6,330 results match your criteria fundus images


RFARN: Retinal vessel segmentation based on reverse fusion attention residual network.

PLoS One 2021 3;16(12):e0257256. Epub 2021 Dec 3.

College of Computer Science and Engineering, Northwest Normal University, Lanzhou Gansu, China.

Accurate segmentation of retinal vessels is critical to the mechanism, diagnosis, and treatment of many ocular pathologies. Due to the poor contrast and inhomogeneous background of fundus imaging and the complex structure of retinal fundus images, this makes accurate segmentation of blood vessels from retinal images still challenging. In this paper, we propose an effective framework for retinal vascular segmentation, which is innovative mainly in the retinal image pre-processing stage and segmentation stage. Read More

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December 2021

Deep level set method for optic disc and cup segmentation on fundus images.

Biomed Opt Express 2021 Nov 18;12(11):6969-6983. Epub 2021 Oct 18.

Institute of Artificial Intelligence and Robotics, Xi'an Jiaotong University, Xi'an 710049, China.

Glaucoma is a leading cause of blindness. The measurement of vertical cup-to-disc ratio combined with other clinical features is one of the methods used to screen glaucoma. In this paper, we propose a deep level set method to implement the segmentation of optic cup (OC) and optic disc (OD). Read More

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November 2021

Inter-eye comparison of retinal vascular growth rate and angiographic findings following unilateral bevacizumab treatment.

Eur J Ophthalmol 2021 Dec 1:11206721211064019. Epub 2021 Dec 1.

Departmant of Health Science University Kanuni Sultan Suleyman Training and Research Hospital, Tertiary ROP Center, Istanbul, Turkey.

Purpose: To compare retinal vascularization progression rate, final retinal vascularization, and fluorescein angiography (FA) findings in infants who received intravitreal bevacizumab (IVB) treatment in one eye and with spontaneous regression in the other eye.

Methods: Thirty eyes of 15 infants who underwent IVB in one eye due to asymmetric retinopathy of prematurity, and who had pre-treatment fundus photographs and fluorescein angiography images were included in the study. Horizontal disc diameter (DD), optic disc-to-fovea distance (FD), and the length of temporal retinal vascularization (LTRV) distance were measured by evaluating pre-treatment and FA images. Read More

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December 2021

In vivo imaging of the human eye using a two-photon excited fluorescence scanning laser ophthalmoscope.

J Clin Invest 2021 Nov 30. Epub 2021 Nov 30.

Physical Chemistry of Biological Systems, Polish Academy of Sciences, Warsaw, Poland.

Background: Noninvasive assessment of metabolic processes that sustain regeneration of human retinal visual pigments (visual cycle) is essential to improve ophthalmic diagnostics and to accelerate development of new treatments to counter retinal diseases. Fluorescent vitamin A derivatives, which are the chemical intermediates of these processes, are highly sensitive to UV light; thus, safe analyses of these processes in humans are currently beyond the reach of even the most modern ocular imaging modalities.

Methods: We present a compact fluorescence scanning laser ophthalmoscope (TPEF-SLO) and spectrally resolved images of the human retina based on two-photon excitation (TPE) with near-infrared (IR) light. Read More

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November 2021

Wide-field swept source optical coherence tomography evaluation of posterior segment changes in highly myopic eyes.

Eur J Ophthalmol 2021 Nov 29:11206721211062362. Epub 2021 Nov 29.

Department of Ophthalmology, 34732Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Background: To investigate the features in the posterior pole of highly myopic (HM) eyes using a wide-field high-resolution swept source optical coherence tomography (SS OCT).

Methods: This observational cross-sectional study involved 262 eyes of 139 patients, who were diagnosed as HM and had consecutively been examined by SS OCT in the Ophthalmology Department of the Peking Union Medical College Hospital between March 2019 and December 2019. The characteristics of OCT images were documented and analyzed. Read More

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November 2021

Optimized Prediction Models from Fundus Imaging and Genetics for Late Age-Related Macular Degeneration.

J Pers Med 2021 Nov 1;11(11). Epub 2021 Nov 1.

iHealthscreen Inc., New York, NY 11418, USA.

Age-related macular degeneration (AMD) is a leading cause of blindness in the developed world. In this study, we compare the performance of retinal fundus images and genetic-information-based machine learning models for the prediction of late AMD. Using data from the Age-related Eye Disease Study, we built machine learning models with various combinations of genetic, socio-demographic/clinical, and retinal image data to predict late AMD using its severity and category in a single visit, in 2, 5, and 10 years. Read More

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November 2021

Scar Tissue after a Cesarean Section-The Management of Different Complications in Pregnant Women.

