81,128 results match your criteria functional characteristics

Safety and Efficacy of Trans-Perineal Urethroplasty for Management of Post-Traumatic Urethral Strictures in Pediatric Age-Group.

Urol Int 2021 Apr 13:1-5. Epub 2021 Apr 13.

Department of Urology, TNMC & BYL Nair Hospital, Mumbai, India.

Introduction: Trans-perineal urethroplasty is the preferred treatment for distraction urethral injuries in adults. However, management of such injuries in children is challenging because of functional implications in a growing child. In the present study, we aim to evaluate the safety and efficacy of perineal urethroplasty for distraction urethral injuries in children. Read More

View Article and Full-Text PDF

A structural enriched functional network: An application to predict brain cognitive performance.

Med Image Anal 2021 Mar 4;71:102026. Epub 2021 Mar 4.

Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, PA, USA. Electronic address:

The structure-function coupling in brain networks has emerged as an important research topic in modern neuroscience. The structural network could provide the backbone of the functional network. The integration of the functional network with structural information can help us better understand functional communication in the brain. Read More

View Article and Full-Text PDF

Paediatric long term continuous positive airway pressure and noninvasive ventilation in France: A cross-sectional study.

Respir Med 2021 Apr 3;181:106388. Epub 2021 Apr 3.

Pediatric Pulmonology and Allergology Unit, Hospices Civils de Lyon, 69677, Bron, France; Sorbonne Université, INSERM UMR-S 938, Centre de Recherche Saint-Antoine (CRSA), F-75014, Paris, France; Centre de Pneumologie de l'enfant, Ramsay Générale de Santé, 92100, Boulogne-Billancourt, France.

Objective: To describe the characteristics of children treated with long term continuous positive airway pressure (CPAP) or noninvasive ventilation (NIV) in France.

Design: Cross-sectional national survey.

Setting: Paediatric CPAP/NIV teams of 28 tertiary university hospitals in France. Read More

View Article and Full-Text PDF

"Do You Need a Doctor's Note?" Factors Leading to Delayed Return to Work after Blunt Chest Trauma.

J Surg Res 2021 Apr 10;264:454-461. Epub 2021 Apr 10.

Department of Surgery, Division of General and Trauma Surgery, WakeMed Health and Hospitals, Raleigh, North Carolina; Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Background: Blunt chest trauma is associated with significant morbidity, but the long-term functional status for these patients is less well-known. Return to work (RTW) is a benchmark for functional recovery in trauma patients, but minimal data exist regarding RTW following blunt chest trauma.

Materials And Methods: Patients ≥ 18 y old admitted to a Level 1 trauma center following blunt chest trauma with ≥ 3 rib fractures and length of stay (LOS) ≥ 3 d were included. Read More

View Article and Full-Text PDF

A multiparametric MRI-based CAD system for accurate diagnosis of bladder cancer staging.

Comput Med Imaging Graph 2021 Mar 31;90:101911. Epub 2021 Mar 31.

Bioengineering Department, University of Louisville, Louisville, KY, USA. Electronic address:

Appropriate treatment of bladder cancer (BC) is widely based on accurate and early BC staging. In this paper, a multiparametric computer-aided diagnostic (MP-CAD) system is developed to differentiate between BC staging, especially T1 and T2 stages, using T2-weighted (T2W) magnetic resonance imaging (MRI) and diffusion-weighted (DW) MRI. Our framework starts with the segmentation of the bladder wall (BW) and localization of the whole BC volume (V) and its extent inside the wall (V). Read More

View Article and Full-Text PDF

Laparoscopic uterovaginal anastomosis in patients with congenital cervicovaginal atresia: An institutional experience with 23 patients.

Eur J Obstet Gynecol Reprod Biol 2021 Mar 31;260:218-224. Epub 2021 Mar 31.

Department of Obstetrics and Gynecology, The 3rd Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, 518000, PR China.

