55,518 results match your criteria fungus candida

Surgical site infection in a Greek general surgery department: who is at most risk?

J Wound Care 2021 Apr;30(4):268-274

Department of Surgery, University Hospital of Ioannina and School of Medicine, University of Ioannina, Greece.

Objective: Surgical site infections (SSIs) are associated with protracted hospitalisation, antibiotics administration, and increased morbidity and mortality. This work investigated the incidence rate of SSIs in the Department of General Surgery at the University Hospital of Ioannina, Greece, the associated risk factors and pathogens responsible.

Method: In this prospective cohort study, patients who underwent elective procedures under general anaesthesia were enrolled. Read More

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Wiad Lek 2021 ;74(1):112-117


Objective: The aim of the study is to reveal in the experiment the morphological features of the infected skin wounds healing, which are a manifestation of acne vulgaris severe and very severe forms, using a gel with carbon dioxide extract of hops.

Patients And Methods: Materials and methods: An experimental study was carried out on 80 male WAG rats of three months of age. The animals were divided into 9 groups. Read More

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Radiation-induced synthesis of copper sulfide nanotubes with improved catalytic and antibacterial activities.

Environ Sci Pollut Res Int 2021 Apr 14. Epub 2021 Apr 14.

Materials Science Lab, Radiation Physics Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt.

In the current paper, copper sulfide nanotubes have been successfully synthesized via the green, simple, and effective gamma-radiolysis method without adding any capping or reducing agents. The structural and morphological characteristics of the as-prepared CuS nanotubes were investigated by X-ray diffraction (XRD), N adsorption-desorption measurements at 77 K, transmission electron microscopy (TEM), and ultraviolet-visible (UV-vis) spectroscopy, which all demonstrated the formation of pure CuS covellite phase with tubular morphology. The synthesized CuS nanotubes possessed not only high activity towards the reduction of both cationic (methylene blue) and anionic (Congo red) dyes in the presence of NaBH but also exhibited excellent reusability. Read More

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Data of common and species-specific transcriptional host responses to pathogenic fungi.

Data Brief 2021 Apr 4;35:106928. Epub 2021 Mar 4.

Department of Internal Medicine and Radboudumc Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.

Using a comparative RNA-Sequencing based transcriptional profiling approach, responses of primary human peripheral blood mononuclear cells (PBMCs) to common human pathogenic fungi have been characterized (Bruno et al. Computational and Structural Biology Journal). Primary human PBMCs were stimulated in vitro with the fungi , and after which RNA was isolated and sequenced. Read More

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Infection-provoked psoriasis: Induced or aggravated (Review).

Exp Ther Med 2021 Jun 29;21(6):567. Epub 2021 Mar 29.

Department of Dermatology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, P.R. China.

Psoriasis is a common chronic, immune-mediated, inflammatory skin disorder, with a reported prevalence of 0.0-2.1% among children and 0. Read More

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Gut mycobiota alterations in patients with COVID-19 and H1N1 infections and their associations with clinical features.

Commun Biol 2021 Apr 13;4(1):480. Epub 2021 Apr 13.

State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

The relationship between gut microbes and COVID-19 or H1N1 infections is not fully understood. Here, we compared the gut mycobiota of 67 COVID-19 patients, 35 H1N1-infected patients and 48 healthy controls (HCs) using internal transcribed spacer (ITS) 3-ITS4 sequencing and analysed their associations with clinical features and the bacterial microbiota. Compared to HCs, the fungal burden was higher. Read More

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Chemotype of damask rose with oleic acid (9 octadecenoic acid) and its antimicrobial effectiveness.

Sci Rep 2021 Apr 13;11(1):8027. Epub 2021 Apr 13.

Department Life and Environmental Sciences, University of Cagliari, Cagliari, Italy.

Essential oils are natural products that have great antimicrobial potential value against many fungi and bacteria. Rosa damascena Mill. is one of the most important aromatic species of the Rosaceae family from which essential oil and economically valuable products can be obtained. Read More

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Natural photosensitizers from Tripterygium wilfordii and their antimicrobial photodynamic therapeutic effects in a Caenorhabditis elegans model.

J Photochem Photobiol B 2021 Mar 29;218:112184. Epub 2021 Mar 29.

Natural Product Informatics Research Center, Gangneung Institute of Natural Products, Korea Institute of Science and Technology, Gangwon-do 25451, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, University of Science and Technology (UST), Gangneung, Gangwon-do 25451, Republic of Korea. Electronic address:

Tripterygium wilfordii Hook. f. is a traditional medicinal plant and has long been used in East Asia to treat many diseases. Read More

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In-silico design of a multivalent epitope-based vaccine against Candida auris.

