304,935 results match your criteria fusion

Convolutional fusion network for monaural speech enhancement.

Neural Netw 2021 May 25;143:97-107. Epub 2021 May 25.

Intelligent Sensing and Communications Research Group, School of Engineering, Newcastle University, Newcastle upon, Tyne NE1 7RU, UK. Electronic address:

Convolutional neural network (CNN) based methods, such as the convolutional encoder-decoder network, offer state-of-the-art results in monaural speech enhancement. In the conventional encoder-decoder network, large kernel size is often used to enhance the model capacity, which, however, results in low parameter efficiency. This could be addressed by using group convolution, as in AlexNet, where group convolutions are performed in parallel in each layer, before their outputs are concatenated. Read More

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Design, synthesis, and biological evaluation of 1-methyl-1H-pyrazolo[4,3-b]pyridine derivatives as novel small-molecule inhibitors targeting the PD-1/PD-L1 interaction.

Bioorg Chem 2021 May 30;114:105034. Epub 2021 May 30.

Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Electronic address:

Blockade of the programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) signalling pathway is a promising tumour immunotherapeutic approach, and small molecule drugs have more advantages than monoclonal antibody macromolecules in clinical applications. Therefore, a series of 1-methyl-1H-pyrazolo[4,3-b]pyridine derivatives as PD-1/PD-L1 interaction novel small-molecule inhibitors were designed employing a ring fusion strategy. The inhibitory activity of compounds was evaluated by the HTRF assay, among which D38 was identified as the most potent PD-1/PD-L1 interaction inhibitor with an IC value of 9. Read More

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External validation of a predictive model of adverse events following spine surgery.

Spine J 2021 Jun 8. Epub 2021 Jun 8.

Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA.

Background Context: We lack models that reliably predict 30-day postoperative adverse events (AEs) following spine surgery.

Purpose: We externally validated a previously developed predictive model for common 30-day adverse events (AEs) after spine surgery.

Study Design/setting: This prospective cohort study utilizes inpatient and outpatient data from a tertiary academic medical center. Read More

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Prospective, Randomized, Double-Blinded Clinical Trial Comparing PEEK and Allograft Spacers in Patients Undergoing Transforaminal Lumbar Interbody Fusion Surgeries.

Spine J 2021 Jun 8. Epub 2021 Jun 8.

Boulder Neurosurgical Associates, Boulder, Colorado, USA; Justin Parker Neurological Institute, Boulder, Colorado, USA. Electronic address:

Background Context: Allograft and polyether-ether-ketone (PEEK) radiographic, biomechanical, histological properties have been extensively studied and both spacers have their advantages and shortcomings. There are no comparative randomized or double-blinded spinal fusion clinical trials reported to date.

Purpose: The study's primary objective was to prospectively investigate clinical and radiological outcomes in patients undergoing lumbar interbody fusions and randomized to receive either PEEK or structural bone allografts. Read More

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Abatacept for treatment-refractory pediatric CTLA4-haploinsufficiency.

Clin Immunol 2021 Jun 8:108779. Epub 2021 Jun 8.

Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany; German Centre for Infection Research (DZIF), Munich, Germany; Munich Centre for Rare Diseases (M-ZSE), University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany. Electronic address:

CTLA4-haploinsufficiency is a complex disease of immune dysregulation presenting with a broad spectrum of clinical manifestations. CTLA4-Fc fusion proteins such as abatacept have been described to alleviate immune dysregulation in several adult cases of CTLA4-haploinsufficiency. However, until now only few cases of pediatric CTLA4-haploinsufficiency treated with abatacept have been described. Read More

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Low back pain.

Lancet 2021 Jun 8. Epub 2021 Jun 8.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA; Neurology, Physical Medicine and Rehabilitation, Johns Hopkins Medical Institutions, Baltimore, MD, USA; Psychiatry and Behavioral Sciences, Johns Hopkins Medical Institutions, Baltimore, MD, USA; Department of Physical Medicine and Rehabilitation and Anesthesiology, Walter Reed National Military Medical Center, Bethesda, MD, USA.

