27,698 results match your criteria further large-scale clinical


The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape.

Biochem Soc Trans 2021 Jun 22. Epub 2021 Jun 22.

Taiwan International Graduate Program in Molecular Medicine, National Yang-Ming Chiao-Tung University and Academia Sinica, Taipei 11529, Taiwan.

Enhancers are cis-regulatory elements that play essential roles in tissue-specific gene expression during development. Enhancer function in the expression of developmental genes requires precise regulation, while deregulation of enhancer function could be the main cause of tissue-specific cancer development. MLL3/KMT2C and MLL4/KMT2D are two paralogous histone modifiers that belong to the SET1/MLL (also named COMPASS) family of lysine methyltransferases and play critical roles in enhancer-regulated gene activation. Read More

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Estimation of Lewis-negative alleles by high-resolution melting analysis of three tag SNPs of FUT3.

Vox Sang 2021 Jun 21. Epub 2021 Jun 21.

Department of Forensic Medicine, Kurume University School of Medicine, Kurume, Japan.

Background And Objectives: The expression of type 1 chain Lewis blood group antigens is regulated by secretor-type α(1,2)fucosyltransferase, encoded by FUT2, and Lewis α(1,3/1,4)fucosyltransferase, encoded by FUT3. Accumulating evidence has linked Lewis phenotypes or genotypes to various clinical conditions. Thus, in addition to FUT2, large-scale FUT3 genotyping is important. Read More

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Inorganic nanomaterials with rapid clearance for biomedical applications.

Chem Soc Rev 2021 Jun 22. Epub 2021 Jun 22.

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu Province, China.

Inorganic nanomaterials that have inherently exceptional physicochemical properties (e.g., catalytic, optical, thermal, electrical, or magnetic performance) that can provide desirable functionality (e. Read More

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Bayesian variable selection with a pleiotropic loss function in Mendelian randomization.

Stat Med 2021 Jun 21. Epub 2021 Jun 21.

MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.

Mendelian randomization is the use of genetic variants as instruments to assess the existence of a causal relationship between a risk factor and an outcome. A Mendelian randomization analysis requires a set of genetic variants that are strongly associated with the risk factor and only associated with the outcome through their effect on the risk factor. We describe a novel variable selection algorithm for Mendelian randomization that can identify sets of genetic variants which are suitable in both these respects. Read More

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Minimally invasive approach to the management of tubo-ovarian abscesses.

Curr Opin Obstet Gynecol 2021 Jun 21. Epub 2021 Jun 21.

Virginia Mason Medical Center, Department of Gynecology, Seattle, Washington, USA.

Purpose Of Review: The purpose of this publication is to review the most up-to-date literature regarding the pathogenesis, diagnosis and management of tubo-ovarian abscesses.

Recent Findings: Prior to the advent of broad-spectrum antibiotics, tubo-ovarian abscesses necessitated total abdominal hysterectomy and bilateral salpingo-oophorectomy. Although it carries a risk of treatment failure, antibiotic therapy enabled fertility-sparing treatment for many women. Read More

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Clinical implications of atrial natriuretic peptide amyloidosis.

BMJ Case Rep 2021 Jun 21;14(6). Epub 2021 Jun 21.

Internal Medicine, The Ohio State University, Columbus, Ohio, USA.

A 74-year-old woman with a history of diastolic heart failure and refractory atrial fibrillation (AF) presented with unstable angina for coronary artery bypass grafting. Routine pathological analysis of tissue specimens obtained from the left atrial appendage revealed subendocardial and interstitial fibrosis and patchy amyloid deposits with Congo red staining demonstrating filamentous deposits. Mass spectrometry was consistent with isolated atrial amyloidosis (IAA). Read More

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Sex Differences in the Human Brain Transcriptome of Cases With Schizophrenia.

Biol Psychiatry 2021 Mar 25. Epub 2021 Mar 25.

Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York; Mental Illness Research, Education and Clinical Centers, James J. Peters VA Medical Center, Bronx, New York. Electronic address:

Background: While schizophrenia differs between males and females in the age of onset, symptomatology, and disease course, the molecular mechanisms underlying these differences remain uncharacterized.

Methods: To address questions about the sex-specific effects of schizophrenia, we performed a large-scale transcriptome analysis of RNA sequencing data from 437 controls and 341 cases from two distinct cohorts from the CommonMind Consortium.

Results: Analysis across the cohorts identified a reproducible gene expression signature of schizophrenia that was highly concordant with previous work. Read More

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Current and Future Projections of Amyotrophic Lateral Sclerosis in the United States Using Administrative Claims Data.

Neuroepidemiology 2021 Jun 21:1-11. Epub 2021 Jun 21.

Formerly Employed by Mitsubishi Tanabe Pharma America, Inc., Jersey City, New Jersey, USA.

Background: Various methodologies have been reported to assess the real-world epidemiology of amyotrophic lateral sclerosis (ALS) in the United States. The aim of this study was to estimate the prevalence, incidence, and geographical distribution of ALS using administrative claims data and to model future trends in ALS epidemiology.

Methods: We performed a retrospective analysis of deidentified administrative claims data for >100 million patients, using 2 separate databases (IBM MarketScan Research Databases and Symphony Health Integrated DataVerse [IDV]), to identify patients with ALS. Read More

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Psychiatric and Physical Health Outcomes Associated with Interpersonal Violence: A Propensity Score Matching Approach.

Psychiatr Q 2021 Jun 21. Epub 2021 Jun 21.

Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.

This study examined the association between interpersonal violence and a range of psychiatric and physical health outcomes and assessed whether these associations changed when controlling for a stress-related diagnosis. An observational case-control study was conducted on a sample of 4,059 victims of violence. Using propensity score matching a number of risk factors (assessed five years prior assault) were used. Read More

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Retroperitoneal versus transperitoneal approach for elective open abdominal aortic aneurysm repair.

Cochrane Database Syst Rev 2021 Jun 21;6:CD010373. Epub 2021 Jun 21.

Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou City, China.

Background: There has been extensive debate in the surgical literature regarding the optimum surgical access approach to the infrarenal abdominal aorta during an operation to repair an abdominal aortic aneurysm. The published trials comparing retroperitoneal (RP) and transperitoneal (TP) aortic surgery show conflicting results. This is an update of the review first published in 2016. Read More

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Informatics-enabled citizen science to advance health equity.

J Am Med Inform Assoc 2021 Jun 21. Epub 2021 Jun 21.

Advisory Board, Residents for Respectful Research, Public Housing Association of Residents, Charlottesville, Virginia, USA.

The COVID-19 pandemic has once again highlighted the ubiquity and persistence of health inequities along with our inability to respond to them in a timely and effective manner. There is an opportunity to address the limitations of our current approaches through new models of informatics-enabled research and clinical practice that shift the norm from small- to large-scale patient engagement. We propose augmenting our approach to address health inequities through informatics-enabled citizen science, challenging the types of questions being asked, prioritized, and acted upon. Read More

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Rapid Repurposing of Novel Combination Drugs for the Treatment of Heart Failure via a Computationally Guided Network Screening Approach.

J Chem Inf Model 2021 Jun 20. Epub 2021 Jun 20.

State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China.

Combination drugs, characterized by high efficacy and few side effects, have received extensive attention from pharmaceutical companies and researchers for the treatment of complex diseases such as heart failure (HF). Traditional combination drug discovery depends on large-scale high-throughput experimental approaches that are time-consuming and costly. Herein we developed a novel, rapid, and potentially universal computer-guided combination drug-network-screening approach based on a set of databases and web services that are easy for individuals to obtain and operate, and we discovered for the first time that the menthol-allethrin combination screened by this approach exhibited a significant synergistic cardioprotective effect . Read More

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Beirut Ammonium Nitrate Blast: Analysis, Review, and Recommendations.

