1,622,590 results match your criteria fungal biomass

Current knowledge about the connection between health status and gut microbiota from birth to elderly. A narrative review.

Front Biosci (Landmark Ed) 2021 May;26(6):135-148

School of Technical Medical Sciences, "Alexander Xhuvani" University of Elbasan, 3001-3006 Elbasan, Albania.

The human body is colonized from the birth by a large number of microorganisms. This will constitute a real "functional microbial organ" that is fundamental for homeostasis and therefore for health in humans. Those microorganisms. Read More

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Different patterns of belowground fungal diversity along altitudinal gradients with respect to microhabitat and guild types.

Environ Microbiol Rep 2021 Jun 23. Epub 2021 Jun 23.

School of Biological Sciences, Institute of Microbiology, Seoul National University, Seoul, South Korea.

Fungi are key components of belowground ecosystems with various ecological roles in forests. Although the changes in the richness and composition of belowground fungi across altitudinal gradients have been widely reported, only a few studies have focused on the microhabitat types along altitudinal gradients. Here, we analysed the effect of altitude on the ectomycorrhizal and non-ectomycorrhizal fungal communities in belowground microhabitats. Read More

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Test, trace, isolate: evidence for declining SARS-CoV-2 PCR sensitivity in a clinical cohort.

Diagn Microbiol Infect Dis 2021 Apr 21;101(2):115392. Epub 2021 Apr 21.

Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. Electronic address:

Real-time reverse transcription-polymerase chain reaction (RT-PCR) on upper respiratory tract (URT) samples is the primary method to diagnose SARS-CoV-2 infections and guide public health measures, with a supportive role for serology. We reinforce previous findings on limited sensitivity of PCR testing, and solidify this fact by statistically utilizing a firm basis of multiple tests per individual. We integrate stratifications with respect to several patient characteristics such as severity of disease and time since onset of symptoms. Read More

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Are other tick-borne infections overlooked in patients investigated for Lyme neuroborreliosis? A large retrospective study from South-eastern Sweden.

Ticks Tick Borne Dis 2021 Jun 4;12(5):101759. Epub 2021 Jun 4.

Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection, Linköping University, Linköping, Sweden; Department of Infectious Diseases, Region Östergötland County, Linköping/Norrköping, Sweden.

In Europe, the hard tick Ixodes ricinus is considered the most important vector of human zoonotic diseases. Human pathogenic agents spread by I. ricinus in Sweden include Borrelia burgdorferi sensu lato (s. Read More

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Whole-genome analysis of drug-resistant Mycobacterium tuberculosis reveals novel mutations associated with fluoroquinolone resistance.

Int J Antimicrob Agents 2021 Jun 20:106385. Epub 2021 Jun 20.

Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Research and Diagnostic Center for Emerging Infectious Diseases (RCEID), Khon Kaen University, Khon Kaen, Thailand. Electronic address:

Background: Multidrug- and extensively drug-resistant tuberculosis (M/XDR-TB) remains a global public health challenge. Known mutations in quinolone resistance-determination regions cannot fully explain phenotypic fluoroquinolone (FQ) resistance in Mycobacterium tuberculosis (Mtb).

Objective: To seek novel mutations of Mtb associated with resistance against fluoroquinolone drugs using whole-genome sequencing (WGS) analysis. Read More

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Prevalence of and risk factors for extended-spectrum beta-lactamase genes carriership in a population-based cohort of middle-aged and elderly.

Int J Antimicrob Agents 2021 Jun 20:106388. Epub 2021 Jun 20.

Department of Epidemiology, Erasmus MC University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands; Department of Internal Medicine, Erasmus MC University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands; Inspectorate of Health Care, PO Box 2518, 6401 DA Heerlen, The Netherlands. Electronic address:

Introduction: The increasing worldwide resistance to beta-lactam antibiotics is an alarming development. We studied fecal carriership of TEM, SHV, CTX-M and CMY in a community-dwelling population of middle-aged and elderly individuals.

Patients And Methods: Feces was obtained from individuals of the Rotterdam Study. Read More

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Single-cell BCR and transcriptome analysis after influenza infection reveals spatiotemporal dynamics of antigen-specific B cells.

Cell Rep 2021 Jun;35(12):109286

Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden. Electronic address:

B cell responses are critical for antiviral immunity. However, a comprehensive picture of antigen-specific B cell differentiation, clonal proliferation, and dynamics in different organs after infection is lacking. Here, by combining single-cell RNA and B cell receptor (BCR) sequencing of antigen-specific cells in lymph nodes, spleen, and lungs after influenza infection in mice, we identify several germinal center (GC) B cell subpopulations and organ-specific differences that persist over the course of the response. Read More

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Immune checkpoint blockade reprograms systemic immune landscape and tumor microenvironment in obesity-associated breast cancer.