Microb Pathog 2021 Apr 10:104879. Epub 2021 Apr 10.

Department of Molecular Biology and Genetic Engineering, India. Electronic address:

Candida auris is a rapidly emerging human pathogenic fungus with a high mortality rate. A recent report suggests that the new clinical isolates are showing resistance to the major classes of antifungal drugs. Due to the emergence of drug resistance, it becomes imperative to seek novel therapies for the treatment of C. Read More

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Novel Prosopis juliflora leaf ethanolic extract as natural antimicrobial agent against food spoiling microorganisms.

Sci Rep 2021 Apr 12;11(1):7871. Epub 2021 Apr 12.

Department of Biological and Environmental Sciences, College of Art and Science, Qatar University, P.O. Box 2713, Doha, Qatar.

Fresh produces spoilage is a worldwide concern that accompany the global increase in food demand. Adverse human health and environmental effects of commercial spoilage control agents are major public concern. In this study, Prosopis juliflora leaves and fruit extracts had their antimicrobial activities evaluated against the growth of selected bacteria and yeast, and against mycelial growth and conidial germination of selected mycotoxins-producing fungi. Read More

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The association between imbalances in vaginal microflora and duration of pregnancy as well as selected maternal and neonatal parameters.

Ginekol Pol 2021 Apr 12. Epub 2021 Apr 12.

Department of Surgical and Oncologic Gynecology, 1st Department of Gynecology and Obstetrics, Medical University of Lodz, Poland.

Objectives: Abnormal vaginal flora (AVF) is a result of excessive growth of some aerobic bacteria and fungi in relation to the scarce presence of Lactobacillus spp. It has been suggested that AVF is responsible for preterm birth and such neonatal conditions as infections or sepsis. The aim of the study was to assess the influence of excessive vaginal colonization with aerobic bacteria and fungi on the selected postnatal parameters of newborns, duration of pregnancy and length of hospitalisation of neonates. Read More

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Direct Detection and Identification of the Most Common Bacteria and Fungi Causing Otitis Externa by a Stepwise Multiplex PCR.

Front Cell Infect Microbiol 2021 25;11:644060. Epub 2021 Mar 25.

Department of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Considering the importance of differential diagnosis of infectious otitis externa (OE), a stepwise PCR-based assay using universal and genus- or species-specific primers for the detection/identification of the most prevalent bacterial and fungal OE was developed and evaluated on the ear aspiration specimens of clinically suspected patients.

Methods And Materials: A total of 120 ear aspiration specimens with otomycosis suspicion were subjected to manual DNA extraction using phenol-chloroform extraction after tissue digestion with a lysis buffer. The multiplex PCR was initially performed using pan-fungal and bacterial homemade primers. Read More

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Characterization of d-xylose reductase, XyrB, from .

Biotechnol Rep (Amst) 2021 Jun 15;30:e00610. Epub 2021 Mar 15.

Fungal Physiology, Westerdijk Fungal Biodiversity Institute and Fungal Molecular Physiology, Utrecht University, Utrecht, the Netherlands.

d-xylose reductase is a member of the aldo-keto reductase family, and is involved in d-xylose and l-arabinose conversion through the Pentose Catabolic Pathway (PCP) in fungi. In this study, we biochemically characterized a newly identified second d-xylose reductase (XyrB) from . This NADPH-dependent reductase is able to efficiently convert d-xylose and l-arabinose, and it has the highest affinity for these sugars of all currently known fungal pentose reductases. Read More

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Editorial: Genomic Characterization of Emerging Human Fungal Pathogens.

Front Genet 2021 25;12:674765. Epub 2021 Mar 25.

National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa.

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Gut microbiota profiles and characterization of cultivable fungal isolates in IBS patients.

Appl Microbiol Biotechnol 2021 Apr 10;105(8):3277-3288. Epub 2021 Apr 10.

Department of Agriculture and Food Sciences, University of Bologna, Viale Fanin 44, 40127, Bologna, Italy.

Studies so far conducted on irritable bowel syndrome (IBS) have been focused mainly on the role of gut bacterial dysbiosis in modulating the intestinal permeability, inflammation, and motility, with consequences on the quality of life. Limited evidences showed a potential involvement of gut fungal communities. Here, the gut bacterial and fungal microbiota of a cohort of IBS patients have been characterized and compared with that of healthy subjects (HS). Read More

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Multicenter evaluation of the VITEK MS matrix-assisted laser desorption/ionization-time of flight mass spectrometry system for identification of bacteria, including Brucella, and yeasts.

Eur J Clin Microbiol Infect Dis 2021 Apr 10. Epub 2021 Apr 10.

R&D Microbiology, bioMérieux, Inc., St. Louis, MO, USA.

