5,827 results match your criteria functional possibilities


Light- and temperature-assisted spin state annealing: accessing the hidden multistability.

Chem Sci 2020 Feb 26;11(12):3281-3289. Epub 2020 Feb 26.

Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education, School of Chemistry, Sun Yat-Sen University Guangzhou 510275 P. R. China

Among responsive multistable materials, spin crossover (SCO) systems are of particular interest for stabilizing multiple spin states with various stimulus inputs and physical outputs. Here, in a 2D Hofmann-type coordination polymer, [Fe(isoq){Au(CN)}] (isoq = isoquinoline), a medium-temperature annealing process is introduced after light/temperature stimulation, which accesses the hidden multistability of the spin state. With the combined effort of magnetic, crystallographic and Mössbauer spectral investigation, these distinct spin states are identified and the light- and temperature-assisted transition pathways are clarified. Read More

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February 2020

A theoretical study of supramolecular aggregation of polydopamine tetramer subunits in aqueous solution.

J Mol Graph Model 2021 May 29;107:107946. Epub 2021 May 29.

Department of Chemistry, Drug Design Development Research Group, Center of Theoretical and Computational Physics (TCP), Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia. Electronic address:

Conformational search for the most stable geometry connection of 16 sets of polydopamine (PDA) tetramer subunits has been systematically investigated using density functional theory (DFT) calculations. Our results indicated that the more planar subunits are, the more stable they are. This finding is in good agreement with recent experimental observations, which have suggested that PDA are composed of the nearly planar subunits that appear to be stacked together via the π-π interactions to form graphite-like layered aggregates associated with the balance of the intramolecular hydrogen bonds and steric effects from the indole and catechol moieties. Read More

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Highly Confined Phonon Polaritons in Monolayers of Perovskite Oxides.

Nano Lett 2021 Jun 8. Epub 2021 Jun 8.

Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, United States.

Two-dimensional (2D) materials are able to strongly confine light hybridized with collective excitations of atoms, enabling electric-field enhancements and novel spectroscopic applications. Recently, freestanding monolayers of perovskite oxides have been synthesized, which possess highly infrared-active phonon modes and a complex interplay of competing interactions. Here, we show that this new class of 2D materials exhibits highly confined phonon polaritons by evaluating central figures of merit for phonon polaritons in the tetragonal phases of the 2D perovskites SrTiO, KTaO, and LiNbO, using density functional theory calculations. Read More

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Nanoparticles and trained immunity: glimpse into the future.

Adv Drug Deliv Rev 2021 Jun 1. Epub 2021 Jun 1.

CINBIO, Universidade de Vigo, Immunology Group, Vigo, Spain; Galicia Sur Health Research Institute (IIS-GS), Hospital Alvaro Cunqueiro, Vigo, Spain.

Emerging evidences show that innate immune cells can display changes in their functional programs after infection or vaccination, which lead to immunomodulation (increased or reduced responsiveness) upon secondary activation to the same stimuli or even to a different one. Innate cells acquire features of immunological memory, nowadays using the new term of "trained immunity" or "innate immune memory", which is different from the specific memory immune response elicited by B and T lymphocytes. The review focused on the concept of trained immunity, mostly on myeloid cells. Read More

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Promoting neuroplasticity and neuropsychological functioning in frailty through an app-based sensorimotor training: study protocol for a randomized trial.

BMC Geriatr 2021 06 3;21(1):343. Epub 2021 Jun 3.

Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159, Mannheim, Germany.

Background: Frailty is characterized by an age-related decline in multiple physiological systems, leading to a high vulnerability to stressors, adverse health outcomes, and low quality of life. Neuroscientific models of pathological aging emphasize the loss of sensorimotor stimulation and reduced neuromodulatory capacities as core processes in age-related cognitive and bodily decline, which may be associated with maladaptive plastic changes in the brain. We plan to increase sensorimotor stimulation in frail persons through a newly developed app-based training program and link the training trials to biological and psychological correlates of age-associated vulnerability and health indices. Read More

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Survival of Floquet-Bloch States in the Presence of Scattering.

Nano Lett 2021 Jun 3. Epub 2021 Jun 3.

Institute for Experimental and Applied Physics, University of Regensburg, Regensburg 93040, Germany.

Floquet theory has spawned many exciting possibilities for electronic structure control with light, with enormous potential for future applications. The experimental demonstration in solids, however, remains largely unrealized. In particular, the influence of scattering on the formation of Floquet-Bloch states remains poorly understood. Read More

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Precision Surgery In Rectal Resection With Hyperspectral and Fluorescence Imaging And Pelvic Intraoperative Neuromonitoring (With Video).

