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Outcome Assessment in Parkinson Disease Prevention Trials: Utility of Clinical and Digital Measures.

Neurology 2022 Aug;99(7 Supplement 1):52-60

From the Sackler School of Medicine and Sagol School of Neuroscience (A.M.), Tel Aviv University, Israel; Department of Neurology (A.S.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; and Department of Neurology (L.C.), University of Pittsburgh, PA.

Background And Objectives: The prodromal phase of Parkinson disease (PD) is accompanied by subtle clinical signs that are not sufficient for diagnosis but could potentially be measured in the context of clinical trials of therapies intended to delay or prevent more definitive clinical features. The objective of this study was to review the available literature on the presence and time course of subtle motor features in prodromal PD in the context of planning for possible clinical trials.

Methods: We reviewed the available literature based on expert opinion. Read More

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Age-Stratified Thirty-Day Rehospitalization and Mortality and Predictors of Rehospitalization among Patients with Systemic Lupus Erythematosus: a Medicare cohort study.

J Rheumatol 2022 Aug 15. Epub 2022 Aug 15.

University of Wisconsin School of Medicine and Public Health, Department of Population Health Sciences, Madison, WI, US; University of Wisconsin School of Medicine and Public Health, Department of Medicine, Madison, WI, US; Center for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, Madison, WI, US; University of Wisconsin School of Medicine and Public Health, Department of Biostatistics and Medical Informatics, Madison, WI, US; Division of Pediatric Rheumatology, Nationwide Children's Hospital, Columbus, OH, US; University of Wisconsin - Madison, School of Nursing, Madison, WI, US. Funding sources: Primary source of funding was National Institute on Minority Health and Health Disparities Research (NIMHD) award number R01MD010243. Additional support from NIMHD award number F30MD015211, the University of Wisconsin Medical Scientist Training Program (grant number T32 GM140935), and the University of Wisconsin Clinical and Translational Science Award (NIH CTSA grant 1UL1TR002373). Conflicts of Interests: CMB receives peer-reviewed institutional grant funding from Independent Grants for Learning and Change (Pfizer) for research unrelated to this study. All other authors declare no conflicts. Corresponding author: Christie M Bartels, MD MS, 1685 Highland Ave #4132, Madison, WI 53705. E-mail:

Objective: Recent studies suggest young adults with lupus have high 30-day readmission rates, which may necessitate tailored readmission reduction strategies. To aid in riskstratification for future strategies, we measured 30-day rehospitalization and mortality among Medicare beneficiaries with lupus and determined rehospitalization predictors by age.

Methods: In a 2014 20% national Medicare sample of hospitalizations, rehospitalization risk and mortality within 30 days of discharge were calculated for young (18-35), middle-aged (36-64), and older (65+) beneficiaries with and without lupus. Read More

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Trends in Artificial Intelligence in Nursing: Impacts on Nursing Management.

J Nurs Manag 2022 Aug 15. Epub 2022 Aug 15.

Department of Dentistry, Tri-Service General Hospital and Department of Dentistry, Taoyuan City, Taiwan.

Objective: Investigate the academic use of artificial intelligence in nursing.

Background: Bibliometric analysis combined with the VOSviewer software quantification method has been utilized for literature analysis. In recent years, this approach has attracted the interest of scholars in various research fields. Read More

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The physiology of experimental overfeeding in animals.

Mol Metab 2022 Aug 12:101573. Epub 2022 Aug 12.

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address:

Background: Body weight is defended by strong homeostatic forces. Several of the key biological mechanisms that counteract weight loss have been unraveled over the last decades. In contrast, the mechanisms that protect body weight and fat mass from becoming too high remain largely unknown. Read More

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Effects of personality on assessments of anxiety and cognition.

Neurosci Biobehav Rev 2022 Aug 12:104827. Epub 2022 Aug 12.

Animal Behaviour and Welfare Team, AgResearch Ltd., Ruakura Research Centre, 10 Bisley Road, Private Bag 3123, Hamilton 3214, New Zealand. Electronic address:

Individual variation in responses to commonly used tests of anxiety and spatial memory is often reported. While this variation is frequently considered to be 'noise', evidence suggests that it is, at least partially, related to consistent individual differences in behavioral responses (i.e. Read More

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A Review of Functional Brain Differences Predicting Relapse in Substance Use Disorder: Actionable Targets for New Methods of Noninvasive Brain Stimulation.

Neurosci Biobehav Rev 2022 Aug 12:104821. Epub 2022 Aug 12.

