102,059 results match your criteria functional outcomes

Complications, Readmissions, Reoperations and Patient-Reported Outcomes in Patients with Multiple Sclerosis Undergoing Elective Spine Surgery- a Propensity Matched Analysis.

Spine J 2022 Jun 29. Epub 2022 Jun 29.

Department of Orthopaedic Surgery, Vanderbilt University Medical Center, 1215 21st Ave S #3200, Nashville, TN 37232; Center for Musculoskeletal Research, Vanderbilt University Medical Center, 1211 Medical Center Dr, Nashville, TN 37232; Department of Neurological Surgery, Vanderbilt University Medical Center, The Village at Vanderbilt, 1500 21st Ave S Suite 1506, Nashville, TN 37212. Electronic address:

Background Context: Multiple sclerosis (MS) is an autoimmune, neurodegenerative disease that can lead to significant functional disability. Improving treatment regimens have extended life expectancy and led to an increase in the number of elective spine surgeries for degenerative conditions in the MS population. Recent literature has reported mixed results regarding the efficacy of elective spine surgery for patients with MS. Read More

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Fast transition from open surgery to endovascular treatment of unruptured anterior communicating artery aneurysms - a retrospective analysis of 128 patients.

World Neurosurg 2022 Jun 29. Epub 2022 Jun 29.

Department of Neurosurgery, Helsinki University Hospital, Helsinki, Finland.

Objective: Anterior communicating artery aneurysms (ACoAAs) are challenging to treat both surgically and endovascularly. In this study, we evaluate the treatment-related morbidity and clinical outcome of microsurgical clipping and endovascular treatment for a consecutive series of unruptured ACoAAs while the treatment paradigm was in transition from surgical to endovascular first.

Methods: We retrospectively reviewed clinical and radiological data of adult patients who underwent microsurgical clipping or endovascular treatment of an unruptured ACoAAs at a high-volume academic neurovascular center (Helsinki University Hospital) during 2012-2019. Read More

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Risk Factors for Post-Repair Elevated Mitral Gradient: A Post-Hoc Analysis of a Randomized Trial.

Ann Thorac Surg 2022 Jun 29. Epub 2022 Jun 29.

Division of Cardiac Surgery, Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, ON, Canada; Department of Surgery, University of Toronto, ON, Canada; Department of Pharmacology and Toxicology, University of Toronto, ON, Canada. Electronic address:

Background: Pre-discharge elevated mean mitral gradients (>5mmHg) may occur after repair for degenerative mitral regurgitation. We sought to identify risk factors associated with elevated gradients as well as to evaluate its impact on functional outcomes at 12 months in this sub-analysis of the Canadian Mitral Research Alliance (CAMRA) CardioLink-2 trial.

Methods: 104 degenerative mitral regurgitation patients undergoing mitral repair were randomized to either a leaflet resection or preservation strategy. Read More

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Impact of end-capped modification of MO-IDT based non-fullerene small molecule acceptors to improve the photovoltaic properties of organic solar cells.

J Mol Graph Model 2022 Jun 21;116:108255. Epub 2022 Jun 21.

Department of Chemistry, University of Agriculture, Faisalabad, 38000, Pakistan. Electronic address:

Density functional theory, along with its time dependent computational approach were employed in order to fine tune the photovoltaic attributes along with the efficiency of the MO-IDIC-2F molecule. Thus, five new molecules were designed by substitution of the different notable acceptor fragments in the MO-IDIC-2F molecule, along with the addition of the "[1, 2, 5] thiadiazolo[3,4-d] pyridazine" spacer moieties between donor core and newly substituted acceptor groups. In this research work, various photovoltaic properties, which could affect the efficiency of an organic chromophores, such as bandgap, oscillator strength, dipole moment, binding energy, light-harvesting efficiency, etc. Read More

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Patient-reported outcome measures for assessing health-related quality of life in people with type 2 diabetes: A systematic review.

Rev Endocr Metab Disord 2022 Jul 2. Epub 2022 Jul 2.

Epidemiology and Data Science, Amsterdam UMC, Location Vrije Universiteit Amsterdam, de Boelelaan 1117, Amsterdam, Netherlands.