Objective: To introduce our experience of laparoscopic uterovaginal anastomosis and operative outcomes following this technique and update the clinical management of congenital cervicovaginal atresia.

Study Design: Between March 2015 and January 2019, twenty-three patients with congenital cervicovaginal atresia underwent laparoscopic uterovaginal anastomosis and Luohu procedure. Their clinical characteristics, surgical outcomes and follow-up data were retrospectively reviewed. Read More

View Article and Full-Text PDF

Criteria for failure and worsening after surgery for lumbar spinal stenosis. A prospective national spine registry observational study.

Spine J 2021 Apr 10. Epub 2021 Apr 10.

Innlandet Hospital Trust, The Research Center for Age-Related Functional Decline and Disease, PO Box 68, N-2313, Ottestad, Norway.

Background Context: Criteria for success after surgical treatment of lumbar spinal stenosis (LSS) have been defined previously; however, there are no clear criteria for failure and worsening after surgery as assessed by patient-reported outcome measures (PROMs).

Purpose: We aimed to quantify changes in standard PROMs that most accurately identified failure and worsening after surgery for LSS.

Study Design /setting: Retrospective analysis of prospective national spine registry data with 12-months follow-up. Read More

View Article and Full-Text PDF

Management of Allen type III nail bed injuries and distal phalangeal fractures with and without fixation.

Erdinc Acar

Hand Surg Rehabil 2021 Apr 10. Epub 2021 Apr 10.

Department of Orthopedics and Traumatology, Hand and Upper Extremity Surgery Division, Ankara City Hospital, Üniversiteler Caddesi, Bilkent Bulvarı No:1, 06800 Çankaya/Ankara, Turkey. Electronic address:

For combined nail bed injuries and distal phalangeal fractures, fixation may be indicated when there is fracture instability and if a K-wire can be successfully placed in the fracture fragments. We determined the outcomes when these criteria were applied for patients with Allen type III injuries without substantial tissue loss. We retrospectively analyzed 57 patients who had surgery for nail bed injuries with distal phalangeal fractures between October 2017 and January 2020. Read More

View Article and Full-Text PDF

Ecofriendly Solution-Combustion-Processed Thin-Film Transistors for Synaptic Emulation and Neuromorphic Computing.

ACS Appl Mater Interfaces 2021 Apr 13. Epub 2021 Apr 13.

Department of Electrical and Electronic Engineering, Xi'an Jiaotong-Liverpool University, Suzhou 215123, China.

The ecofriendly combustion synthesis (ECS) and self-combustion synthesis (ESCS) have been successfully utilized to deposit high- aluminum oxide (AlO) dielectrics at low temperatures and applied for aqueous InO thin-film transistors (TFTs) accordingly. The ECS and ESCS processes facilitate the formation of high-quality dielectrics at lower temperatures compared to conventional methods based on an ethanol precursor, as confirmed by thermal analysis and chemical composition characterization. The aqueous InO TFTs based on ECS and ESCS-AlO show enhanced electrical characteristics and counterclockwise transfer-curve hysteresis. Read More

View Article and Full-Text PDF

A comparison of oncologic and functional outcomes in patients with pt3a renal cell carcinoma treated with partial and radical nephrectomy.

Int Braz J Urol 2021 Jul-Aug;47(4):777-783

Department of Surgery, Urology Service, Memorial Sloan Kettering Cancer Center, NY, USA.

Hypothesis: Partial Nephrectomy is oncological safe in patients with pT3a RCC.

Purpose: To compare the oncological and functional outcomes of patients with pT3a RCC scheduled for PN and RN.

Materials And Methods: We retrospectively reviewed patients with pT3a N0 M0 RCC who underwent partial or radical nephrectomy from 2005 to 2016. Read More

View Article and Full-Text PDF
February 2020

Comparison of nutrition and quality of life of esophagogastrostomy and the double-tract reconstruction after laparoscopic proximal gastrectomy.

Medicine (Baltimore) 2021 Apr;100(15):e25453

Center for Gastric Cancer, National Cancer Center, Goyang.

