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CORRELATION OF CD4+Т LYMPHOCYTES ACTIVATION WITH INTERLEUKIN IL-9, IL-17, IL- 22 PROFILES IN THE PERIPHERAL BLOOD OF PATIENTS WITH PLAQUE PSORIASIS.

Georgian Med News 2021 Mar(312):75-78

3Ilia State University, School of Natural Sciences and Medicine, Tbilisi, Georgia.

Psoriasis is a T cell mediated chronic inflammatory skin disease affecting about 2% of the population worldwide. Recently has established the central role of IL-23/Th17 immune axis in the pathogenesis of psoriasis and different subclasses of T cells including Th1 and Th17 cells are involved in initiation and amplification of the skin inflammation process, in addition, in cases of recurrent psoriasis, Th22 cells play the role of memory cells with the help of Th9 cells, which are also important in this process. The main goal was to evaluate the ratio of T cell profile and IL23/Th17 axis by evaluating IL17A, IL22, IL9 in peripheral blood of persons with moderate to severe plaque psoriasis. Read More

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Impact of CO overpressure on yeast mitochondrial associated proteome during the "prise de mousse" of sparkling wine production.

Int J Food Microbiol 2021 May 4;348:109226. Epub 2021 May 4.

Department of Agricultural Chemistry, Edaphology and Microbiology, Severo Ochoa (C6) building, Agrifood Campus of International Excellence CeiA3, University of Cordoba, Ctra. N-IV-A mm 396, 14014 Cordoba, Spain. Electronic address:

The "prise de mousse" stage during sparkling wine elaboration by the traditional method (Champenoise) involves a second fermentation in a sealed bottle followed by a prolonged aging period, known to contribute significantly to the unique organoleptic properties of these wines. During this stage, CO overpressure, nutrient starvation and high ethanol concentrations are stress factors that affect yeast cells viability and metabolism. Since mitochondria are responsible for energy generation and are required for cell aging and response to numerous stresses, we hypothesized that these organelles may play an essential role during the prise de mousse. Read More

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Application of an indigenous microorganisms-based fixed-bed GAC-biofilm reactor for passive and sustainable treatment of oil sands process water through combined adsorption and biodegradation processes.

Chemosphere 2021 Apr 30;280:130635. Epub 2021 Apr 30.

Department of Civil and Environmental Engineering, University of Alberta, Edmonton, Alberta, T6G 1H9, Canada. Electronic address:

In this study, a fixed-bed biofilm reactor (biofilter) was developed and applied for oil sands process water (OSPW) remediation by using granular activated carbon (GAC) as packing media. Using quantitative polymerase chain reaction (qPCR) detection, the total bacterial copy number (16S) in the GAC biofiltration system was found to reach a relatively stable level (1.3 ± 0. Read More

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Sino-orbital mucormycosis in a COVID-19 patient: A case report.

Int J Surg Case Rep 2021 May 4;82:105957. Epub 2021 May 4.

Department Of Oral and Maxillofacial Surgery, D. Y. Patil University, Sector 7 Nerul, Navi Mumbai 400706, India.

Introduction: We report a case of post COVID-19 Sino-orbital Mucormycosis infection caused by Rhizopus oryzae and its management.

Presentation Of Case: The patient was diagnosed with COVID-19 and treated according to the persisting protocols. Following recovery, on the 18th day, the patient developed chemosis and pain in the left eye. Read More

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Diagnosis of knee prosthetic joint infection; aspiration and biopsy.

Knee 2021 May 5;30:249-253. Epub 2021 May 5.

Department of Microbiology, Royal Devon and Exeter Hospitals, Barrack Road, United Kingdom.

Background: Prosthetic joint infection (PJI) is a significant cause of morbidity and mortality following knee replacement surgery. The diagnosis can be challenging and is based on a combination of clinical suspicion, radiographic findings and also biochemical/ microbiological investigations. Our Aim was to review the role of aspiration and biopsy in the diagnosis of PJI in Total Knee Arthroplasty (TKA). Read More

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Batrachochytrium fungi: stealth invaders in amphibian skin.

