1,595 results match your criteria gabapentin dosage

Neurodevelopmental outcomes in children exposed to newer antiseizure medications: A systematic review.

Epilepsia 2021 Jun 14. Epub 2021 Jun 14.

Division of Evolution and Genomic Science, University of Manchester, Manchester, UK.

As prenatal exposure to certain older antiseizure medications (ASMs) has been linked with poorer neurodevelopmental outcomes in children, the use of newer ASMs throughout pregnancy has increased. The current review aimed to delineate the impact of in utero exposure to these newer ASMs on child neurodevelopment. A systematic search of MEDLINE, Embase, Web of Science, Cumulative Index to Nursing and Allied Health Literature Plus, and PsycINFO was conducted, limiting results to articles available in English and published after the year 2000. Read More

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Pilot randomized placebo-controlled clinical trial of high-dose gabapentin for alcohol use disorder.

Alcohol Clin Exp Res 2021 Jun 12. Epub 2021 Jun 12.

Division on Substance Use Disorders, New York State Psychiatric Institute, New York, NY, USA.

Background: Despite advances in the development of pharmacotherapy for alcohol use disorder (AUD), there remains a need for medications that can be administered to actively drinking outpatients to promote a reduction in harmful alcohol consumption. The primary aim of this pilot study was to determine whether high-dose gabapentin (3600 mg/daily) is more effective than placebo in reducing harmful alcohol consumption in outpatients with AUD.

Methods: Forty patients (27 men) who met DSM-IV-TR criteria for alcohol dependence and reporting at least 4 heavy drinking days (HDD) per week were recruited at a single site. Read More

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Efficacy of a fixed combination of palmitoylethanolamide and acetyl-l-carnitine (PEA+ALC FC) in the treatment of neuropathies secondary to rheumatic diseases.

Minerva Med 2021 Aug 31;112(4):492-499. Epub 2021 May 31.

Unit of Rheumatology, Città della Salute e della Scienza, Turin, Italy.

Background: The neurologic complications of rheumatic diseases (RDs) are highly variable, and their manifestations are linked to the pathogenesis and clinical phenotype of the specific RDs. In rheumatoid arthritis, for example, the peripheral nervous system is most commonly involved and mononeuritis multiplex, nerve entrapment and vasculitic sensorimotor neuropathies are not uncommon. Often the therapy for these disorders is not easy and is characterized by the use of different drugs. Read More

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Coprescription of Opioids With Other Medications and Risk of Opioid Overdose.

Clin Pharmacol Ther 2021 May 28. Epub 2021 May 28.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Polypharmacy is common among patients taking prescription opioids long-term, and the codispensing of interacting medications may further increase opioid overdose risk. To identify nonopioid medications that may increase opioid overdose risk in this population, we conducted a case-crossover-based screening of electronic claims data from IBM MarketScan and Optum Clinformatics Data Mart spanning 2003 through 2019. Eligible patients were 18 years of age or older and had at least 180 days of continuous enrollment and 90 days of prescription opioid use immediately before an opioid overdose resulting in an emergency room visit or hospitalization. Read More

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The analgesic evaluation of gabapentin for arthroscopy: A meta-analysis of randomized controlled trials.

Medicine (Baltimore) 2021 May;100(20):e25740

Department of Orthopedics, Affiliated Yueqing Hospital,Wenzhou Medical University, Wenzhou, Zhejiang Province, P.R. China.

Introduction: The efficacy of gabapentin for pain management of arthroscopy remains controversial. We conduct a systematic review and meta-analysis to explore the influence of gabapentin versus placebo on the postoperative pain intensity of arthroscopy.

Methods: We search PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through April 2020 for randomized controlled trials assessing the effect of gabapentin versus placebo on pain control of arthroscopy. Read More

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Protracted Hiccups Induced by Aripiprazole and Regressed after Administration of Gabapentin.

Case Rep Psychiatry 2021 22;2021:5567152. Epub 2021 Apr 22.

Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 57, 56100 Pisa, Italy.