Patient-Reported Outcome Measures (PROMs) are important tools to assess outcomes relevant to patients, with Health-Related Quality Of Life (HRQOL) as an important construct to be measured. Many different HRQOL PROMs are used in the type 2 diabetes field, however a complete overview of these PROMs is currently lacking. We therefore aimed to systematically describe and classify the content of all PROMs that have specifically been developed or validated to measure (aspects of) HRQOL in people with type 2 diabetes. Read More

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The Association Between the Occurrence of Common Treatment-Emergent Adverse Events and Efficacy Outcomes After Lasmiditan Treatment of a Single Migraine Attack: Secondary Analyses from Four Pooled Randomized Clinical Trials.

CNS Drugs 2022 Jul 2. Epub 2022 Jul 2.

Albert Einstein School of Medicine, Bronx, NY, USA.

Background: In controlled clinical trials, compared with placebo, a significantly greater proportion of participants using lasmiditan to treat a migraine attack achieved 2-h pain freedom (PF) and experienced ≥ 1 treatment-emergent adverse event (TEAE).

Objective: To better inform clinicians about treatment expectations by evaluating the association between TEAEs and efficacy outcomes after lasmiditan treatment.

Methods: Pooled data from SAMURAI, SPARTAN, MONONOFU, and CENTURION were analyzed. Read More

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Risk Factors for Feeding Tube Dependency in Patients Undergoing Function Preservation Surgery for Advanced-Stage Laryngohypopharyngeal Cancer.

Dysphagia 2022 Jul 2. Epub 2022 Jul 2.

Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Dysphagia and feeding tube dependency commonly occur in patients with laryngeal or hypopharyngeal cancer (LHC) during and after treatment, often leading to poor functional outcomes. Therefore, we examined the factors related to feeding tube dependency among advanced-stage LHC patients undergoing curative surgery. This study included 69 consecutive patients who underwent conservative surgery for previously untreated, advanced-stage LHC (squamous cell carcinoma) between 2006 and 2016. Read More

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Chronic critical illness and post-intensive care syndrome: from pathophysiology to clinical challenges.

Ann Intensive Care 2022 Jul 2;12(1):58. Epub 2022 Jul 2.

Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, 94143, USA.

Background: Post-intensive care syndrome (PICS) encompasses physical, cognition, and mental impairments persisting after intensive care unit (ICU) discharge. Ultimately it significantly impacts the long-term prognosis, both in functional outcomes and survival. Thus, survivors often develop permanent disabilities, consume a lot of healthcare resources, and may experience prolonged suffering. Read More

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Do Patients With Chronic Diabetes Have Worse Motor Outcomes After Cervical ASIA C Traumatic Spinal Cord Injury?

Clin Spine Surg 2022 Jun 29. Epub 2022 Jun 29.

Department of Orthopedic Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH.

Study Design: This was a level IV retrospective prognostic study.

Objective: The objective of this study was to determine if patients with chronic diabetes have worse functional outcomes and motor recovery after cervical traumatic spinal cord injury (TSCI).

Summary Of Background Data: Diabetes mellitus has multiple deleterious neurological effects and has been shown to worsen elective cervical spine surgery outcomes. Read More

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Immunotherapy for people with clinically isolated syndrome or relapsing-remitting multiple sclerosis: treatment response by demographic, clinical, and biomarker subgroups (PROMISE)-a systematic review protocol.

Syst Rev 2022 Jul 1;11(1):134. Epub 2022 Jul 1.

Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.

Background: Multiple sclerosis (MS) is an inflammatory and degenerative disease of the central nervous system with an increasing worldwide prevalence. Since 1993, more than 15 disease-modifying immunotherapies (DMTs) have been licenced and have shown moderate efficacy in clinical trials. Based on the heterogeneity of the disease and the partial effectiveness of therapies, a personalised medicine approach would be valuable taking individual prognosis and suitability of a chosen therapy into account to gain the best possible treatment effect. Read More

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Patient Experience in Early-Stage Parkinson's Disease: Using a Mixed Methods Analysis to Identify Which Concepts Are Cardinal for Clinical Trial Outcome Assessment.

Neurol Ther 2022 Jul 1. Epub 2022 Jul 1.

Parkinson's Foundation, New York, NY, USA.

Introduction: Qualitative research on patient experiences in early-stage Parkinson's disease (PD) is limited. It is increasingly acknowledged that clinical outcome assessments used in trials do not fully capture the range of symptoms/impacts that are meaningful to people with early-stage PD. We aimed to conceptualize the patient experience in early-stage PD and identify, from the patient perspective, those cardinal symptoms/impacts which might be more useful to measure in clinical trials. Read More

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InSpace Implant Compared with Partial Repair for the Treatment of Full-Thickness Massive Rotator Cuff Tears: A Multicenter, Single-Blinded, Randomized Controlled Trial.

