15,147 results match your criteria fvc

Early respiratory diagnosis: benefits of enhanced lung function assessment.

BMJ Open Respir Res 2021 Jul;8(1)

COPD Centre, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Introduction: The National Health Service for England Long Term Plan identifies respiratory disease as one of its priority workstreams. To assist with earlier and more accurate diagnosis of lung disease they recommend improvement in delivery of quality-assured spirometry. However, there is a likelihood that patients will present with abnormal gas exchange when spirometry results are normal and therefore there will be a proportion of patients whose time to diagnosis is still protracted. Read More

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Natural -Based Nerve Guidance Conduit as a Potential Biomaterial for Peripheral Nerve Regeneration: In Vitro and In Vivo Studies.

ACS Biomater Sci Eng 2021 Jul 23. Epub 2021 Jul 23.

Department of Biomedical Engineering and Hubei Province Key Laboratory of Allergy and Immune Related Diseases, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.

The treatment and repair of serious peripheral nerve injuries remain challenging in the clinical practice, while the application of multifunctional nerve guidance conduits (NGCs) based on naturally derived polymers has attracted much attention in recent years because of their excellent physicochemical properties and biological characteristics. (Curt. ex FV) is a popular edible mushroom characterized by hollow tubular structures, antibacterial activities, and high nutritional properties. Read More

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Postoperative Pulmonary Function After Complex Segmentectomy.

Ann Surg Oncol 2021 Jul 22. Epub 2021 Jul 22.

Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Minami-ku, Hiroshima, Japan.

Background: Segmentectomy has been increasingly used for lung cancer treatment, however there are very limited data evaluating the postoperative pulmonary function of patients treated with complex segmentectomy. We evaluated the postoperative pulmonary function of patients who underwent complex segmentectomy compared with simple segmentectomy, wedge resection, and lobectomy.

Methods: We retrospectively analyzed data from 580 patients who underwent surgical resection. Read More

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A comparison of alternative selection methods for reporting spirometric parameters in healthy adults.

Sci Rep 2021 Jul 22;11(1):14945. Epub 2021 Jul 22.

Airborne Hazards and Burn Pits Center of Excellence, War Related Illness and Injury Study Center, VA New Jersey Health Care System, East Orange, NJ, USA.

Alternative methods have been proposed to report spirometry indices from test sessions (forced expiratory volume 1 s, FEV; forced vital capacity, FVC). However, most use the American and European Societies' standard (ATS/ERS) which stops sessions once a repeatability threshold is met which may not accurately represent intra-session variability. Our goal was to repeat trials beyond the repeatability threshold and evaluate alternative reporting methods. Read More

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Lung function, COPD and cognitive function: a multivariable and two sample Mendelian randomization study.

BMC Pulm Med 2021 Jul 22;21(1):246. Epub 2021 Jul 22.

MRC Integrative Epidemiology Unit (IEU), University of Bristol, Oakfield Grove, Bristol, BS8 2BN, UK.

Background: Observational studies show an association between reduced lung function and impaired cognition. Cognitive dysfunction influences important health outcomes and is a precursor to dementia, but treatments options are currently very limited. Attention has therefore focused on identifying modifiable risk factors to prevent cognitive decline and preserve cognition. Read More

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Efficacy of lower dose pirfenidone for idiopathic pulmonary fibrosis in real practice: a retrospective cohort study.

Korean J Intern Med 2021 Jul 27. Epub 2021 Jul 27.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

Background/aims: Pirfenidone slows the progression of idiopathic pulmonary fibrosis (IPF). We investigated its efficacy and safety in terms of dose and disease severity in real-world patients with IPF.

Methods: This multicenter retrospective cohort study investigated 338 patients treated with pirfenidone between July 2012 and March 2018. Read More

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The association between sleep quality, health status, and disability due to breathlessness in COPD patients.

Clin Respir J 2021 Jul 26. Epub 2021 Jul 26.

MD, Department of Psychiatry, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Chronic obstructive pulmonary disease (COPD) increases susceptibility to sleep disturbances. This study aimed to evaluate the association between COPD severity criteria with sleep quality.

Methods: 158 patients in Rasul Akram Hospital of Iran university of medical sciences, Tehran, Iran, from April 2019 to March 2021 diagnosed with COPD were examined using the Pittsburgh Sleep Quality Index (PSQI), COPD assessment test (CAT), modified Medical Research Council (mMRC) dyspnea scale, spirometry, and pulse oximetry. Read More

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Analytical data on respiratory symptoms and pulmonary impairments due to exposure to non-combusted liquefied petroleum gas.