Low back pain covers a spectrum of different types of pain (eg, nociceptive, neuropathic and nociplastic, or non-specific) that frequently overlap. The elements comprising the lumbar spine (eg, soft tissue, vertebrae, zygapophyseal and sacroiliac joints, intervertebral discs, and neurovascular structures) are prone to different stressors, and each of these, alone or in combination, can contribute to low back pain. Due to numerous factors related to low back pain, and the low specificity of imaging and diagnostic injections, diagnostic methods for this condition continue to be a subject of controversy. Read More

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Preclinical Safety of a 3D-Printed Hydroxyapatite-Demineralized Bone Matrix Scaffold for Spinal Fusion.

Spine (Phila Pa 1976) 2021 Jun 10. Epub 2021 Jun 10.

Department of Orthopaedic Surgery, Northwestern University, Chicago, IL Center for Regenerative Nanomedicine, Simpson Querrey Institute, Chicago, IL Dimension Inx Corp, Chicago, IL Department of Radiology, Northwestern University, Chicago, IL.

Study Design: Prospective, randomized, controlled preclinical study.

Objective: The objective of this study was to compare the host inflammatory response of our previously described hyperelastic, 3D-printed (3DP) hydroxyapatite (HA)-demineralized bone matrix (DBM) composite scaffold to the response elicited with the use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in a preclinical rat posterolateral lumbar fusion model.

Summary Of Background Data: Our group previously found that this 3D-printed HA-DBM composite material shows promise as a bone graft substitute in a preclinical rodent model, but its safety profile had yet to be assessed. Read More

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18F-Choline PET/CT, MRI, and Software-Based Image Fusion Analysis in Patients With Primary Hyperparathyroidism.

Clin Nucl Med 2021 Jun 10. Epub 2021 Jun 10.

From the Institute of Nuclear Medicine and Endocrinology, Kepler University Hospital Linz GmbH Medical Faculty, Johannes Kepler University Linz Central Radiology Institute Department of General Surgery, Kepler University Hospital Linz GmbH, Linz Department of Nuclear Medicine, Medical University of Innsbruck, Innsbruck, Austria.

Purpose: The aim of this study was to evaluate the diagnostic performance of 18F-choline PET and MRI in patients with primary hyperparathyroidism. Furthermore, the additional value of software-based PET/MRI scan fusion was analyzed.

Patients And Methods: This retrospective study includes 42 patients (38 women) with an age between 32. Read More

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Clinical Utility of Anchored Multiplex Solid Fusion Assay for Diagnosis of Bone and Soft Tissue Tumors.

Am J Surg Pathol 2021 Jun 10. Epub 2021 Jun 10.

James Homer Wright Pathology Laboratories Department of Internal Medicine, Division of Hematology/Oncology Departments of Orthopedic Oncology Surgical Oncology Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

Sarcoma diagnosis has become increasingly complex, requiring a combination of morphology, immunohistochemistry, and molecular studies to derive specific diagnoses. We evaluated the role of anchored multiplex polymerase chain reaction-based gene fusion assay in sarcoma diagnostics. Between 2015 and 2018, bone and soft tissue sarcomas with fusion assay results were compared with the histologic diagnosis. Read More

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Spontaneous Reduction of Chiari Malformation and Syringomyelia After Posterior Spinal Fusion for Scoliosis: A Case Report.

JBJS Case Connect 2021 Jun 11;11(2). Epub 2021 Jun 11.

Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan.

Case: A 22-year-old skeletally mature man with scoliosis accompanied by syringomyelia associated with Chiari malformation type 1 was presented to our hospital. Because the maximal syrinx/cord ratio was small, and he had no neurological deficit, he underwent corrective surgery without the treatment of the syringomyelia.

Conclusion: The scoliosis was corrected without any neurological complications. Read More

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Real-Time and Adaptive Reservoir Computing With Application to Profile Prediction in Fusion Plasma.

IEEE Trans Neural Netw Learn Syst 2021 Jun 11;PP. Epub 2021 Jun 11.

Nuclear fusion is a promising alternative to address the problem of sustainable energy production. The tokamak is an approach to fusion based on magnetic plasma confinement, constituting a complex physical system with many control challenges. We study the characteristics and optimization of reservoir computing (RC) for real-time and adaptive prediction of plasma profiles in the DIII-D tokamak. Read More

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Determining the Dependence of Interfacial Tension on Molecular Area for Phospholipid Monolayers Formed at Silicone Oil-Water and Tricaprylin-Water Interfaces by Vesicle Fusion.