Curr Opin Microbiol 2021 May 4;61:124-132. Epub 2021 May 4.

Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA.

Amphibian populations around the world have been affected by two pathogenic fungi within the phylum Chytridiomycota. Batrachochytrium dendrobatidis (Bd) has infected hundreds of species and led to widespread declines and some species extinctions. Batrachochytrium salamandrivorans (Bsal) has devastated some native European salamanders, especially the iconic fire salamanders (Salamandra salamandra). Read More

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Evaluation of the chemopreventive effects of Hypericum perforatum L on DMBA-applied rat oral mucosa.

Arch Oral Biol 2021 Apr 30;127:105139. Epub 2021 Apr 30.

Ankara University, Faculty of Medicine, Department of Medical Biochemistry, Ankara, Turkey.

Objective: Hypericum perforatum L also known as St. John's wort is known to have many beneficial properties for the organism including its antioxidant and anticancer activities. It is also known to have shown antiproliferative and cytotoxic effects against various cancer cell lines. Read More

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Efficient conversion of hemicellulose sugars from spent sulfite liquor into optically pure L-lactic acid by Enterococcus mundtii.

Bioresour Technol 2021 Apr 27;333:125215. Epub 2021 Apr 27.

Institute of Microbiology and Microbial Biotechnology, Department of Biotechnology, BOKU-University of Natural Resources and Life Sciences, Vienna, Muthgasse 18, 1190 Vienna, Austria. Electronic address:

Spent sulfite liquor (SSL), a waste stream from wood pulp production, has great potential as carbon source for future industrial fermentations. In the present study, SSL was separated into a hemicellulose derived sugar syrup (HDSS) and a lignosulfonic fraction by simulated moving bed chromatography. The recovery of SSL sugars in the HDSS was 89% and the fermentation inhibitors furfural, 5-hydroxymethylfurfural and acetic acid were removed by 98. Read More

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Bacillus circulans MTCC 7906 aided facile development of bioconjugate nano-silica alkaline protease formulation with superlative dehairing potential.

Environ Pollut 2021 Apr 27;285:117181. Epub 2021 Apr 27.

Department of Veterinary Pathology, College of Veterinary Science, Guru Angad Dev Veterinary & Animal Sciences University, Ludhiana, 141 004, Punjab, India.

The tannery industries utilize environmentally hazardous chemicals to achieve dehairing of animal hides, which causes enormous waterbed pollution & high TDS load. Alkaline protease enzyme for dehairing can be an effective solution to resolve the environmental problems of the tannery industry waste. However, stable, cost-efficient and eco-benign formulations of alkaline protease need to be developed for commercial applications in the tannery industry. Read More

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Outcomes of hematopoietic cell transplantation (HCT) in patients with mixed response to treatment of confirmed or suspected invasive fungal infection before HCT.

Transplant Cell Ther 2021 May 5. Epub 2021 May 5.

Department of Medicine, University of Washington, Seattle, WA; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA.

Background: Patients with hematologic malignancy or bone marrow failure are typically required to achieve radiographic improvement or stabilization of invasive fungal infection (IFI) prior to hematopoietic cell transplant (HCT) due to concern for progression prior to engraftment. Refractory IFI with a mixture of improvement and progression on serial imaging (or a "mixed response") poses a clinical dilemma, as delay in HCT may allow hematologic relapse or other complications. Further, HCT itself may yield the immune reconstitution necessary for clearance of infection. Read More

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Clinical characteristics and outcome of bacteremia caused by Enterobacter cloacae and Klebsiella aerogenes: more similarities than differences.

J Glob Antimicrob Resist 2021 May 5. Epub 2021 May 5.

Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Infectious Diseases Research Group, Institute of Biomedicine of Seville (IBiS), University of Seville/CSIC/ Virgen del Rocío University Hospital, Seville, Spain.