Data Brief 2021 Jun 29;36:107106. Epub 2021 Apr 29.

Federal School of Medical Laboratory Technology (Science), Jos, Nigeria.

The article is aimed at assessing the effects of chronic exposure to non-combusted LPG on the prevalence of respiratory symptoms and appraising the potential pulmonary impairments among LPG vendors. A case control design in which vendors and non-vendors of LPG from Calabar, Nigeria were used for the data collection. Seventy five (75) apparently healthy LPG vendors and Seventy five (75) apparently healthy non LPG vendors, aged 18 to 50 years were considered. Read More

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Continuous Glucose Monitoring as a Valuable Tool in the Early Detection of Diabetes Related to Cystic Fibrosis.

Front Pediatr 2021 9;9:659728. Epub 2021 Jul 9.

Department of Pulmonology, The Institute for Health Protection of Mother and Child Serbia, Belgrade, Serbia.

We evaluated the impact of cystic fibrosis-related diabetes (CFRD) on lung disease and nutritional status. The retrospective cohort study evaluated the subjects' medical records from 2004 to 2019. All participants older than 10 years diagnosed by a 30-minutely sampled OGTT formed OGTT-CFRD subgroup. Read More

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Medicolegal Evaluation of Long-Term Respiratory Functions in Patients Injured Due to Traffic Accidents.

Cureus 2021 Jun 14;13(6):e15642. Epub 2021 Jun 14.

Department of Forensic Medicine, Dokuz Eylul University, Faculty of Medicine, İzmir, TUR.

Aim Blunt chest trauma is a frequent injury in developing countries, with motor vehicle accidents being the most common cause. Most studies about the effects of post-traumatic injuries on pulmonary functions are related to the acute phase. The aim of this study is to compare the effect of injury type on pulmonary function tests as a long-term disability in patients with severe chest trauma due to traffic accidents. Read More

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Reference Value for the Distance Walked in the Six-Minute Walk Test in Obese Brazilian Men in the Preoperative Period of Bariatric Surgery.

J Obes 2021 8;2021:9577412. Epub 2021 Jul 8.

Rehabilitation Sciences Postgraduation Program, Augusto Motta University Centre (UNISUAM), RJ, Brazil.

Background: Obesity has several effects on the mechanics of the rib cage that may impair the exercise performance of obese individuals and therefore impact the assessment of surgical risk. This study aimed to establish a reference value for the 6-minute walk distance (6 MWD) in obese Brazilian men in the preoperative period of bariatric surgery that considers the effect of lung function.

Methods: This was a cross-sectional study in which 104 obese men underwent the six-minute walk test (6 MWT) before bariatric surgery. Read More

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Responses of two dominant desert plant species to the changes in groundwater depth in hinterland natural oasis, Tarim Basin.

Ecol Evol 2021 Jul 16;11(14):9460-9471. Epub 2021 Jun 16.

Key Laboratory of Oasis Ecology College of Resources and Environmental Science Xinjiang University Urumqi China.

Groundwater is increasingly becoming a permanent and steady water source for the growth and reproduction of desert plant species due to the frequent channel cutoff events in arid inland river basins. Although it is widely acknowledged that the accessibility of groundwater has a significant impact on plant species maintaining their ecological function, little is known about the water use strategies of desert plant species to the groundwater availability in Daryaboyi Oasis, Central Tarim Basin. This study initially determined the desirable and stressing groundwater depths based on ecological and morphological parameters including UAV-based fractional vegetation cover (FVC) images and plant growth status. Read More

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Effect of cardiopulmonary rehabilitation nursing on exercise endurance and quality of life of stable COPD patients.

Am J Transl Res 2021 15;13(6):7356-7362. Epub 2021 Jun 15.

Department II of Respiratory and Critical Care Medicine, Cangzhou Central Hospital Cangzhou, China.

Objective: To investigate the effect of cardiopulmonary rehabilitation nursing on exercise endurance and quality of life (QOL) of patients with stable chronic obstructive pulmonary disease (COPD).

Methods: This randomized trial was conducted on 84 subjects with stable COPD recruited in our hospital from March 2018 to December 2019 and they were divied into the observation group (n=42) and the control group (n=42) based on nursing methods. The control group adopted conventional nursing, and the observation group received cardiopulmonary rehabilitation nursing in addition to conventional method. Read More

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Clinical efficacy of glucocorticoid and terbutaline in the treatment of acute exacerbation of chronic obstructive pulmonary disease.