Surg Technol Int 2021 Jun 3;38. Epub 2021 Jun 3.

Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany.

Oncologic visceral surgery has recently been revolutionized by robotics, artificial intelligence (AI), sparing of functionally important structures and innovative intraoperative imaging tools. These techniques enable new dimensions of precision surgery and oncology. Currently, data-driven, cognitive operating rooms are standing at the forefront of the latest technical and didactic developments in abdominal surgery. Read More

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Adsorption Enthalpies for Catalysis Modeling through Machine-Learned Descriptors.

Acc Chem Res 2021 Jun 3;54(12):2741-2749. Epub 2021 Jun 3.

Chair for Theoretical Chemistry and Catalysis Research Center, Technische Universität München, Lichtenbergstr. 4, 85747 Garching, Germany.

ConspectusHeterogeneous catalysts are rather complex materials that come in many classes (e.g., metals, oxides, carbides) and shapes. Read More

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Reconstruction of circRNA-miRNA-mRNA associated ceRNA networks reveal functional circRNAs in intracerebral hemorrhage.

Sci Rep 2021 Jun 2;11(1):11584. Epub 2021 Jun 2.

Department of Biopharmaceutical Sciences (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), College of Pharmacy, Harbin Medical University, 157 Baojian Road, Nangang District, P. O. Box 19, Harbin, 150081, Heilongjiang, China.

Circular RNA (circRNA), a novel class of noncoding RNAs, has been used extensively to complement transcriptome remodeling in the central nervous system, although the genomic coverage provided has rarely been studied in intracerebral hemorrhage (ICH) and is limited and fails to provide a detailed picture of the cerebral transcriptome landscape. Here, we described sequencing-based transcriptome profiling, providing comprehensive analysis of cerebral circRNA, messenger RNA (mRNA) and microRNA (miRNA) expression in ICH rats. In the study, male Sprague-Dawley rats were subjected to ICH, and next-generation sequencing of RNAs isolated from non-hemorrhagic (Sham) and hemorrhagic (ICH) rat brain samples collected 7 (early phase) and 28 (chronic phase) days after insults, was conducted. Read More

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Recent Advancements in Receptor Layer Engineering for Applications in SPR-Based Immunodiagnostics.

Sensors (Basel) 2021 May 29;21(11). Epub 2021 May 29.

Faculty of Chemistry, The Chair of Medical Biotechnology, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland.

The rapid progress in the development of surface plasmon resonance-based immunosensing platforms offers wide application possibilities in medical diagnostics as a label-free alternative to enzyme immunoassays. The early diagnosis of diseases or metabolic changes through the detection of biomarkers in body fluids requires methods characterized by a very good sensitivity and selectivity. In the case of the SPR technique, as well as other surface-sensitive detection strategies, the quality of the transducer-immunoreceptor interphase is crucial for maintaining the analytical reliability of an assay. Read More

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Development and Characterization of Bioactive Poly(butylene-succinate) Films Modified with Quercetin for Food Packaging Applications.

Polymers (Basel) 2021 May 29;13(11). Epub 2021 May 29.

Center of Bioimmobilisation and Innovative Packaging Materials, Faculty of Food Sciences and Fisheries, West Pomeranian University of Technology Szczecin, Janickiego 35, 71-270 Szczecin, Poland.

The preparation of biodegradable active packaging materials is still a major challenge. Here, we report the fabrication and characterization of poly(butylene succinate)-based (PBS) films enriched with a natural polyphenolic antioxidant-quercetin. The PBS-based films with various quercetin content (0. Read More

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Mitochondrial K Transport: Modulation and Functional Consequences.

Molecules 2021 May 14;26(10). Epub 2021 May 14.

Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo 05508-000, SP, Brazil.

The existence of a K cycle in mitochondria has been predicted since the development of the chemiosmotic theory and has been shown to be crucial for several cellular phenomena, including regulation of mitochondrial volume and redox state. One of the pathways known to participate in K cycling is the ATP-sensitive K channel, MitoK. This channel was vastly studied for promoting protection against ischemia reperfusion when pharmacologically activated, although its molecular identity remained unknown for decades. Read More

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Prospects of Using Biocatalysis for the Synthesis and Modification of Polymers.

Molecules 2021 May 7;26(9). Epub 2021 May 7.

Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Lenin Hills 1, bldg. 73, 119991 Moscow, Russia.

