127 results match your criteria fusion hu-b


Synthesis of Succinimide Spiro-Fused Sultams from the Reaction of -(Phenylsulfonyl)acetamides with Maleimides via C(sp)-H Activation.

J Org Chem 2021 Jul 21. Epub 2021 Jul 21.

NMPA Key Laboratory for Research and Evaluation of Innovative Drug, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, China.

Presented herein is an effective preparation of succinimide spiro-fused sultams through the coupling reaction of -(phenylsulfonyl)acetamides with maleimides. It is deduced that this reaction should proceed through a cascade process including Rh(III)-catalyzed C(sp)-H bond cleavage of -(phenylsulfonyl)acetamide, maleimide double bond insertion into the C-Rh bond, β-hydride elimination, reductive elimination, and intramolecular aza-Michael addition. Notably, this cascade procedure features simultaneous annulation and spirocyclization through traceless fusion of the directing group into target product by using air as an economical oxidant to assist the regeneration of the active Rh(III) catalyst. Read More

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Unmasking BCL-2 Addiction in Synovial Sarcoma by Overcoming Low NOXA.

Cancers (Basel) 2021 May 12;13(10). Epub 2021 May 12.

Sarcoma Program, School of Medicine and Massey Cancer Center, Virginia Commonwealth University, Goodwin Research Building, Rm 382, 401 College St. P.O. Box 980037, Richmond, VA 23298, USA.

Synovial sarcoma (SS) is frequently diagnosed in teenagers and young adults and continues to be treated with polychemotherapy with variable success. The SS18-SSX gene fusion is pathognomonic for the disease, and high expression of the anti-apoptotic BCL-2 pathologically supports the diagnosis. As the oncogenic SS18-SSX fusion gene itself is not druggable, BCL-2 inhibitor-based therapies are an appealing therapeutic opportunity. Read More

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Clinical features and prognostic impact of TCF3-PBX1 in childhood acute lymphoblastic leukemia: A single-center retrospective study of 837 patients from China.

Curr Probl Cancer 2021 May 16:100758. Epub 2021 May 16.

Department of Hematology-oncology, Children's Hospital of Zhejiang University School of Medicine, the Pediatric Leukemia Diagnostic and Therapeutic Technology Research Center of Zhejiang Province, National Clinical Research Center for Child Health, Zhejiang University, Hangzhou, China. Electronic address:

Objectives: Conflicting data have been published regarding the prognostic impact of the t(1;19)/TCF3-PBX1 translocation in childhood ALL. The objective of this study was to explore the correlation between the TCF3-PBX1 fusion gene and clinical outcome in Chinese children with newly diagnosed ALL.

Methods: In order to address this issue in our setting, we summarized and analyzed the data of 837 Chinese children with ALL diagnosed between 2010 and 2017. Read More

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HU-AB simulacrum: Fusion of HU-B and HU-A into HU-B-A, a functional analog of the Escherichia coli HU-AB heterodimer.

Biochem Biophys Res Commun 2021 Jun 5;560:27-31. Epub 2021 May 5.

Centre for Protein Science, Design and Engineering (CPSDE), Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Knowledge City, Sector-81, SAS Nagar, Punjab, 140306, India. Electronic address:

In enteric bacteria such as Escherichia coli, there are two homologs of the DNA-binding nucleoid associated protein (NAP) known as HU. The two homologs are known as HU-A and HU-B, and exist either in the form of homodimers (HU-AA, or HU-BB) or as heterodimers (HU-AB), with different propensities to form higher-order oligomers. The three different dimeric forms dominate different stages of bacterial growth, with the HU-AB heterodimer dominating cultures in the stationary phase. Read More

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Fever as a rare combined symptom of degenerative cervical myelopathy: a case report and literature review.

Br J Neurosurg 2021 Apr 29:1-4. Epub 2021 Apr 29.

Department of Spine surgery, Changzheng Hospital, Naval Medical University, Shanghai, China.

A 60-year-old male patient complained of weakness of both legs for one year, intermittent fever for two months, up to 38.0 °C. Physical examination showed bilateral hyperreflexia of knee tendon and positive Hoffman sign on the right side. Read More

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Potential role of mitochondria in gastric cancer detection: Fission and glycolysis.

