87,549 results match your criteria functional outcomes


Genetic variants modify the associations of concentrations of methylmalonic acid, vitamin B-12, vitamin B-6, and folate with bone mineral density.

Am J Clin Nutr 2021 May 8. Epub 2021 May 8.

Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.

Background: Elevated plasma homocysteine has been found to be associated with an increased risk of osteoporosis, especially hip and vertebral fractures. The plasma concentration of homocysteine is dependent on the activities of several B vitamin-dependent enzymes, such as methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), methionine synthase reductase (MTRR), and cystathionine β-synthase (CBS).

Objectives: We investigated whether genetic variants in some of the genes involved in 1 carbon metabolism modify the association of B vitamin-related measures with bone mineral density (BMD) and strength. Read More

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Development of a patient-reported outcome tool for assessing symptom burden during perioperative care in liver surgery: The MDASI-PeriOp-Hep.

Eur J Oncol Nurs 2021 Apr 28;52:101959. Epub 2021 Apr 28.

Institute for Cancer Care Innovation, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Purpose: Based on the MD Anderson Symptom Inventory (MDASI), we developed a Patient-reported outcomes tool for hepatectomy perioperative care (MDASI-PeriOp-Hep).

Methods: To establish the content validity, we generated PeriOp-Hep-specific candidate items from qualitative interviews of patients (n = 30), and removed items that lacked clinical relevance on the basis of input from panels of patients, caregivers, and clinicians. The psychometric properties of the MDASI-PeriOp-Hep were validated (n = 150). Read More

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Microwave ablation of cT1a renal cell carcinoma: oncologic and functional outcomes at a single center.

Clin Imaging 2021 May 3;76:199-204. Epub 2021 May 3.

Department of Urology, Weill Cornell Medicine/New York Presbyterian, NY, New York, USA; Department of Interventional Radiology, Weill Cornell Medicine/New York Presbyterian, NY, New York, USA. Electronic address:

Purpose: Percutaneous ablation is an established alternative to surgical intervention for small renal masses. Radiofrequency and cryoablation have been studied extensively in the literature. To date, series assessing the efficacy and safety of microwave ablation (MWA) are limited. Read More

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The Venous Occlusion Image Score: A Novel Quantitative Scoring Instrument for Cerebral Venous Sinus Thrombosis.

J Stroke Cerebrovasc Dis 2021 May 5;30(7):105845. Epub 2021 May 5.

Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University, No. 1, Youyi Road, Yuanjiagang, Yuzhong District, Chongqing 400016, P R China. Electronic address:

Purpose: This study aims to test the validity of a new quantitative scoring instrument-the Venous Occlusion Image Score (VOIS), and assess the diagnostic and prognostic value of VOIS for cerebral venous sinus thrombosis (CVST).

Methods: The VOIS divided the major cerebral venous sinuses and internal jugular veins into nine parts of interest. CT venography and DSA source images and reconstruction were extracted from the database, then interpreted and scored independently according to VOIS by a panel of three reviewers. Read More

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Association of Early White Blood Cell Trend with Outcomes in Aneurysmal Subarachnoid Hemorrhage.

World Neurosurg 2021 May 5. Epub 2021 May 5.

Department of Neurology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI.

Background: An increasing white blood cell (WBC) count in early course of aneurysmal subarachnoid hemorrhage (SAH) can indicate a systemic inflammatory state triggered by the initial insult. We sought to determine the significance of the early WBC trend as a potential predictor of outcomes.

Methods: We analyzed a cohort of consecutive patients with aneurysmal SAH. Read More

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Outcomes of Posterior Labral Repair with or without Concomitant High-Grade Glenohumeral Chondral Pathology: a retrospective cohort with minimum 2-year follow-up.

J Shoulder Elbow Surg 2021 May 5. Epub 2021 May 5.

Carolinas Medical Center, Atrium Musculoskeletal Institute, 1025 Morehead Medical Dr., Suite #300, Charlotte, NC, 28204, USA. Electronic address:

Background: The purpose of this study was to compare outcomes of patients who underwent posterior labral repair with and without concomitant glenohumeral chondral pathology.