Introduction: The genus Enterobacter is a common cause of nosocomial infections. Historically, the most frequent Enterobacter species were those of the Enterobacter cloacae complex and Enterobacter aerogenes. In 2019, E. Read More

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Design, synthesis and biological evaluation of a series of iron and copper chelating deferiprone derivatives as new agents active against Candida albicans.

Bioorg Med Chem Lett 2021 May 5:128087. Epub 2021 May 5.

Department of Chimica e Tecnologia del Farmaco, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.

Candida albicans, in specific conditions, is responsible of severe invasive systemic candidiasis that are related to its ability to produce biofilm on biological and artificial surfaces. Many studies reported the role of iron in fungal growth and virulence and the ability of metal chelating agents to interfere with C. albicans metabolism, virulence and biofilm formation. Read More

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Exploring Boron Applications in Modern Agriculture: A Structure-Activity Relationship Study of a Novel Series of Multi-Substitution Benzoxaboroles for Identification of Potential Fungicides.

Bioorg Med Chem Lett 2021 May 5:128089. Epub 2021 May 5.

Boragen, Inc., 5 Laboratory Drive, Suite 2150, Research Triangle Park, Durham, NC 27709, USA.

Several boron-containing small molecules have been approved by the US FDA to treat human diseases. We explored potential applications of boron-containing compounds in modern agriculture by pursuing multiple research and development programs. Here, we report a novel series of multi-substitution benzoxaboroles (1-36), a compound class that we recently reported as targeting geranylgeranyl transferase I (GGTase I) and thereby inhibiting protein prenylation. Read More

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Comparative biochemical and transcriptome analyses in tomato and eggplant reveal their differential responses to Tuta absoluta infestation.

Genomics 2021 May 5. Epub 2021 May 5.

State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Key Lab of Biopesticide and Chemical Biology, Ministry of Education & Fujian Province Key Laboratory of Insect Ecology, College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou 350002, Fujian, China. Electronic address:

Tomato is more prone to Tuta absoluta invasion and damages as compared to other host plants but the mechanism behind this preference has not been elucidated. Here, two contrasting host preference plants, tomato and eggplant, were used to investigate biochemical and transcriptomic modifications induced by T. absoluta infestation. Read More

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Effects of a combination of Mass and Dutch variant as an inactivated vaccine against variant 2 avian infectious bronchitis virus challenge.

Microb Pathog 2021 May 5:104937. Epub 2021 May 5.

Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.

The present study aimed to evaluate the effects of inactivated vaccines combining Mass and Dutch variants as vaccine boosters after H120 priming on inhibiting variant 2 viral load in the kidneys (as the target organ) and reducing fecal shedding. Ciliostasis score and antibody response were investigated as well. A total of 150 specific-pathogen-free (SPF) chicken were divided into six groups. Read More

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A basic helix-loop-helix transcription factor CabHLH113 positively regulate pepper immunity against Ralstonia solanacearum.

Microb Pathog 2021 May 5:104909. Epub 2021 May 5.

Innovative Institute for Plant Health, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, People's Republic of China; College of Agriculture and Biology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, People's Republic of China. Electronic address:

Pepper's (Capsicum annum) response to bacterial pathogen Ralstonia solanacearm inoculation (RSI) and abiotic stresses is known to be synchronized by transcriptional network; however, related molecular mechanisms need extensive experimentation. We identified and characterized functions of CabHLH113 -a basic helix-loop-helix transcription factor-in pepper immunity to R. solanacearum infection. Read More

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Molecular identity of human limbal heterogeneity involved in corneal homeostasis and privilege.

Ocul Surf 2021 May 5. Epub 2021 May 5.

State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Qingdao, China; Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China; Eye Hospital of Shandong First Medical University, Jinan, China. Electronic address:

Purpose: The corneal limbus maintains the homeostasis, immune and angiogenic privilege of cornea. This study aimed to depict the landscape of human limbus tissues by single-cell RNA sequencing (scRNA-seq).