Am J Transl Res 2021 15;13(6):7029-7034. Epub 2021 Jun 15.

Department of Respiratory and Critical Care Medicine, The 3rd Affiliated Hospital of Chengdu Medical College Chengdu 611700, Sichuang Province, China.

Background: To investigate the efficacy of glucocorticoid and terbutaline in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD).

Methods: 248 patients with AECOPD were assigned into two groups, 124 patients in the control group were only given terbutaline treatment, while 124 patients in the experimental group were treated with glucocorticoid and terbutaline. The effect on lung function and blood gas indexes were compared between the two groups. Read More

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Effect of terbutaline plus doxofylline on chronic obstructive pulmonary disease.

Am J Transl Res 2021 15;13(6):6959-6965. Epub 2021 Jun 15.

Department of Geriatrics, Sichuan Provincial People's Hospital Chengdu, Sichuan Province, China.

Objectives: This study focused on patients with chronic obstructive pulmonary disease (COPD) and aimed at investigating the effect of terbutaline plus doxofylline on their pulmonary function and quality of life.

Methods: Ninety COPD patients were divided by using a random number table into a control group (administration of doxofylline) and experimental group (administration of terbutaline combined with doxofylline), with 45 patients in each group. The therapeutic efficacy, pre- and post-treatment pulmonary function and the quality of life were compared between the control and experimental groups. Read More

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The effect of montelukast sodium plus budesonide on the clinical efficacy, inflammation, and pulmonary function in children with cough variant asthma.

Am J Transl Res 2021 15;13(6):6807-6816. Epub 2021 Jun 15.

Department of Pediatrics, Affiliated Nanhua Hospital, University of South China Hengyang 421000, Hunan Province, China.

Objective: The aim of this study is to explore the clinical efficacy of montelukast sodium (MKST) combined with budesonide (BUD) on children with cough variant asthma (CVA) and its influence on inflammation and pulmonary function (PF).

Methods: One hundred and sixty-six children with CVA treated in the Affiliated Nanhua Hospital, University of South China from May 2017 to August 2019 were randomized into a joint group (JG, n=92) for the combination therapy of MKST and BUD, and a control group (CG, n=74) for BUD monotherapy. Their clinical symptoms, total response rates (RR), PF, and inflammatory factor expressions were evaluated before and after treatment. Read More

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Effect of cefoperazone sulbactam sodium combined with meropenem on the immune function in the treatment of neonatal pneumonia caused by multidrug-resistant bacteria.

Am J Transl Res 2021 15;13(6):6342-6351. Epub 2021 Jun 15.

Hospital Infection Management Office, The Hospital of Xinjiang Production and Construction Corps Urumqi 830002, Xinjiang Uygur Autonomous Region, China.

Objective: To explore the effect of cefoperazone sulbactam sodium combined with meropenem on the immune function in the treatment of neonatal multi-drug resistant pneumonia.

Methods: Altogether 130 children with pneumonia caused by multi-drug resistant bacteria admitted to our hospital from January 2016 to January 2019 were recruited as the study cohort. The children were randomly divided into a combined group (n=80, combined therapy) and a control group (n=50, cefoperazone sulbactam sodium therapy). Read More

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[Clinical efficacy of the combined diagnosis and management for children with airway allergic diseases].

Zhonghua Yu Fang Yi Xue Za Zhi 2021 Jul;55(7):818-826

Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Otolaryngology Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.

To evaluate the clinical efficacy of the combined diagnosis and management in children with airway allergic diseases(bronchial asthma, allergic rhinitis). This observational study belongs to cluster sampling cases, which included the clinical data from children with airway allergic diseases in Allergy Department and Otorhinolaryngology Department of Beijing Children's Hospital from April to December in 2015. They were followed up every three months during 12 months. Read More

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Effects of Exercise Training on Cardiopulmonary Function and Quality of Life in Elderly Patients with Pulmonary Fibrosis: A Meta-Analysis.

Int J Environ Res Public Health 2021 Jul 18;18(14). Epub 2021 Jul 18.

Faculty of Sport Science, Research Academy of Grand Health, Ningbo University, Ningbo 315211, China.