Front Public Health 2021 4;9:657996. Epub 2021 Jun 4.

Office of Research and Development, Department of Veterans Affairs, Washington, DC, United States.

A massive chemical detonation occurred on August 4, 2020 in the Port of Beirut, Lebanon. An uncontrolled fire in an adjacent warehouse ignited ~2,750 tons of Ammonium Nitrate (AN), producing one of the most devastating blasts in recent history. The blast supersonic pressure and heat wave claimed the lives of 220 people and injured more than 6,500 instantaneously, with severe damage to the nearby dense residential and commercial areas. Read More

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Blood-Based Biomarkers for Glioma in the Context of Gliomagenesis: A Systematic Review.

Front Oncol 2021 4;11:665235. Epub 2021 Jun 4.

Department of Neurosurgery, Brain Tumor Center Amsterdam, Cancer Center Amsterdam, Amsterdam UMC, VU University Medical Center and Academic Medical Center, Amsterdam, Netherlands.

Background: Gliomas are the most common and aggressive tumors of the central nervous system. A robust and widely used blood-based biomarker for glioma has not yet been identified. In recent years, a plethora of new research on blood-based biomarkers for glial tumors has been published. Read More

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An Update on Treatment Modalities for Ulnar Nerve Entrapment: A Literature Review.

Anesth Pain Med 2020 Dec 24;10(6):e112070. Epub 2020 Dec 24.

Southcoast Health Physicians Group Pain Medicine, Wareham, Massachusetts.

Context: Ulnar nerve entrapment is a relatively common entrapment syndrome second only in prevalence to carpal tunnel syndrome. The potential anatomic locations for entrapment include the brachial plexus, cubital tunnel, and Guyon's canal. Ulnar nerve entrapment is more so prevalent in pregnancy, diabetes, rheumatoid arthritis, and patients with occupations involving periods of prolonged elbow flexion and/or wrist dorsiflexion. Read More

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December 2020

Transcranial Magnetic Stimulation in Treatment of Adolescent Attention Deficit/Hyperactivity Disorder: A Narrative Review of Literature.

Authors:
Aksha M Memon

Innov Clin Neurosci 2021 Jan-Mar;18(1-3):43-46. Epub 2021 Jan 1.

Dr. Memon is an Assistant Professor with the Department of Foundational Medical Studies at Oakland University William Beaumont School of Medicine in Rochester Hills, Michigan.

Attention deficit/hyperactivity disorder (ADHD), one of the most common neurodevelopmental disorders, affected 3.3 million adolescents in the United States (US) in 2016. Ten to 30 percent of these patients do not respond to standard pharmacotherapy and, as a result, suffer adverse physical/mental health and socioeconomic consequences. Read More

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January 2021

Expression of the Body-Weight Signaling Players: GDF15, GFRAL and RET and their clinical relevance in Gastric Cancer.

J Cancer 2021 4;12(15):4698-4709. Epub 2021 Jun 4.

Department of Clinical Pathomorphology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Poland.

The existence, the functional role and clinical relevance of GDF15 and its signaling through a GFRAL/RET-dependent complex in gastric cancer (GC) and other human tumors remain to be elucidated, despite the widespread recognition of obesity as an important cancer-predisposing factor. Therefore, we aimed to analyze the expression levels of GDF15, GFRAL and RET in GC tissues in relation to each other and clinicopathological features, including patient survival, in order to establish a potential implication of the body-weight signaling pathway in the pathology and clinical outcome of GC. Protein expression was examined by immunohistochemistry on tissue microarrays containing 104 and 30 consecutive GC and normal gastric mucosa samples, whereas gene expression data for The Cancer Genome Atlas cohort of 413 GC patients were obtained from public sources. Read More

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Does Nonalcoholic Pancreatic Steatosis Always Correlate with Nonalcoholic Fatty Liver Disease?

Clin Exp Gastroenterol 2021 11;14:269-275. Epub 2021 Jun 11.