J Bone Joint Surg Am 2022 Apr 22. Epub 2022 Apr 22.

Division of Shoulder and Elbow Surgery, The Sidney Kimmel Medical College, Thomas Jefferson University, Rothman Orthopaedic Institute, Philadelphia, Pennsylvania.

Background: The purpose of this study was to prospectively evaluate the efficacy and safety of a subacromial balloon spacer (InSpace implant; Stryker) compared with arthroscopic partial repair in patients with irreparable, posterosuperior massive rotator cuff tears.

Methods: Patients ≥40 years of age with symptomatic, irreparable, posterosuperior, massive rotator cuff tears and an intact subscapularis who underwent failed nonoperative management were included in this randomized controlled trial comparing the InSpace implant with partial repair. Clinical outcome data were collected at baseline through a 24-month follow-up. Read More

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Identifying the top research priorities in medically not yet explained symptoms (MNYES): a James Lind Alliance priority setting partnership.

BMJ Open 2022 Jul 1;12(7):e061263. Epub 2022 Jul 1.

James Lind Alliance, Southampton, UK.

Objectives: This study establishes research priorities for medically not yet explained symptoms (MNYES), also known as persistent physical symptoms or medically unexplained symptoms, from the perspective of patients, caregivers and clinicians, in a priority setting partnership (PSP) following the James Lind Alliance (JLA) approach. Research into such symptoms in general has been poorly funded over the years and so far has been primarily researcher-led with minimal input from patients, caregivers and clinicians; and sometimes has been controversial.

Design: JLA PSP method. Read More

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Recovery in Stroke Patients Treated With Fluoxetine Versus Placebo: A Pooled Analysis of 7165 Patients.

Neurologist 2022 Jul 1. Epub 2022 Jul 1.

Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Background: Stroke is a major cause of disability and death. Stroke recovery outcomes range from functional impairment to disability. This study was designed to compare the recovery results of stroke patients treated with fluoxetine to those treated with placebo. Read More

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Emergency department evaluation, treatment, and functional outcomes among patients presenting with low back pain.

Am J Emerg Med 2022 Jun 25;59:37-41. Epub 2022 Jun 25.

University of Utah, Salt Lake City, UT, United States of America. Electronic address:

Objectives: Low back pain (LBP) leads to more than 4.3 million emergency department (ED) visits annually. Despite the number of ED visits for LBP, emergency medicine societies have not established clear guidelines for the evaluation and care of these patients. Read More

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Stroke severity modified the effect of chronic atrial fibrillation on the outcome of thrombolytic therapy.

Medicine (Baltimore) 2022 Jul 1;101(26):e29322. Epub 2022 Jul 1.

Neurological Intensive Care Department, Shengli Oilfield Central Hospital, Dongying City, Shandong Province, China.

There is conflicting information regarding the impact of chronic atrial fibrillation (AF) on the outcomes of thrombolyzed patients with stroke. This study was designed to identify high-risk patients with chronic AF who had undergone thrombolysis treatment and to explore whether the baseline National Institutes of Health Stroke Scale (NIHSS) could be used to distinguish poor clinical outcomes in thrombolyzed patients. A total of 164 acute ischemic stroke patients with chronic AF were enrolled in this study. Read More

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Functional outcomes of COVID-19 patients with acute ischemic stroke: A prospective, observational, single-center study in North Jordan.

Medicine (Baltimore) 2022 Jul 1;101(26):e29834. Epub 2022 Jul 1.

Department of Neurosciences, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.

We assessed whether stroke severity, functional outcome, and mortality in patients with ischemic stroke differed between patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and those without. We conducted a prospective, single-center cohort study in Irbid, North Jordan. All patients diagnosed with ischemic stroke and SARS-CoV-2 infection were consecutively recruited from October 15, 2020, to October 16, 2021. Read More

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A prospective study on sex differences in functional capacity, quality of life and prognosis in patients with heart failure.

Medicine (Baltimore) 2022 Jul 1;101(26):e29795. Epub 2022 Jul 1.

Cardiology Department, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.

Background: Due to the lack of evidence and inconsistency of sex differences in Heart failure (HF) in the Chinese population, this study aimed to compare sex differences in functional capacity and quality of life (QoL) between women and men after standard HF medications therapies, and analyze whether sex differences were associated with the composite endpoints of all-cause mortality or HF-related hospitalization and cardiac event-free survival rate in Chinese patients with HF.