Cell Rep 2021 Jun;35(12):109285

Department of Medicine, Division of Hematology and Oncology, Department of Medicine, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA; Department of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN 38163, USA; Department of Microbiology, Immunology, and Biochemistry, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA; UTHSC Center for Cancer Research, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA. Electronic address:

Immune checkpoint blockade (ICB) has improved outcomes in some cancers. A major limitation of ICB is that most patients fail to respond, which is partly attributable to immunosuppression. Obesity appears to improve immune checkpoint therapies in some cancers, but impacts on breast cancer (BC) remain unknown. Read More

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Long-term survivors of murine sepsis are predisposed to enhanced LPS-induced lung injury and pro-inflammatory immune reprogramming.

Am J Physiol Lung Cell Mol Physiol 2021 06 23. Epub 2021 Jun 23.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, United States.

Millions of people who survive sepsis each year are rehospitalized and die due to late pulmonary complications. In order to prevent and treat these complications, biomarkers and molecular mediators must be identified. Persistent immune reprogramming in the form of immunoparalysis and impaired host defense is proposed to mediate late pulmonary complications after sepsis, particularly new pulmonary infections. Read More

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Molecular Details of a Coupled Binding and Folding Reaction between the Amyloid Precursor Protein and a Folded Domain.

ACS Chem Biol 2021 Jun 23. Epub 2021 Jun 23.

Department of Medical Biochemistry and Microbiology, Uppsala University, BMC, Box 582, SE-75123 Uppsala, Sweden.

Intrinsically disordered regions in proteins often function as binding motifs in protein-protein interactions. The mechanistic aspects and molecular details of such coupled binding and folding reactions, which involve formation of multiple noncovalent bonds, have been broadly studied theoretically, but experimental data are scarce. Here, using a combination of protein semisynthesis to incorporate phosphorylated amino acids, backbone amide-to-ester modifications, side chain substitutions, and binding kinetics, we examined the interaction between the intrinsically disordered motif of amyloid precursor protein (APP) and the phosphotyrosine binding (PTB) domain of Mint2. Read More

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Practical Methods for Expression of Recombinant Protein in the Pichia pastoris System.

Curr Protoc 2021 Jun;1(6):e155

Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

One of the most critical challenges of genetic engineering is the expression of recombinant proteins using biological expression systems. Nowadays, different expression systems from bacteria to mammalian tissue culture cells are available for the production of recombinant proteins for medical and industrial purposes. Among various choices, yeast expression systems such as Pichia pastoris are promising candidates. Read More

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Impacts of different treatment methods for cattle manure on the spread of faecal indicator organisms from soil to lettuce in Nigeria.

J Appl Microbiol 2021 Jun 23. Epub 2021 Jun 23.

Department of Microbiology, Nasarawa State University, Nasarawa State, Keffi-Abuja expressway, Keffi, Nigeria.

Aim: This study investigated impacts of different organic waste treatment methods on reduction and spread of faecal indicator organisms to food crops in a developing country.

Methods And Results: Fresh cattle manure was subjected to three different treatments; anaerobic digestion, burning and composting. E. Read More

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COVID-19 and progress towards achieving universal health coverage in Africa: A case of Nigeria.

Int J Health Plann Manage 2021 Jun 23. Epub 2021 Jun 23.

Global Health Focus, London, UK.

Universal Health Coverage (UHC) 2030 is a global health target, and countries are making efforts to convert plans into tangible results. Nigeria, the most populated country in Africa, has made commitments towards UHC2030 target but is underperforming across many building blocks of health and progress has been slow. The arrival of COVID-19 poses additional pressure on the already feeble health system causing the government to direct focus towards containing the pandemic. Read More

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Skewed endosomal RNA responses from TLR7 to TLR3 in RNase T2-deficient macrophages.

Int Immunol 2021 Jun 23. Epub 2021 Jun 23.

Division of Innate Immunity, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639 Japan.

RNase T2, a ubiquitously expressed RNase, degrades RNAs in the endosomal compartments. RNA sensors, double-stranded RNA (dsRNA)-sensing TLR3 and single-stranded RNA (ssRNA)-sensing TLR7, are localized in the endosomal compartment in mouse macrophages. We here studied the role of RNase T2 in TLR3 and TLR7 responses in macrophages. Read More

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Reply to Choe et al.