Oncol Lett 2021 Jun 1;21(6):439. Epub 2021 Apr 1.

Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.

Gastric cancer (GC) is characterized by high morbidity and mortality rates worldwide. Helicobacter pylori infection, high salt intake, smoking, alcohol, low fiber intake, family history of GC, obesity and precancerous lesions, including chronic atrophic gastritis and intestinal metaplasia, are considered general risk factors for GC. Image enhancement endoscopy methods, which improve the visualization of mucosal structures and vascularity, may be used for the early diagnosis of GC, such as narrow band imaging, which can reveal fine details of subtle superficial abnormalities of early gastric cancer (EGC). Read More

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ZFTA-RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma.

Cancer Discov 2021 Mar 19. Epub 2021 Mar 19.

Texas Children's Cancer Center.

Over 60% of supratentorial (ST) ependymomas harbor a ZFTA-RELA (ZRfus) gene fusion (formerly C11orf95-RELA). To study the biology of ZRfus, we developed an autochthonous mouse tumor model using in utero electroporation (IUE) of the embryonic mouse brain. Integrative epigenomic and transcriptomic mapping was performed on IUE driven ZRfus tumors by CUT&RUN, ChIP, ATAC, and RNA sequencing and compared to human ZRfus driven ependymoma. Read More

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Deep Learning for Automatic Differential Diagnosis of Primary Central Nervous System Lymphoma and Glioblastoma: Multi-Parametric Magnetic Resonance Imaging Based Convolutional Neural Network Model.

J Magn Reson Imaging 2021 Mar 11. Epub 2021 Mar 11.

Academy for Engineering and Technology, Fudan University, Shanghai, China.

Background: Differential diagnosis of primary central nervous system lymphoma (PCNSL) and glioblastoma (GBM) is useful to guide treatment strategies.

Purpose: To investigate the use of a convolutional neural network (CNN) model for differentiation of PCNSL and GBM without tumor delineation.

Study Type: Retrospective. Read More

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[Treatment of lumbar degenerative diseases with recapping laminoplasty and nerve root canal's decompression preserving the continuity of supraspinous ligament].

Zhonghua Yi Xue Za Zhi 2021 Mar;101(9):641-646

Department of Orthopedics, Luohe Central Hospital, Luohe 462000, China.

To explore the clinical effect of lumbar discectomy and nerve root canal's enlargement preserving the continuity of supraspinous ligament in the treatment of lumbar degenerative disease. The data of patients with lumbar degenerative disease who underwent operation from 2016 to 2018 were analyzed retrospectively, and the patients were divided into two groups according to the different operation. The treatment group (17 cases) was treated with recapping laminoplasty, lumbar discectomy and nerve root canal's enlargement, and the control group (28 cases) was treated with total laminectomy, nerve root canal's enlargement, lumbar discectomy, interbody fusion and internal fixation (PLIF). Read More

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Generated SecPen_NY-ESO-1_ubiquitin-pulsed dendritic cell cancer vaccine elicits stronger and specific T cell immune responses.

Acta Pharm Sin B 2021 Feb 25;11(2):476-487. Epub 2020 Aug 25.

Shanghai Engineering Research Center of ImmunoTherapeutics, School of Pharmacy, Fudan University, Shanghai 201203, China.

Dendritic cell-based cancer vaccines (DC vaccines) have been proved efficient and safe in immunotherapy of various cancers, including melanoma, ovarian and prostate cancer. However, the clinical responses were not always satisfied. Here we proposed a novel strategy to prepare DC vaccines. Read More

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February 2021

A novel consciousness emotion recognition method using ERP components and MMSE.

J Neural Eng 2021 04 18;18(4). Epub 2021 Apr 18.

School of Information Science and Engineering, Shandong Normal University, Jinan, People's Republic of China.

Electroencephalogram (EEG) based emotion recognition mainly extracts traditional features from time domain and frequency domain, and the classification accuracy is often low for the complex nature of EEG signals. However, to the best of our knowledge, the fusion of event-related potential (ERP) components and traditional features is not employed in emotion recognition, and the ERP components are only identified and analyzed by the psychology professionals, which is time-consuming and laborious.In order to recognize the consciousness and unconsciousness emotions, we propose a novel consciousness emotion recognition method using ERP components and modified multi-scale sample entropy (MMSE). Read More

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Proximal junctional kyphosis in Lenke 5 AIS patients: the important factor of pelvic incidence.