Abstract: This study aims to compare the nutritional outcomes and quality of life between patients who underwent esophagogastrostomy (EG) and those who underwent the double-tract reconstruction (DTR) after laparoscopic proximal gastrectomy for early gastric cancer.We retrospectively reviewed the prospectively established database of 45 patients who underwent EG with anti-reflux procedure and 58 patients who underwent the DTR after laparoscopic proximal gastrectomy between December 2013 and June 2017. Then, we compared the baseline characteristics, clinical outcomes, postoperative nutritional parameters, and quality of life (QOL) using European Organization for Research and Treatment of Cancer (EORTC) QLQ STO-22 between the EG and DTR groups. Read More

View Article and Full-Text PDF

Occurrence and risk factors associated with seizures in infants with severe bronchiolitis.

Eur J Pediatr 2021 Apr 12. Epub 2021 Apr 12.

Hospices Civils de Lyon, réanimation pédiatrique, Hôpital Femme Mère Enfant, F-69500, Bron, France.

Neurological morbidity is a growing concern in children with severe bronchiolitis. The aim of the study was to evaluate the frequency of occurrence and the factors associated with seizures in very young infants < 3 months of age, admitted to a pediatric intensive care unit (PICU) for severe bronchiolitis. We performed a single center retrospective cohort study evaluating occurrence of seizures in infants admitted to the PICU between 2010 and 2018 for severe bronchiolitis. Read More

View Article and Full-Text PDF

Bias-controlled multi-functional transport properties of InSe/BP van der Waals heterostructures.

Sci Rep 2021 Apr 12;11(1):7843. Epub 2021 Apr 12.

School of Materials Science and Engineering, Gwangju Institute of Science and Technology (GIST), 123 Cheomdangwagi-ro, Buk-gu, Gwangju, 61005, Republic of Korea.

Van der Waals (vdW) heterostructures, consisting of a variety of low-dimensional materials, have great potential use in the design of a wide range of functional devices thanks to their atomically thin body and strong electrostatic tunability. Here, we demonstrate multi-functional indium selenide (InSe)/black phosphorous (BP) heterostructures encapsulated by hexagonal boron nitride. At a positive drain bias (V), applied on the BP while the InSe is grounded, our heterostructures show an intermediate gate voltage (V) regime where the current hardly changes, working as a ternary transistor. Read More

View Article and Full-Text PDF

Comprehensive surgical treatment strategy for spinal metastases.

Sci Rep 2021 Apr 12;11(1):7988. Epub 2021 Apr 12.

Department of Neurosurgery, Klinikum Rechts Der Isar, Technical University Munich School of Medicine, Ismaninger Str. 22, 81675, Munich, Germany.

The management of patients with spinal metastases (SM) requires a multidisciplinary team of specialists involved in oncological care. Surgical management has evolved significantly over the recent years, which warrants reevaluation of its role in the oncological treatment concept. Any patient with a SM was screened for study inclusion. Read More

View Article and Full-Text PDF

Atlas of breast cancer infiltrated B-lymphocytes revealed by paired single-cell RNA-sequencing and antigen receptor profiling.

Nat Commun 2021 04 12;12(1):2186. Epub 2021 Apr 12.

National Institute of Biological Sciences, Beijing, China.

To gain mechanistic insights into the functions and developmental dynamics of tumor-infiltrated immune cells, especially B-lymphocytes, here we combine single-cell RNA-sequencing and antigen receptor lineage analysis to characterize a large number of triple-negative breast cancer infiltrated immune cells and report a comprehensive atlas of tumor-infiltrated B-lymphocytes. The single-cell transcriptional profiles reveal significant heterogeneity in tumor-infiltrated B-cell subgroups. The single-cell antigen receptor analyses demonstrate that compared with those in peripheral blood, tumor-infiltrated B-cells have more mature and memory B-cell characteristics, higher clonality, more class switching recombination and somatic hypermutations. Read More

View Article and Full-Text PDF

Spatial heterogeneity of oxygenation and haemodynamics in breast cancer resolved in vivo by conical multispectral optoacoustic mesoscopy.