Mai-Juan Ma

J Infect Dis 2021 Jun 23. Epub 2021 Jun 23.

State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.

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Detection of serum cross-reactive antibodies and memory response to SARS-CoV-2 in pre-pandemic and post-COVID-19 convalescent samples.

J Infect Dis 2021 Jun 23. Epub 2021 Jun 23.

Department of Clinical Infection, Microbiology and Immunology, Institute of Infection, veterinary and Ecological Sciences, University of Liverpool, UK.

Background: A notable feature of COVID-19 is that children are less susceptible to severe disease. Children are known to experience more infections with endemic human coronaviruses (HCoVs) compared to adults. Little is known whether HCoV infections lead to cross-reactive anti-SARS-CoV-2 antibodies. Read More

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Comparison of two pandemics: H1N1 and SARS-CoV-2.

Rev Assoc Med Bras (1992) 2021 Jan;67(1):115-119

Karadeniz Technical University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology - Trabzon, Turkey.

Objective: We aimed to compare the clinical, epidemiological, and prognostic features of the H1N1 pandemic in 2009 and the severe acute respiratory syndrome coronavirus 2 pandemic in 2020.

Methods: This retrospective study involved subjects from seven centers that were admitted and found to be positive for H1N1 or COVID-19 real-time polymerase chain reaction test.

Results: A total of 143 patients with H1N1 and 309 patients with COVID-19 were involved in the study. Read More

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January 2021

Amazonian soil fungi are efficient degraders of glyphosate herbicide; novel isolates of Penicillium, Aspergillus, and Trichoderma.

Braz J Biol 2021 21;83:e242830. Epub 2021 Jun 21.

Universidade do Estado do Amazonas - UEA, Escola Superior de Ciências da Saúde, Manaus, AM, Brasil.

Pesticide residues that contaminate the environment circulate within the hydrological cycle can accumulate within the food chain and cause problems to both environmental and human health. Microbes, however, are well known for their metabolic versatility and the ability to degrade chemically stable substances, including recalcitrant xenobiotics. The current study focused on bio-prospecting within Amazonian rainforest soils to find novel strains fungi capable of efficiently degrading the agriculturally and environmentally ubiquitous herbicide, glyphosate. Read More

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Arbuscular mycorrhizal fungi activity in the rhizosphere of tree seedlings subjected to residual herbicides.

Braz J Biol 2021 21;83:e242676. Epub 2021 Jun 21.

Universidade Federal dos Vales do Jequitinhonha e Mucuri - UFVJM, Departamento de Agronomia, Diamantina, MG, Brasil.

Trees occurring on the margins of agricultural areas can mitigate damage from residual herbicides. Rhizospheric microbial activity associated with trees is one of the main remedial capacity indicators. The objective of this study was to evaluate the rhizospheric microbiological activity in tree species subjected to the herbicides atrazine and sulfentrazone via the rhizosphere. Read More

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Filtrates from cultures of endophytic fungi isolated from leaves of Copaifera oblongifolia (Fabaceae) affect germination and seedling development differently.

Braz J Biol 2021 21;83:e242070. Epub 2021 Jun 21.

Universidade Estadual de Montes Claros - Unimontes, Departamento de Biologia Geral, Programa de Pós-graduação em Biodiversidade e Uso dos Recursos Naturais, Montes Claros, MG, Brasil.

Interactions between endophytic fungi (EFs) and their host plants range from positive to neutral to negative. The results of such interactions can vary depending on the organ of the infected host plant. EFs isolated from the leaves of some species of plants have potential for use as agents to inhibit seed germination and control invasive plants. Read More

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Effect of different protein based feed on the growth of mahseer.

Braz J Biol 2021 7;82:e243670. Epub 2021 May 7.

Department of Zoology, Abbottabad University of Science & Technology, Pakistan.

For the proper growth of fish, it is necessary to feed the fish with a proper and balanced diet. A study was conducted to find out the effect of different protein-based diets on fingerlings of Tor putitora (mahseer). A feed with dietary protein levels of 35%, 40%, 45%, and 50% were prepared. Read More

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Episode of Hepatitis C viral infection in the people of Swat, Pakistan.

Braz J Biol 2021 21;82:e243283. Epub 2021 Jun 21.

Center for Animal Sciences & Fisheries, University of Swat, Swat, Pakistan.