Int J Environ Res Public Health 2021 Nov 15;18(22). Epub 2021 Nov 15.

Department of Obstetrics and Pathology of Pregnancy, Independent Public Teaching Hospital No 1 in Lublin, Medical University of Lublin, 20-081 Lublin, Poland.

The definition of a cesarean scar pregnancy (CSP) is the localization of the gestational sac (GS) in the cicatrix tissue, which is created in the front wall of the uterus after a previous cesarean section (CS). The worldwide prevalence of CSP has been growing rapidly. However, there are no general recommendations regarding prophylaxis and treatment of the abnormalities of the anterior wall of the uterus discovered in a non-pregnant myometrium, or how to deal with existing cases of CSP. Read More

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November 2021

Detecting Progression of Treated Choroidal Melanomas: Is Ultrasonography Necessary?

Cancers (Basel) 2021 Nov 20;13(22). Epub 2021 Nov 20.

Ocular Oncology Service, Moorfields Eye Hospital, London EC1V 2PD, UK.

Prompt detection and treatment of local treatment failure after radiotherapy for choroidal melanoma optimises any opportunities for conserving vision and the eye, possibly reducing an increased risk of metastatic disease. Long-term surveillance is therefore required but is hampered by the perceived need to perform ultrasonography, which may not be available at a patient's local hospital. The aim of this study was to determine whether local treatment failure can reliably be detected with colour fundus photography alone, and, if so, in which patients. Read More

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November 2021

A Trust-Based Methodology to Evaluate Deep Learning Models for Automatic Diagnosis of Ocular Toxoplasmosis from Fundus Images.

Diagnostics (Basel) 2021 Oct 21;11(11). Epub 2021 Oct 21.

Departamento de Retina, Cátedra de Oftalmología, Hospital de Clínicas, Facultad de Ciencias Médicas, Universidad Nacional de Asunción, San Lorenzo 2169, Paraguay.

In the automatic diagnosis of ocular toxoplasmosis (OT), Deep Learning (DL) has arisen as a powerful and promising approach for diagnosis. However, despite the good performance of the models, decision rules should be interpretable to elicit trust from the medical community. Therefore, the development of an evaluation methodology to assess DL models based on interpretability methods is a challenging task that is necessary to extend the use of AI among clinicians. Read More

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October 2021

Identifying Peripheral Neuropathy in Colour Fundus Photographs Based on Deep Learning.

Diagnostics (Basel) 2021 Oct 20;11(11). Epub 2021 Oct 20.

NIHR Moorfields Biomedical Research Centre, 162 City Road, London EC1V 2PD, UK.

The aim of this study was to develop and validate a deep learning-based system to detect peripheral neuropathy (DN) from retinal colour images in people with diabetes. Retinal images from 1561 people with diabetes were used to predictDN diagnosed on vibration perception threshold. A total of 189 had diabetic retinopathy (DR), 276 had DN, and 43 had both DR and DN. Read More

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October 2021

Sensitivity and Specificity of Handheld Fundus Cameras for Eye Disease: A Systematic Review and Pooled Analysis.

Surv Ophthalmol 2021 Nov 22. Epub 2021 Nov 22.

Department of Surgery, Division of Ophthalmology, University of Vermont Medical Center & Larner College of Medicine, Burlington VT, United States. Electronic address:

In order to evaluate the accuracy of commercially available handheld fundus cameras for a variety of ophthalmic diagnoses, we conducted a systematic review, searching PubMed and PubMed Central and performing a bivariate analysis to determine the pooled sensitivity and specificity of handheld fundus cameras. Eleven studies validating handheld fundus cameras against a gold-standard method for disease diagnosis were included. For non-mydriatic images, pooled sensitivity was 83% (95% CI: 77-88%) and specificity was 92% (95% CI: 79-97%). Read More

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November 2021

Erratum: Evaluation of asymmetry in right and left eyes of normal individuals using extracted features from optical coherence tomography and fundus images.

Authors:

J Med Signals Sens 2021 Oct-Dec;11(4):291. Epub 2021 Oct 20.

[This corrects the article on p. 12 in vol. 11, PMID: 34026586. Read More

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October 2021

Single-Examination Risk Prediction of Severe Retinopathy of Prematurity.

Pediatrics 2021 Dec;148(6)

Departments of Ophthalmology.