Psychology Clinical Neuroscience Center, Department of Psychology, University of New Mexico, Albuquerque, NM 87131; Department of Psychology, University of New Mexico, Albuquerque, NM 87131; The Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM 87106. Electronic address:

Neuroimaging studies have identified a variety of brain regions whose activity predicts substance use (i.e., relapse) in patients with substance use disorder (SUD), suggesting that malfunctioning brain networks may exacerbate relapse. Read More

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A review of study designs and data analyses in metabolomics studies in myopia.

Anal Biochem 2022 Aug 12:114850. Epub 2022 Aug 12.

School of Public Health, Medical College of Soochow University, Suzhou, China. Electronic address:

Metabolomics analyzes the entire range of small molecule metabolites in biological systems to reveal the response signals that are transmitted from "genetics and environment", which could help us understand complex phenotypes of diseases. Metabolomics has been successfully applied to the study of eye diseases including age-related macular degeneration, glaucoma, and diabetic retinopathy. In this review, we summarize the findings of myopic metabolomics and discuss them from a design and analysis perspective. Read More

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Expression profiling and cellular localization of myxozoan minicollagens during nematocyst formation and sporogenesis.

Int J Parasitol 2022 Aug 12. Epub 2022 Aug 12.

Institute of Parasitology, Biology Centre, Academy of Sciences of the Czech Republic, Ceske Budejovice, Czech Republic; Faculty of Science, University of South Bohemia, Ceske Budejovice, Czech Republic.

In free-living cnidarians, minicollagens are major structural components in the biogenesis of nematocysts. Recent sequence mining and proteomic analysis demonstrate that minicollagens are also expressed by myxozoans, a group of evolutionarily ancient cnidarian endoparasites. Nonetheless, the presence and abundance of nematocyst-associated genes/proteins in nematocyst morphogenesis have never been studied in Myxozoa. Read More

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Does land-based exercise-therapy improve physical activity in people with knee osteoarthritis? A systematic review with meta-analyses.

Osteoarthritis Cartilage 2022 Aug 12. Epub 2022 Aug 12.

La Trobe Sport & Exercise Medicine Research Centre (LASEM), School of Allied Health, Human Services and Sport, La Trobe University, Bundoora, Australia; Department of Physiotherapy, Podiatry, Prosthetics and Orthotics, School of Allied Health, Human Services and Sport, La Trobe University; Department of Surgery, St Vincent's Hospital, University of Melbourne, Australia.

Primary Objective: Investigate the effects of land-based exercise-therapy on physical activity in people with knee osteoarthritis (KOA).

Design: Systematic review and meta-analysis of randomised or quasi-randomised trials investigating land-based exercise-therapy on physical activity, fitness, and general health in people with KOA. We updated a 2013 Cochrane review search on exercise-therapy for KOA in April 2021 and applied the Cochrane Risk-of-Bias Tool 1. Read More

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Methods for estimating physical activity and energy expenditure using raw accelerometry data or novel analytical approaches: a repository, framework, and reporting guidelines.

Physiol Meas 2022 Aug 15. Epub 2022 Aug 15.

College of Education, Michigan State University, 308 W. Circle Dr., Room 27R, East Lansing, Michigan, 48824, UNITED STATES.

The proliferation of approaches for analyzing accelerometer data using raw acceleration or novel analytic approaches like machine learning ('novel methods') outpaces their implementation in practice. This may be due to lack of accessibility, either because authors do not provide their developed models or because these models are difficult to find when included as supplementary material. Additionally, when access to a model is provided, authors may not include example data or instructions on how to use the model. Read More

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ENDOSCOPIC ULTRASOUND THROUGH-THE-NEEDLE BIOPSY OF PANCREATIC CYSTS: TOWARDS PROCEDURE STANDARDIZATION.

Dig Dis 2022 Aug 15. Epub 2022 Aug 15.

Background And Aims: EUS-guided through-the-needle microforceps biopsy (EUS-TTNB) was introduced as a new diagnostic tool to establish pancreatic cyst histotype and help to better risk stratify the patients. The aim of this study was to describe the technical success, diagnostic yield and adverse events of through-the-needle biopsy and discuss the technique variations, focusing on future procedure standardization.

Methods: We performed a prospective single-center study including patients with presumed mucinous cysts harboring worrisome features or indeterminate cyst type on imaging, submitted to EUS-TTNB using Moray® microforceps between March 2018 and September 2021. Read More

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Covid 19: Acing the Treatment.

Med Princ Pract 2022 Aug 15. Epub 2022 Aug 15.