Methods: This was a 1-year longitudinal study. Participants included patients with HF from March 2017 to December 2018. Read More

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Plasma neurofilament light chain: A biomarker predicting severity in patients with acute ischemic stroke.

Medicine (Baltimore) 2022 Jul 1;101(26):e29692. Epub 2022 Jul 1.

Department of Neurology, Bengbu First People's Hospital, Bengbu, Anhui Province, China.

Neurofilament light chain (NfL) levels have proved to be a good biomarker in cerebrospinal fluid (CSF) correlating with the degree of neuronal injury and neurodegeneration. However, little is known about the value of plasma neurofilament light chain (pNfL) levels in predicting the clinical prognosis of patients with acute cerebral infarction. This study aimed to explore whether pNfL could be used as a biomarker to predict the severity of the outcomes of acute ischemic stroke (AIS). Read More

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A Polygenic Risk Score for Hand Grip Strength Predicts Muscle Strength and Proximal and Distal Functional Outcomes among Older Women.

Med Sci Sports Exerc 2022 Jun 30. Epub 2022 Jun 30.

Institute for Molecular Medicine Finland, Helsinki, FINLAND.

Purpose: Hand grip strength (HGS) is a widely used indicator of overall muscle strength and general health. We computed a polygenic risk score (PRS) for HGS, and examined, whether it predicted muscle strength, functional capacity and disability outcomes.

Methods: Genome-wide association study summary statistics for HGS from the Pan-UK Biobank was utilized. Read More

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Induction of antigenic immune tolerance to delay type 1 diabetes - challenges for clinical translation.

Curr Opin Endocrinol Diabetes Obes 2022 Jul 4. Epub 2022 Jul 4.

Global Chief Medical Office, Novo Nordisk A/S, Søborg, Denmark.

Purpose Of Review: Dissect the field of antigen-specific immunotherapy (ASIT) in type 1 diabetes (T1D), highlighting the major barriers currently blocking clinical translation.

Recent Findings: ASIT remains a promising approach in T1D to re-establish the proper balance in the immune system to avoid the autoimmune-mediated attack or destruction of beta-cells in the pancreas. Despite some encouraging preclinical results, ASIT has not yet successfully translated into clinical utility, predominantly due to the lack of validated and clinically useful biomarkers. Read More

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Tourniquet use in total knee arthroplasty and the risk of infection: a meta-analysis of randomised controlled trials.

J Exp Orthop 2022 Jul 1;9(1):62. Epub 2022 Jul 1.

Department of Trauma and Orthopaedic Surgery, University College Hospital, 235 Euston Road, Fitzrovia, London, NW1 2BU, UK.

Purpose: The intra-operative use of tourniquets during Total Knee Arthroplasty (TKA) is common practice. The advantages of tourniquet use include decreased operating time and the creation of a bloodless visualisation field. However, tourniquet use has recently been linked with increased post-operative pain, reduced range of motion, and slower functional recovery. Read More

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Surgical treatment of adrenal tumors during pregnancy.

Rev Endocr Metab Disord 2022 Jul 1. Epub 2022 Jul 1.

Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.

While most adrenal tumors are identified incidentally and are non-functional, hormone-secreting tumors can cause morbidity and mortality. Hemodynamic lability and hypertension in pregnancy are associated with worse maternal and fetal outcomes. Achieving a diagnosis of hormone excess due to adrenal tumors can be clinically more difficult in the gravid patient due to normal physiologic alterations in hormones and symptoms related to pregnancy. Read More

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Community-based outpatient cancer rehabilitation services for women with gynecologic cancer: acceptability and impact on patient-reported outcomes.

Support Care Cancer 2022 Jul 1. Epub 2022 Jul 1.

Select Medical, ReVital Cancer Rehabilitation, 4714 Gettysburg Rd, Mechanicsburg, PA, 17055, USA.

Objective: Women with gynecologic cancers often experience functional impairments impacting quality of life. Physical and occupational therapy (PT/OT) treat functional impairment; however, the acceptability and impact of these services for women with gynecologic cancer are unknown.

Methods: We reviewed rehabilitation charts of women with gynecologic cancer who received PT/OT (i. Read More

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Revision surgery for periprosthetic elbow infection: eradication rate, complications, and functional outcomes-a systematic review.

Arch Orthop Trauma Surg 2022 Jul 1. Epub 2022 Jul 1.

Department of Orthopaedic and Trauma Surgery, "Mater Domini" University Hospital, "Magna Græcia" University, V.le Europa, (Loc. Germaneto), 88100, Catanzaro, Italy.