Light Sci Appl 2020 Apr 13;9(1):57. Epub 2020 Apr 13.

Institute of Biological and Medical Imaging, Helmholtz Zentrum München, Ingolstädter Landstr. 1, D-85764, Neuherberg, Germany.

The characteristics of tumour development and metastasis relate not only to genomic heterogeneity but also to spatial heterogeneity, associated with variations in the intratumoural arrangement of cell populations, vascular morphology and oxygen and nutrient supply. While optical (photonic) microscopy is commonly employed to visualize the tumour microenvironment, it assesses only a few hundred cubic microns of tissue. Therefore, it is not suitable for investigating biological processes at the level of the entire tumour, which can be at least four orders of magnitude larger. Read More

View Article and Full-Text PDF

Longitudinal Peripheral Blood Transcriptional Analysis Reveals Molecular Signatures of Disease Progression in COVID-19 Patients.

J Immunol 2021 Apr 12. Epub 2021 Apr 12.

State Key Laboratory of Respiratory Disease, Guangdong Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China;

Coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with some patients developing severe illness or even death. Disease severity has been associated with increased levels of proinflammatory cytokines and lymphopenia. To elucidate the atlas of peripheral immune response and pathways that might lead to immunopathology during COVID-19 disease course, we performed a peripheral blood RNA sequencing analysis of the same patient's samples collected from symptom onset to full recovery. Read More

View Article and Full-Text PDF

Short- and Mid-Term Impact of Tobacco Smoking on Donor Renal Function Following Living Kidney Donation at a Tertiary Referral Hospital.

Rev Invest Clin 2021 Apr 12. Epub 2021 Apr 12.

Department of Urology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Background: The negative impact of tobacco smoking on renal function has been widely studied. However, there is limited knowledge about the effect of smoking on pre-operative and post-operative renal function in living kidney donors.

Objective: The objective of the study was to evaluate the short- and mid-term impact of smoking on donor renal function. Read More

View Article and Full-Text PDF

The Concept of Pathogenic TH2 Cells: Collegium Internationale Allergologicum Update 2021.

Int Arch Allergy Immunol 2021 Apr 12;182(5):365-380. Epub 2021 Apr 12.

Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

T helper (TH) cells have evolved into distinct subsets that mediate specific immune responses to protect the host against a myriad of infectious and noninfectious challenges. However, if dysregulated, TH-cell subsets can cause inflammatory disease. Emerging evidence now suggests that human allergic disease is caused by a distinct subpopulation of pathogenic TH2 cells. Read More

View Article and Full-Text PDF

The predictive value of neurobiological measures for recidivism in delinquent male young adults.

J Psychiatry Neurosci 2021 Apr 12;46(2):E271-E280. Epub 2021 Apr 12.

From the Amsterdam University Medical Centers, Department of Child and Adolescent Psychiatry, Amsterdam, Netherlands (Zijlmans, Marhe, Bevaart, van Duin, Luijks, Popma); the Erasmus University Rotterdam, Department of Psychology, Education and Child Studies, Rotterdam, Netherlands (Marhe, Franken); the Harvard T. H. Chan School of Public Health, Department of Social and Behavioral Sciences, Boston, Massachusetts (Tiemeier); the Erasmus University Medical Center, Department of Child and Adolescent Psychiatry, Rotterdam, Netherlands (Tiemeier); and Leiden University, Department of Criminal Law and Criminology, Leiden, Netherlands (Popma).

Background: Neurobiological measures have been associated with delinquent behaviour, but little is known about the predictive power of these measures for criminal recidivism and whether they have incremental value over and above demographic and behavioural measures. This study examined whether selected measures of autonomic functioning, functional neuroimaging and electroencephalography predict overall and serious recidivism in a sample of 127 delinquent young adults.

