211,783 results match your criteria functional ability


An update on cell division of Giardia duodenalis trophozoites.

Microbiol Res 2021 Jun 10;250:126807. Epub 2021 Jun 10.

Department of Genetics and Molecular Biology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV), Mexico City, Mexico. Electronic address:

Giardia duodenalis is a flagellated protozoan that is responsible for many cases of diarrheal disease worldwide and is characterized by its great divergence from the model organisms commonly used in studies of basic cellular processes. The life cycle of Giardia involves an infectious cyst form and a proliferative and mobile trophozoite form. Each Giardia trophozoite has two nuclei and a complex microtubule cytoskeleton that consists of eight flagellar axonemes, basal bodies, the adhesive disc, the funis and the median body. Read More

View Article and Full-Text PDF

Nutritional Risk at intensive care unit admission and outcomes in survivors of critical illness.

Clin Nutr 2021 May 11;40(6):3868-3874. Epub 2021 May 11.

Critical Illness, Brain Dysfunction, and Survivorship (CIBS) Center, Nashville, TN, USA; Division of Pulmonary, Critical Care, and Sleep Medicine, The Ohio State University College of Medicine, Columbus OH, USA; Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address:

Background And Aims: Risk factors for poor outcomes after critical illness are incompletely understood. While nutritional risk is associated with mortality in critically ill patients, its association with disability, cognitive, and health-related quality of life is unclear in survivors of critical illness. This study's objective was to determine whether greater nutritional risk at ICU admission is associated with greater disability, worse cognition, and worse HRQOL at 3 and 12-month follow-up. Read More

View Article and Full-Text PDF

Predicting ACL Reinjury from Return to Activity Assessments at 6-months Post-Surgery: A Prospective Cohort Study.

J Athl Train 2021 Jun 15. Epub 2021 Jun 15.

Department of Kinesiology. University of Virginia, Charlottesville, VA.

Context: Return to activity(RTA) assessments are commonly administered following ACL-Reconstruction(ACLR) to manage post-operative progressions back to activity. To date, there is little knowledge on the clinical utility of these assessments to predict patient outcomes such as secondary ACL injury once returned to activity.

Objective: To identify what measures of patient function at 6-months post-ACLR best predict return to activity and second ACL injury at a minimum of 2-years following ACLR. Read More

View Article and Full-Text PDF

Cryotherapy Produces Pain Relief in Young People with Primary Dysmenorrhea.

Ther Hypothermia Temp Manag 2021 Jun 15. Epub 2021 Jun 15.

Bioscience and Health Posgraduate Program, Universidade Estadual do Oeste do Paraná (UNIOESTE), Cascavel, Brazil.

Primary dysmenorrhea is characterized as painful menstruation without associated pelvic disease and has been considered common among young people of reproductive age. Cryotherapy is a technique aimed at analgesia and anti-inflammatory action. The objective of this study was to analyze the analgesic efficacy of cryotherapy in sedentary youth with primary dysmenorrhea. Read More

View Article and Full-Text PDF

Obesogenic Behaviors of Rural Children on School and Nonschool Days.

Child Obes 2021 Jun 15. Epub 2021 Jun 15.

School of Social Work, College of Health Professions and Sciences, University of Central Florida, Orlando, FL, USA.

Children living in rural areas are at increased risk of overweight and obesity compared with their urban-dwelling counterparts. The purpose of this study was to provide preliminary evidence of rural children's obesogenic behaviors ( activity, sedentary behaviors, sleep, and diet) during school days, nonschool weekdays, and weekend days. A repeated measures 14-day observational study was conducted early March 2020. Read More

View Article and Full-Text PDF

Construction of a pH/TGase "Dual Key"-Responsive Gold Nano-radiosensitizer with Liver Tumor-Targeting Ability.

ACS Biomater Sci Eng 2021 Jun 15. Epub 2021 Jun 15.

Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, People's Republic of China.

The method of tumor microenvironment (TME)-responsive aggregation has become a promising approach to enhance treatment effect by improving the accumulation of nanoparticles in tumors. The enzymatic cross-linking strategy has widely attracted attention owing to its good aggregation stability and biocompatibility. However, the enzymes in nontumor tissue can also catalyze the cross-linking reaction and reduce accumulation of nanoparticles in tumor. Read More

View Article and Full-Text PDF

Photoacid Generators Activated through Sequential Two-Photon Excitation: 1-Sulfonatoxy-2-alkoxyanthraquinone Derivatives.