Background And Objectives: Retinopathy of prematurity (ROP) is a leading cause of childhood blindness. Screening and treatment reduces this risk, but requires multiple examinations of infants, most of whom will not develop severe disease. Previous work has suggested that artificial intelligence may be able to detect incident severe disease (treatment-requiring retinopathy of prematurity [TR-ROP]) before clinical diagnosis. Read More

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December 2021

Using ultra-widefield red channel images to improve the detection of ischemic central retinal vein occlusion.

PLoS One 2021 23;16(11):e0260383. Epub 2021 Nov 23.

Department of Ophthalmology and Micro-Technology, Yokohama City University, Kanagawa, Japan.

Purpose: To examine the usefulness of red channel fundus imaging to detect the ischemic status in eyes with central retinal vein occlusion (CRVO).

Methods: Ultra-widefield (UWF) fundus images were obtained from 42 eyes with CRVO. Twenty-one eyes were ischemic, and 21 eyes were non-ischemic. Read More

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November 2021

Best disease presenting as subretinal pigment epithelium hyperreflectivite lesion on spectral-domain optical coherence tomography: Multimodal imaging features.

Eur J Ophthalmol 2021 Nov 20:11206721211055961. Epub 2021 Nov 20.

498107Istanbul Retina Institute, Istanbul, Turkey.

Purpose: To report clinical and multimodal imaging features of Best disease in patients presenting with subretinal pigment epithelium hyperreflective lesions.

Design: Retrospective study.

Methods: Clinical examination findings and multimodal imaging features, including color fundus photography, spectral-domain optical coherence tomography (SD-OCT), fundus autofluorescence, fluorescein and indocyanine green angiography (ICGA), and optical coherence tomography angiography (OCTA) images were evaluated retrospectively. Read More

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November 2021

Deep Learning for Detecting Subretinal Fluid and Discerning Macular Status by Fundus Images in Central Serous Chorioretinopathy.

Front Bioeng Biotechnol 2021 5;9:651340. Epub 2021 Nov 5.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Subretinal fluid (SRF) can lead to irreversible visual loss in patients with central serous chorioretinopathy (CSC) if not absorbed in time. Early detection and intervention of SRF can help improve visual prognosis and reduce irreversible damage to the retina. As fundus image is the most commonly used and easily obtained examination for patients with CSC, the purpose of our research is to investigate whether and to what extent SRF depicted on fundus images can be assessed using deep learning technology. Read More

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November 2021

RF-GANs: A Method to Synthesize Retinal Fundus Images Based on Generative Adversarial Network.

Comput Intell Neurosci 2021 10;2021:3812865. Epub 2021 Nov 10.

Information and Computer Engineering College, Northeast Forestry University, Harbin, China.

Diabetic retinopathy (DR) is a diabetic complication affecting the eyes, which is the main cause of blindness in young and middle-aged people. In order to speed up the diagnosis of DR, a mass of deep learning methods have been used for the detection of this disease, but they failed to attain excellent results due to unbalanced training data, i.e. Read More

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November 2021

Retinal vessel tortuosity as a prognostic marker for disease severity in Fabry disease.

Orphanet J Rare Dis 2021 Nov 20;16(1):485. Epub 2021 Nov 20.

Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.

Purpose: The aim of this case control study was to evaluate the prognostic value of automatically quantified retinal vessel tortuosity from fundus images and vessel density from OCT-A in Fabry disease and to evaluate the correlation of these with systemic disease parameters.

Methods: Automatically quantified perimacular retinal vessel tortuosity (MONA REVA software), acquired by fundus imaging, and perifoveal retinal vessel density, acquired by optic coherence tomography angiography (OCT-A) were compared between 26 FD patients and 26 controls. Gender and FD phenotype were analyzed to the obtained retinovascular data and correlated to the Mainz severity score index (MSSI) and plasma lyso-Gb3. Read More

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November 2021

Image Mosaic Algorithm-Based Analysis of Pathological Characteristics of Gastric Polyp Patients Using Computed Tomography Images.

J Healthc Eng 2021 9;2021:6086106. Epub 2021 Nov 9.

Department of General Surgery, Wuxi Second People's Hospital, Wuxi 214002, Jiangsu, China.

The application value of image mosaic algorithm (IMA) based CT imaging technology in the analysis of pathological characteristics of gastric polyp (GP) patients was explored in this work. 588 cases of GP patients in the hospital were selected as the research objects, and CT images based on IMA were adopted for examination. The patient's basic information, image performance, and gastroscopy results were recorded. Read More

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November 2021

Appearance of Tumor Vessels in Patients With Choroidal Osteoma Using Swept-Source Optical Coherence Tomographic Angiography.