Department of Gastroenterology, Medeniyet University, Goztepe Education and Research Hospital, Istanbul, Turkey.

Purpose: To identify the correlation of nonalcoholic pancreatic steatosis (NAPS) with nonalcoholic fatty liver disease (NAFLD) in an outpatient group. Based on its metabolic and imaging properties, NAPS has been increasingly recognized in recent years; however, its interaction with NAFLD is still not clear.

Patients And Methods: In this cross-sectional observational study, 345 consecutive patients without any chronic illness who were referred to the senior radiologist for abdominal ultrasound (US) were included. Read More

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Contemporary Management of Stable Coronary Artery Disease - Implications of the ISCHEMIA Trial.

Circ J 2021 Jun 18. Epub 2021 Jun 18.

Department of Cardiology, Saitama Medical University International Medical Center.

Coronary artery disease (CAD) remains a leading cause of mortality and morbidity in developed countries. Although urgent revascularization is the cornerstone of management of acute coronary syndrome (ACS), for patients with stable CAD recent large-scale clinical trials indicate that a mechanical 'fix' of a narrowed artery is not obviously beneficial; ACS and stable CAD are increasingly recognized as different clinical entities. We review the perspectives on (1) modifying the diagnostic pathway of stable CAD with the incorporation of modern estimates of pretest probability, (2) non-imaging evaluations based on their availability, (3) the optimal timing of invasive coronary angiography and revascularization, and (4) the implementation of medical therapy during the work-up. Read More

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NTRK fusions are extremely rare in bone tumours.

Histopathology 2021 Jun 20. Epub 2021 Jun 20.

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

Introduction: Due to the efficacy of tropomyosin receptor kinase (TRK) inhibitor therapy in tumours with rearrangements of neurotrophic tyrosine kinase receptor (NTRK) genes, there has been a surge in demand for NTRK fusion screening. To date, most studies involving mesenchymal tumours have been focusing on soft tissue tumours, while data on bone tumours are sparse. Hence, we aimed to explore the frequency of NTRK fusions in a large series of primary bone tumours. Read More

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Structural Connectivity Gradients of the Temporal Lobe Serve as Multiscale Axes of Brain Organization and Cortical Evolution.

Cereb Cortex 2021 Jun 19. Epub 2021 Jun 19.

McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, H3A 2B4, Canada.

The temporal lobe is implicated in higher cognitive processes and is one of the regions that underwent substantial reorganization during primate evolution. Its functions are instantiated, in part, by the complex layout of its structural connections. Here, we identified low-dimensional representations of structural connectivity variations in human temporal cortex and explored their microstructural underpinnings and associations to macroscale function. Read More

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A merged method for targeted analysis of amino acids and derivatives using parallel reaction monitoring combined with untargeted profiling by HILIC-Q-Orbitrap HRMS.

J Pharm Biomed Anal 2021 Jun 15;203:114208. Epub 2021 Jun 15.

Frontiers Science Center for Disease-related Molecular Network, Institutes for Systems Genetics, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address:

With continuously increased scan rate and sensitivity, high resolution mass spectrometry (HRMS) allows for both reliable targeted analysis (e.g., parallel reaction monitoring, PRM) and a global overview for discovery-based untargeted profiling (e. Read More

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Technological advances towards extracellular vesicles mass production.

Adv Drug Deliv Rev 2021 Jun 17:113843. Epub 2021 Jun 17.

Laboratoire MSC Matière et Systèmes Complexes, CNRS UMR 7057, Université de Paris, 750013 Paris.

Extracellular vesicles (EVs) are becoming essential actors in bio-therapeutics, as much for their regenerative or immunomodulatory properties as for their potential as cargo delivery vehicles. To enable the democratization of these EV-based therapies, many challenges remain such as large-scale production which is necessary to reduce costs of treatment. Herein, we review some advanced works on high-yield EV manufacturing. Read More

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Correcting Physiological Noise in Whole-Head Functional Near-Infrared Spectroscopy.