Langmuir 2021 Jun 11. Epub 2021 Jun 11.

Research Center for Functional Materials, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.

Phospholipid monolayers formed at oil-water interfaces have been used to explore biological interface properties. Thus, monolayer systems need to be quantitatively understood. Previously, we investigated the formation of 1-palmitoyl-2-oleoyl--glycero-3-phosphocholine (POPC) monolayers at silicone oil-water interfaces to determine the dependence of interfacial tension, γ, on the area per lipid, , compared to that of the closely packed monolayers, . Read More

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Survival motor neuron deficiency slows myoblast fusion through reduced myomaker and myomixer expression.

J Cachexia Sarcopenia Muscle 2021 Jun 11. Epub 2021 Jun 11.

Department of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, F. Edward Hébert School of Medicine, Bethesda, MD, USA.

Background: Spinal muscular atrophy is an inherited neurodegenerative disease caused by insufficient levels of the survival motor neuron (SMN) protein. Recently approved treatments aimed at increasing SMN protein levels have dramatically improved patient survival and have altered the disease landscape. While restoring SMN levels slows motor neuron loss, many patients continue to have smaller muscles and do not achieve normal motor milestones. Read More

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Interspecific hybridization between Ganoderma lingzhi and G. applanatum through protoplast fusion.

World J Microbiol Biotechnol 2021 Jun 11;37(7):114. Epub 2021 Jun 11.

Mushroom Research Division, National Institute of Horticultural & Herbal Science, RDA, Chungbuk, Eumseong, 27709, South Korea.

Interspecific hybridization between Ganoderma lingzhi and G. applanatum was attempted through polyethylene glycol (PEG) induced fusion technique. The protoplast isolation procedure was simplified, and we obtained a significant number of protoplasts from both Ganoderma species. Read More

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Pharmacogenomic-Guided Therapy in Colorectal Cancer.

Clin Pharmacol Ther 2021 Jun 11. Epub 2021 Jun 11.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, 55905, USA.

Approximately twenty drugs have been shown to be effective for the treatment of colorectal cancer (CRC). These drugs are from several classes of agents and include cytotoxic drugs, therapeutics that target cell signaling pathways at the extracellular and/or intracellular levels, and combination therapies that contain multiple targeted agents and/or cytotoxic compounds. Targeted therapeutics can include monoclonal antibodies, fusion proteins, and small molecule drugs. Read More

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Mitochondrial function in development and disease.

Dis Model Mech 2021 Jun 11;14(6). Epub 2021 Jun 11.

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 01238, USA.

Mitochondria are organelles with vital functions in almost all eukaryotic cells. Often described as the cellular 'powerhouses' due to their essential role in aerobic oxidative phosphorylation, mitochondria perform many other essential functions beyond energy production. As signaling organelles, mitochondria communicate with the nucleus and other organelles to help maintain cellular homeostasis, allow cellular adaptation to diverse stresses, and help steer cell fate decisions during development. Read More

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Efficacy of percutaneous pedicle screws for thoracic and lumbar spine fractures compared with open technique.

J Neurosurg Sci 2021 Jun 10. Epub 2021 Jun 10.

Neurosurgery, XII de Octubre University Hospital, Madrid, Spain.

Background: The objective of this study is to compare percutaneous techniques (MIS) with the open technique in terms of angle correction, long-term maintenance and clinical results.

Methods: The authors collected a prospective database of thoraco-lumbar fractures treated with posterior stabilization without fusion from 2013 to 2019. The statistical analysis has been carried out retrospectively. Read More

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[Adjacent segment degeneration after posterolateral lumbar fusion: results and complications of posterior revision surgery].

J Neurosurg Sci 2021 Jun 10. Epub 2021 Jun 10.

Post-Graduation in Health Sciences - IAMSPE, São Paulo, São Paulo, Brazil.

Background: Lumbar fusion is an important technique for the treatment of degenerative pathologies. Adjacent segment degeneration is a known complication after lumbar fusion that causes significant morbidity. Our objective was to evaluate the demographics, risk factors, type of surgery, and surgical complications in patients who underwent reoperation through a posterior route due to adjacent segment degeneration. Read More

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Safety evaluation of atmospheric pressure plasma jets in and experiments.