(1) Objective: Our objective was to conduct a meta-analysis of randomized controlled trials that have evaluated the benefits of exercise training for elderly pulmonary fibrosis (PF) patients. (2) Methods: Studies in either English or Chinese were retrieved from the China National Knowledge Infrastructure (CNKI) and the Wanfang, PubMed, Web of Science and SPORTDiscus databases from inception until the first week of April 2021. Age, body mass index (BMI), and exercise frequency, intensity, type, and duration were considered for each participant. Read More

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Assessment of Metal Concentrations and Associations with Pulmonary Function among Children with Asthma in Chicago, Illinois.

Int J Environ Res Public Health 2021 Jul 7;18(14). Epub 2021 Jul 7.

Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, Chicago, IL 60612, USA.

Individuals living in areas with the potential for elevated metal exposure from industrial sources may have reduced pulmonary function. We evaluated cross-sectional associations of toenail concentrations of 17 metals within a community area of residence and asthma control in 75 children, and pulmonary function measures [forced expiratory volume in one second (FEV1; liters), forced vital capacity (FVC; liters), FEV1 to FVC ratio (FEV1:FVC), and mid-exhalation forced expiratory flow rate (FEF 25-75%; liters/second)], in a subsample of 39 children with diagnosed asthma in Chicago, Illinois. Linear regression models were used to estimate adjusted regression coefficients and standard errors (SE) for the associations between ≥ median versus Read More

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An Analytical Cross-sectional Study to Compare Pulmonary Function and Respiratory Morbidity-Related Quality of Life between Construction Workers with Age-and Gender-Matched Controls.

Indian J Occup Environ Med 2021 Jan-Mar;25(1):22-26. Epub 2021 Apr 26.

Department of Pulmonary Medicine, Chalmeda Anandarao Institute of Medical Sciences, Karimnagar, Telangana, India.

Context: Respiratory morbidity among construction workers is one of the most neglected occupational diseases, in spite of the high risk.

Aims: The aim of this study is to compare the respiratory symptoms, pulmonary function, and respiratory morbidity-related quality of life between people working in construction sites and the age- and gender-matched controls.

Settings And Design: It is an analytical cross-sectional study. Read More

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Outcomes of patients with advanced idiopathic pulmonary fibrosis treated with nintedanib or pirfenidone in a real-world multicentre cohort.

Respirology 2021 Jul 22. Epub 2021 Jul 22.

Department of Respiratory Medicine, Oslo University Hospital - Rikshospitalet, Oslo, Norway.

Background And Objective: Antifibrotic therapy with nintedanib or pirfenidone slows disease progression and reduces mortality in patients with idiopathic pulmonary fibrosis (IPF). However, patients with advanced IPF, as defined by forced vital capacity (FVC) < 50% and/or diffusion capacity for carbon monoxide (DLCO) < 30% of predicted, have not been included in randomized trials, and the outcomes of such patients who initiate treatment are not well understood. We determined lung function, disease progression and mortality outcomes following initiation of antifibrotic therapy in patients with advanced IPF at the time of treatment initiation compared to those with mild-moderate IPF. Read More

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Diagnostic sensitivity of impulse oscillometry in early detection of patients exposed to risk factors chronic obstructive pulmonary diseases.

Med J Islam Repub Iran 2021 12;35:89. Epub 2021 Jul 12.

Air Pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Impulse oscillometry (IOS) is a method that does not depend on the cooperation of the patient and can detect small airway diseases with higher sensitivity than spirometry. However, the clinical application value of IOS in the screening of patients exposed to risk factors COPD and early diagnosis remains unclear. The aim of this study is to evaluate diagnostic sensitivity of IOS in the early detection of patients exposed to risk factors COPD. Read More

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Long-term respiratory and developmental outcomes in children with bronchopulmonary dysplasia and history of tracheostomy.

J Perinatol 2021 Jul 21. Epub 2021 Jul 21.

Division of Pulmonary Medicine, Boston Children's Hospital, Boston, MA, USA.

Objective: The long-term morbidity among children with severe bronchopulmonary dysplasia who require tracheostomy (tBPD) relative to those without tracheostomy (sBPD) is not well characterized. We compared childhood lung function and neurodevelopmental outcomes in tBPD and sBPD.

Study Design: Retrospective case-control study of N = 49 tBPD and N = 280 sBPD subjects in Boston Children's Hospital Preterm Lung Patient Registry and medical record. Read More

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Serum levels of small HDL particles are negatively correlated with death or lung transplantation in an observational study of idiopathic pulmonary fibrosis.

