51,899 results match your criteria functional impairment

Functional outcome of ligament reconstruction with tendon interposition after failed first carpometacarpal joint prosthesis.

Acta Orthop Belg 2021 Mar;87(1):137-142

The purpose is to determine if ligament reconstruction with tendon interposition (LRTI) is a recommendable salvage option for failed total joint prosthesis of the first carpometacarpal joint. Twenty-two patients in our database met the in- clusion criteria for this retrospective study, with at least 6 months follow-up. Fourteen participated and were invited for a clinical examination and asked to fill out two questionnaires. Read More

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Treatment for grade 4 peripheral intravenous infiltration with type 3 skin tears: A case report and literature review.

Int Wound J 2021 Jun 15. Epub 2021 Jun 15.

Ottawa Hospital Research Institute Clinical Epidemiology Program, Ottawa, Ontario, Canada.

Grade 4 peripheral intravenous infiltration with skin tears has seldom been reported. On 4 August 2020, a 35-year-old female patient was admitted to the emergency department of our hospital because of postprandial abdominal pain for 2 hours. She was diagnosed with a severe acute pancreatitis with type II diabetes mellitus. Read More

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The phosphatase PRL-3 affects intestinal homeostasis by altering the crypt cell composition.

J Mol Med (Berl) 2021 Jun 15. Epub 2021 Jun 15.

European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany.

Expression of the phosphatase of regenerating liver-3 (PRL-3) is known to promote tumor growth in gastrointestinal adenocarcinomas, and the incidence of tumor formation upon inflammatory events correlates with PRL-3 levels in mouse models. These carcinomas and their onset are associated with the impairment of intestinal cell homeostasis, which is regulated by a balanced number of Paneth cells and Lgr5 expressing intestinal stem cells (Lgr5+ ISCs). Nevertheless, the consequences of PRL-3 overexpression on cellular homeostasis and ISC fitness in vivo are unexplored. Read More

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Chronic Pelvic Pain in Women: A Review.

JAMA 2021 Jun;325(23):2381-2391

Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles.

Importance: Chronic pelvic pain (CPP) is a challenging condition that affects an estimated 26% of the world's female population. Chronic pelvic pain accounts for 40% of laparoscopies and 12% of hysterectomies in the US annually even though the origin of CPP is not gynecologic in 80% of patients. Both patients and clinicians are often frustrated by a perceived lack of treatments. Read More

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Similarities between Cognitive Models of Language Production and Everyday Functioning: Implications for Development of Interventions for Functional Difficulties.

Top Cogn Sci 2021 Jun 14. Epub 2021 Jun 14.

Department of Psychology, Temple University.

The loss of the ability to independently complete activities of daily living, such as meal preparation and household chores, is a defining characteristic of clinical dementia; however, minor difficulties in completing everyday activities emerge in the mild cognitive impairment stage, and even healthy older adults exhibit subtle functional difficulties compared to younger adults. These functional difficulties are associated with an array of negative outcomes, including decreased quality of life, higher costs of care, and increased frustration, depression, caregiver burden, and institutionalization. While cognitive models have been proposed to explain the functional deficits seen in dementia and subtler forms of cognitive decline, in contrast to other cognitive disorders such as aphasia, there are essentially no theoretically motivated interventions to address difficulties in everyday functioning. Read More

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Hypertension-induced cognitive impairment: from pathophysiology to public health.

Nat Rev Nephrol 2021 Jun 14. Epub 2021 Jun 14.

Vascular Cognitive Impairment and Neurodegeneration Program, Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Hypertension affects two-thirds of people aged >60 years and significantly increases the risk of both vascular cognitive impairment and Alzheimer's disease. Hypertension compromises the structural and functional integrity of the cerebral microcirculation, promoting microvascular rarefaction, cerebromicrovascular endothelial dysfunction and neurovascular uncoupling, which impair cerebral blood supply. In addition, hypertension disrupts the blood-brain barrier, promoting neuroinflammation and exacerbation of amyloid pathologies. Read More

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Long-Term Effectiveness of Lurasidone in Pediatric Bipolar Depression: Response, Remission and Recovery.

CNS Spectr 2021 Apr;26(2):148

Sunovion Pharmaceuticals Inc., Marlborough, MA, USA.

Background: Bipolar disorder frequently has an early onset, with an estimated 1.8% prevalence of bipolar I disorder in children and adolescents. Childhood onset of bipolar disorder is typically associated with a chronic, severe, and disabling course of illness. Read More

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Efficacy of Lurasidone in Antipsychotic-Naive vs. Antipsychotic-Exposed Adolescents with Schizophrenia: Post-Hoc Analysis of a Two-Year, Open-Label Study.