Methods: We assessed demographics; education and intelligence; previous delinquency and drug use; behavioural traits, including aggression and psychopathy; and neurobiological measures, including heart rate, heart rate variability, functional brain activity during an inhibition task and 2 electroencephalographic measures of error-processing. Read More

View Article and Full-Text PDF

Understanding the molecular mechanism of γ-elimination of nitrous acid in the framework of the molecular electron density theory.

J Comput Chem 2021 Apr 12. Epub 2021 Apr 12.

Cracow University of Technology, Institute of Organic Chemistry and Technology, Cracow, Poland.

The reactions of γ-dehydronitration of furaxanenitrolic acids have been studied within the density functional theory using molecular electron density theory scheme at the MPWB1K(PCM)/6-311G(d,p) level of theory. The alteration of bonding along the course of the reaction is studied in the topology of the electron density functional within the bonding evolution theory perspective. The characteristics of electron density changes indicate that we can distinguish six different phases in the nitrous acid extrusion from furaxanenitrolic acid 1a. Read More

View Article and Full-Text PDF

Dissection of the Endolymphatic Sac from Mice.

J Vis Exp 2021 Mar 29(169). Epub 2021 Mar 29.

Otolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health;

The study of mutant mouse models of human hearing and balance disorders has unraveled many structural and functional changes which may contribute to the human phenotypes. Although important progress has been done in the understanding of the development and function of the neurosensory epithelia of the cochlea and vestibula, limited knowledge is available regarding the development, cellular composition, molecular pathways and functional characteristics of the endolymphatic sac. This is, in large part, due to the difficulty of visualizing and microdissecting this tissue, which is an epithelium comprised of only one cell layer. Read More

View Article and Full-Text PDF

Advanced Dementia: Brain-State Characteristics and Clinical Indicators of Early Mortality.

J Alzheimers Dis 2021 Apr 8. Epub 2021 Apr 8.

Clinical Research Center for Brain Sciences, Herzog Medical Center, Hebrew University Jerusalem, Israel.

There is an urgent need in advanced dementia for evidence-based clinical prognostic predictors that could positively influence ethical decisions allowing health provider and family preparation for early mortality. Accordingly, the authors review and discuss the prognostic utility of clinical assessments and objective measures of pathological brain states in advanced dementia patients associated with accelerated mortality. Overall, due to the paucity of brain-activity and clinical-comorbidity predictors of survival in advanced dementia, authors outline the potential prognostic value of brain-state electroencephalography (EEG) measures and reliable clinical indicators for forecasting early mortality in advanced dementia patients. Read More

View Article and Full-Text PDF

Maternal protein restriction changes structural and metabolic gene expression in the skeletal muscle of aging offspring rats.

Histol Histopathol 2021 Apr 12:18337. Epub 2021 Apr 12.

Department of Structural and Functional Biology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.

Maternal protein restriction affects postnatal skeletal muscle physiology with impacts that last through senility. To investigate the morphological and molecular characteristics of skeletal muscle in aging rats subjected to maternal protein restriction, we used aged male rats (540 days old) born of dams fed a protein restricted diet (6% protein) during pregnancy and lactation. Using morphological, immunohistochemical and molecular analyses, we evaluated the soleus (SOL) and extensor digitorum longus (EDL) muscles, muscle fiber cross-sectional area (CSA) (n=8), muscle fiber frequency (n=5) and the gene expression (n=8) of the oxidative markers (succinate dehydrogenase-Sdha and citrate synthase-CS) and the glycolytic marker (lactate dehydrogenase-Ldha). Read More

View Article and Full-Text PDF

Robot-assisted radical prostatectomy versus standard laparoscopic radical prostatectomy: an evidence-based analysis of comparative outcomes.

World J Urol 2021 Apr 11. Epub 2021 Apr 11.

Division of Urology, VCU Health, Richmond, VA, 23298-0118, USA.