Methods: A retrospective review was performed on patients ≥ 18 years of age who underwent primary posterior labral repair over 5 years. Charts were reviewed to determine the presence and location of high-grade (Outerbridge Grade III/IV) pathology. Read More

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Bone Marrow Lesions on Preoperative MRI Correlate with Outcomes following Isolated Osteochondral Allograft Transplantation.

Arthroscopy 2021 May 5. Epub 2021 May 5.

Rush University Medical Center, Chicago, IL 60612. Electronic address:

Purpose: The purpose of this study was to investigate the role of preoperative bone marrow lesion (BML) size and location on (1) postoperative patient reported outcomes and (2) postoperative failure and time to failure after osteochondral allograft (OCA) transplantation.

Materials And Methods: Consecutive patients from two senior surgeons who underwent isolated OCA transplantation to the knee from 2009-2018 were identified for the case series. Preoperative magnetic resonance imaging (MRI) was evaluated for BMLs based on two classification systems (Welsch, et al. Read More

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The Efficacy of Platelet-Rich Plasma on Improving Pain and Function for Lateral Epicondylitis: A Systematic Review and Meta-analysis with Risk-of-Bias Assessment.

Arthroscopy 2021 May 5. Epub 2021 May 5.

Department of Orthopaedic Surgery, Keck School of Medicine of USC, Los Angeles, California. Electronic address:

Purpose: To assess the efficacy of PRP for lateral epicondylitis and evaluate its impact on pain and functional outcomes.

Methods: This study followed Preferred Reporting Items and Systematic Reviews and Meta-Analyses guidelines. A comprehensive literature search was conducted in September 2019 and repeated in April 2020 using electronic databases PubMed, MEDLINE, and the Cochrane Library. Read More

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Left ventricular mechanics and cardiovascular outcomes in non-compaction phenotype.

Int J Cardiol 2021 May 5. Epub 2021 May 5.

Department of Cardiology, University Heart Center, University Hospital Zürich, Zurich, Switzerland. Electronic address:

Aims: This study aims at understanding left ventricular (LV) mechanics of non-compaction (LVNC) phenotype using echocardiographic strain analysis and at assessing the association of functional parameters with cardiovascular (CV) outcomes.

Methods And Results: Longitudinal (GLS) and circumferential strain (GCS) as well as rotation of the LV were analyzed in 55 LVNC patients and 55 matched controls. Cardiovascular outcomes were documented for a median follow-up duration of 6 years. Read More

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3-month, 6-month, 9-month, and 12-month respiratory outcomes in patients following COVID-19-related hospitalisation: a prospective study.

Lancet Respir Med 2021 May 5. Epub 2021 May 5.

Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK; Institute for Life Sciences, University of Southampton, Southampton, UK; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Southampton, UK. Electronic address:

Background: The consequences of COVID-19 in those who recover from acute infection requiring hospitalisation have yet to be clearly defined. We aimed to describe the temporal trends in respiratory outcomes over 12 months in patients hospitalised for severe COVID-19 and to investigate the associated risk factors.

Methods: In this prospective, longitudinal, cohort study, patients admitted to hospital for severe COVID-19 who did not require mechanical ventilation were prospectively followed up at 3 months, 6 months, 9 months, and 12 months after discharge from Renmin Hospital of Wuhan University, Wuhan, China. Read More

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Functional Link Convolutional Neural Network for the Classification of Diabetes Mellitus.

Int J Numer Method Biomed Eng 2021 May 8:e3496. Epub 2021 May 8.

Dept. of Computer Science and Engineering, Bennett University, Noida, Uttar Pradesh, India.

Diabetes is a faction of metabolic ailments distinguished by hyperglycemia which is the consequence of a defect ,in the action of insulin, insulin secretion, or both and producing various abnormalities in the human body. In recent years, the utilization of intelligent systems has been expanded in disease classification and numerous researches have been proposed. In this research article, a variant of Convolutional Neural Network i. Read More

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Surgical repair techniques, functional outcome, and return to sports after apophyseal avulsion fractures of the ischial tuberosity in adolescents.

Int Orthop 2021 May 8. Epub 2021 May 8.

Department Orthopeadic and Sports Trauma Surgery, Sportklinik Stuttgart GmbH, Taubenheimstrasse 8, 70372, Stuttgart, Germany.