CNS Spectr 2021 Apr;26(2):147

Sunovion Pharmaceuticals Inc., Fort Lee, NJ and Marlborough, MA, USA.

Background: Few studies have examined treatment response in adolescents with schizophrenia who are treatment-naive; and there is no placebo-controlled study that we are aware of in first episode treatment-naive patients with schizophrenia. The aim of this analysis was to evaluate the long-term efficacy of lurasidone in antipsychotic-naive adolescents with schizophrenia.

Method: Patients aged 13-17 years with schizophrenia, and a PANSS total score ≥70 and <120, were randomized to 6 weeks of double-blind (DB) treatment with lurasidone (40 or 80 mg/day) or placebo. Read More

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An innovative training based on robotics for older people with subacute stroke: study protocol for a randomized controlled trial.

Trials 2021 Jun 14;22(1):400. Epub 2021 Jun 14.

Clinical Unit of Physical Rehabilitation, IRCCS INRCA, Ancona, Italy.

Background: Stroke is a leading cause of disability, injury, and death in elderly people and represents a major public health problem with substantial medical and economic consequences. The incidence of stroke rapidly increases with age, doubling for each decade after age 55 years. Gait impairment is one of the most important problems after stroke, and improving walking function is often a key component of any rehabilitation program. Read More

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A pH ratiometrically responsive surface enhanced resonance Raman scattering probe for tumor acidic margin delineation and image-guided surgery.

Chem Sci 2020 Apr 7;11(17):4397-4402. Epub 2020 Apr 7.

Key Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University Shanghai 201203 China

Surgery remains the mainstay for most solid tumor treatments. However, surgeons face challenges in intra-operatively identifying invasive tumor margins due to their infiltrative nature. Incomplete excision usually leads to early recurrence, while aggressive resection may injure adjacent functional tissues. Read More

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Hypertrophic olivary degeneration following cerebral trauma managed with rehabilitation - A case report.

J Pak Med Assoc 2021 Apr;71(4):1252-1254

Department of Rehabilitation Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Hypertrophic olivary degeneration is a kind of trans-synaptic degeneration, caused by the interruption of dentato rubro olivary pathway. Magnetic resonance imaging (MRI) has been the best modality to show the signals of olivary nucleus hypertrophy. It appears on T2-weighted magnetic resonance imaging as hyper-intensities. Read More

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The generalizability of empirically derived syndromes of collateral-reported elder psychopathology across 11 societies.

Res Nurs Health 2021 Jun 14. Epub 2021 Jun 14.

Department of Psychology, Academia Pedagogiki Specjalnej, University of Warsaw, Warsaw, Poland.

The purpose of this study was to test whether a syndrome model of elder psychopathology derived from collateral ratings, such as from spouses and adult children, in the United States would be generalizable in 11 other societies. Societies represented South America, Asia, and Europe. The Older Adult Behavior Checklist (OABCL) was completed by collateral informants for 6141 60- to 102-year-olds. Read More

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Navigating the Cancer Screening Decision for Patients with Dementia.

Curr Oncol Rep 2021 Jun 14;23(8):90. Epub 2021 Jun 14.

Icahn School of Medicine at Mount Sinai Hospital, One Gustave Levy L. Place, Box 1070, New York, NY, 10029, USA.

Purpose Of Review: The risks of developing cancer and dementia both increase with age, giving rise to the complex question of whether continued cancer screening for older dementia patients is appropriate. This paper offers a practice-based clinical approach to determine an answer to this challenging question.

Recent Findings: There is no consensus on the prevalence of cancer and dementia as co-diagnoses. Read More

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The Cognitive Scale of Basic and Instrumental Activities of Daily Living for Multidomain Mild Cognitive Impairment and Dementia Patients: Validation of its Extended Version.

J Int Neuropsychol Soc 2021 Jun 14:1-14. Epub 2021 Jun 14.

Department of Physiotherapy (Occupational Therapy), University of Malaga, Malaga, Spain.

Objective: To validate an informant-based tool - the extended version of the Cognitive Scale of Basic and Instrumental Activities of Daily Living (BADL and IADL) or Ext. Cog-ADL Scale - in a larger sample and with a broader range of cognitive-functional items related to activities of daily living (ADL).

Method: The Ext. Read More

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Mechanisms of Physical Fatigue and its Applications in Nutritional Interventions.

J Agric Food Chem 2021 Jun 14. Epub 2021 Jun 14.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, Beijing Key Laboratory for Food Non-thermal Processing, China Agricultural University, No.17 Qinghua East Road, Haidian District, Beijing 100083, China.

Physical fatigue during exercise can be defined as an impairment of physical performance. Multiple factors have been found contributing to physical fatigue, including neurotransmitter-mediated defense action, insufficient energy supply, and induction of oxidative stress. These mechanistic findings provide a sound theoretical rationale for nutritional intervention since most of these factors can be modulated by nutrient supplementation. Read More

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The degeneration changes of basal forebrain are associated with prospective memory impairment in patients with Wilson's disease.

