: a retrospective analysis of Swiss healthcare claims data.

Swiss Med Wkly 2021 Jan 10;151:w20386. Epub 2021 Jan 10.

Service of Pharmacy, Lausanne University Hospital and University of Lausanne, Switzerland / Institute of Primary Health Care (BIHAM), University of Bern, Switzerland.

Aims Of The Study: The prevalence of the use of valproate during pregnancy and by women of childbearing age in Switzerland is not known. We aimed to study the use of antiseizure drugs by these women in Switzerland, with a particular focus on valproate.

Methods: We conducted a retrospective descriptive study using the healthcare claims database of the Swiss health insurance Helsana (2014–18). Read More

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January 2021

Efficacy of uremic pruritus treatment in patients undergoing hemodialysis, a network meta-analysis for randomized clinical trials.

Nephrol Ther 2021 Feb 14;17(1):30-34. Epub 2020 Nov 14.

Nephrology Department, Ningbo Yinzhou No. 2 Hospital, 315010 Ningbo, China.

Introduction: Uremic pruritus is very common in hemodialysis or renal failure patients, there were lots of available treatments such as gabapentin, pregabalin, ondansetron, etc. However, there is no quantified study comparing these treatments together, it is impossible to conduct a clinical trial involving so many treatments, so we conduct a network meta-analysis to compare them.

Method: We collected mean difference and standard error of visual analogue scale data as outcome. Read More

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February 2021

Baclofen: To Screen or Not to Screen in Postmortem Blood?

J Anal Toxicol 2021 Jul;45(6):612-618

Toxicology Unit, Imperial College London, Toxicology Unit, London, W6 8RP, UK.

Baclofen (BLF) has been prescribed in the UK since 1972 for the alleviation of spasticity. However, evidence suggests BLF is also recreationally misused. It has been associated with ethanol, gamma-hydroxybutyric acid (GHB), pregabalin (PGL) and gabapentin (GBP) use/abuse, and deaths have been reported. Read More

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Basketball and drugs: Wastewater-based epidemiological estimation of discharged drugs during basketball games in Kentucky.

Sci Total Environ 2021 Jan 15;752:141712. Epub 2020 Aug 15.

Department of Chemistry, Murray State University, Murray, KY, United States. Electronic address:

High school sports gather a significantly larger number of fans than college and professional sports in the U.S. Adolescent and adult students in high schools and colleges (aged 12-25) are among the most vulnerable population to substance use. Read More

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January 2021

Antiepileptic combination therapy with Stevens-Johnson syndrome and toxic epidermal necrolysis: Analysis of a Japanese pharmacovigilance database.

Epilepsia 2020 09 6;61(9):1979-1989. Epub 2020 Aug 6.

Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University, Gifu, Japan.

Objective: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are immune-mediated diseases characterized by an extensive loss of the epidermal skin layer, often resulting in death. SJS and TEN are often triggered by certain drugs, including antiepileptic drugs (AEDs). Epilepsy is very difficult to treat and often involves the combination of two or more AEDs. Read More

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September 2020

Plasma disposition of gabapentin after the intragastric administration of escalating doses to adult horses.

J Vet Intern Med 2020 Mar 8;34(2):933-940. Epub 2020 Feb 8.

Department of Veterinary Clinical Sciences, Washington State University, Pullman, Washington.

Background: In humans, gabapentin an analgesic, undergoes non-proportional pharmacokinetics which can alter efficacy. No information exists on the pharmacokinetics of dosages >20 mg/kg, escalating dosages or dose proportionality of gabapentin in horses.

Hypothesis And Objectives: Gabapentin exposure in plasma would not increase proportionally relative to the dose in horses receiving dosages ≥20 mg/kg. Read More

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Anticonvulsants in the treatment of low back pain and lumbar radicular pain: a systematic review and meta-analysis.

CMAJ 2018 07;190(26):E786-E793

The University of Sydney (Enke, H.A. New, C.H. New), Sydney Medical School Nepean, Kingswood, Australia; Westmead Hospital (H.A. New), Westmead, Australia; The University of Sydney (Mathieson, Latimer, Maher, Lin), Sydney School of Public Health; The University of Sydney and Concord Hospital (McLachlan), Faculty of Pharmacy and Centre for Education and Research on Ageing, Sydney, Australia.

Background: The use of anticonvulsants (e.g., gabapentin, pregabalin) to treat low back pain has increased substantially in recent years despite limited supporting evidence. Read More

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Widespread Micropollutant Monitoring in the Hudson River Estuary Reveals Spatiotemporal Micropollutant Clusters and Their Sources.

Environ Sci Technol 2018 06 16;52(11):6187-6196. Epub 2018 May 16.

School of Civil and Environmental Engineering , Cornell University , Ithaca , New York 14853 , United States.

The objective of this study was to identify sources of micropollutants in the Hudson River Estuary (HRE). We collected 127 grab samples at 17 sites along the HRE over 2 years and screened for up to 200 micropollutants. We quantified 168 of the micropollutants in at least one of the samples. Read More

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The risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptic drugs.