ACE 2 is the functional receptor that SARS-Cov-2 virus requires to enter cells and cause dysregulated inflammatory conditions that contribute towards acute lung injuries. The RAAS with its physiological surveillance and regulation system can be implicated in both harm and therapeutic benefit. The initial observational studies suggesting the discontinuation of ACE-I and ARBs have been firmly rebutted by international societies. Read More

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Belongingness in undergraduate/pre-licensure nursing students in the clinical learning environment: A scoping review.

Nurse Educ Pract 2022 Aug 6;64:103422. Epub 2022 Aug 6.

Harris College of Nursing & Health Sciences, Texas Christian University, 2800 West Bowie Street, Fort Worth, TX 76129, the United States of America.

Aim: The aim of this scoping review was to map the literature investigating belongingness in undergraduate/pre-licensure nursing students in the clinical learning environment.

Background: The concept of belongingness, which encompasses feelings of acceptance, connection and value alignment, has been tied to positive outcomes in undergraduate/pre-licensure nursing students including increased learning, participation, confidence and professional socialization. It is critical for educators and clinical staff to foster a sense of belongingness for nursing students to promote positive and effective clinical learning experiences. Read More

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FDG-PET combined with learning vector quantization allows classification of neurodegenerative diseases and reveals the trajectory of idiopathic REM sleep behavior disorder.

Comput Methods Programs Biomed 2022 Jul 28;225:107042. Epub 2022 Jul 28.

Bernoulli Institute for Mathematics, Computer Science and Artificial Intelligence, University of Groningen, Groningen, the Netherlands; SMQB, Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, Birmingham, United Kingdom.

Background And Objectives: F-fluorodeoxyglucose (FDG) positron emission tomography (PET) combined with principal component analysis (PCA) has been applied to identify disease-related brain patterns in neurodegenerative disorders such as Parkinson's disease (PD), Dementia with Lewy Bodies (DLB) and Alzheimer's disease (AD). These patterns are used to quantify functional brain changes at the single subject level. This is especially relevant in determining disease progression in idiopathic REM sleep behavior disorder (iRBD), a prodromal stage of PD and DLB. Read More

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Effects of probiotic/prebiotic/synbiotic supplementation on blood glucose profiles: a systematic review and meta-analysis of randomized controlled trials.

Public Health 2022 Aug 12;210:149-159. Epub 2022 Aug 12.

Department of Epidemiology and Biostatistics, Key Laboratory of Molecular Cancer Epidemiology, Tianjin, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, 300060, China. Electronic address:

Objectives: Previous studies have evaluated the effects of probiotic/prebiotic/synbiotic supplementation on blood glucose profiles among diabetic patients. However, the results were inconsistent.

Study Design: Systematic review and meta-analysis. Read More

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Trends in Robot-Assisted Procedures for General Surgery in the Veterans Health Administration.

J Surg Res 2022 Aug 11;279:788-795. Epub 2022 Aug 11.

Evidence Synthesis Program Coordinating Center, VA Portland Health Care System, Portland, Oregon; Research Integrity Office, Oregon Health and Science University, Portland, Oregon; Department of Early Cancer Detection Science, American Cancer Society, Kennesaw, Georgia.

Introduction: Implementation of robot-assisted procedures is growing. Utilization within the country's largest healthcare network, the Veterans Health Administration, is unclear.

Methods: A retrospective cohort study using data from the Department of Veterans Affairs Corporate Data Warehouse from January 2015 through December 2019. Read More

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Brazilein as an alternative pigment: Isolation, characterization, stability enhancement and food applications.

Food Chem 2022 Aug 9;398:133898. Epub 2022 Aug 9.

Advanced Food Processing Research Laboratory, Department of Food Engineering, Faculty of Engineering, King Mongkut's University of Technology Thonburi, 126 Pracha u-tid Road, Tungkru, Bangkok 10140, Thailand; The Academy of Science, The Royal Society of Thailand, Dusit, Bangkok 10300, Thailand. Electronic address:

This review gives, for the first time, a systematic presentation and discussion on the chemistry and use of brazilein in foods. Processes of isolation, purification and quantification of this alternative pigment are firstly reviewed. Molecular structure and color stabilities as well as ways to enhance stability of the pigment are then discussed. Read More

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Assessing the comparative feasibility, acceptability and equivalence of videoconference interviews and face-to-face interviews using the time trade-off technique.

Soc Sci Med 2022 Aug 5;309:115227. Epub 2022 Aug 5.

Nuffield Department of Primary Care Health Sciences, University of Oxford, UK.

