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Association Between Celiac Disease and Autism Spectrum Disorder: A Systematic Review.

J Pediatr Gastroenterol Nutr 2021 May;72(5):704-711

Department of Community Health Sciences.

Objective: The aim of the study was to perform a systematic review assessing the research investigating the association between celiac disease (CD) and autism spectrum disorder (ASD).

Methods: A literature search of MEDLINE and EMBASE was performed without limits placed on year or language. Observational studies reporting on the occurrence of CD among patients with ASD and/or the occurrence of ASD among patients with CD were included. Read More

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Disparities and interventions in the timeliness of endometrial cancer diagnosis and treatment in the United States: a scoping review protocol.

Syst Rev 2021 Apr 13;10(1):107. Epub 2021 Apr 13.

Department of Obstetrics and Gynecology, Mayo Clinic, Jacksonville, FL, USA.

Background: Disparities in the stage at diagnosis of endometrial cancer (EC) account for a significant proportion of the disparities in morbidity and mortality experienced by vulnerable groups in the USA. Evidence suggests that disparities in timeliness of care and treatment play a significant role in stage at diagnosis. Despite an increase in literature on EC disparities, the issue remains largely unchanged. Read More

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Research progress of pre-hospital emergency during 2000-2020: a bibliometric analysis.

Am J Transl Res 2021 15;13(3):1109-1124. Epub 2021 Mar 15.

Department of Nursing, Changhai Hospital, Naval Medical University Shanghai, China.

Background: The past decade has witnessed the preliminary development of pre-hospital emergency. We analyzed the scientific output related to pre-hospital emergency in the past two decades, aiming to evaluate the publication status of the literature related to pre-hospital emergency through bibliometrics analysis, and hope to provide enlightenment of trends and hotspots for the development of pre-hospital emergency.

Method: By web of science, all literature on pre-hospital emergency from 2000 to 2 October 2020 was retrieved and screened by two researchers. Read More

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We need to do better: A systematic review and meta-analysis of diagnostic test accuracy of restless legs syndrome screening instruments.

Sleep Med Rev 2021 Mar 13;58:101461. Epub 2021 Mar 13.

Departments of Psychiatry and Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

This systematic review and meta-analysis evaluated the diagnostic accuracy of screening instruments for restless legs syndrome (RLS) and reports sensitivity, specificity, positive (PPV) and negative predictive values (NPV). Searches for primary studies were conducted in electronic databases. Of the 1541 citations identified, 52 were included in the meta-analysis. Read More

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Barriers and facilitators to implementing perinatal mental health care in health and social care settings: a systematic review.

Lancet Psychiatry 2021 Apr 7. Epub 2021 Apr 7.

Centre for Maternal and Child Health, City, University of London, London, UK.

The improvement of perinatal mental health formed part of WHO's Millennium Development Goals. Research suggests that the implementation of perinatal mental health care is variable. To ensure successful implementation, barriers and facilitators to implementing perinatal mental health services need to be identified. Read More

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Artificial intelligence with kidney disease: A scoping review with bibliometric analysis, PRISMA-ScR.

Medicine (Baltimore) 2021 Apr;100(14):e25422

Department of Neurology, Inje University Haeundae Paik Hospital, Busan, Korea.

Background: Artificial intelligence (AI) has had a significant impact on our lives and plays many roles in various fields. By analyzing the past 30 years of AI trends in the field of nephrology, using a bibliography, we wanted to know the areas of interest and future direction of AI in research related to the kidney.

Methods: Using the Institute for Scientific Information Web of Knowledge database, we searched for articles published from 1990 to 2019 in January 2020 using the keywords AI; deep learning; machine learning; and kidney (or renal). Read More

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Italian neonatologists and SARS-CoV-2: lessons learned to face coming new waves.

Pediatr Res 2021 Apr 7. Epub 2021 Apr 7.

Department of Women's and Children's Health, Neonatal Intensive Care Unit, University Hospital of Padua, Padua, Italy.

The aim of this review was threefold: (a) to retrieve all SARS-CoV-2 evidences published by Italian neonatologists working in maternity centers and NICUs during the pandemic; (b) to summarize current evidence for the management of term and preterm infants with a SARS-CoV-2-related illness; and (c) to provide an update for dealing with the second wave of COVID-19 and discuss open questions. A review was conducted using MEDLINE/PubMed and the national COVID-19 registry of the Italian Society of Neonatology including citations from December 1, 2019 to October 28, 2020. Sixty-three articles were included. Read More

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Interventions to promote family member involvement in adult critical care settings: a systematic review.