Front Oncol 2021 1;11:762394. Epub 2021 Nov 1.

SVision Imaging, Inc., Milpitas, CA, United States.

Objective: To report the morphologic characteristics of tumor-related vasculatures and their association with secondary choroidal neovascularization (CNV), subretinal fluid (SRF), choroidal thickness, retinal pigment epithelium (RPE) alterations, subretinal hemorrhage, and tumor decalcification in eyes with choroidal osteoma (CO), using swept-source optical coherence tomographic angiography (SS-OCTA).

Design: Cross-sectional observational study.

Participants: We included 26 patients recruited from Beijing Tongren Hospital with a diagnosis of CO, based on the presence of yellow-orange mass deep to the RPE under indirect ophthalmoscopy and occupying the choroid with well-defined margins and bone density on ultrasonography or computed tomography and focal hyperfluorescent spots with no homogeneous pattern on fluorescein angiography/indocyanine green angiography (FA/ICGA). Read More

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November 2021

Optic Nerve Angle in Idiopathic Intracranial Hypertension.

J Neuroophthalmol 2021 Dec;41(4):e464-e469

Departments of Ophthalmology (BSC, MYL, BBB, JHL, RAS, NJN, VB), Radiology and Imaging Sciences (SA, AMS), Epidemiology (BBB), Neurology (BBB, NJN, VB), and Neurological Surgery (NJN), Emory University, Atlanta, Georgia.

Background: The tortuosity of the optic nerve can be quantified radiologically by measuring the angle of optic nerve deformation (the "optic nerve angle" [ONA]). In patients with idiopathic intracranial hypertension (IIH), lowering the intracranial pressure (ICP) to a normal range by lumbar puncture leads to straightening of the optic nerve and an increase in the measured sagittal ONA on MRI. It is uncertain whether there is any correlation between ONA and cerebrospinal fluid (CSF) opening pressure or visual function. Read More

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December 2021

Retinal Imaging Techniques Based on Machine Learning Models in Recognition and Prediction of Mild Cognitive Impairment.

Neuropsychiatr Dis Treat 2021 6;17:3267-3281. Epub 2021 Nov 6.

Department of Rehabilitation Medicine, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, People's Republic of China.

Background And Purpose: Mild Cognitive Impairment (MCI) is thought to be the signal of many progressive diseases but is easily ignored. Therefore, a simple and easy screening method for recognizing and predicting MCI is urgently needed. The study aimed to establish machine learning models of retinal vascular features to categorize and predict MCI. Read More

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November 2021

Non-Mydriatic Ultra-Widefield Fundus Photography in a Hematology Clinic Shows Utility for Screening of Sickle Cell Retinopathy.

Am J Ophthalmol 2021 Nov 12. Epub 2021 Nov 12.

Wilmer Eye Institute, 1800 Orleans Street, Baltimore, MD 21287. Electronic address:

Purpose: To determine the feasibility and accuracy of non-mydriatic ultra-widefield (UWF) fundus photographs taken in a hematology clinic setting for screening of sickle cell retinopathy (SCR) DESIGN: Prospective cohort study METHODS: Setting: Single-site study at the Johns Hopkins Sickle Cell Center for Adults and the Wilmer Eye Institute Study Population: Ninety eyes of 46 consecutive adult participants with sickle cell disease (SCD) Observation Procedure: Bilateral non-mydriatic fundus photos taken by clinic personnel during the participants' routine hematology appointment were graded by two masked retina specialists at the Wilmer Eye Institute for the presence of non-proliferative SCR (NPSR) and proliferative sickle retinopathy (PSR). A third retina specialist adjudicated in cases of grader disagreement. All participants underwent the standard dilated fundus exam (DFE) within two years of acquisition of UWF photos. Read More

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November 2021

Pivotal Evaluation of an Artificial Intelligence System for Autonomous Detection of Referrable and Vision-Threatening Diabetic Retinopathy.

JAMA Netw Open 2021 Nov 1;4(11):e2134254. Epub 2021 Nov 1.

Eyenuk Inc, Los Angeles, California.

Importance: Diabetic retinopathy (DR) is a leading cause of blindness in adults worldwide. Early detection and intervention can prevent blindness; however, many patients do not receive their recommended annual diabetic eye examinations, primarily owing to limited access.