Trends in the dynamically developing application of biocatalysis for the synthesis and modification of polymers over the past 5 years are considered, with an emphasis on the production of biodegradable, biocompatible and functional polymeric materials oriented to medical applications. The possibilities of using enzymes not only as catalysts for polymerization but also for the preparation of monomers for polymerization or oligomers for block copolymerization are considered. Special attention is paid to the prospects and existing limitations of biocatalytic production of new synthetic biopolymers based on natural compounds and monomers from biomass, which can lead to a huge variety of functional biomaterials. Read More

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Complement Components in the Diagnosis and Treatment after Kidney Transplantation-Is There a Missing Link?

Biomolecules 2021 May 21;11(6). Epub 2021 May 21.

Department of Diagnostics, Chair of Clinical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Kopernika 15A St., 31-501 Kraków, Poland.

Currently, kidney transplantation is widely accepted as the renal replacement therapy allowing for the best quality of life and longest survival of patients developing end-stage renal disease. However, chronic transplant rejection, recurrence of previous kidney disease or newly acquired conditions, or immunosuppressive drug toxicity often lead to a deterioration of kidney allograft function over time. Complement components play an important role in the pathogenesis of kidney allograft impairment. Read More

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Localization of a Gaussian beam in an electrically tunable curved Airy channel in a paraelectric Mn:KLTN crystal.

Opt Lett 2021 Jun;46(11):2610-2613

An optical Airy channel is built in a paraelectric Mn: KLTN crystal via a photo-induced Airy beam based on the photo-refractive effect. A laser beam, incident with the main lobe of the Airy channel, propagates along the Airy channel with a bias field as the control parameter. We find that the light beam is nicely confined in the Airy channel and propagates along it, presenting Airy-like properties of non-diffraction and bending action under a certain voltage range; then a breathing soliton can be formed with bias electric field rising, originating from space-charge-field-induced nonlocal refractive index perturbation. Read More

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Wearable Devices: Current Status and Opportunities in Pain Assessment and Management.

Digit Biomark 2021 Jan-Apr;5(1):89-102. Epub 2021 Apr 19.

Department of Anesthesiology, University of Colorado, Aurora, Colorado, USA.

Introduction: We investigated the possibilities and opportunities for using wearable devices that measure physical activity and physiometric signals in conjunction with ecological momentary assessment (EMA) data to improve the assessment and treatment of pain.

Methods: We considered studies with cross-sectional and longitudinal designs as well as interventional or observational studies correlating pain scores with measures derived from wearable devices. A search was also performed on studies that investigated physical activity and physiometric signals among patients with pain. Read More

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Synthesis and characterization of TiO NPs by aqueous leaf extract of Coleus aromaticus and assess their antibacterial, larvicidal, and anticancer potential.

Environ Res 2021 May 27;200:111335. Epub 2021 May 27.

School of Renewable Energy, Maejo University, Chiang Mai, 50290, Thailand; College of Medical and Health Science, Asia University, Taichung, Taiwan. Electronic address:

The frequent applications of synthetic chemical insecticides and drugs create resistance among insects and microbes, creating a new threat to human and environmental welfare. This investigation focused on evaluating the possibilities of fabricating and characterizing the titanium dioxide nanoparticles (TiO NPs) from titanium dioxide (TiO) through the aqueous leaf extract of Coleus aromaticus. Their biological applications were studied against the larvae of Aedes aegypti human pathogenic bacteria, and cancer cell line. Read More

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Multicomponent Covalent Chemical Patterning of Graphene.

ACS Nano 2021 May 28. Epub 2021 May 28.

Department of Chemistry, Division of Molecular Imaging and Photonics, KU Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium.

The chemical patterning of graphene is being pursued tenaciously due to exciting possibilities in electronics, catalysis, sensing, and photonics. Despite the intense efforts, spatially controlled, multifunctional covalent patterning of graphene has not been achieved. The lack of control originates from the inherently poor reactivity of the basal plane of graphene, which necessitates the use of harsh chemistries. Read More

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Strategies for Surface Immobilization of Whole Bacteriophages: A Review.

ACS Biomater Sci Eng 2021 06 26;7(6):1987-2014. Epub 2021 May 26.

Université Grenoble Alpes, CNRS, CEA, IRIG, SyMMES, 38000 Grenoble, France.