BMJ Open 2021 Apr 7;11(4):e042556. Epub 2021 Apr 7.

Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care, King's College London, London, England, UK.

Objective: To identify, appraise and synthesise evidence of interventions designed to promote family member involvement in adult critical care units; and to develop a working typology of interventions for use by health professionals and family members.

Design: Mixed-method systematic review.

Data Sources: Bibliographic databases were searched without date restriction up to June 2019: MEDLINE, EMBASE and CINAHL; the Cochrane Central Register of Controlled Trials, Joanna Briggs and Cochrane Libraries. Read More

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Correlation Between Social Media Postings and Academic Citations of Hand Surgery Research Publications: A Pilot Study Using Twitter and Google Scholar.

J Hand Surg Am 2021 Apr 4. Epub 2021 Apr 4.

Department of Orthopaedic Surgery, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA.

Purpose: The relationship between social media postings and academic citations of hand surgery research publications is not known. The objectives of this study were (1) to quantify adoption of social media for the dissemination of original research publications by 3 hand surgery journals, and (2) to determine the correlation between social media postings and academic citations in recent hand surgery research publications.

Methods: An Internet-based study was performed of all research articles from 3 hand surgery journals published from January 2018 to March 2019. Read More

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Impact of Level of Evidence on Citation of Orthopaedic Articles.

J Am Acad Orthop Surg 2021 Apr 7. Epub 2021 Apr 7.

From the Department of Orthopaedic Surgery and Rehabilitation Medicine, University of Chicago, Chicago, IL (Scott, Dirschl), and the Department of Orthopaedic Surgery, University of Kentucky, Lexington, KY (Landy).

Introduction: Level of evidence grading has become widely used in orthopaedics. This study reviewed clinical research articles published in leading orthopaedic journals to describe the association between level of evidence and number of future citations, which is one measure of an article's impact in the field.

Methods: The first 100 clinical research articles published in 2014 by each of the Journal of Bone and Joint Surgery, Clinical Orthopaedics and Related Research, and the American Journal of Sports Medicine were reviewed for level of evidence and article characteristics. Read More

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Effects of the COVID-19 pandemic on maternal and perinatal outcomes: a systematic review and meta-analysis.

Lancet Glob Health 2021 Mar 31. Epub 2021 Mar 31.

Fetal Medicine Unit, Department of Obstetrics and Gynaecology, St George's University Hospitals NHS Foundation Trust, UK; Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George's University of London, UK. Electronic address:

Background: The COVID-19 pandemic has had a profound impact on health-care systems and potentially on pregnancy outcomes, but no systematic synthesis of evidence of this effect has been undertaken. We aimed to assess the collective evidence on the effects on maternal, fetal, and neonatal outcomes of the pandemic.

Methods: We did a systematic review and meta-analysis of studies on the effects of the pandemic on maternal, fetal, and neonatal outcomes. Read More

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Long-term effectiveness of mHealth physical activity interventions: a systematic review and meta-analysis of randomized-controlled trials.

J Med Internet Res 2021 Apr 2. Epub 2021 Apr 2.

Center for Digital Health Interventions, Institute of Technology Management, University of St. Gallen, St. Gallen, CH.

Background: mHealth interventions can increase physical activity (PA), but their long-term impact is not well understood. The increasing number of primary studies reporting long-term follow-up measurements supports a meta-analysis of this evidence.

Objective: This systematic review and meta-analysis aimed to understand the immediate and long-term impact of mHealth interventions on PA. Read More

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A Bibliometric Analysis on Dengue Outbreaks in Tropical and Sub-Tropical Climates Worldwide Since 1950.

Int J Environ Res Public Health 2021 Mar 19;18(6). Epub 2021 Mar 19.

Department of Paediatrics, Chi Mei Medical Center, Tainan 700, Taiwan.