Objective: To evaluate the safety and accuracy of an artificial intelligence (AI) system (the EyeArt Automated DR Detection System, version 2. Read More

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November 2021

Development of 3D Printed Smartphone-Based Multi-Purpose Fundus Camera (MultiScope) for Retinopathy of Prematurity.

Ann Biomed Eng 2021 Nov 12. Epub 2021 Nov 12.

Department of Mechanical Engineering, Coimbatore Institute of Technology, Coimbatore, 641 014, India.

Retinopathy of Prematurity (ROP) is a prominent source of low vision and blindness in preterm babies. Wide-Field Digital Retinal Imaging (WFDRI) systems acquire accurate digital images which are very useful for identification, documentation and transmitting the various retinal diseases. This telemedicine technique has potential for an alternative tool for Binocular Indirect Ophthalmoscopy (BIO) in ROP screening, but it is very expensive and accessibility for poor communities is limited. Read More

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November 2021

Visual assessment of the placenta in antenatal magnetic resonance imaging across gestation in normal and compromised pregnancies: Observations from a large cohort study.

Placenta 2021 Oct 14;117:29-38. Epub 2021 Oct 14.

Centre for the Developing Brain, King's College London, London, United Kingdom; Biomedical Engineering Department, King's College London, London, United Kingdom.

Introduction: Visual assessment of the placenta in antenatal magnetic resonance imaging is important to confirm healthy appearances or to identify pathology complicating fetal anomaly or maternal disease.

Methods: We assessed the placenta in a large cohort of 228 women with low and high risk pregnancies across gestation. All women gave written informed consent and were imaged using either a 3T Philips Achieva or 1. Read More

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October 2021

In-Person Verification of Deep Learning Algorithm for Diabetic Retinopathy Screening Using Different Techniques Across Fundus Image Devices.

Transl Vis Sci Technol 2021 Nov;10(13):17

Department of Industrial Engineering, Kasetsart University, Bangkok, Thailand.

Purpose: To evaluate the clinical performance of an automated diabetic retinopathy (DR) screening model to detect referable cases at Siriraj Hospital, Bangkok, Thailand.

Methods: A retrospective review of two sets of fundus photographs (Eidon and Nidek) was undertaken. The images were classified by DR staging prior to the development of a DR screening model. Read More

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November 2021

Validation of Artificial Intelligence Algorithm in the Detection and Staging of Diabetic Retinopathy through Fundus Photography: An Automated Tool for Detection and Grading of Diabetic Retinopathy.

Middle East Afr J Ophthalmol 2021 Apr-Jun;28(2):81-86. Epub 2021 Sep 25.

Department of Ophthalmology, LEBEN CARE Technologies Pvt. Ltd, Singapore.

Purpose: Diabetic retinopathy (DR) is one of the leading causes of vision loss globally, and early detection plays a significant role in the prognosis. Several studies have been done on the single field fundus photography and artificial intelligence (AI) in DR screening using standardized data sets in urban outpatient settings. This study was carried out to validate AI algorithm in the detection of DR severity using fundus photography in real-time rural setting. Read More

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November 2021

Efficacy of Subtenonal Administration of Triamcinolone Acetate in a Patient with Malignant Hypertension-a Case Report.

Acta Inform Med 2021 Sep;29(3):231-235

Polyclinic with Daily Hospital "Doboj Jug" - Medical Retina Department, Doboj Jug, Bosnia and Herzegovina.

Background: Malignant hypertension is a condition characterized by severe hypertension and multiorganic ischemic complications. The underlying cause of malignant hypertension can be primary or secondary hypertension, and identification of the cause is mandatory to select the correct treatment to control blood pressure and reduce end-organ damage. Hypertensive retinopathy is a disease that has short-term and long-term consequences for the overall health and mortality of patients. Read More

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September 2021

[Retinal Imaging as Potential Biomarkers for Dementia].

Authors:
Mariko Sasaki

Brain Nerve 2021 Nov;73(11):1209-1216

Department of Ophthalmology, Tachikawa hospital.

Alzheimer's disease (AD) is a leading cause of dementia, and the current diagnostic methods of AD, such as positron emission tomography imaging, have a high cost and poor accessibility. Amyloidβ accumulates in the brain long before the symptomatic onset of AD, and can also be found in the inner retina. Anatomically and developmentally, the retina is an extension of the brain, and is the only part of the central nervous system that can be imaged non-invasively. Read More

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November 2021