Methods: Single cells of human limbus collected from donor corneas were performed scRNA-seq using 10x Genomics platform, followed by clustering cell types through the t-distributed stochastic neighbor embedding (t-SNE) and unbiased computational informatic analysis. Read More

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Diagnostic accuracy of rapid nucleic acid tests for group A streptococcal pharyngitis: systematic review and meta-analysis.

Clin Microbiol Infect 2021 May 5. Epub 2021 May 5.

Université de Paris, Centre of Research in Epidemiology and Statistics (CRESS), INSERM, F-75004, Paris, France; Necker-Enfants malades Hospital, APHP, Université de Paris, Department of General Pediatrics and Pediatric Infectious Diseases, Paris, France. Electronic address:

Background: Acute pharyngitis is one of the most common conditions in outpatient settings and an important source of inappropriate antibiotic prescribing. Rapid antigen detection tests (RADTs) offer diagnosis of group A streptococcus (GAS) at the point of care but have limited sensitivity. Rapid nucleic acid tests (RNATs) are now available; a systematic review of their accuracy is lacking. Read More

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Understanding HBcrAg components helps the better interpretation of clinical HBcrAg assay results.

J Hepatol 2021 May 5. Epub 2021 May 5.

Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA. Electronic address:

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Neuroprotective effect of 6-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline mediated via regulation of antioxidant system and inhibition of inflammation and apoptosis in a rat model of cerebral ischemia/reperfusion.

Biochimie 2021 May 5. Epub 2021 May 5.

Department of Pathological Anatomy, Voronezh State Medical University named after N.N. Burdenko, Russia.

The aim of the study was the assessment of the neuroprotective potential of 6-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline (DHQ) and its effect on inflammation, apoptosis, and transcriptional regulation of the antioxidant system in cerebral ischemia/reperfusion (CIR) in rats. The CIR rat model was constructed using the bilateral common carotid artery occlusion followed by reoxygenation. DHQ was administered at a dose of 50 mg/kg for three days. Read More

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p-Coumaric acid loaded into liquid crystalline systems as a novel strategy to the treatment of vulvovaginal candidiasis.

Int J Pharm 2021 May 5:120658. Epub 2021 May 5.

Department of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil.

Vulvovaginal candidiasis (VVC) is an extremely common type of vaginal infection, which is mainly caused by Candida albicans. However, non-albicans Candida species are frequently more resistant to conventional antifungal agents and can represent up to 30% of cases. Due to side effects and increasing antifungal resistance presented by standard therapies, phenolic compounds, such as p-coumaric acid (p-CA), have been studied as molecules from natural sources with potential antifungal activity. Read More

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Clinical outcome and the role of antivirals in congenital cytomegalovirus infection.

Antiviral Res 2021 May 5:105083. Epub 2021 May 5.

Departments of Pediatrics, University of Alabama at Birmingham, Birmingham, AL.

Congenital cytomegalovirus (cCMV) infection is a leading cause of hearing loss and neurological disabilities in children worldwide. Although a minority of infants with cCMV will have symptoms at a birth, these children are at high risk of long-term sequelae. Most infants with cCMV have no clinical signs at birth (asymptomatic), but 10-15% will develop hearing loss. Read More

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Relative frequency and clinicopathologic characteristics of MYC-rearranged follicular lymphoma.

Hum Pathol 2021 May 5. Epub 2021 May 5.

Department of Pathology, University of Michigan, Ann Arbor, MI, USA. Electronic address:

MYC rearrangement is a relatively rare genetic abnormality in follicular lymphoma (FL). In this study, we evaluated the relative frequency of MYC rearrangement in 522 cases of FL and studied their clinicopathologic, cytogenetic and molecular characteristics. FISH studies for MYC (break-apart probe), MYC/IGH, IGH/BCL2, and BCL6 rearrangements were performed on tissue microarrays. Read More

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Early humoral response among lung transplant recipients vaccinated with BNT162b2 vaccine.

Lancet Respir Med 2021 May 5. Epub 2021 May 5.

Pulmonary Division, Rabin Medical Center, Petach Tikva 49100, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

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Monitoring of diverse enteric pathogens across environmental and host reservoirs with TaqMan array cards and standard qPCR: a methodological comparison study.