Severe dengue outbreaks (DOs) affect the majority of Asian and Latin American countries. Whether all DOs always occurred in sub-tropical and tropical areas (STTA) has not been verified. We downloaded abstracts by searching keywords "dengue (MeSH Major Topic)" from Pubmed Central since 1950, including three collections: country names in abstracts (CNA), no abstracts (WA), and no country names in abstracts (Non-CNA). Read More

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A Quantitative and Qualitative Review on the Main Research Streams Regarding Blockchain Technology in Healthcare.

Healthcare (Basel) 2021 Mar 1;9(3). Epub 2021 Mar 1.

Medical Management Research Center, School of Business, Yeungnam University, Gyeongsan 38541, Korea.

(1) Background: Blockchain technology has been gaining high popularity in the healthcare domain. This has brought about a spate of recent studies regarding blockchain technology in healthcare, creating high demand for quantitative or qualitative reviews on the main research streams thereof. In order to contribute to satisfying the high demand, this research presents a quantitative and qualitative review on studies regarding blockchain technology in healthcare. Read More

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Ethnopharmacological Studies of Medicinal Plants in Central Zagros, Lorestan Province, Iran.

J Ethnopharmacol 2021 Mar 30:114080. Epub 2021 Mar 30.

Department of Pharmacogonosy, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Traditional Pharmacy, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Ethnopharmacological Relevance: Lorestan Province (Iran) has a great diversity of habitats and plant diversity and the people living in this province have a good knowledge of herbal therapies.

Aim Of The Study: In this study, the authors aimed to identify and report the medicinal plants used in the folk medicine of Lorestan.

Material And Methods: The indigenous medicinal information was collected with a semi-structured open-ended questionnaire, interviews, and personal observations. Read More

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Patient-centered outcomes used in pediatric focused manual therapies research studies: a secondary data analysis of a systematic review.

J Patient Rep Outcomes 2021 Apr 1;5(1):31. Epub 2021 Apr 1.

Parker University, 2540 Walnut Hill Lane, Dallas, TX, 75229, USA.

Background: Patient-reported outcome measurements (PROM) are instruments that seek a patient's health or functional status. Inclusion of standardized PROMs in research studies and clinical practice provides a more comprehensive understanding of an intervention from the patient's viewpoint. This secondary analysis identified PROM usage and appropriateness of references for property measurements from clinical trials included in a recent systematic review of pediatric manual therapy. Read More

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Systematic literature review for the association of biomarkers with efficacy of anti-PD-1 inhibitors in advanced melanoma.

Future Oncol 2021 Mar 30. Epub 2021 Mar 30.

The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.

Summarize the literature assessing biomarkers in predicting efficacy of anti-PD-1 therapy for patients with high-risk unresectable or metastatic melanoma. Relevant studies were identified via a systematic literature review. About 334 unique biomarkers or biomarker combinations were identified from 121 citations. Read More

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Systematic review of ambient temperature exposure during pregnancy and stillbirth: methods and evidence.

Environ Res 2021 Mar 26:111037. Epub 2021 Mar 26.

University of Queensland, Brisbane, Australia.

Background: Associations between ambient temperature exposure during pregnancy and stillbirth have been reviewed and described in the literature. However, there is no existing review of environmental and epidemiologic methods applied to measure stillbirths resulting from exposure to ambient temperatures during pregnancy. The objective of this study is to systematically review published methods, data sources, and data linkage practices to characterize associations between ambient temperature and stillbirth to inform stillbirth prevention and risk management strategies. Read More

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What is the future for immersive virtual reality in memory rehabilitation? A systematic review.

NeuroRehabilitation 2021 Mar 24. Epub 2021 Mar 24.

National Institute of Mental Health, Klecany, Czechia.

Background: A growing interest in non-pharmacological approaches aimed at cognitive rehabilitation and cognitive enhancement pointed towards the application of new technologies. The complex virtual reality (VR) presented using immersive devices has been considered a promising approach.

Objective: The article provides a systematic review of studies aimed at the efficacy of VR-based rehabilitation. Read More

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Prognostic impact of antiplatelet therapy in Takotsubo syndrome: a systematic review and meta-analysis of the literature.

Heart Fail Rev 2021 Mar 29. Epub 2021 Mar 29.

Division of Cardiology, Department of Medicine, University of Verona, Verona, Italy.