Hiccups are sudden, repeated, and involuntary contractions of the diaphragm muscle (myoclonic contraction). It involves a reflex arc that, once activated, causes a strong contraction of the diaphragm immediately followed by the closure of the glottis translating into the classic "hic" sound. Hiccups can be short, persistent, and intractable depending on the duration. Read More

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Vincristine-Induced Peripheral Neuropathy (VIPN) in Pediatric Tumors: Mechanisms, Risk Factors, Strategies of Prevention and Treatment.

Int J Mol Sci 2021 Apr 16;22(8). Epub 2021 Apr 16.

Pediatric Oncology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica Sacro Cuore, 00168 Rome, Italy.

Vincristine-induced peripheral neurotoxicity (VIPN) is a very common side effect of vincristine chemotherapy among pediatric patients with cancer. Neuropathy may be sensory, motor and/or autonomic, with consequent reduction, delay or discontinuation of vincristine-chemotherapy, but also pain, disability, reduced quality of life of patients and an increase in medical costs. Vincristine acts out its antineoplastic function by altering the normal assembly and disassembly of microtubules, with their consequent mitosis block and death. Read More

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Average narcotic usage in a group of TKA patients following a modern TKA protocol.

Knee 2021 Mar 13;29:426-431. Epub 2021 Mar 13.

The University of Maryland St. Joseph Medical Center, 7601 Osler Dr., Towson, MD 21204, United States. Electronic address:

Introduction: The optimal dosing of post-operative total knee arthroplasty (TKA) narcotics is unclear. We report on the average narcotic usage in a group of patients treated with an identical multimodal pain protocol following TKA.

Materials And Methods: 49 patients undergoing TKA participated in the survey. Read More

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National surveillance of oral medication prescription for children with dystonic cerebral palsy.

J Paediatr Child Health 2021 Mar 3. Epub 2021 Mar 3.

Kids Rehab, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.

Aim: Oral medications are often first-line medical management for children with cerebral palsy who have generalised dystonia; however, evidence for their effectiveness is limited and dosing practices are inconsistent. As a first step to improve consistency, this study aimed to examine current clinical practice of expert doctors for prescribing medications for children with dystonic cerebral palsy including prescribing patterns and combinations of medications used.

Methods: This was a prospective surveillance study of medical doctors working in major Australian centres who manage children with cerebral palsy. Read More

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Should we prescribe anticonvulsants for acute herpes zoster neuralgia and to prevent postherpetic neuralgia?: A protocol for meta-analysis and benefit-risk assessment.

Medicine (Baltimore) 2021 Feb;100(7):e24343

Guangzhou University of Traditional Chinese Medicine.

Background: Herpes zoster-associated pain [i.e., acute herpes zoster neuralgia (AHN) and postherpetic neuralgia (PHN)] has the potential to cause significant patients' burden and heath resource expenditure. Read More

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February 2021

Association Between Dual Trajectories of Opioid and Gabapentinoid Use and Healthcare Expenditures Among US Medicare Beneficiaries.

Value Health 2021 02 11;24(2):196-205. Epub 2021 Jan 11.

Department of Pharmaceutical Outcomes and Policy, University of Florida, Gainesville, FL, USA; Center for Drug Evaluation and Safety, University of Florida, Gainesville, FL, USA. Electronic address:

Objectives: Little is known about relationships between opioid- and gabapentinoid-use patterns and healthcare expenditures that may be affected by pain management and risk of adverse outcomes. This study examined the association between patients' opioid and gabapentinoid prescription filling/refilling trajectories and direct medical expenditures in US Medicare.

Methods: This cross-sectional study included a 5% national sample (2011-2016) of fee-for-service beneficiaries with fibromyalgia, low back pain, neuropathy, or osteoarthritis newly initiating opioids or gabapentinoids. Read More

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February 2021

Gabapentin add-on treatment for drug-resistant focal epilepsy.

Cochrane Database Syst Rev 2021 01 12;1:CD001415. Epub 2021 Jan 12.

Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

Background: This is an updated version of the Cochrane Review previously published in 2018. Epilepsy is a common neurological disorder characterised by recurrent seizures. Most people with epilepsy have a good prognosis and their seizures are well controlled by a single antiepileptic drug, but up to 30% develop drug-resistant epilepsy, especially people with focal seizures. Read More

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January 2021

Association of Gabapentinoids With the Risk of Opioid-Related Adverse Events in Surgical Patients in the United States.

JAMA Netw Open 2020 12 1;3(12):e2031647. Epub 2020 Dec 1.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Importance: The use of gabapentinoids in multimodal postoperative analgesia is increasing; however, when coadministered with opioids, these drugs may potentiate central nervous system and respiratory depression.

Objective: To evaluate the association between perioperative coadministration of gabapentinoids and opioids with inpatient opioid-related adverse events in surgical patients.

Design, Setting, And Participants: This cohort study used propensity score trimming, stratification, and weighting of adults admitted for a major surgery between October 2007 and December 2017 who were treated with opioids on the day of surgery and included in the Premier Research database. Read More

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December 2020

Understanding Deformation Behavior and Compression Speed Effect in Gabapentin Compacts.

J Pharm Sci 2021 05 23;110(5):2157-2166. Epub 2020 Dec 23.

Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Ave, Pittsburgh, PA 15282, USA. Electronic address:

Deformation mechanism and strain rate sensitivity of gabapentin powder was investigated in this work. Heckel analysis, specific surface area and indentation hardness measurements revealed an intermediate yield pressure and brittle fracture as the dominant type of deformation mechanism during consolidation. Strain rate sensitivity of gabapentin was studied by compressing it at 1 mm/min and 500 mm/min compression speeds. Read More

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Treatment-induced diabetes neuropathy: description of singular clinical signs to reach a prompt diagnosis.

BMJ Case Rep 2020 Dec 17;13(12). Epub 2020 Dec 17.

Endocrinology, Complejo hospitalario Ruber Juan Bravo, Madrid, Spain.

A 23-year-old woman diagnosed with type 1 diabetes mellitus in 2011 came to our outpatient office because of an inability to walk correctly. She was under a basal bolus insulin regimen. In the summer of 2016, she experienced a rapid improvement in her glycaemic control. Read More

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December 2020

Trends in Opioid and Psychotropic Prescription in Pregnancy in the United States From 2001 to 2015 in a Privately Insured Population : A Cross-sectional Study.

Ann Intern Med 2020 12;173(11 Suppl):S19-S28

University of Utah Health, Salt Lake City, Utah (M.C.S.).

Background: Opioid and psychotropic prescriptions are common during pregnancy. Little is known about coprescriptions of both medications in this setting.

Objective: To describe opioid prescription among women who are prescribed psychotropics compared with women who are not. Read More

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December 2020

Co-prescription of gabapentinoids and opioids among adults with and without osteoarthritis in the United Kingdom between 1995 and 2017.

Rheumatology (Oxford) 2021 04;60(4):1942-1950

Primary Care Centre Versus Arthritis, School of Medicine, Community and Social Care, Keele University, Keele, UK.

Objectives: To produce national and regional estimates and trends for gabapentinoid-opioid co-prescribing rates in patients with OA, both in absolute terms and relative to matched controls without OA.

Methods: Using the UK Clinical Practice Research Datalink database we first constructed age-sex-practice-date 1:1 matched cohorts of patients aged ≥40 years with and without a new diagnosis of OA between 1995-2017 and estimated the relative incidence of a first gabapentinoid prescription. Incident gabapentinoid users in both cohorts were followed to estimate and compare the event rate of gabapentinoid-opioid co-prescription (prescription from both classes within the same 28-day window). Read More

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Application and Therapeutic Effect of Puncturing of the Costal Transverse Process for Pulsed Radiofrequency Treated T1-T3 Herpes Zoster Neuralgia.

J Pain Res 2020 7;13:2519-2527. Epub 2020 Oct 7.