Lancet Planet Health 2021 May;5(5):e297-e308

Department of Civil Engineering, Monash University, Clayton, VIC, Australia. Electronic address:

Background: Multiple bacteria, viruses, protists, and helminths cause enteric infections that greatly impact human health and wellbeing. These enteropathogens are transmited via several pathways through human, animal, and environmental reservoirs. Individual qPCR assays have been extensively used to detect enteropathogens within these types of samples, whereas the TaqMan array card (TAC), which allows simultaneous detection of multiple enteropathogens, has only previously been validated in human clinical samples. Read More

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Association of Preoperative Infections, Nasal Staphylococcus Aureus Colonization and Gut Microbiota With Left Ventricular Assist Device Outcomes.

Eur J Heart Fail 2021 May 8. Epub 2021 May 8.

Department of Medicine, Division of Cardiology, Columbia University Irving Medical Center, New York, New York, USA.

Aims: Infections are common following left ventricular assist device (LVAD) and predict adverse events. Infections are frequent prior to LVAD although their impact on postoperative outcomes remains unknown. Gut and nasal microbial imbalance may predispose to mucosal colonization with pathogens. Read More

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Inoculation with Bacillus amyloliquefaciens and mycorrhiza confers tolerance to drought stress and improve seed yield and quality of soybean plant.

Physiol Plant 2021 May 8. Epub 2021 May 8.

Department of Agricultural Microbiology, Faculty of Agriculture, Mansoura University, Mansoura, Egypt.

The present study aimed to evaluate the effect of Bacillus amyloliquefaciens and/or Arbuscular Mycorrhizal Fungi (AMF) as natural biofertilizers on biomass, yield and seed nutritive quality of soybean (Giza 111). The conditions investigated include a well-watered (WW) control and irrigation withholding at the seed development stage (R5, after 90 days from sowing) (DS). Co-inoculation with B. Read More

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Directed Evolution of Unspecific Peroxygenase in Organic Solvents.

Biotechnol Bioeng 2021 May 8. Epub 2021 May 8.

Department of Biocatalysis, Institute of Catalysis, CSIC, Cantoblanco, Madrid, Spain.

Fungal unspecific peroxygenases (UPOs) are efficient biocatalysts that insert oxygen atoms into non-activated C-H bonds with high selectivity. Many oxyfunctionalization reactions catalyzed by UPOs are favored in organic solvents, a milieu in which their enzymatic activity is drastically reduced. Using as departure point the UPO secretion mutant from Agrocybe aegerita (PaDa-I variant), in the current study we have improved its activity in organic solvents by directed evolution. Read More

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Molecular characterization of ESBL- producing uropathogenic Escherichia coli recovered from urine samples of patients attending a University Teaching hospital in Nigeria.

Acta Microbiol Immunol Hung 2021 May 7. Epub 2021 May 7.

3Microbial Physiology and Biochemistry Laboratory, Department of Microbiology, University of Ibadan, Nigeria.

Infection of the urinary tract ranks as one of the most common infections affecting people worldwide and its treatment is made complicated by the rising incidence of antibiotic resistance. This study aimed to detect extended spectrum beta-lactamase (ESBL) genes and antibiotic resistance profile of uropathogenic Escherichia coli (E. coli) recovered from patients attending a University Teaching hospital in Nigeria. Read More

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Insights into the skin microbiome of sickle cell disease leg ulcers.

Wound Repair Regen 2021 May 8. Epub 2021 May 8.

Department of Dermatology and Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

Leg ulcers are estimated to occur in 1%-10% of North American patients with sickle cell disease (SCD). Their pathophysiology remains poorly defined, but as with other chronic wounds, it is hypothesised that the microbial milieu, or microbiome, contributes to their healing and clinical outcomes. This study utilises 16S ribosomal RNA (rRNA) gene sequencing to describe, for the first time, the microbiome of the SCD leg ulcer and its association with clinical factors. Read More

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