J Phys Chem A 2021 Jun 15. Epub 2021 Jun 15.

Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, United States.

Two sulfonate ester derivatives of anthraquinone, 1-tosyloxy-2-methoxy-9,10-anthraquinone () and 1-trifluoromethylsulfonoxy-2-methoxy-9,10-anthraquinone (), were prepared and their ability to produce strong acids upon photoexcitation was examined. It is shown that these compounds generate acid with a yield that increases with light intensity when the applied photon dose is held constant. Additional experiments show that the rate of acid generation increases fourfold when visible light (532 nm) laser pulses are combined with ultraviolet (355 nm) compared with ultraviolet alone. Read More

View Article and Full-Text PDF

Bioinformatics analysis of the key potential ceRNA biomarkers in human thymic epithelial tumors.

Medicine (Baltimore) 2021 Jun;100(24):e26271

Department of Thoracic Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang.

Background: Thymic epithelial tumors (TETs), originating from the thymic epithelial cells, are the most common primary neoplasms of the anterior mediastinum. Emerging evidence demonstrated that the competing endogenous RNAs (ceRNAs) exerted a crucial effect on tumor development. Hence, it is urgent to understand the regulatory mechanism of ceRNAs in TETs and its impact on tumor prognosis. Read More

View Article and Full-Text PDF

Effectiveness of Personalized Cognitive Stimulation in Older Adults with Mild Possible Cognitive Impairment: A 12-month Follow-up Cognitive Stimulation in Mild Cognitive Impairment.

Clin Gerontol 2021 Jun 15:1-13. Epub 2021 Jun 15.

Departamento de Fisiatría y Enfermería, Facultad de Ciencias de la Salud, Universidad de Zaragoza, Zaragoza, Spain.

: The objective of this study was to analyze the long-term effects of a personalized cognitive stimulation (PCS) program on the global cognition, cognitive aspects, activities of daily living (ADLs), anxiety, and depression in older adults with possible mild cognitive impairment (MCI).: A 12-month follow-up analysis was carried out in a single-blind, randomized clinical trial to research the long-term effects of a 10-week PCS program evaluating the cognitive level, depression, and anxiety of older adults with possible MCI.: Fifty older adults were assessed 12 months after the CS program, 23 in the intervention group and 27 in the control group. Read More

View Article and Full-Text PDF

Reliability and validity of Six-Spot Step Test (SSST) in stroke survivors.

Eur J Phys Rehabil Med 2021 Jun 15. Epub 2021 Jun 15.

School of Nursing, The Hong Kong Polytechnic University, Hong Kong.

Background: The Six-Spot Step Test (SSST) was originally developed to assess walking ability while challenging balance during walking in patients with multiple sclerosis. It provides more comprehensive information on ambulatory abilities than several existing measures such as the Timed Up & Go test (TUG test), the Functional Gait Assessment, and the Dynamic Gait Index. To assess the advanced balance control ability of stroke survivors, we modified the SSST to serve this purpose. Read More

View Article and Full-Text PDF

Similarities between Cognitive Models of Language Production and Everyday Functioning: Implications for Development of Interventions for Functional Difficulties.

Top Cogn Sci 2021 Jun 14. Epub 2021 Jun 14.

Department of Psychology, Temple University.

The loss of the ability to independently complete activities of daily living, such as meal preparation and household chores, is a defining characteristic of clinical dementia; however, minor difficulties in completing everyday activities emerge in the mild cognitive impairment stage, and even healthy older adults exhibit subtle functional difficulties compared to younger adults. These functional difficulties are associated with an array of negative outcomes, including decreased quality of life, higher costs of care, and increased frustration, depression, caregiver burden, and institutionalization. While cognitive models have been proposed to explain the functional deficits seen in dementia and subtler forms of cognitive decline, in contrast to other cognitive disorders such as aphasia, there are essentially no theoretically motivated interventions to address difficulties in everyday functioning. Read More

View Article and Full-Text PDF

Association Between Problem Gambling and Functional Disability: A Nationally Representative Study Conducted in the United Kingdom.