Epilepsia 2017 12 13;58(12):2178-2185. Epub 2017 Oct 13.

Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacy and Epidemiology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.

Objective: Older antiepileptic drugs (AEDs) are known to cause Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN). However, evidence for newer AED is sparse. We quantified risks of SJS/TEN in association with use of all AEDs in the United Kingdom. Read More

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December 2017

Vagal nerve stimulation modifies neuronal activity and the proteome of excitatory synapses of amygdala/piriform cortex.

J Neurochem 2017 02 3;140(4):629-644. Epub 2017 Feb 3.

Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, USA.

Vagal Nerve Stimulation (VNS) Therapy is a United States Food and Drug Administration approved neurotherapeutic for medically refractory partial epilepsy and treatment-resistant depression. The molecular mechanisms underlying its beneficial effects are unclear. We hypothesized that one mechanism involves neuronal activity-dependent modifications of central nervous system excitatory synapses. Read More

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February 2017

Comparative efficacy of nonhormonal drugs on menopausal hot flashes.

Eur J Clin Pharmacol 2016 Sep 24;72(9):1051-8. Epub 2016 Jul 24.

Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, Shanghai, 201203, China.

Purpose: The effects of nonhormonal drugs on menopausal hot flashes are still not well quantified. We therefore did a model-based meta-analysis (MBMA) to quantitate and compare the efficacy features of nonhormonal drugs on menopausal hot flashes.

Methods: Literature was searched in the public databases to extract data of clinical trials on nonhormonal drugs, including selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs), gabapentin, clonidine, and soy isoflavones. Read More

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September 2016

Development of a multi-residue method for scrutinizing psychotropic compounds in natural waters.

J Chromatogr B Analyt Technol Biomed Life Sci 2017 Mar 7;1047:160-172. Epub 2016 Jul 7.

Laboratoire National de métrologie et d'Essais (LNE), 1 rue Gaston Boissier, 75724 Paris, France.

The present work describes a multi-residue SPE-UPLC-MS/MS method aiming at the characterization of 68 compounds in natural waters, including parent compounds as well as their major metabolites and glucuronide conjugates. Development was conducted toward the quantitative determination of a broad range of analytes belonging to different class of psychotropic drugs such as benzodiazepines, antidepressants, stimulants, opiates and opioids, anticonvulsants, anti-dementia drugs, analgesic and anti-inflammatory drugs (as anthropic indicators) in the low ngL range of concentration. Satisfactory extraction recoveries >70% were obtained for the majority of analytes (49 out of 68) allowing low limits of quantification. Read More

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Effects of Delta-9-Tetrahydrocannabinol and Cannabidiol on Cisplatin-Induced Neuropathy in Mice.

Planta Med 2016 Aug 23;82(13):1169-72. Epub 2016 May 23.

National Center for Natural Products Research, University of Mississippi, University, MS, USA.

Sativex, a cannabinoid extract with a 1 : 1 ratio of tetrahydocannabinol and cannabidiol, has been shown to alleviate neuropathic pain associated with chemotherapy. This research examined whether tetrahydocannabinol or cannabidiol alone could attenuate or prevent cisplatin-induced tactile allodynia. In experiment 1, mice (C57BL/6) received eight administrations of 2. Read More

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Development of a SPE-HPLC-MS/MS method for the determination of most prescribed pharmaceuticals and related metabolites in urban sewage samples.

J Chromatogr B Analyt Technol Biomed Life Sci 2015 May 23;990:23-30. Epub 2015 Mar 23.

Institute of Clinical Pharmacology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Fiedlerstraße 27, D-01307 Dresden, Germany.

Based on regional prescription data several pharmaceuticals with variable amounts of prescription and corresponding metabolites were selected and analyzed in influent and effluent samples of the sewage treatment plant (STP) in Dresden, Germany. Pharmaceuticals of the following most prescribed therapeutic groups were chosen: antibiotics, antifungals, anticonvulsants, antipsychotics, antidepressants, and cardiovascular active compounds like beta blockers and angiotensin-converting enzyme inhibitors. To analyze the selected compounds, a multi-target method was developed and applied to 24-h composite wastewater samples for three single days in May and June 2014. Read More

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Pharmacotherapies for cannabis dependence.

Cochrane Database Syst Rev 2014 17(12):CD008940. Epub 2014 Dec 17.

Discipline of Pharmacology, University of Adelaide, Adelaide, Australia.

Background: Cannabis is the most prevalent illicit drug in the world. Demand for treatment of cannabis use disorders is increasing. There are currently no pharmacotherapies approved for treatment of cannabis use disorders. Read More

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January 2015

Safety and tolerability of gabapentin for aneurysmal subarachnoid hemorrhage (sah) headache and meningismus.

Neurocrit Care 2015 Jun;22(3):414-21

Department of Critical Care, Mayo Clinic, Jacksonville, FL, USA.

Background: Headache after aneurysmal subarachnoid hemorrhage (SAH) is very common and is often described as the "worst headache imaginable." SAH-associated headache can persist for days to weeks and is traditionally treated with narcotics. However, narcotics can have significant adverse effects. Read More

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Permeability analysis of neuroactive drugs through a dynamic microfluidic in vitro blood-brain barrier model.