Purpose: To provide a systematic analysis of the comparative outcomes of robot-assisted radical prostatectomy (RARP) versus laparoscopic radical prostatectomy (LRP) in the treatment of prostate cancer based on the best currently available evidence.

Methods: An independent systematic review of the literature was performed up to February 2021, using MEDLINE, EMBASE, and Web of Science databases. Preferred reporting items for systematic review and meta-analysis (PRISMA) recommendations were followed to design search strategies, selection criteria, and evidence reports. Read More

View Article and Full-Text PDF

Personality differences in brain network mechanisms for placebo analgesia and nocebo hyperalgesia in experimental pain: a functional magnetic resonance imaging study.

Ann Transl Med 2021 Mar;9(5):371

Department of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou, China.

Background: Placebo and nocebo responses have been increasingly gaining the attention of clinical and scientific researchers. Inconsistent conclusions from current studies indicate that different factors potentially affect both placebo and nocebo responses. Increasing evidence suggests that personality differences may affect the mechanisms of both two responses. Read More

View Article and Full-Text PDF

Pediatric Challenges in Robot-Assisted Kidney Transplantation.

Front Surg 2021 25;8:649418. Epub 2021 Mar 25.

Department of Urology, ERN eUROGEN Accredited Centre, Ghent University Hospital, Ghent University, Ghent, Belgium.

Kidney transplantation is universally recognized as the gold standard treatment in patients with End-stage Kidney Disease (ESKD, or according to the latest nomenclature, CKD stage 5). Robot-assisted kidney transplantation (RAKT) is gradually becoming preferred technique in adults, even if applied in very few centra, with potentially improved clinical outcomes compared with open kidney transplantation. To date, only very few RAKT procedures in children have been described. Read More

View Article and Full-Text PDF

A multilayered cross-species analysis of GRAS transcription factors uncovered their functional networks in plant adaptation to the environment.

J Adv Res 2021 Mar 29;29:191-205. Epub 2020 Oct 29.

Joint Center for Single Cell Biology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.

Introduction: Environmental stress is both a major force of natural selection and a prime factor affecting crop qualities and yields. The impact of the GRAS [gibberellic acid-insensitive (GAI), repressor of GA1-3 mutant (RGA), and scarecrow (SCR)] family on plant development and the potential to resist environmental stress needs much emphasis.

Objectives: This study aims to investigate the evolution, expansion, and adaptive mechanisms of of important representative plants during polyploidization. Read More

View Article and Full-Text PDF

Computed tomography-based visual assessment of chronic obstructive pulmonary disease: comparison with pulmonary function test and quantitative computed tomography.

J Thorac Dis 2021 Mar;13(3):1495-1506

Department of Internal Medicine and Environmental Health Center, School of Medicine, Kangwon National University, Chuncheon, Republic of Korea.

Background: Chronic obstructive pulmonary disease (COPD) has variable subtypes involving mixture of large airway inflammation, small airway disease, and emphysema. This study evaluated the relationship between visually assessed computed tomography (CT) subtypes and clinical/imaging characteristics.

Methods: In total, 452 participants were enrolled in this study between 2012 and 2017. Read More

View Article and Full-Text PDF

Production and characterization of soft Sardaigne-type cheese by using almond gum as a functional additive.

Food Sci Nutr 2021 Apr 20;9(4):2032-2041. Epub 2021 Feb 20.

Laboratoire d'Amélioration des Plantes et Valorisation des Agroressources National School of Engineering of Sfax (ENIS) Sfax University Sfax Tunisia.

The effect of almond gum (AG), as natural polysaccharide with high nutritional value and important functional properties, on physicochemical and textural characteristics of Sardaigne-type cheese was investigated. Response surface methodology (RSM) using Box-Behnken design was applied to determine optimal levels of three selected processing variables such as coagulation temperature (25-45°C), stirring period (20-30 min), and AG concentration (0.25%-0. Read More

View Article and Full-Text PDF