This study examines the comparative equivalence, feasibility and acceptability of video and in-person interviews in generating time trade-off (TTO) values. Sample participants in England were recruited using a blended approach of different methods and sampled based on age, gender, ethnicity, and index of multiple deprivation. Participants were randomly allocated to be interviewed either via video or in-person. Read More

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Spectro-electrochemical, fluorometric and biothermodynamic evaluation of pharmacologically active morpholine scaffold single crystal ligand and its metal(II) complexes: A comparative study on in-vitro and in-silico screening towards DNA/BSA/SARS-CoV-19.

J Inorg Biochem 2022 Aug 8;236:111953. Epub 2022 Aug 8.

Department of Physics, University College of Engineering, Anna University, Nagercoil, Tamil Nadu 629 004, India.

A novel series of metal(II) complexes (1-5) [M(L)]{Where M = Cu (1), Co (2), Mn (3), Ni (4) and Zn (5)} constructed from 2-(4-morpholinobenzylideneamino)phenol Schiff base ligand (HL) in a 1:2 M ratio and the spectral and analytical results put forward square planar geometry. Spectro-electrochemical, hydrodynamic, gel electrophoresis, and DNA binding/cleavage results for all the compounds demonstrate that complex (1) had excellent DNA binding/cleavage properties compared to other compounds. The observation also suggests that test compounds could intercalate with DNA, and the biothermodynamic property more strongly supports the stabilizing of the double helix DNA with the complexes. Read More

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A Closer Look at the Rising Epidemic of Mass Shootings in the United States and Its Association With Gun Legislation, Laws, and Sales.

J Surg Res 2022 Aug 12;280:103-113. Epub 2022 Aug 12.

Department of Surgical Education, Orlando Regional Medical Center, Orlando, Florida; Department of Surgery, Division of Trauma and Surgical Critical Care, Orlando Regional Medical Center, Orlando, Florida. Electronic address:

Introduction: Mass shootings pose a considerable threat to public safety and significantly cost the United States in terms of lives and expenses. The following are the specific aims of this study: (1) to assess US mass shootings, firearm-related sales, laws, and regional differences from 2015 to 2021 and (2) to investigate changes in mass shootings and firearm sales before and during the Coronavirus Disease 2019 pandemic.

Methods: A retrospective review was conducted of mass shootings, gun sales, and laws regarding the minimum age required to purchase a firearm within the United States from 2015 to 2021. Read More

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Patterns of physical activity and sedentary behavior before and during pregnancy and cardiometabolic outcomes.

Midwifery 2022 Aug 6;114:103452. Epub 2022 Aug 6.

Department of Epidemiology and Biostatistics, School of Public Health, West Virginia University.

Objective: To assess how physical activity and sedentary behavior change from pre-pregnancy to pregnancy, and if pre-pregnancy and pregnancy physical activity and sedentary behavior are related to gestational weight gain, blood pressure, or blood glucose across pregnancy.

Design: Secondary analysis of two prospective cohort studies.

Setting: Prenatal research centers in Pittsburgh, PA and Iowa City, IA. Read More

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Effects of Interventions Involving Speech Output Technologies on Communication Outcomes for Individuals With Developmental Disabilities: A Scoping Review.

Am J Speech Lang Pathol 2022 Aug 15:1-20. Epub 2022 Aug 15.

Department of Speech, Hearing, and Language Sciences, The University of Texas at Austin.

Purpose: This scoping review aimed to map the literature on the effects of interventions involving speech output technologies on communication outcomes for individuals with developmental disabilities other than autism spectrum disorder.

Method: A scoping review methodology was used to limit bias in searching, selecting, coding, and synthesizing relevant intervention studies. This involved a multifaceted search for studies conducted between 1991 and March 2021 using various electronic databases, ancestry searches, and forward citation searches from selected articles. Read More

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The Kuroshio Regulates the Air-Sea Exchange of PCBs in the Northwestern Pacific Ocean.

Environ Sci Technol 2022 Aug 15. Epub 2022 Aug 15.

Application Laboratory, Japan Agency for Marine-Earth Science and Technology, 3173-25, Showa-machi, Kanazawa-ku, Yokohama-City, Kanagawa 236-0001, Japan.

Calculating accurate air-sea fluxes for polychlorinated biphenyls (PCBs) is an essential condition for evaluating their transport in the atmosphere. A three-dimensional hydrodynamic-ecosystem-PCB coupled model was developed for the northwestern Pacific Ocean to assess the air-sea fluxes of four PCBs and examine the influences of ocean currents on the fluxes. The model revealed a fine structure in the air-sea flux that is sensitive to the Kuroshio, a western boundary current with a high surface speed. Read More

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Suppressing Methane Production to Boost High-Purity Hydrogen Production in Microbial Electrolysis Cells.