Department of Anesthesiology and Pain Research Center, The First Hospital of Jiaxing or The Affiliated Hospital of Jiaxing University, Jiaxing, People's Republic of China.

Purpose: In CT-guided dorsal root ganglion puncture, especially T1-T3, it is often difficult to reach the target due to obstruction of the lamina, transverse process, and ribs. Therefore, a safe and effective puncture method with high success rate is urgently needed to guide us in our clinical work.

Patients And Methods: A total of 44 patients with dorsal root ganglion underwent pulsed radiofrequency therapy for pain T1-T3 herpes zoster neuralgia at the pain department of Affiliated Hospital of Jiaxing University from January 2019 to February 2020 were retrospectively reviewed. Read More

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October 2020

Postoperative Dexamethasone Following Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis.

J Bone Joint Surg Am 2020 Oct;102(20):1807-1813

Children's Healthcare of Atlanta, Atlanta, Georgia.

Background: Surgeons have hesitated to use steroids in patients undergoing posterior spinal fusion because of the risk of wound complications. The literature has supported the use of postoperative steroids in other areas of orthopaedics on the basis of more rapid recovery and improved postoperative pain control. We hypothesized that a short course of postoperative dexamethasone following posterior spinal fusion for the treatment of adolescent idiopathic scoliosis (AIS) would decrease opioid usage without increasing wound-healing problems. Read More

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October 2020

Development and Validation of a Model to Predict Neonatal Abstinence Syndrome.

J Pediatr 2021 02 17;229:154-160.e6. Epub 2020 Oct 17.

Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN; Department of Health Policy, Vanderbilt University Medical Center, Nashville, TN.

Objectives: To develop and validate clinical risk prediction tools for neonatal abstinence syndrome (NAS).

Study Design: We developed prediction models for NAS based on a set of 30 demographic and antenatal exposure covariates collected during pregnancy. Data (outpatient prescription, vital, and administrative records), were obtained from enrollees in the Tennessee Medicaid Program from 2009 to 2014. Read More

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February 2021

Supraorbital Nerve Radiofrequency for Severe Neuralgia Caused by Herpes Zoster Ophthalmicus.

Pain Res Manag 2020 25;2020:3191782. Epub 2020 Sep 25.

Department of Anesthesiology and Pain Medicine, First Affiliated Hospital of Jiaxing University, Jiaxing, China.

Background: Radiofrequency of the Gasserian ganglion can be used for ophthalmic herpetic neuralgia (OHN), but it is associated with complications. This study aimed to use the supraorbital nerve for computed tomography- (CT-) guided radiofrequency thermocoagulation to treat refractory OHN.

Methods: This was a retrospective case series study of patients with simple or combined OHN treated at our hospital between 06/2012 and 06/2018. Read More

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A Qualitative Examination of Gabapentin Misuse Inside of Treatment and Recovery Settings.

J Stud Alcohol Drugs 2020 09;81(5):681-686

Center for Applied Research on Substance Use and Health Disparities, Nova Southeastern University, Miami, Florida.

Objective: Gabapentin, an anti-convulsant medication used to treat seizures and neuralgia, is also prescribed off-label for the treatment of substance use disorders and withdrawal symptoms in treatment settings. Yet, reports of gabapentin misuse are increasing in the United States. The present study examines the misuse of gabapentin in treatment and transitional living facility settings. Read More

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September 2020

The use of antineuropathic medications for the treatment of chronic pain.

Best Pract Res Clin Anaesthesiol 2020 Sep 8;34(3):493-506. Epub 2020 Aug 8.

University of Arizona College of Medicine-Phoenix, Phoenix, AZ, USA; Creighton University School of Medicine, Department of Anesthesiology, Omaha, NE, USA; Louisiana State University Health Shreveport, Department of Anesthesiology, Shreveport, LA, USA; Valley Pain Consultants - Envision Physician Services, Phoenix, AZ, USA.