Eur Respir J 2021 Jul 21. Epub 2021 Jul 21.

Laboratory of Asthma and Lung Inflammation, Pulmonary Branch, NHLBI, NIH, Bethesda, MD, USA.

Background: Serum lipoproteins, such as high density lipoproteins (HDL), may influence disease severity in idiopathic pulmonary fibrosis (IPF). Here, we investigated associations between serum lipids and lipoproteins and clinical endpoints in IPF.

Methods: Clinical data and serum lipids were analyzed from a discovery cohort (59 IPF subjects, 56 healthy volunteers) and validated using an independent, multicenter cohort (207 IPF subjects) from the Pulmonary Fibrosis Foundation registry. Read More

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Community-based intervention for prevention and management of chronic obstructive pulmonary disease in Nepal (COBIN-P trial): study protocol for a cluster-randomized controlled trial.

Trials 2021 Jul 21;22(1):474. Epub 2021 Jul 21.

Department of Public Health, Section for Global Health, Aarhus University, Aarhus, Denmark.

Background: Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death worldwide and the commonest of non-communicable diseases (NCDs) in Nepal. Risk factors like indoor and outdoor air pollution, a high prevalence of smoking, and the lack of awareness of COPD make it a serious public health concern. However, no attempt has been made in Nepal to estimate its burden and address the disease at the community level. Read More

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Phenotypic differences between highlanders and lowlanders in Papua New Guinea.

PLoS One 2021 21;16(7):e0253921. Epub 2021 Jul 21.

Laboratoire Évolution and Diversité Biologique (EDB UMR5174), Université de Toulouse Midi-Pyrénées, CNRS, IRD, UPS, Toulouse, France.

Objectives: Altitude is one of the most demanding environmental pressures for human populations. Highlanders from Asia, America and Africa have been shown to exhibit different biological adaptations, but Oceanian populations remain understudied [Woolcock et al., 1972; Cotes et al. Read More

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Hyperpolarized Helium MRI Measured Apparent Diffusion Coefficient and its Correlations with Pulmonary Functions Tests in Patients with Chronic Obstructive Pulmonary Disease: A Meta-Analysis.

Clin Respir J 2021 Jul 19. Epub 2021 Jul 19.

Department of Stomatology, Heilongjiang Provincial Hospital, Harbin, Heilongjiang, China.

Background: This study evaluates role of hyperpolarized helium ( He) MRI measured apparent diffusion coefficient (ADC) in examining pulmonary function of chronic obstructive pulmonary disease (COPD) patients.

Methods: After literature search in electronic databases, studies were selected by following precise eligibility criteria. Meta-analyses were performed to estimate mean difference in ADC between COPD patients and healthy individuals, and to seek correlations between lung ADC and pulmonary function. Read More

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LncRNA CRNDE correlates negatively with miR-33a and miR-495 and positively with inflammatory cytokines in asthmatic children.

Clin Respir J 2021 Jul 20. Epub 2021 Jul 20.

Second Department of Pediatrics, Xingtai People's Hospital, Xingtai, Hebei, China.

Objectives: It is reported that long non-coding RNA (lncRNA) colorectal neoplasia differentially expressed (CRNDE) targets microRNA (miR)-33a, miR-181a and miR-495 to regulate inflammation process, while few studies report their clinical application for pediatric asthma management. Therefore, this study aimed to explore the interaction of lncRNA CRNDE with miR-33a, miR-181a and miR-495, as well as their correlation with inflammation, exacerbation risk and severity in pediatric patients with asthma.

Methods: Asthmatic exacerbation children (N=65), asthmatic controlled children (N=65) and controls (N=65) were recruited. Read More

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Sleep quality and architecture in COPD: the relationship with lung function abnormalities.

J Bras Pneumol 2021 19;47(3):e20200612. Epub 2021 Jul 19.

. Division of Respiratory & Sleep Medicine, Department of Medicine, Queen's University, Kingston (ON) Canada.

Objective: Impaired respiratory mechanics and gas exchange may contribute to sleep disturbance in patients with COPD. We aimed to assess putative associations of different domains of lung function (airflow limitation, lung volumes, and gas exchange efficiency) with polysomnography (PSG)-derived parameters of sleep quality and architecture in COPD.

Methods: We retrospectively assessed data from COPD 181 patients ≥ 40 years of age who underwent spirometry, plethysmography, and overnight PSG. Read More

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