Infectious agents cause serious diseases in humans worldwide and are responsible for the high rate of morbidity and mortality. The prevalence and epidemiology of infectious disease (HCV) in the hospital visited patients referred by the physicians through the initial findings and their associated risk factors were studied in Swat. The data of 174 infected patients were collected during the period of 2015 to 2017 from two clinical laboratories of Tehsil Matta Swat. Read More

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Biodiversity of orb-web spiders (family: araneidae) of buner valley, Pakistan.

Braz J Biol 2021 21;82:e238339. Epub 2021 Jun 21.

Centre for Animal Sciences & Fisheries, University of Swat, Khyber Pakhtunkhwa, Pakistan.

The present research was carried out to explore the spider fauna of Buner valley with taxonomic study from February 2018 to January 2019. For this purpose samples were collected, four times at each month from 4 tehsils: Daggar, Gagra, Mandan and Totalai. Two methods were used, hand picking and sweep net for collection of samples. Read More

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Agents causing genital infections in routine cytological tests: frequency and characteristics of Papanicolaou smears.

Braz J Biol 2021 21;82:e238180. Epub 2021 Jun 21.

Centro Universitário Cesmac, Maceió, AL, Brasil.

Urinary tract infections are responsible for most human infections, these are caused by bacteria, fungi, protozoa and associated microorganisms. The goal of this study was to determine the rate of vaginal infection-causing agents in routine cytological exams and also to evaluate the characteristics of positive tested Pap smears. A retrospective documental with descriptive aspect research was performed in a Clinical Pathology laboratory from Maceió-AL. Read More

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Genome-wide association study of signature genetic alterations among pseudomonas aeruginosa cystic fibrosis isolates.

PLoS Pathog 2021 Jun 23;17(6):e1009681. Epub 2021 Jun 23.

Department of Microbiology and Immunology, Seoul, Republic of Korea.

Pseudomonas aeruginosa (PA) is an opportunistic pathogen that causes diverse human infections including chronic airway infection in patients with cystic fibrosis (CF). Comparing the genomes of CF and non-CF PA isolates has great potential to identify the genetic basis of pathogenicity. To gain a deeper understanding of PA adaptation in CF airways, we performed a genome-wide association study (GWAS) on 1,001 PA genomes. Read More

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The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody.

PLoS One 2021 23;16(6):e0253487. Epub 2021 Jun 23.

Biological Defence Programme, DSO National Laboratories, Singapore, Singapore.

Although SARS-CoV-2-neutralizing antibodies are promising therapeutics against COVID-19, little is known about their mechanism(s) of action or effective dosing windows. We report the generation and development of SC31, a potent SARS-CoV-2 neutralizing antibody, isolated from a convalescent patient. Antibody-mediated neutralization occurs via an epitope within the receptor-binding domain of the SARS-CoV-2 Spike protein. Read More

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Zinc biofortification potential of diverse mungbean [Vigna radiata (L.) Wilczek] genotypes under field conditions.

PLoS One 2021 23;16(6):e0253085. Epub 2021 Jun 23.

Departmnet of Agronomy, Faculty of Agricultural Sciences, Ghazi University, Dera Ghazi Khan, Pakistan.

Zinc (Zn) is an important micronutrient for crop plants and essential for human health. The Zn-deficiency is an important malnutrition problem known globally. Biofortified foods could overcome Zn deficiency in humans. Read More

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Socioeconomic determinants of Schistosoma mansoni infection using multiple correspondence analysis among rural western Kenyan communities: Evidence from a household-based study.

PLoS One 2021 23;16(6):e0253041. Epub 2021 Jun 23.

Neglected Tropical Diseases Branch, Center for Global Health Research, Kenya Medical Research Institute (KEMRI), Kisumu, Kenya.

Background: Socioeconomic inequality including wealth distribution is a barrier to implementation of health policies. Wealth distribution can be measured effectively using household data on durable assets. Compared to other methods of analysing Socio-economic Status (SES) using durable assets, Multiple Correspondence Analysis (MCA) can create more reliable wealth quintiles. Read More

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Global seroprevalence of SARS-CoV-2 antibodies: A systematic review and meta-analysis.

PLoS One 2021 23;16(6):e0252617. Epub 2021 Jun 23.

Divisions of Infectious Diseases and Medical Microbiology, McGill University Health Centre, Montreal, Quebec, Canada.

Background: Many studies report the seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies. We aimed to synthesize seroprevalence data to better estimate the level and distribution of SARS-CoV-2 infection, identify high-risk groups, and inform public health decision making.

Methods: In this systematic review and meta-analysis, we searched publication databases, preprint servers, and grey literature sources for seroepidemiological study reports, from January 1, 2020 to December 31, 2020. Read More

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