Chronic pain syndromes cost the US healthcare system over $600 billion per year. A subtype of chronic pain is neuropathic pain (NP), which is defined as "pain caused by a lesion or disease of the somatosensory system," according to the International Association for the Study of Pain (IASP). The pathophysiology of neuropathic pain is very complex, and more research needs to be done to find the exact mechanism. Read More

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September 2020

Drugs for menopausal symptoms.


Med Lett Drugs Ther 2020 08;62(1604):124-128

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Preoperative Gabapentin Administration and Its Impact on Postoperative Opioid Requirement and Pain in Sinonasal Surgery.

Otolaryngol Head Neck Surg 2021 04 8;164(4):889-894. Epub 2020 Sep 8.

Department of Otolaryngology-Head and Neck Surgery, University of California Davis, Sacramento, California, USA.

Objective: To determine the efficacy of preoperative gabapentin on patient-reported pain levels and postoperative opioid requirements following sinonasal surgery.

Study Design: Retrospective review.

Setting: Academic institution. Read More

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Paracervical blocks facilitate timely brachytherapy amidst COVID-19.

Brachytherapy 2021 Jan-Feb;20(1):284-289. Epub 2020 Aug 7.

Department of Radiation Oncology, Dan L. Duncan Comprehensive Cancer Center Baylor College of Medicine, Houston, TX. Electronic address:

Purpose: The COVID-19 pandemic presents serious challenges for brachytherapists, and in the time-sensitive case of locally advanced cervical cancer, the need for curative brachytherapy (BT) is critical for survival. Given the high-volume of locally advanced cervical cancer in our safety-net hospital, we developed a strategy in close collaboration with our gynecology oncology and anesthesia colleagues to allow for completely clinic-based intracavitary brachytherapy (ICBT).

Methods And Materials: This technical report will highlight our experience with the use of paracervical blocks (PCBs) and oral multimodal analgesia (MMA) for appropriately selected cervical ICBT cases, allowing for completely clinic-based treatment. Read More

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February 2021

Opioid-Sparing Cardiac Anesthesia: Secondary Analysis of an Enhanced Recovery Program for Cardiac Surgery.

Anesth Analg 2020 12;131(6):1852-1861

From the Department of Anesthesiology and Critical Care Medicine.

Background: Cardiac anesthetics rely heavily on opioids, with the standard patient receiving between 70 and 105 morphine sulfate equivalents (MSE; 10-15 µg/kg of fentanyl). A central tenet of Enhanced Recovery Programs (ERP) is the use of multimodal analgesia. This study was performed to assess the association between nonopioid interventions employed as part of an ERP for cardiac surgery and intraoperative opioid administration. Read More

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December 2020

Effects of Gabapentin Suspension and Rectal Acetaminophen on Postoperative Pain of Adenotonsillectomy in Children.

Iran J Otorhinolaryngol 2020 Jul;32(111):197-205

Rhino-Sinus, Ear, and Skull Base Diseases Research Center, Department of Otolaryngology and Head and Neck Surgery, Amiralmomenin Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.

Introduction: Adenotonsillectomy is the main treatment for symptomatic tonsillar hypertrophy with postoperative pain as the most common associated complication. The present study aimed to compare the efficacy of gabapentin with that reported for acetaminophen on the postoperative pain of adenotonsillectomy in children.

Materials And Methods: In this double-blind clinical trial, a total of 60 children within the age range of 7-15 years undergoing adenotonsillectomy were randomly allocated to two groups of gabapentin (n=30) and acetaminophen (n=30). Read More

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CACNA1S haploinsufficiency confers resistance to New World arenavirus infection.

Proc Natl Acad Sci U S A 2020 08 27;117(32):19497-19506. Epub 2020 Jul 27.

Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL 60612

Understanding the genetics of susceptibility to infectious agents is of great importance to our ability to combat disease. Here, we show that voltage-gated calcium channels (VGCCs) are critical for cellular binding and entry of the New World arenaviruses Junín and Tacaribe virus, suggesting that zoonosis via these receptors could occur. Moreover, we demonstrate that α1s haploinsufficiency renders cells and mice more resistant to infection by these viruses. Read More

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