J Periodontal Implant Sci 2021 Jun;51(3):213-223

Department of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.

Purpose: The atmospheric pressure plasma jet (APPJ) has been introduced as an effective disinfection method for titanium surfaces due to their massive radical generation at low temperatures. Helium (He) has been widely applied as a discharge gas in APPJ due to its bactericidal effects and was proven to be effective in our previous study. This study aimed to evaluate the safety and effects of He-APPJ application at both the cell and tissue levels. Read More

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A Review on Green Synthesis, Characterization and Anticancer Application of Metallic Nanoparticles.

Appl Biochem Biotechnol 2021 Jun 10. Epub 2021 Jun 10.

School of Sciences, MATS University, Raipur, Chhattisgarh, 492001, India.

Cancer is one of the leading causes of death worldwide and also the main obstacle of accelerating anticipation. It is globally recognized as overwhelmingly challenging in terms of clinical management. Cancer is taken into account because a prime lethal disease affects different organs of the body. Read More

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Impact of Opioid Prescribing Guidelines on Postoperative Opioid Prescriptions Following Elective Spine Surgery: Results From an Institutional Quality Improvement Initiative.

Neurosurgery 2021 Jun 10. Epub 2021 Jun 10.

Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA.

Background: With a dramatic rise in prescription opioid use, it is imperative to review postsurgical prescribing patterns given their contributions to the opioid epidemic.

Objective: To evaluate the impact of departmental postoperative prescribing guidelines on opioid prescriptions following elective spine surgery.

Methods: Patients undergoing elective cervical or lumbar spine surgery between 2017 and 2018 were identified. Read More

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Letter: Prognostic Factors for Adjacent Segment Disease After L4-L5 Lumbar Fusion.

Neurosurgery 2021 Jun 10. Epub 2021 Jun 10.

Department of Spine Surgery Hong Hui Hospital Xi'an Jiaotong University Xi'an, China.

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Front-Back Cervical Deformity Correction by Anterior Cervical Discectomy and Fusion With Posterior Instrumentation: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 Jun 10. Epub 2021 Jun 10.

Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina, USA.

Front-back procedures for cervical deformity permit the correction of cervical kyphosis in the setting of unfused facets. Here, we highlight the operative treatment of a 65-yr-old female entailing a 4-level anterior cervical discectomy and fusion (ACDF) at C3-C4, C4-C5, C5-C6, and C6-C7 with hyperlordotic interbody implants, supplemented by a posterior C2-T2 instrumented fusion. The patient initially presented with symptoms of treatment-refractory neck pain while neurologically intact on examination. Read More

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Outcomes of Surgical Treatment for One Hundred Thirty-Eight Patients With Severe Sagittal Deformity at a Minimum 2-Year Follow-up: A Case Series.

Oper Neurosurg (Hagerstown) 2021 Jun 10. Epub 2021 Jun 10.

Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.

Background: Operative treatment of adult spinal deformity (ASD) can be very challenging with high complication rates. It is well established that patients benefit from such treatment; however, the surgical outcomes for patients with severe sagittal deformity have not been reported.

Objective: To report the outcomes of patients undergoing surgical correction for severe sagittal deformity. Read More

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Magnetic resonance/ultrasound fusion targeted biopsy of the prostate can be improved by adding systematic biopsy.

Med Ultrason 2021 Jun 3. Epub 2021 Jun 3.

"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

Aim: Magnetic resonance/ ultrasound fusion targeted biopsy (Tbs) is widely used for diagnosing prostate cancer (PCa). The aim of our study was to compare the cancer detection rate (CDR) and the clinically significant prostate cancer detection rate (csPCa) of the magnetic resonance/ultrasound fusion targeted biopsy with those of the standard systematic biopsy (Sbs) and of the combination of both techniques.

Material And Methods: A total of 182 patients underwent magnetic resonance/ultrasound fusion Tbs on the prostate for PCa suspicion based on multiparametric magnetic resonance imaging (mMRI) detection of lesions with PI-RADSv2 score ≥3. Read More

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Systemic administration of monovalent follistatin-like 3-Fc-fusion protein increases muscle mass in mice.

iScience 2021 May 14;24(5):102488. Epub 2021 May 14.

Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.

Targeting the signaling pathway of growth differentiation factor 8 (GDF8), also known as myostatin, has been regarded as a promising strategy to increase muscle mass in the elderly and in patients. Accumulating evidence in animal models and clinical trials has indicated that a rational approach is to inhibit a limited number of transforming growth factor β (TGF-β) family ligands, including GDF8 and activin A, without affecting other members. Here, we focused on one of the endogenous antagonists against TGF-β family ligands, follistatin-like 3 (FSTL3), which mainly binds and neutralizes activins, GDF8, and GDF11. Read More

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Imaging Assessment of the Postoperative Spine: An Updated Pictorial Review of Selected Complications.

Biomed Res Int 2021 18;2021:9940001. Epub 2021 May 18.

Directorate of Research, Hospital General de Mexico "Dr. Eduardo Liceaga", Mexico City, Mexico.

Imaging of the postoperative spine requires the identification of several critical points by the radiologist to be written in the medical report: condition of the underlying cortical and cancellous bone, intervertebral disc, and musculoskeletal tissues; location and integrity of surgical implants; evaluation of the success of decompression procedures; delineation of fusion status; and identification of complications. This article presents a pictorial narrative review of the most common findings observed in and postoperative spines. Complications in the spine were grouped in (hematomas, pseudomeningocele, and postoperative spine infection) and findings (arachnoiditis, radiculitis, recurrent disc herniation, spinal stenosis, and textiloma). Read More

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Antigenic and Molecular Characterization of Virulent Newcastle Disease Viruses Circulating in Ethiopia Between 1976 and 2008.

Vet Med (Auckl) 2021 4;12:129-140. Epub 2021 Jun 4.

Institute of Infectology, Friedrich-Loeffler-Institut, Greifswald, Germany.

Introduction: Newcastle disease virus (NDV) cultures held in the isolate collections in Ethiopia between 1976 and 2008 were not characterized using biological and molecular techniques. The already characterized NDV isolates belonged to genotype VI but the genetic nature of previously collected isolates, which could shade light on the history of introduction into the country and their evolutionary relationships, were not established.

Methods: A total of 14 NDVs (11 obtained from outbreak cases in chickens and three commercial vaccinal strains used in the country) were inoculated into specific pathogen free (SPF) embryonated chicken eggs (ECE). Read More

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Surgical Management of Thoracolumbar Spondylodiscitis in End-Stage Renal Disease.

Indian J Orthop 2021 May 6;55(Suppl 1):176-181. Epub 2020 May 6.

Department of Orthopaedics, M S Ramaiah Medical College, Bangalore, India.

Background: In recent times due to the advancement of haemodialysis techniques, there is increase in the life span of the patients with end-stage renal disease, which tends to increase the risk of complications of bacteraemia due to skin penetration for blood access and leading to propensity for more skeletal and spinal complications. Hence, early diagnosis of spine infection and early initiation of appropriate therapy are important in ensuring successful treatment and preventing further morbidity.

Materials And Methods: The study included 22 males and 12 females who were known case of end-stage renal disease undergoing haemodialysis therapy and diagnosed with spondylodiscitis based on the clinical and radiological signs. Read More

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The Role of Mitophagy in Regulating Cell Death.

Oxid Med Cell Longev 2021 18;2021:6617256. Epub 2021 May 18.

Department of Forensic Sciences, School of Basic Medicine and Biological Sciences, Affilated Guangji Hospital, Soochow University, Suzhou, China.

Mitochondria are multifaceted organelles that serve to power critical cellular functions, including act as power generators of the cell, buffer cytosolic calcium overload, production of reactive oxygen species, and modulating cell survival. The structure and the cellular location of mitochondria are critical for their function and depend on highly regulated activities such as mitochondrial quality control (MQC) mechanisms. The MQC is regulated by several sets of processes: mitochondrial biogenesis, mitochondrial fusion and fission, mitophagy, and other mitochondrial proteostasis mechanisms such as mitochondrial unfolded protein response (mtUPR) or mitochondrial-derived vesicles (MDVs). Read More

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