J Addict Med 2021 Jun 14. Epub 2021 Jun 14.

Research and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, Dr. Antoni Pujadas, 42, Sant Boi de Llobregat, Barcelona 08830, Spain (LJ, AK, JMH); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain (LJ); Faculty of Medicine, University of Versailles Saint-Quentin-en-Yvelines, Montigny-le-Bretonneux 78180, France (LJ); Vision and Eye Research Institute, School of Medicine, Faculty of Health, Education, Medicine and Social Care, Anglia Ruskin University-Cambridge Campus, Cambridge, United Kingdom (GFL-S, SP); University of Southern California, Suzanne Dworak Peck School of Social Work, 1149 South Hill Street Suite 1422, Los Angeles, CA, 90015 (HO); Philipps University of Marburg, Marburg, Germany (KK); ICREA, Pg. Lluis Companys 23, Barcelona, Spain (AK); Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea (JIS); The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge, United Kingdom (LS).

Objectives: Problem gambling is associated with multiple detrimental health outcomes. However, to date, no study has investigated the association between problem gambling and functional disability. Therefore, the aim of this study was to investigate the association between problem gambling and functional disability in a UK nationally representative sample. Read More

View Article and Full-Text PDF

Expanding the Differentiation Potential of Already-Established Pluripotent Stem Cells.

Methods Mol Biol 2021 Jun 15. Epub 2021 Jun 15.

Cell Division and Cancer group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

Pluripotent stem cells (PSCs) have proven to be an essential tool in many research fields including basic cell biology, development, or human disease. In addition, we are only starting to see their potential in regenerative medicine. Manipulation and culture of PSCs, however, imposes limitations in the quality of these cells and their ability to differentiate into functional cells with physiological function. Read More

View Article and Full-Text PDF

Fungal brain infection modelled in a human-neurovascular-unit-on-a-chip with a functional blood-brain barrier.

Nat Biomed Eng 2021 Jun 14. Epub 2021 Jun 14.

Department of Biotechnology, Yonsei University, Seoul, Republic of Korea.

The neurovascular unit, which consists of vascular cells surrounded by astrocytic end-feet and neurons, controls cerebral blood flow and the permeability of the blood-brain barrier (BBB) to maintain homeostasis in the neuronal milieu. Studying how some pathogens and drugs can penetrate the human BBB and disrupt neuronal homeostasis requires in vitro microphysiological models of the neurovascular unit. Here we show that the neurotropism of Cryptococcus neoformans-the most common pathogen causing fungal meningitis-and its ability to penetrate the BBB can be modelled by the co-culture of human neural stem cells, brain microvascular endothelial cells and brain vascular pericytes in a human-neurovascular-unit-on-a-chip maintained by a stepwise gravity-driven unidirectional flow and recapitulating the structural and functional features of the BBB. Read More

View Article and Full-Text PDF

Fabrication and characterization of Rhizochitosan and its incorporation with platelet concentrates to promote wound healing.

Carbohydr Polym 2021 Sep 21;268:118239. Epub 2021 May 21.

School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan, ROC. Electronic address:

Composite dressing composed of Rhizochitosan and Regenplex™ to promote wound healing were assessed. Rhizochitosan was fabricated by deacetylation of Rhizochitin, which obtained by simply depigmenting sporangium-free mycelial mattress produced from Rhizopus stolonifer F6. Physicochemical characterizations of Rhizochitosan demonstrated that it contained 13. Read More

View Article and Full-Text PDF
September 2021

Clinical Pharmacology of Hyperammonemia by Sodium Valproate and Carbamazepine in People Living with HIV.

CNS Spectr 2021 Apr;26(2):143

Argentine Society of Neuropsychopharmacology, Buenos Aires City, Buenos Aires, Argentina.

Introduction: Hyperammonaemia (HA) is observed in decompensated liver disease. The picture of hyperammonemic encephalopathy in non-cirrhotic patients was reported mostly associated with valproic acid. There are few reports of hyperammonemia in people living with human immunodeficiency virus (PLHIV) and they are associated with other comorbidities and few with antiretrovirals (HAART), but not as adverse drug reactions associated with psychotropic drugs associated with the virus. Read More

View Article and Full-Text PDF

GPS driving: a digital biomarker for preclinical Alzheimer disease.