Introduction: The aim of this systematic review was to investigate the outcomes of revision surgery after periprosthetic elbow infection (PEI).

Material And Methods: Eighteen studies with 332 PEI that underwent revision surgery were included. Demographics, laboratory and microbiological data, types of implants, surgical techniques with complications and reoperations, eradication rates, and clinical and functional outcomes were reported. Read More

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No evidence in support of arthroscopic partial meniscectomy in adults with degenerative and nonobstructive meniscal symptoms: a level I evidence-based systematic review.

Knee Surg Sports Traumatol Arthrosc 2022 Jul 1. Epub 2022 Jul 1.

Department of Medicine, Surgery and Dentistry, University of Salerno, 84081, Baronissi, SA, Italy.

Purpose: It is unclear whether the results of arthroscopic partial meniscectomy (APM) are comparable to a structured physical therapy (PT). This systematic review investigated efficacy of APM in the management of symptomatic meniscal damages in middle aged patients. Current available randomised controlled trials (RCTs) which compared APM performed in isolation or combined with physical therapy versus sham arthroscopy or isolated physical therapy were considered in the present systematic review. Read More

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Commercial Sexual Exploitation During Adolescence: A US-Based National Study of Adolescent to Adult Health.

Public Health Rep 2022 Jul-Aug;137(1_suppl):53S-62S

8783 Department of Pediatrics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA.

Objectives: National data on the health of children and adolescents exposed to commercial sexual exploitation (CSE) are lacking, during both adolescence and adulthood. Using nationally representative data, we examined the health of male and female adolescents in grades 7-12 who experienced CSE exposure and subsequent adult health outcomes and access to health care.

Methods: Our retrospective cohort study used data from Waves I-IV of the National Longitudinal Study of Adolescent to Adult Health (1994-2008) to characterize relationships between CSE exposure before or during adolescence and health during adolescence and adulthood. Read More

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[Long-term outcome follow-up of Oxford unicompartmental knee arthroplasty for medial compartment osteoarthropathy:a single center's experience for 10 years].

Zhonghua Wai Ke Za Zhi 2022 Jul;60(7):703-708

Department of Orthopedics,the Affiliated Hospital of Qingdao University,Qingdao 266000,China.

To investigate the long-term outcomes of minimally invasive Oxford phase Ⅲ unicompartmental knee arthroplasty (UKA) for patients with medial compartment osteoarthropathy. The clinical data of 594 patients (701 knees) who underwent minimally invasive UKA with Oxford phase Ⅲ unicompartmental prosthesis at Department of Orthopedics,the Affiliated Hospital of Qingdao University from January 2007 to January 2016 were retrospectively analyzed.There were 155 males and 439 females,aged (62. Read More

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Surgical challenges, novel techniques, and systemic treatment of giant cell tumour of bone of the distal radius : clinical outcomes and systematic review of the literature.

Bone Jt Open 2022 Jul;3(7):515-528

Orthopaedic Oncology and Reconstructive Surgery, Azienda Ospedaliero Universitaria Careggi, Florence, Italy.

Aims: Giant cell tumour of bone (GCTB) treatment changed since the introduction of denosumab from purely surgical towards a multidisciplinary approach, with recent concerns of higher recurrence rates after denosumab. We evaluated oncological, surgical, and functional outcomes for distal radius GCTB, with a critically appraised systematic literature review.

Methods: We included 76 patients with distal radius GCTB in three sarcoma centres (1990 to 2019). Read More

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Oxidized zirconium versus cobalt-chrome femoral heads in total hip arthroplasty: a multicentre prospective randomized controlled trial with ten years' follow-up.

Bone Joint J 2022 Jul;104-B(7):833-843

Department of Trauma and Orthopaedics, University College Hospital, London, UK.

Aims: This study reports the ten-year wear rates, incidence of osteolysis, clinical outcomes, and complications of a multicentre randomized controlled trial comparing oxidized zirconium (OxZr) versus cobalt-chrome (CoCr) femoral heads with ultra-high molecular weight polyethylene (UHMWPE) and highly cross-linked polyethylene (XLPE) liners in total hip arthroplasty (THA).

Methods: Patients undergoing primary THA were recruited from four institutions and prospectively allocated to the following treatment groups: Group A, CoCr femoral head with XLPE liner; Group B, OxZr femoral head with XLPE liner; and Group C, OxZr femoral head with UHMWPE liner. All study patients and assessors recording outcomes were blinded to the treatment groups. Read More

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