While the most recent evidence suggests a lack of benefit, antithrombotic therapy is still extensively prescribed in patients with Takotsubo syndrome (TTS). The objective of this study was to determine whether patients with TTS benefit from anti-aggregation, in terms of either short-term or long-term outcomes. A systematic review and meta-analysis was conducted. Read More

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Evidence Supporting the Management of Medical Conditions During Long-Duration Spaceflight: Protocol for a Scoping Review.

JMIR Res Protoc 2021 Mar 29;10(3):e24323. Epub 2021 Mar 29.

Faculty of Medicine, Université Laval, Quebec, QC, Canada.

Background: Future long-duration space exploration missions, such as traveling to Mars, will create an increase in communication time delays and disruptions and remove the viability of emergency returns to Earth for timely medical treatment. Thus, higher levels of medical autonomy are necessary. Crew selection is proposed as the first line of defense to minimize medical risk for future missions; however, the second proposed line of defense is medical preparedness and crew member autonomy. Read More

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Interventions to increase migrants' care-seeking behaviour for stigmatised conditions: a scoping review.

Soc Psychiatry Psychiatr Epidemiol 2021 Mar 29. Epub 2021 Mar 29.

Karolinska Institutet, Stockholm, Sweden.

Background: Despite availability of effective treatments, migrants in high-income countries seek care for conditions associated with stigma to a lower extent than the rest of the population. We conducted a scoping review to map the literature on interventions to increase migrants' care-seeking behaviour in high-income countries for stigmatised conditions. Main body of the abstract: We searched 15 electronic databases and journals, hand-searched references and citations, to identify studies on interventions to increase migrants' care-seeking in high-income countries for stigmatised conditions. Read More

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Effects of pollution on adolescent mental health: a systematic review protocol.

Syst Rev 2021 Mar 27;10(1):85. Epub 2021 Mar 27.

Trinity Centre for Global Health, Trinity College Dublin, Dublin, Ireland.

Background: Whilst there is little uncertainty about the deleterious impact of pollution on human and planetary health, pollution's impact on adolescent mental health is less well understood. This is particularly true for young people in underdeveloped and developing world contexts, about whom research is generally lacking. Furthermore, although adolescent resilience continues to be a research priority, little attention has been paid to adolescent pathways of resilience in the face or aftermath of pollution exposure. Read More

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Frailty inclusive care in acute and community-based settings: a systematic review protocol.

Syst Rev 2021 Mar 26;10(1):83. Epub 2021 Mar 26.

Division of Geriatric Medicine, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, 1-198 Clinical Sciences Building, 11350 83 Ave, Edmonton, Alberta, T6G 2G3, Canada.

Background: Frailty is a known risk factor for an array of adverse outcomes including more frequent and prolonged health services use and high health care costs. Aging of the population has implications for care provision across the care continuum, particularly for people living with frailty. Despite known risks associated with frailty, there has been limited research on care pathways that address the needs of persons living with frailty. Read More

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Efficacy and Safety of Domperidone and Metoclopramide in Breastfeeding: A Systematic Review and Meta-Analysis.

Breastfeed Med 2021 Mar 25. Epub 2021 Mar 25.

School of Health Sciences, Wuhan University, Wuhan, China.

To evaluate the efficacy and safety of domperidone and metoclopramide used by breastfeeding women. A systematic literature search retrieved citations from PubMed, Embase, The Cochrane Library, Medline, EBSCO, Web of Science, ClinicalTrials.gov (from inception to January, 2021) and bibliographies of known articles. Read More

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Continuous flow insufflation of oxygen for cardiac arrest: Systematic review of human and animal model studies.

Resuscitation 2021 Mar 22;162:292-303. Epub 2021 Mar 22.

Faculté de Médecine, Université Laval, Québec, Canada; Centre de recherche du CHU de Québec-Université Laval, Québec, Canada; VITAM - Centre de recherche en santé durable de l'Université Laval, Québec, Canada. Electronic address:

Objective: To synthetize the evidence regarding the effect of constant flow insufflation of oxygen (CFIO) on the rate of return of spontaneous circulation (ROSC) and other clinical outcomes during cardiac arrest (CA).

Methods: A systematic review was performed using four databases (PROSPERO: CRD42020071960). Studies reporting on adult CA patients or on animal models simulating CA and assessing the effect of CFIO on ROSC or other clinical outcomes were considered. Read More

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