Purpose: Among juvenile apophyseal avulsion injuries of the pelvis in adolescents, fractures of the ischial tuberosity are rare but sustainably debilitating. Also because informations on surgical repair options are very sparse and so far limited to general reviews, reports of individual cases or heterogeous small case series, practitioners, patients and their parental environment still feel a comprehensible hesitation regarding operative treatment. Therefore we intended to investigate patient related outcome measurements and return to sports rates after different types of surgical intervention in an own case series, so far unprecendented in its size. Read More

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The presence of an additional ventricular chamber does not change the outcome of Fontan circulation: a comparative study.

Eur J Cardiothorac Surg 2021 May 8. Epub 2021 May 8.

Pediatric and Congenital Cardiac Surgery, Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padova, Padova, Italy.

Objectives: The role of an additional ventricle in patients with a functional single ventricle undergoing the Fontan operation has been debated due to conflicting data. Our goal was to report our experience with Fontan circulation for complex congenital heart disease, with a focus on the influence that an additional ventricular chamber may have on early and long-term clinical outcomes.

Methods: We performed a retrospective clinical study including all patients undergoing the Fontan procedure between 1978 and 2019. Read More

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Advanced Oncoplastic Breast Conserving Surgery: Single Institution Experience with 823 Patients.

Chirurgia (Bucur) 2021 Mar-Apr;116(2 Suppl):59-72

Oncoplastic breast conserving surgery (BCS) becomes the standard of care in multidisciplinary breast cancer treatment. From our perspective, the aim of oncoplastic BCS is the best oncological, aesthetic and functional surgical treatment results. The study's objective is to present our approaches to the selection of surgical techniques and determine operative and oncological outcomes of oncoplastic surgery. Read More

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Percutaneous vertebroplasty versus conservative treatment and placebo in osteoporotic vertebral fractures: meta-analysis and critical review of the literature.

Eur Radiol 2021 May 7. Epub 2021 May 7.

Department of Radiology, Virgen de las Nieves University Hospital, Fuerzas Armadas Av. 2, 18014, Granada, Spain.

Objectives: To assess the current evidence regarding the efficacy of percutaneous vertebroplasty (PVP) over conservative treatment (CT) and placebo in osteoporotic vertebral fractures (OVFs) by performing a meta-analysis of randomized controlled trials (RCTs).

Materials And Methods: A systematic search was conducted on PubMed, EMBASE, and Cochrane databases. The main outcomes were pain relief, improvement of functional disability, and quality of life at different time points: short-term (1-2 weeks), medium-term (1-3 months), and long-term (≥ 6 months). Read More

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Association of transport time with adverse outcome in paediatric trauma.

BJS Open 2021 May;5(3)

Department of Clinical Sciences, Paediatrics, Lund University, Lund, Sweden.

Background: It is unclear how the length of prehospital transport time affects outcome in paediatric trauma. This study evaluated the association of transport time from alarm to arrival at hospital with adverse outcome in paediatric trauma patients in Sweden.

Methods: This was a retrospective study based on prospectively collected data from the Swedish trauma registry between 2012 and 2019 of children less than 18 years with major trauma (New Injury Severity Score (NISS) greater than 15). Read More

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A hierarchical expert-guided machine learning framework for clinical decision support systems: an application to traumatic brain injury prognostication.

NPJ Digit Med 2021 May 7;4(1):78. Epub 2021 May 7.

Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.

Prognosis of the long-term functional outcome of traumatic brain injury is essential for personalized management of that injury. Nonetheless, accurate prediction remains unavailable. Although machine learning has shown promise in many fields, including medical diagnosis and prognosis, such models are rarely deployed in real-world settings due to a lack of transparency and trustworthiness. Read More

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Network pharmacology integrated with experimental validation revealed the anti-inflammatory effects of Andrographis paniculata.

Sci Rep 2021 May 7;11(1):9752. Epub 2021 May 7.

Department of Minimally Invasive Spinal Surgery, The Affiliated Hospital of Chengde Medical College, Chengde, 067000, China.