BMC Musculoskelet Disord 2021 Feb 15;22(1):185. Epub 2021 Feb 15.

Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, NO. 37 GuoXue Road, 610041, Chengdu, Sichuan, China.

Background: The purpose of the study was to investigate whether pelvic incidence (PI) will affect the occurrence of PJK in Lenke 5 AIS patients after correction surgery and try to explore a better surgical scheme based on PI.

Methods: Lenke 5C AIS patients that underwent correction surgery with a minimum of a 2-year follow-up were identified. Demographic and radiographic data were collected preoperatively, postoperatively, and at the final follow-up. Read More

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February 2021

Mink SLAM V-Region V74I Substitutions Contribute to the Formation of Syncytia Induced by Canine Distemper Virus.

Front Vet Sci 2020 21;7:570283. Epub 2021 Jan 21.

College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, China.

The Signal lymphatic activation molecule (SLAM, also known as CD150) as the cellular receptor of canine distemper virus (CDV) plays an important role in the virus-host interaction. However, it is still unknown whether amino acid differences in the SLAM variable (V) region affect the formation of syncytia. Here, using raccoon dog SLAM (rSLAM) and mink SLAM (mSLAM), we performed SLAM-V homologous modeling, site-directed mutagenesis, and surface expression analysis, as well as a cell fusion assay, to study the interaction between SLAM and CDV. Read More

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January 2021

An Aided Navigation Method Based on Strapdown Gravity Gradiometer.

Sensors (Basel) 2021 Jan 27;21(3). Epub 2021 Jan 27.

Department of Navigation Engineering, Naval University of Engineering, Wuhan 430000, China.

The gravity gradient is the second derivative of gravity potential. A gravity gradiometer can measure the small change of gravity at two points, which contains more abundant navigation and positioning information than gravity. In order to solve the problem of passive autonomous, long-voyage, and high-precision navigation and positioning of submarines, an aided navigation method based on strapdown gravity gradiometer is proposed. Read More

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January 2021

[Predictive abilities of O-C2 angle, O-EA angle, and Oc-Ax angle for the development of dysphagia in patients after occipitocervical fusion].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Jan;35(1):33-38

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China;Orthopedic Research Institute of West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.

Objective: To compare the predictive abilities of O-C2 angle (O-C2a), O-EA angle (O-EAa), and Oc-Ax angle (Oc-Axa) for development of dysphagia in patients after occipitocervical fusion (OCF).

Methods: Between April 2010 and May 2019, 114 patients who underwent OCF and met the selection criteria were selected as the research objects. Among them, 54 were males and 60 were females; they were 14-76 years old, with an average of 50. Read More

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January 2021

Predictive ability of pharyngeal inlet angle for the occurrence of postoperative dysphagia after occipitocervical fusion.

BMC Musculoskelet Disord 2021 Jan 9;22(1):54. Epub 2021 Jan 9.

Department of Orthopedics Surgery and Orthopaedics Research Institute, West China Hospital, Sichuan University, No. 37 GuoXue Road, 610041, Chengdu, Sichuan, China.

Background: PIA has been proven to be a predictor for postoperative dysphagia in patients who undergo occipitospinal fusion. However, its predictive effect for postoperative dysphagia in patients who undergo OCF is unknown. The aim of this study was to evaluate the predictive ability of the pharyngeal inlet angle (PIA) for the occurrence of postoperative dysphagia in patients who undergo occipitocervical fusion (OCF). Read More

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January 2021

A Lightweight Spatial and Temporal Multi-Feature Fusion Network for Defect Detection.

IEEE Trans Image Process 2021 24;30:472-486. Epub 2020 Nov 24.

This article proposes a hybrid multi-dimensional features fusion structure of spatial and temporal segmentation model for automated thermography defects detection. In addition, the newly designed attention block encourages local interaction among the neighboring pixels to recalibrate the feature maps adaptively. A Sequence-PCA layer is embedded in the network to provide enhanced semantic information. Read More

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November 2020

Prediction of Proximal Junctional Kyphosis After Posterior Scoliosis Surgery With Machine Learning in the Lenke 5 Adolescent Idiopathic Scoliosis Patient.