The use of matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry has proven to be rapid and accurate for the majority of clinical isolates. Some gaps remain concerning rare, emerging, or highly pathogenic species, showing the need to continuously expand the databases. In this multicenter study, we evaluated the accuracy of the VITEK MS v3. Read More

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A modified culture medium and hyphae isolation method can increase quality of the RNA extracted from mycelia of a dimorphic fungal species.

Curr Genet 2021 Apr 10. Epub 2021 Apr 10.

Department of Genetics and Applied Microbiology, Faculty of Science and Technology, University of Debrecen, Egyetem tér 1, 4032, Debrecen, Hungary.

The capability of RNA isolation with good efficiency and high quality is essential for a downstream application such as RNA sequencing. It requires successful cell culturing and an effective RNA isolation method. Although effective methods are available, production of the homogenous mycelia and extraction of good-quality mycelial RNA from true invasive hyphae, which penetrated into the agar plates, are difficult. Read More

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Influence of Proton Pump Inhibitors and Histamine Receptor 2 Antagonists on Blastocystis ST3 and Selected Microorganisms of Intestinal Microbiota In Vitro.

Clin Transl Gastroenterol 2021 Apr 9;12(4):e00325. Epub 2021 Apr 9.

Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

Introduction: Proton pump inhibitors (PPIs) and histamine receptor 2 (H2) antagonists are commonly prescribed medications. Association between PPIs and alteration of the gut microbiota has been reported. Blastocystis, the most common intestinal protozoan worldwide, occurs in both healthy and symptomatic people with gastrointestinal or cutaneous disorders, with controversial pathogenicity. Read More

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Prevalence, species distribution, and risk factors of fungal colonization and infection in patients at a burn intensive care unit in Vietnam.

Curr Med Mycol 2020 Sep;6(3):42-49

Department of Parasitology, Vietnam Military Medical University, Ha Dong, Ha Noi, Vietnam.

Background And Purpose: Burn patients are at a higher risk of infections caused by different organisms. This study aimed to address the prevalence, causative species, and factors related to fungal colonization or infection in patients with acute severe injuries admitted to the intensive care unit (ICU) of a burn hospital in northern Vietnam.

Materials And Methods: This prospective study was conducted on 400 patients in a burn ICU between 2017 and 2019. Read More

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September 2020

Candidemia in pediatric burn patients: Risk factors and outcomes in a retrospective cohort study.

Curr Med Mycol 2020 Sep;6(3):33-41

Department of Plastic Surgery, Burn Research Center, Motahari Hospital, Iran University of Medical Sciences, Tehran, Iran.

Background And Purpose: Despite advances in burn care and management, infections are still a major contributor to morbidity and mortality rates in patients with burn injuries. Regarding this, the present study was conducted to investigate the prevalence and importance of candidemia in pediatric burn patients.

Materials And Methods: Blood samples were collected from the patients and cultured in an automated blood culture system. Read More

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September 2020

Metabolic fitness of is indispensable for functional drug efflux, ergosterol, and chitin biosynthesis.

Curr Med Mycol 2020 Sep;6(3):9-14

Amity Institute of Biotechnology, Amity University Haryana, Gurugram (Manesar)-122413, India.

Background And Purpose: The increment in fungal infections, particularly due to species, is alarming due to the emergence of multidrug resistance (MDR). Hence, the identification of novel drug targets to circumvent the problem of MDR requires immediate attention. The metabolic pathway, such as glyoxylate cycle (GC), which utilizes key enzymes (isocitrate lyase [ICL] and malate synthase [MLS]), enables to adapt under glucose-deficient conditions. Read More

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September 2020

aromatic water: A traditional drink with considerable anti- activity.

Curr Med Mycol 2020 Sep;6(3):1-8

Department of Pharmacognosy, Shiraz University of Medical Sciences, Shiraz, Iran.

Background And Purpose: Aromatic waters (AWs) are therapeutic distillates, which harbor both essential oil and water-soluble components of a plant. Due to the dispersion of the light amount of essence through the AWs, they have their specific pleasant smell, taste, and medicinal properties. In Iranian traditional medicine, AW is used to treat gastrointestinal disorders. Read More

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September 2020

Chronic endogenous fungal endophthalmitis: diagnostic and treatment challenges: A case report.

Medicine (Baltimore) 2021 Apr;100(14):e25459

Department of Ophthalmology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Malaysia.

Rationale: Endogenous fungal endophthalmitis (EFE) is a sight-threatening complication of systemic fungemia. As the prevalence rises, treatment remains a challenge especially when there is a failure in first-line treatment or drug-resistant fungus. This case report studies a case of chronic EFE, focusing on the diagnostic procedures, treatment options, monitoring parameters and the treatment outcome. Read More

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Simultaneous action of microbial phospholipase C and lipase on model bacterial membranes - Modeling the processes crucial for bioaugmentation.