Inflammation is a key factor in the development and complications of various diseases because it has a complex pathogenesis. Andrographis paniculate (Burm. f. Read More

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Reference values and validation of the 1-minute sit-to-stand test in healthy 5-16-year-old youth: a cross-sectional study.

BMJ Open 2021 May 7;11(5):e049143. Epub 2021 May 7.

Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland

Objectives: It is essential to have simple, reliable and valid tests to measure children's functional capacity in schools or medical practice. The 1-minute sit-to-stand (STS) test is a quick fitness test requiring little equipment or space that is increasingly used in both healthy populations and those with chronic disease. We aimed to provide age-specific and sex-specific reference values of STS test in healthy children and adolescents and to evaluate its short-term reliability and construct validity. Read More

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Elective Lumbar Spine Surgery in Depressed Patients: Is it Worth it?

Int J Spine Surg 2021 May 7. Epub 2021 May 7.

Institut Català Traumatologia Medicina Esportiva, Institut Universitari Quirón-Dexeus, Universitat Autònoma de Barcelona, Barcelona, Spain.

Background: The objective of this study is to compare surgical results (pain, function, and satisfaction) between a group of depressed patients and a nondepressed group who had been operated on for a degenerative lumbar condition.

Methods: Prospective observational study. Preoperative pain (lumbar and radicular visual analog scale [VAS]), function (Oswestry Disability Index [ODI]), and depression (Zung depression scale) data were collected in patients listed to be operated on for a lumbar degenerative condition. Read More

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In response to letter to the editor regarding: Functional outcomes after extracapsular dissection with partial facial nerve dissection for small and large parotid neoplasms.

Am J Otolaryngol 2021 Apr 21:103071. Epub 2021 Apr 21.

Rush Medical College, Rush University Medical Center, 1725 West Harrison Street, Suite 855, Chicago, IL 60612, United States of America.

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A Systematic Review of the Impact of Surgeon and Hospital Caseload Volume on Oncological and Nononcological Outcomes After Radical Prostatectomy for Nonmetastatic Prostate Cancer.

Eur Urol 2021 May 4. Epub 2021 May 4.

Department of Urology, University Hospital, St. Etienne, France.

Context: The impact of surgeon and hospital volume on outcomes after radical prostatectomy (RP) for localised prostate cancer (PCa) remains unknown.

Objective: To perform a systematic review on the association between surgeon or hospital volume and oncological and nononcological outcomes following RP for PCa.

Evidence Acquisition: Medline, Medline In-Process, Embase, and the Cochrane Central Register of Controlled Trials were searched. Read More

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Predictors of no-reflow phenomenon following percutaneous coronary intervention for ST-segment elevation myocardial infarction.

Ann Cardiol Angeiol (Paris) 2021 May 4. Epub 2021 May 4.

ABVIMS and Dr RML Hospital, New Delhi, India. Electronic address:

Objectives: No reflow during percutaneous coronary intervention (PCI) is a complex issue with serious outcomes. Multiple studies have studied predictors of no-reflow during primary PCI, but data on patients with the late presentation is sparse, which constitutes the majority of patients in peripheral centers. This study aimed to determine predictors of no-reflow during PCI in patients with ST-segment elevation myocardial infarction (STEMI) in 7 days. Read More

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Neurocognitive Empowerment for Addiction Treatment (NEAT): study protocol for a randomized controlled trial.

Trials 2021 May 7;22(1):330. Epub 2021 May 7.

Laureate Institute for Brain Research, 6655 South Yale Ave., Tulsa, OK, 74136, USA.

Background: Neurocognitive deficits (NCDs) and associated meta-cognition difficulties associated with chronic substance use often delay the learning and change process necessary for addiction recovery and relapse prevention. However, very few cognitive remediation programs have been developed to target NCDs and meta-cognition for substance users. The study described herein aims to investigate the efficacy of a multi-component neurocognitive rehabilitation and awareness program termed "Neurocognitive Empowerment for Addiction Treatment" (NEAT). Read More

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Education With Therapeutic Alliance Did Not Influence the Improvement of Symptoms of Patients With Chronic Low Back Pain and Low Risk of Poor Prognosis Compared to Education Without Therapeutic Alliance: A Randomized Controlled Trial.