Brain Behav 2021 Jun 14. Epub 2021 Jun 14.

School of Medical Information Engineering, Anhui University of Chinese Medicine, Hefei, Anhui, China.

Introduction: Degeneration changes of the basal forebrain (BF) are suggested to play an important role in cognitive impairment and memory loss in patients with Alzheimer's disease and Parkinson's disease. However, little is known about if and how the structure and function of BF are abnormal in Wilson's disease (WD).

Methods: Here, we employed the structural and resting-state functional magnetic resonance imaging (fMRI) data from 19 WD individuals and 24 healthy controls (HC). Read More

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Paeonol Induces Protective Autophagy in Retinal Photoreceptor Cells.

Front Pharmacol 2021 26;12:667959. Epub 2021 May 26.

Eye Institute, Eye and ENT Hospital, College of Medicine, Fudan University, Shanghai, China.

Retinal photoreceptor (RP) cells are widely involved in retina-related diseases, and oxidative stress plays a critical role in retinal secondary damage. Herein, we investigated the effectiveness and potential mechanisms of autophagy of paeonol (Pae) in terms of oxidation resistance. The animal model was induced by light damage (LD) , whereas the model was established by HO stimulation. Read More

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Right Frontoinsular Cortex: A Potential Imaging Biomarker to Evaluate T2DM-Induced Cognitive Impairment.

Front Aging Neurosci 2021 28;13:674288. Epub 2021 May 28.

Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.

Cognitive impairment in type 2 diabetes mellitus (T2DM) is associated with functional and structural abnormalities in the intrinsic brain network. The salience network (SN) is a neurocognitive network that maintains normal cognitive function, but it has received little attention in T2DM. We explored SN changes in patients with T2DM with normal cognitive function (DMCN) and in patients with T2DM with mild cognitive impairment (DMCI). Read More

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Case Report: Deep Brain Stimulation of the Nucleus Basalis of Meynert for Advanced Alzheimer's Disease.

Front Hum Neurosci 2021 26;15:645584. Epub 2021 May 26.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Patients with advanced Alzheimer's disease (AD) experience cognitive impairment and physical disabilities in daily life. Currently, there are no treatments available to slow down the course of the disease, and limited treatments exist only to treat symptoms. However, deep brain stimulation of the nucleus basalis of Meynert (NBM-DBS) has been reported to improve cognitive function in individuals with AD. Read More

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An Evaluation of Gaming-Related Harms in Relation to Gaming Disorder and Loot Box Involvement.

Int J Ment Health Addict 2021 Jun 7:1-16. Epub 2021 Jun 7.

College of Education, Psychology and Social Work, Flinders University, Adelaide, Australia.

The specific nature of harm and functional impairment in the context of gaming disorder (GD) has received limited attention. In this study, we present one of the first concerted attempts to measure the types and degree of harm experienced by people displaying signs of problem gaming. Attempts were made to assess the extent to which types of harm were attributable to gaming as opposed to other factors. Read More

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Ventral Tegmental Area Disconnection Contributes Two Years Early to Correctly Classify Patients Converted to Alzheimer's Disease: Implications for Treatment.

J Alzheimers Dis 2021 Jun 9. Epub 2021 Jun 9.

'Rita Levi Montalcini' Department of Neuroscience University of Torino, Turin, Italy.

Background: Recent cross-sectional studies highlighted the loss of dopaminergic neurons in the ventral tegmental area (VTA) as an early pathophysiological event in Alzheimer's disease (AD).

Objective: In this study, we longitudinally investigated by resting-state fMRI (RS-fMRI) a cohort of patients with mild cognitive impairment (MCI) due to AD to evaluate the impact of VTA disconnection in predicting the conversion to AD.

Methods: A cohort of 35 patients with MCI due to AD were recruited and followed-up for 24 months. Read More

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Challenges and Growth: Lived Experience of Adolescents and Young Adults (AYA) with a Sibling with ASD.

J Autism Dev Disord 2021 Jun 13. Epub 2021 Jun 13.

Benson-Henry Institute for Mind Body Medicine, Mass General Hospital, Boston, USA.

Adolescent and young adult (AYA) siblings of individuals with autism experience unique challenges that can promote both growth and emotional maladjustment. This study explored sibling and parent reports of siblings' lived experiences and identified learning, stressors, and concerns from those experiences. 20 neurotypical (NT) AYA siblings (ages 13-24), and 21 parents were interviewed. Read More

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Talking to multi-morbid patients about critical illness: an evolving conversation.

Age Ageing 2021 Jun 11. Epub 2021 Jun 11.