Front Bioeng Biotechnol 2020 6;8:559387. Epub 2020 Oct 6.

Center for Computational Systems Medicine, School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX, United States.

Objective: To build a model for proximal junctional kyphosis (PJK) prognostication in Lenke 5 adolescent idiopathic scoliosis (AIS) patients undergoing long posterior instrumentation and fusion surgery by machine learning and analyze the risk factors for PJK.

Materials And Methods: In total, 44 AIS patients (female/male: 34/10; PJK/non-PJK: 34/10) who met the inclusion criteria between January 2013 and December 2018 were retrospectively recruited from West China Hospital. Thirty-seven clinical and radiological features were acquired by two independent investigators. Read More

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October 2020

Loss of Correction After Removal of Spinal Implants in Congenital Scoliosis.

World Neurosurg 2020 12 25;144:e916-e925. Epub 2020 Sep 25.

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, China.

Background: Previous studies have reported the progression of deformity in patients with adolescent idiopathic scoliosis after implant removal. However, for patients with congenital scoliosis, few studies have investigated the prognosis after implant removal.

Methods: We observed 24 patients with congenital scoliosis, who underwent implant removal, for at least 3 years. Read More

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December 2020

Coronavirus Antiviral Research Database (CoV-RDB): An Online Database Designed to Facilitate Comparisons between Candidate Anti-Coronavirus Compounds.

Viruses 2020 09 9;12(9). Epub 2020 Sep 9.

Division of Infectious Diseases, Stanford University School of Medicine, Stanford, CA 94305, USA.

Background: To prioritize the development of antiviral compounds, it is necessary to compare their relative preclinical activity and clinical efficacy.

Methods: We reviewed in vitro, animal model, and clinical studies of candidate anti-coronavirus compounds and placed extracted data in an online relational database.

Results: As of August 2020, the Coronavirus Antiviral Research Database (CoV-RDB; covdb. Read More

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September 2020

[A case control study of lumbar fusion surgery with the Wiltse approach and the traditional approach].

Zhongguo Gu Shang 2019 Oct;32(10):965-970

Department of Orthopaedics, Tianyou Hospital Affiliated to Wuhan University of Science and Technology, Wuhan 430000, Hubei, China;

Objective: To compare the clinical results between the Wiltse approach and traditional approach in lumbar fusion.

Methods: The clinical data of 70 patients with lumbar disc herniation or lumbar spondylolisthesis within Meyerding II degree who underwent lumbar fusion surgery from May 2016 to May 2017 were retrospectively analyzed. According to the surgical approach, the patients were divided into Wiltse approach group and traditional approach group. Read More

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October 2019

Emotion Recognition From Multimodal Physiological Signals Using a Regularized Deep Fusion of Kernel Machine.

IEEE Trans Cybern 2020 May 14;PP. Epub 2020 May 14.

These days, physiological signals have been studied more broadly for emotion recognition to realize emotional intelligence in human-computer interaction. However, due to the complexity of emotions and individual differences in physiological responses, how to design reliable and effective models has become an important issue. In this article, we propose a regularized deep fusion framework for emotion recognition based on multimodal physiological signals. Read More

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Greatly enhancing the enantioselectivity of PvEH2, a Phaseolus vulgaris epoxide hydrolase, towards racemic 1,2-epoxyhexane via replacing its partial cap-loop.

Int J Biol Macromol 2020 Aug 12;156:225-232. Epub 2020 Apr 12.

Wuxi School of Medicine, Jiangnan University, Wuxi 214122, PR China. Electronic address:

To achieve the kinetic resolution and enantioconvergent hydrolysis of rac-1,2-epoxyhexane, the E value of PvEH2 was enhanced by substituting its partial cap-loop. Based on the experimental results reported previously and computer-aided analysis, the flexible and variable cap-loop, especially its middle segment, was speculated to be related to the catalytic properties of PvEH2. In view of this, four PvEH2's hybrids, Pv2St, Pv2Pv1, Pv2Vr1 and Pv2Vr2, were designed by substituting the middle segment (EGMGSNLNTSMP) of a cap-loop in PvEH2 with the corresponding ones in StEH, PvEH1, VrEH1 and VrEH2, respectively. Read More

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Computed tomography-based bronchial tree three-dimensional reconstruction and airway resistance evaluation in adolescent idiopathic scoliosis.