Biochim Biophys Acta Biomembr 2021 Apr 6;1863(7):183620. Epub 2021 Apr 6.

Department of Environmental Chemistry, Faculty of Chemistry, Jagiellonian University in Krakow, Gronostajowa 2, 30-387 Kraków, Poland. Electronic address:

Bioaugmentation is a promising method of the remediation of soils polluted by persistent organic pollutants (POP). Unfortunately, it happens frequently that the microorganisms inoculated into the soil die out due to the presence of enzymes secreted by autochthonous microorganisms. Especially destructive are here phospholipases C (PLC) and lipases which destruct the microorganism's cellular membrane. Read More

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Targeting Candida albicans in dual-species biofilms with antifungal treatment reduces Staphylococcus aureus and MRSA in vitro.

PLoS One 2021 8;16(4):e0249547. Epub 2021 Apr 8.

Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.

Polymicrobial biofilms consisting of fungi and bacteria are frequently formed on endotracheal tubes and may contribute to development of ventilator associated pneumonia (VAP) in critically ill patients. This study aimed to determine the role of early Candida albicans biofilms in supporting dual-species (dual-kingdom) biofilm formation with respiratory pathogens in vitro, and investigated the effect of targeted antifungal treatment on bacterial cells within the biofilms. Dual-species biofilm formation between C. Read More

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Enhanced Eradication of Bacterial/Fungi Biofilms by Glucose Oxidase-Modified Magnetic Nanoparticles as a Potential Treatment for Persistent Endodontic Infections.

ACS Appl Mater Interfaces 2021 Apr 7. Epub 2021 Apr 7.

Department of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China.

Bacterial/fungal biofilm-mediated persistent endodontic infections (PEIs) are one of the most frequent clinical lesions in the oral cavity, resulting in apical periodontitis and tooth damage caused by loss of minerals. The conventional root canal disinfectants are poorly bio-safe and harmful to teeth and tissues, making them ineffective in treating PEIs. The development of nanomaterials is emerging as a promising strategy to eradicate disease-related bacteria/fungi. Read More

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Evolution of the complex transcription network controlling biofilm formation in species.

Elife 2021 Apr 7;10. Epub 2021 Apr 7.

Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, United States.

We examine how a complex transcription network composed of seven 'master' regulators and hundreds of target genes evolved over a span of approximately 70 million years. The network controls biofilm formation in several species, a group of fungi that are present in humans both as constituents of the microbiota and as opportunistic pathogens. Using a variety of approaches, we observed two major types of changes that have occurred in the biofilm network since the four extant species we examined last shared a common ancestor. Read More

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Effect of LongZhang Gargle on Dual-Species Biofilm of Candida albicans and Streptococcus mutans.

Biomed Res Int 2021 22;2021:6654793. Epub 2021 Mar 22.

State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No.14, 3rd Section of South RenMin Rd, Chengdu, Sichuan 610041, China.

Bioactive natural products have become a hot spot for oral disease treatments. At the present study, LongZhang Gargle was investigated for its effects on single-species biofilms of and dual-species biofilms of and . Two different models of single and dual-species biofilms were grown in YNBB medium under appropriate conditions. Read More

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Bioactivity of EtOH and MeOH Extracts of Basidiomycetes Mushroom (Stereum hirsutum) on Atherosclerosis.

Arch Razi Inst 2021 Mar 1;76(1):87-94. Epub 2021 Mar 1.

Department of Medical Biology, Faculty of Medicine, Nigde Ömer Halisdemir University, Nigde, Turkey.

Mushrooms are cosmopolitan organisms living on different substrates and have different pharmacological properties, such as antioxidant, antimicrobial, and anti-inflammatory effects thanks to many bioactive compounds. Edible and medicinal higher fungi have been used by humankind for millennia. They are collected and used directly not only for their nutritional values as a main source of food or as a part of a regular diet but also for their medicinal purpose as a source of powerful new bioactive compounds. Read More

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Mycosands: Fungal diversity and abundance in beach sand and recreational waters - Relevance to human health.

Sci Total Environ 2021 Mar 26;781:146598. Epub 2021 Mar 26.

Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

The goal of most studies published on sand contaminants is to gather and discuss knowledge to avoid faecal contamination of water by run-offs and tide-retractions. Other life forms in the sand, however, are seldom studied but always pointed out as relevant. The Mycosands initiative was created to generate data on fungi in beach sands and waters, of both coastal and freshwater inland bathing sites. Read More

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