Bacteriophage immobilization is a key unit operation in emerging biotechnologies, enabling new possibilities for biodetection of pathogenic microbes at low concentration, production of materials with novel antimicrobial properties, and fundamental research on bacteriophages themselves. Wild type bacteriophages exhibit extreme binding specificity for a single species, and often for a particular subspecies, of bacteria. Since their specificity originates in epitope recognition by capsid proteins, which can be altered by chemical or genetic modification, their binding specificity may also be redirected toward arbitrary substrates and/or a variety of analytes in addition to bacteria. Read More

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[Possibilities of neurotrophic therapy for delayed speech development].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(4):44-47

Children's Regional Clinical Hospital, Belgorod, Russia.

The article provides an analysis of the possibility of neurotrophic therapy of delayed speech development (DSD) in 266 children who underwent dynamic clinical, laboratory, functional and neuropsychological examinations and received neurotrophic therapy. This study confirmed the effectiveness of neurotrophic therapy in the treatment of as isolated speech disorder (ISD) as well speech disorder in the structure of the general psychomotor developmental delay (PDD). The lack of effect in the use of neuroprotective therapy in every sixth child of the latter group can be a marker for the individualization of the treatment of each individual with an emphasis on non-drug rehabilitation methods. Read More

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Multifunctional metasurfaces enabled by simultaneous and independent control of phase and amplitude for orthogonal polarization states.

Light Sci Appl 2021 May 25;10(1):107. Epub 2021 May 25.

National Laboratory of Solid-State Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, College of Engineering and Applied Sciences, Nanjing University, 210093, Nanjing, China.

Monochromatic light can be characterized by its three fundamental properties: amplitude, phase, and polarization. In this work, we propose a versatile, transmission-mode all-dielectric metasurface platform that can independently manipulate the phase and amplitude for two orthogonal states of polarization in the visible frequency range. For proof-of-concept experimental demonstration, various single-layer metasurfaces composed of subwavelength-spaced titanium-dioxide nanopillars are designed, fabricated, and characterized to exhibit the ability of polarization-switchable multidimensional light-field manipulation, including polarization-switchable grayscale nanoprinting, nonuniform cylindrical lensing, and complex-amplitude holography. Read More

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Agrobacterium rhizogenes rolB oncogene: An intriguing player for many roles.

Plant Physiol Biochem 2021 Aug 14;165:10-18. Epub 2021 May 14.

Dipartimento di Biologia, Università degli Studi di Firenze, via Madonna del Piano 6, 50019, Sesto f.no, FI, Italy. Electronic address:

The rolB oncogene is one of the so-called rol genes found in the T-DNA region of the Agrobacterium rhizogenes Ri plasmid and involved in the hairy root syndrome, a tumour characterized by adventitious root overgrowth on plant stem. rolB produces in plants a peculiar phenotype that, together with its root-inducing capacity, has been connected to auxin sensitivity. The gene is able to modify the plant genetic programme to induce meristem cells and direct them to differentiate not only roots, but also other cells, tissues or organs. Read More

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Iron oxide and gold bimetallic radiosensitizers for synchronous tumor chemoradiation therapy in 4T1 breast cancer murine model.

J Mater Chem B 2021 Jun;9(22):4510-4522

Cancer Gene Therapy Research Center, Zanjan University of Medical Sciences, Zanjan, Iran. and Joint Ukraine-Azerbaijan International Research and Education Center of Nanobiotechnology and Functional Nanosystems, Drohobych, Ukraine, Baku, Azerbaijan and Zanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan 45139-56184, Iran.

The development of highly integrated multifunctional nanomaterials with a superadditive therapeutic effect and good safety is an urgent but challenging task in cancer therapy research. The present study aims to design a nanoplatform that offers the opportunity to enhance antitumor activity while minimizing side effects. Given the Au-mediated X-ray radiation enhancement and the ability of Fe-based nanomaterials to create reactive oxygen species (ROS) and DNA damage, we anticipated that bimetallic Fe3O4-Au heterodimer would bring strong radiosensitizing capacity. Read More

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Natural Killer Cells Generated From Human Induced Pluripotent Stem Cells Mature to CD56CD16NKp80 and Express KIR2DL2/DL3 and KIR3DL1.

Front Immunol 2021 4;12:640672. Epub 2021 May 4.

Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany.

The differentiation of human induced pluripotent stem cells (hiPSCs) into T and natural killer (NK) lymphocytes opens novel possibilities for developmental studies of immune cells and generation of cell therapy products. In particular, iPSC-derived NK cells gained interest in adoptive anti-cancer immunotherapies, since they enable generation of homogenous populations of NK cells with and without genetic engineering that can be grown at clinical scale. However, the phenotype of generated NK cells is not well characterized. Read More

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[Manual medicine, manual treatment : Principles, mode of action, indications and evidence].