J Orthop Sports Phys Ther 2021 May 7:1-26. Epub 2021 May 7.

Master's and Doctoral Program in Physical Therapy, Universidade Cidade de São Paulo, São Paulo, SP, Brazil.

Objectives: To assess the effectiveness of an educational intervention with or without the addition of the therapeutic alliance in patients with nonspecific chronic low back pain (LBP) and low risk of poor prognosis.

Design: Randomized controlled trial. Randomization was performed using random generated numbers. Read More

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The safety profile and angioarchitectural changes after acute targeted embolization of ruptured arteriovenous malformations.

J Neurosurg 2021 May 7:1-10. Epub 2021 May 7.

2Division of Neuroradiology, Department of Medical Imaging, and.

Objective: The aim of this study was to 1) compare the safety and efficacy of acute targeted embolization of angiographic weak points in ruptured brain arteriovenous malformations (bAVMs) versus delayed treatment, and 2) explore the angioarchitectural changes that follow this intervention.

Methods: The authors conducted a retrospective analysis of a prospectively acquired database of ruptured bAVMs. Three hundred sixteen patients with ruptured bAVMs who presented to the hospital within 48 hours of ictus were included in the analysis. Read More

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Ortho_Sim_Loc: Essential protein prediction using orthology and priority-based similarity approach.

Comput Biol Chem 2021 Apr 28;92:107503. Epub 2021 Apr 28.

Department of Computer Science & Engineering, Netaji Subhash Engineering College, Techno City, Panchpota, Garia, Kolkata, 700152, India. Electronic address:

Proteins are the essential macro-molecules of living organism. But all proteins cannot be considered as essential in different relevant studies. Essentiality of a protein is thus computed by computation methods rather than biological experiments which in turn save both time and effort. Read More

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Long-term follow-up after acute achilles tendon rupture - Does treatment strategy influence functional outcomes?

Foot (Edinb) 2021 Jan 13;47:101769. Epub 2021 Jan 13.

Orthopaedic Research Unit, Aalborg University Hospital, Aalborg, Denmark; Physiotherapy and Occupational Therapy, Aalborg University Hospital, Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark. Electronic address:

Background: Patients struggle to fully recover after an Achilles tendon rupture. Although several studies has investigated surgical and non-surgical treatment, the best treatment is still uncertain. The aim of this study was to investigate long-term patient-reported outcomes and objective measures 4 years after acute Achilles tendon rupture and compare whether outcomes differed between patients treated on basis of the previous regimen preferring surgical treatment and the new regimen preferring functional rehabilitation. Read More

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January 2021

Kidney Transplantation in Monoclonal Immunoglobulin Deposition Disease: A Report of 6 Cases.

Am J Kidney Dis 2021 May 4. Epub 2021 May 4.

Nephrology and Renal Transplantation Department, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain. Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Barcelona, Spain; Amyloidosis and Myeloma Unit.Hospital Clínic de Barcelona; Centro de Referencia en Enfermedad Glomerular Compleja del Sistema Nacional de Salud (CSUR), Barcelona, Spain. Electronic address:

Monoclonal immunoglobulin deposition disease (MIDD) usually leads to kidney failure. Treatment of patients with a bortezomib-based regimen followed by autologous stem cell transplantation has been increasingly used, with improvements in the response rates and the allograft outcomes in kidney transplant recipients. The objective of this report was to analyze the outcomes of 6 patients who underwent kidney transplantation in our institution after treatment of MIDD between 2010 and 2019. Read More

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Response and Adherence of Nursing Home Residents to a Nutrition/Exercise Intervention.

J Am Med Dir Assoc 2021 May 4. Epub 2021 May 4.

Stockholms Sjukhem R&D Unit, Stockholm, Sweden; Theme Aging, Karolinska University Hospital, Stockholm, Sweden; Division of Nursing, Department of Neurobiology, Care Science and Society, Karolinska Institutet, Stockholm, Sweden.

Objectives: Interindividual response variability to nutrition and exercise interventions is extensive in older adults. A group of nursing home (NH) residents participated in a combined intervention. The objective of this post-hoc analysis was to identify factors associated with intervention response measured by change in physical function and body composition. Read More

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