Environ Sci Technol 2022 Aug 15. Epub 2022 Aug 15.

State Key Laboratory of Urban Water Resource and Environment, School of Environment, Harbin Institute of Technology, Harbin 150090, China.

Hydrogen gas (H) is an attractive fuel carrier due to its high specific enthalpy; moreover, it is a clean source of energy because in the combustion reaction with oxygen (O) it produces water as the only byproduct. The microbial electrolysis cell (MEC) is a promising technology for producing H from simple or complex organics present in wastewater and solid wastes. Methanogens and non-archaeal methane (CH)-producing microorganisms (NAMPMs) often grow in the MECs and lead to rapid conversion of produced H to CH. Read More

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Considerations in ureteral stent selection in order to minimize symptoms.

Can J Urol 2022 Aug;29(4):11231-11242

Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Introduction: Ureteral stent-related symptoms are common after stent placement. Various characteristics of stent design have been previously investigated to mitigate this issue. Our review summarizes available literature on stent design parameters (diameter, material, position, length, distal loop modifications) and their effect on stent-related symptoms, including pain. Read More

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Control Matters in Elder Care Technology:: Evidence and Direction for Designing It In.

DIS (Des Interact Syst Conf) 2022 Jun 13;2022:1831-1848. Epub 2022 Jun 13.

Oregon Health & Science University.

Studies find that older adults want control over how technologies are used in their care, but how it can be operationalized through design remains to be clarified. We present findings from a large survey (n=825) of a well-characterized U.S. Read More

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Comparison of Sample Preparation Techniques for the (-)ESI-FT-ICR-MS Analysis of Humic and Fulvic Acids.

Environ Sci Technol 2022 Aug 15. Epub 2022 Aug 15.

Department of Chemistry and Biochemistry, Old Dominion University, 4501 Elkhorn Avenue, Norfolk, Virginia 23529, United States.

Soil organic matter (SOM) plays a key role in the global carbon and nitrogen cycles. Soil biogeochemistry is regularly studied by extracting the base-soluble fractions of SOM: acid-insoluble humic acid (HA) and acid-soluble fulvic acid (FA). Electrospray ionization-Fourier transform-ion cyclotron resonance-mass spectrometry (ESI-FT-ICR-MS) is commonly utilized for molecularly characterizing these fractions. Read More

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High-Resolution Low-Power Hyperspectral Line-Scan Imaging of Fast Cellular Dynamics Using Azo-Enhanced Raman Scattering Probes.

J Am Chem Soc 2022 Aug 15. Epub 2022 Aug 15.

Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education Institutes, Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, Anhui 230027, China.

Small-molecule Raman probes for cellular imaging have attracted great attention owing to their sharp peaks that are sensitive to environmental changes. The small cross section of molecular Raman scattering limits dynamic cellular Raman imaging to expensive and complex coherent approaches that acquire single-channel images and lose hyperspectral Raman information. We introduce a new method, dynamic azo-enhanced Raman imaging (DAERI), to couple the new class of azo-enhanced Raman probes with a high-speed line-scan Raman imaging system. Read More

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Deep learning-based near-fall detection algorithm for fall risk monitoring system using a single inertial measurement unit.

IEEE Trans Neural Syst Rehabil Eng 2022 Aug 15;PP. Epub 2022 Aug 15.

Proactively detecting falls and preventing injuries are among the primary keys to a healthy life for the elderly. Near-fall remote monitoring in daily life could provide key information to prevent future falls and obtain quantitative rehabilitation status for patients with weak balance ability. In this study, we developed a deep learning-based novel classification algorithm to precisely categorize three classes (falls, near-falls, and activities of daily living (ADLs)) using a single inertial measurement unit (IMU) device attached to the waist. Read More

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Adapting integrative cognitive-affective therapy for adolescents with full and subthreshold bulimia nervosa: A feasibility study.

Eur Eat Disord Rev 2022 Aug 15. Epub 2022 Aug 15.

Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, Minnesota, USA.

Background: Integrative Cognitive Affective Therapy (ICAT) is an empirically supported treatment for bulimia nervosa (BN) in adults. However, it is unclear whether a modified version, Integrative Cognitive Affective Therapy-Adolescent (ICAT-A) is feasible and beneficial for adolescents. This study evaluated the feasibility of ICAT-A for adolescents with BN or subthreshold BN. Read More

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