Authors:
Hermann Locher

Unfallchirurg 2021 Jun 19;124(6):433-445. Epub 2021 May 19.

Zentrum für Orthopädie und Unfallchirurgie, Lindauerstr. 16, 88069, Tettnang, Deutschland.

Manual medicine is the medical discipline that comprehensively deals with the diagnosis, treatment and prevention of reversible functional disorders of the musculoskeletal system and other related organ systems. The article illustrates the neuroanatomical and neurophysiological basic elements and mechanisms of manual medical diagnostics and treatment. Based on the most recent literature and in consideration of various scientific guidelines, the evidence-based effectiveness of manual medical procedures is presented. Read More

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Efficacy of preclinical pharmacological interventions against alterations of neuronal network oscillations in Alzheimer's disease: A systematic review.

Exp Neurol 2021 May 14:113743. Epub 2021 May 14.

Neuronal Oscillations Laboratory, Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Akademiska Stråket 1, J10:30, 17164 Solna, Stockholm, Sweden. Electronic address:

Despite the development of multiple pharmacological approaches over the years aimed at treating Alzheimer's Disease (AD) only very few have been approved for clinical use in patients. To date there still exists no disease-modifying treatment that could prevent or rescue the cognitive impairment, particularly of memory aquisition, that is characteristic of AD. One of the possibilities for this state of affairs might be that the majority of drug discovery efforts focuses on outcome measures of decreased neuropathological biomarkers characteristic of AD, without taking into acount neuronal processes essential to the generation and maintenance of memory processes. Read More

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Computational Tools to Assess the Functional Consequences of Rare and Noncoding Pharmacogenetic Variability.

Clin Pharmacol Ther 2021 May 17. Epub 2021 May 17.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Interindividual differences in drug response are a common concern in both drug development and across layers of care. While genetics clearly influences drug response and toxicity of many drugs, a substantial fraction of the heritable pharmacological and toxicological variability remains unexplained by known genetic polymorphisms. In recent years, population-scale sequencing projects have unveiled tens of thousands of coding and noncoding pharmacogenetic variants with unclear functional effects that might explain at least part of this missing heritability. Read More

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Stress-induced cortisol response is associated with right amygdala volume in early childhood.

Neurobiol Stress 2021 May 22;14:100329. Epub 2021 Apr 22.

Department of Psychology & Neuroscience, Duke University, Reuben-Cooke Building, 417 Chapel Drive, Durham, NC, 27708, USA.

Rodent research suggests that dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and the resulting cortisol stress response can alter the structure of the hippocampus and amygdala. Because early-life changes in brain structure can produce later functional impairment and potentially increase risk for psychiatric disorder, it is critical to understand the relationship between the cortisol stress response and brain structure in early childhood. However, no study to date has characterized the concurrent association between cortisol stress response and hippocampal and amygdala volume in young children. Read More

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Development of a multi-functional preclinical device for the treatment of glioblastoma.

Biomed Opt Express 2021 Apr 23;12(4):2264-2279. Epub 2021 Mar 23.

Aix Marseille Univ, CNRS, Centrale Marseille, Institut Fresnel, Marseille, France.

Glioblastoma multiforme (GBM) is one of the most common and aggressive malignant primary brain tumors in adults. The treatment of GBM is limited by the blood-brain barrier (BBB), which limits the diffusion of appropriate concentrations of therapeutic agents at the tumor site. Among experimental therapies, photo-thermal therapy (PTT) mediated by nanoparticles is a promising strategy. Read More

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Transformation of CoO nanoparticles to CoO monitored by TEM and predicted ferromagnetism at the CoO/CoO interface from first principles.

J Mater Chem C Mater 2021 Mar 27;9(17):5662-5675. Epub 2021 Mar 27.

Soft Condensed Matter, Debye Institute for Nanomaterials Science, Utrecht University Princetonplein 5 3584 CC Utrecht The Netherlands

Nanoparticles of CoO and CoO are of paramount importance because of their chemical properties propelling their applications in catalysis and battery materials, and because of their intriguing magnetic properties. Here we elucidate the transformation of CoO nanoparticles to CoO into nanoscale detail by heating in the transmission electron microscope (TEM), and we decipher the energetics and magnetic properties of the CoO/CoO interface from first principles calculations. The transformation was found to start at a temperature of 350 °C, and full conversion of all particles was achieved after heating to 400 °C for 10 minutes. Read More

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