William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK.

Conversations around critical illness outcomes and benefits from intensive care unit (ICU) treatment have begun to shift away from binary discussions on living versus dying. Increasingly, the reality of survival with functional impairment versus survival with a late death is being recognised as relevant to patients. Most ICU admissions are associated with new functional and cognitive disabilities that are significant and long lasting. Read More

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Minimal clinically important difference in walking velocity, gait profile score and two minute walk test for individuals with lower limb amputation.

Gait Posture 2021 Jun 10;88:221-224. Epub 2021 Jun 10.

West of Scotland Rehabilitation and Mobility Centre, Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde, 1345 Govan Road, Glasgow, G51 4TF, UK.

Background: Individuals with lower limb amputation are routinely assessed with a variety outcome measures, however there is a lack of published data to indicate minimal clinically important differences (MCID) for many of these outcome measures. Three such important gait-specific outcome measures include walking velocity, gait profile score (GPS) and the two minute walk test (2MWT).

Research Question: Determine the MCIDs for walking velocity, GPS and 2MWT for individuals with lower limb amputation. Read More

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Protective effect of mitophagy against aluminum-induced MC3T3-E1 cells dysfunction.

Chemosphere 2021 Jun 4;282:131086. Epub 2021 Jun 4.

Key Laboratory of the Provincial Education, Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China. Electronic address:

Aluminum (Al) is a ubiquitous environmental metal toxicant that causes osteoblast (OB) damage which leads to Al-related bone diseases. Mitochondrial damage plays a key role in Al-related bone diseases, and while mitophagy can clear damaged mitochondria and improve OB function, the relationship between mitophagy and Al-induced OB dysfunction is unknown. To explore the role of mitophagy in Al-induced OB dysfunction in vitro, we used 2 μM carbonyl cyanide m-chlorophenylhydrazone (CCCP) and 0. Read More

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Cell-specific effects of Dyt1 knock-out on sensory processing, network-level connectivity, and motor deficits.

Exp Neurol 2021 Jun 10:113783. Epub 2021 Jun 10.

Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA; Department of Neurology, University of Florida, Gainesville, FL, USA; Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.

DYT1 dystonia is a debilitating movement disorder characterized by repetitive, unintentional movements and postures. The disorder has been linked to mutation of the TOR1A/DYT1 gene encoding torsinA. Convergent evidence from studies in humans and animal models suggest that striatal medium spiny neurons and cholinergic neurons are important in DYT1 dystonia. Read More

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Identification of two pathogenic mutations in SORL1 in early-onset Alzheimer's disease.

J Clin Neurosci 2021 Jul 13;89:243-248. Epub 2021 May 13.

The Third Affiliated Hospital of Shenzhen University, Cognitive Impairment Ward of Neurology Department, Shenzhen, Guangdong Province, China.

The sortilin-related receptor 1 (SORL1) gene has been the subject of many studies focusing on frequent polymorphisms, which is associated with increased risk for Alzheimer's Disease (AD). By whole-exome sequencing (WES), we identified two pathogenic missense mutations c.579C > G (p. Read More

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Differential lncRNA expression profiling of cognitive function in middle and old aged monozygotic twins using generalized association analysis.

J Psychiatr Res 2021 Jun 2;140:197-204. Epub 2021 Jun 2.

Unit of Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Denmark; Unit of Human Genetics, Department of Clinical Research, University of Southern Denmark, Denmark. Electronic address:

Cognitive impairment is the most prominent symptom in neurodegenerative disorders affecting quality of life and mortality. However, despite years of research, the molecular mechanism underlying the regulation of cognitive function and its impairment is poorly understood. This study aims to elucidate the role of long non-coding RNAs (lncRNAs) expression and lncRNA-mRNA interaction networks, by analyzing lncRNA expression in whole blood samples of 400 middle and old aged monozygotic twins in association with cognitive function using both linear models and a generalized correlation coefficient (GCC) to capture the diverse patterns of correlation. Read More

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Cardiac pathology and outcomes vary between Kawasaki disease and PIMS-TS.

Clin Immunol 2021 Jun 9;229:108780. Epub 2021 Jun 9.

Department of Rheumatology, Alder Hey Children's NHS Foundation Trust Hospital, Liverpool L14 5AB, UK; Department of Women's & Children's Health, Life Course and Medical Sciences, University of Liverpool, Liverpool L69 3BX, UK. Electronic address:

Overlapping clinical features promoted the discussion of whether Kawasaki disease (KD) and PIMS-TS share pathophysiological features and disease outcomes. Medical records from English patients with KD (2015-02/20, N = 27) and PIMS-TS (02/2020-21, N = 34) were accessed to extract information. Children with PIMS-TS were older and more frequently of minority ethnicity background. Read More

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