R Booth H Kim

Ann Biomed Eng 2014 Dec 13;42(12):2379-91. Epub 2014 Aug 13.

Department of Bioengineering, University of Utah, SMBB 3100, 36 S. Wasatch Dr., Salt Lake City, UT, 84112, USA,

This paper presents the permeability analysis of neuroactive drugs and correlation with in vivo brain/plasma ratios in a dynamic microfluidic blood-brain barrier (BBB) model. Permeability of seven neuroactive drugs (Ethosuximide, Gabapentin, Sertraline, Sunitinib, Traxoprodil, Varenicline, PF-304014) and trans-endothelial electrical resistance (TEER) were quantified in both dynamic (microfluidic) and static (transwell) BBB models, either with brain endothelial cells (bEnd.3) in monoculture, or in co-culture with glial cells (C6). Read More

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December 2014

Differential pharmacological alleviation of oxaliplatin-induced hyperalgesia/allodynia at cephalic versus extra-cephalic level in rodents.

Neuropharmacology 2014 Apr 19;79:432-43. Epub 2013 Dec 19.

INSERM U894 - CPN, Université Pierre et Marie Curie - Paris 6, Faculté de Médecine Pierre et Marie Curie, Site Pitié-Salpêtrière, UMR S677, 91, Boulevard de l'Hôpital, Paris F-75013, France.

Previous data showed that neuropathic pain induced by mechanical lesion of peripheral nerves responds differently to alleviating drugs at cephalic versus extracephalic level. Because neuropathic pain evoked by anti-cancer drugs differs from that triggered by mechanical nerve lesion, we investigated whether differences between cephalic and extracephalic levels could also be characterized in rodents rendered neuropathic by treatment with the anti-cancer platinum derivative oxaliplatin. C57BL/6J mice received two injections and Sprague-Dawley rats three injections of oxaliplatin (10 mg/kg, i. Read More

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A model to estimate the population contributing to the wastewater using samples collected on census day.

Environ Sci Technol 2014 19;48(1):517-25. Epub 2013 Dec 19.

The University of Queensland , The National Research Centre for Environmental Toxicology (Entox), 39 Kessels Road, Coopers Plains, QLD 4108, Australia.

An important uncertainty when estimating per capita consumption of, for example, illicit drugs by means of wastewater analysis (sometimes referred to as "sewage epidemiology") relates to the size and variability of the de facto population in the catchment of interest. In the absence of a day-specific direct population count any indirect surrogate model to estimate population size lacks a standard to assess associated uncertainties. Therefore, the objective of this study was to collect wastewater samples at a unique opportunity, that is, on a census day, as a basis for a model to estimate the number of people contributing to a given wastewater sample. Read More

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October 2015

Assessment of paclitaxel induced sensory polyneuropathy with "Catwalk" automated gait analysis in mice.

PLoS One 2013 15;8(10):e76772. Epub 2013 Oct 15.

Klinik und Hochschulambulanz für Neurologie, Charité Universitätsmedizin Berlin, Berlin, Germany ; Cluster of Excellence NeuroCure, Charité Universitätsmedizin Berlin, Berlin, Germany.

Neuropathic pain as a symptom of sensory nerve damage is a frequent side effect of chemotherapy. The most common behavioral observation in animal models of chemotherapy induced polyneuropathy is the development of mechanical allodynia, which is quantified with von Frey filaments. The data from one study, however, cannot be easily compared with other studies owing to influences of environmental factors, inter-rater variability and differences in test paradigms. Read More

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Effects of chronic administration of amitriptyline, gabapentin and minocycline on spinal brain-derived neurotrophic factor expression and neuropathic pain behavior in a rat chronic constriction injury model.

Reg Anesth Pain Med 2013 Mar-Apr;38(2):124-30

Department of Anesthesiology, Intensive Care, Emergency Care and Pain Therapy, Ziekenhuis Oost-Limburg, Genk, Belgium.

Background: In animal models of neuropathic pain (NP), promising results have been reported with the administration of minocycline, possibly through inhibition of spinal brain-derived neurotrophic factor (BDNF) expression. No data are available on the effect of amitriptyline and gabapentin on spinal BDNF expression. If the mechanism of action of the latter drugs does not involve brain-derived NP inhibition, further clinical research in BDNF is warranted. Read More

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Effects of a single 1200-mg preoperative dose of gabapentin on anxiety and memory.

Ann Fr Anesth Reanim 2012 Oct 6;31(10):e223-7. Epub 2012 Jul 6.

Department of Anesthesia, hôpital Ambroise-Paré, Assistance publique-Hôpitaux de Paris, 9, avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France.

Background: Gabapentin has antihyperalgesic and potential anxiolytic effects. We therefore evaluated the effects of gabapentin premedication on anxiety, amnesia, and sedation. We tested the primary hypothesis that 1200mg of oral gabapentin 2 to 3h before surgery reduces preoperative anxiety. Read More

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October 2012