J Neurosci Methods 2021 Jun 16:109262. Epub 2021 Jun 16.

Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, USA; Institute for Biomedical Engineering, Science and Technology, University of Oklahoma, Norman, OK, USA. Electronic address:

Background: Functional near-infrared spectroscopy (fNIRS) has been increasingly employed to monitor cerebral hemodynamics in normal and diseased conditions. However, fNIRS suffers from its susceptibility to superficial activity and systemic physiological noise. The objective of the study was to establish a noise reduction method for fNIRS in a whole-head montage. Read More

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Interaction Between Cerebellum and Cerebral Cortex, Evidence from Dynamic Causal Modeling.

Cerebellum 2021 Jun 19. Epub 2021 Jun 19.

Department of Psychology, Northeastern University, Boston, MA, USA.

The interaction of the cerebellum with cerebral cortical dynamics is still poorly understood. In this paper, dynamical causal modeling is used to examine the interaction between cerebellum and cerebral cortex as indexed by MRI resting-state functional connectivity in three large-scale networks on healthy young adults (N = 200; Human Connectome Project dataset). These networks correspond roughly to default mode, task positive, and motor as determined by prior cerebellar functional gradient analyses. Read More

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Neurobiology Youth Follow-up Study: protocol to establish a longitudinal and prospective research database using multimodal assessments for current and past mental health treatment-seeking young people within an early intervention service.

BMJ Open 2021 06 18;11(6):e044731. Epub 2021 Jun 18.

Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.

Introduction: Approximately 75% of major mental illness occurs before the age of 25 years. Despite this, our capacity to provide effective, early and personalised interventions is limited by insufficient evidence for characterising early-stage, and less specific, presentations of major mental disorders in youth populations. This article describes the protocol for setting up a large-scale database that will collect longitudinal, prospective data that incorporate clinical, social and occupational function, neuropsychological, circadian, metabolic, family history and genetic metrics. Read More

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Effectiveness of robot therapy in the management of behavioural and psychological symptoms for individuals with dementia: A systematic review and meta-analysis.

J Psychiatr Res 2021 Jun 5;140:381-394. Epub 2021 Jun 5.

Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Robot therapy presents a promising alternative in dementia care. However, its effectiveness has not been verified comprehensively. This systematic review and meta-analysis aim at evaluating the effectiveness of robot therapy in the management of behavioural and psychological symptoms for individuals with dementia. Read More

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Integration of quantitative imaging biomarkers in clinical trials for MR-guided radiotherapy: Conceptual guidance for multicentre studies from the MR-Linac Consortium Imaging Biomarker Working Group.

Eur J Cancer 2021 Jun 15;153:64-71. Epub 2021 Jun 15.

Department of Radiation Oncology, The Netherlands Cancer Institute, Plesmanlaan 102, Amsterdam, 1066CX, the Netherlands. Electronic address:

Quantitative imaging biomarkers (QIBs) derived from MRI techniques have the potential to be used for the personalised treatment of cancer patients. However, large-scale data are missing to validate their added value in clinical practice. Integrated MRI-guided radiotherapy (MRIgRT) systems, such as hybrid MRI-linear accelerators, have the unique advantage that MR images can be acquired during every treatment session. Read More

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A refined genome phage display methodology delineates the human antibody response in patients with Chagas disease.

iScience 2021 Jun 15;24(6):102540. Epub 2021 May 15.

Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, SP, 05508-000, Brazil.

Large-scale mapping of antigens and epitopes is pivotal for developing immunotherapies but challenging, especially for eukaryotic pathogens, owing to their large genomes. Here, we developed an integrated platform for genome phage display (gPhage) to show that unbiased libraries of the eukaryotic parasite enable the identification of thousands of antigens recognized by serum samples from patients with Chagas disease. Because most of these antigens are hypothetical proteins, gPhage provides evidence of their expression during infection. Read More

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