Eur Spine J 2020 08 26;29(8):1981-1992. Epub 2020 Mar 26.

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 37 Guoxue Rd, Chengdu, 610041, China.

Purpose: To investigate airway development and airway resistance by computed tomographic three-dimensional (3D) reconstruction of the bronchial tree in patients with adolescent idiopathic scoliosis (AIS). We evaluated factors predicting postoperative respiratory complications to provide timely treatment, prevent complications, and improve operative and anesthetic safety.

Methods: From August 2015 to August 2017, 53 AIS patients with a mean age of 15. Read More

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Surgical Treatment of Scoliosis-Associated with Syringomyelia: The Role of Syrinx Size.

Neurol India 2020 Mar-Apr;68(2):299-304

Department of Neurosurgery, West China Hospital, Sichuan University, No. 37 GuoXue Road, Chengdu, Sichuan, China.

Background: The treatment of the syrinx prior to correction of the scoliosis in syringomyelia-associated scoliosis (SMS) patients remains controversial. The aim of this study is to evaluate the role of the syrinx size in the management of SMS patients.

Materials And Methods: This was a retrospective study of 36 SMS patients. Read More

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[Clinical safety and efficiency of ultrasonic bone curette used in anterior cervical discectomy and fusion surgery].

Zhonghua Yi Xue Za Zhi 2020 Mar;100(9):669-673

Department of Orthopedics, Luohe Central Hospital, Luohe 462000, China.

To investigate the safety and efficiency of ultrasonic bone curette used in anterior cervical discectomy and fusion surgery. As a retrospective study, we collected and analyzed the clinical data of 47 patients receiving anterior cervical discectomy and fusion surgery in Luohe Central Hospital from January 2014 to January 2017, there were 26 males and 21 females with a mean age of (52±9) years. According to the different surgical tools used in the process of decompression by resecting osteophytes or bone like an inverted Chinese character "" located at the posterior margin of the vertebral body, the patients were divided into two groups: ultrasonic bone curette group (group A) and traditional tools group (group B). Read More

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[Early effectiveness of oblique lateral interbody fusion combined with pedicle screw fixation via small incision Wiltse approach for lumbar spondylolisthesis].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2020 Mar;34(3):294-299

Department of Orthopedics, Jingzhou Center Hospital, Jingzhou Hubei, 434020, P.R.China.

Objective: To investigate the early effctiveness of oblique lateral interbody fusion (OLIF) combined with pedicle screw fixation via small incision Wiltse approach for the treatment of lumbar spondylolisthesis.

Methods: Between January 2016 and December 2016, 21 patients with lumbar spondylolisthesis were treated with OLIF and pedicle screw fixation via small incision Wiltse approach. There were 9 males and 12 females, aged 57-73 years, with an average age of 64. Read More

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High Rate of Detection of Human ESPL1-HBV S Fusion Gene in Patients With HBV-related Liver Cancer: A Chinese Case-Control Study.

Anticancer Res 2020 Jan;40(1):245-252

Department of Infectious Diseases, The First Affiliated Hospital of Guangxi Medical University, Nanning, P.R. China

Aim: It has been shown that the integration of hepatitis B virus (HBV) gene into the host genome is a high-risk factor for development of hepatocellular carcinoma (HCC). However, the relationship between HBV S-integrated human extra spindle pole bodies-like 1 (ESPL1) gene and HCC is unknown. This study was designed to detect HBV S-integrated human ESPL1 fusion gene in patients with HCC for potentially using this fusion gene as a biomarker for HCC diagnosis. Read More

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January 2020

MFN1-dependent alteration of mitochondrial dynamics drives hepatocellular carcinoma metastasis by glucose metabolic reprogramming.

Br J Cancer 2020 01 10;122(2):209-220. Epub 2019 Dec 10.

Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China.

Background: Mitochondrial dynamics plays an important role in tumour progression. However, how these dynamics integrate tumour metabolism in hepatocellular carcinoma (HCC) metastasis is still unclear.

Methods: The mitochondrial fusion protein mitofusin-1 (MFN1) expression and its prognostic value are detected in HCC. Read More

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January 2020