Alzheimers Res Ther 2021 Jun 14;13(1):115. Epub 2021 Jun 14.

Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.

Background: Alzheimer disease (AD) is the most common cause of dementia. Preclinical AD is the period during which early AD brain changes are present but cognitive symptoms have not yet manifest. The presence of AD brain changes can be ascertained by molecular biomarkers obtained via imaging and lumbar puncture. Read More

View Article and Full-Text PDF

Surgical and functional outcomes and survival following Colon Cancer surgery in the aged: a study protocol for a prospective, observational multicentre study.

BMC Cancer 2021 Jun 14;21(1):698. Epub 2021 Jun 14.

Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tays Hatanpää, P.O. Box 2000, 33521, Tampere, Finland.

Background: The number of colorectal cancer patients increases with age. The decision to go through major surgery can be challenging for the aged patient and the surgeon because of the heterogeneity within the older population. Differences in preoperative physical and cognitive status can affect postoperative outcomes and functional recovery, and impact on patients' quality of life. Read More

View Article and Full-Text PDF

Comparative Biofilm Assays Using Enterococcus faecalis OG1RF Identify New Determinants of Biofilm Formation.

mBio 2021 Jun 15:e0101121. Epub 2021 Jun 15.

Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.

Enterococcus faecalis is a common commensal organism and a prolific nosocomial pathogen that causes biofilm-associated infections. Numerous E. faecalis OG1RF genes required for biofilm formation have been identified, but few studies have compared genetic determinants of biofilm formation and biofilm morphology across multiple conditions. Read More

View Article and Full-Text PDF

Metabolic inhibitors of bacterial glycan biosynthesis.

Chem Sci 2020 Jan 8;11(7):1761-1774. Epub 2020 Jan 8.

Department of Chemistry & Biochemistry, Bowdoin College 6600 College Station Brunswick ME 04011 USA

The bacterial cell wall is a quintessential drug target due to its critical role in colonization of the host, pathogen survival, and immune evasion. The dense cell wall glycocalyx contains distinctive monosaccharides that are absent from human cells, and proper assembly of monosaccharides into higher-order glycans is critical for bacterial fitness and pathogenesis. However, the systematic study and inhibition of bacterial glycosylation enzymes remains challenging. Read More

View Article and Full-Text PDF
January 2020

Incorporation of a FRET pair within a phosphonate diester.

Bioorg Chem 2021 May 30;114:105048. Epub 2021 May 30.

Department of Chemistry, The University of Iowa, Iowa City, IA 52245, United States; Department of Pharmacology, University of Iowa, Iowa City, IA 52242, United States. Electronic address:

Cell-cleavable protecting groups are an effective tactic for construction of biological probes because such compounds can improve problems with instability, solubility, and cellular uptake. Incorporation of fluorescent groups in the protecting groups may afford useful probes of cellular functions, especially for payloads containing phosphonates that would be highly charged if not protected, but little is known about the steric or electronic factors that impede release of the payload. In this report we present a strategy for the synthesis of a coumarin fluorophore and a 4-((4-(dimethylamino)phenyl)diazenyl)benzoic acid (DABCYL) ester chromophore incorporated as a FRET pair within a single phosphonate. Read More

View Article and Full-Text PDF

Modular Synthesis of Amphiphilic Chitosan Derivatives Based on Copper-Free Click Reaction for Drug Delivery.

Int J Pharm 2021 Jun 11:120798. Epub 2021 Jun 11.

State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing 210009, P.R. China. Electronic address:

Amphiphilic chitosan derivatives have attracted wide attention as drug carriers due to their physicochemical properties. However, obtaining a desired amphiphilic chitosan derivative by tuning the various functional groups was complex and time-consuming. Therefore, a facile and common synthesis strategy would be promising. Read More

View Article and Full-Text PDF

Fabrication of self-healing nanocomposite hydrogels with the cellulose nanocrystals-based Janus hybrid nanomaterials.

Int J Biol Macromol 2021 Jun 11;184:259-270. Epub 2021 Jun 11.

School of Chemistry and Materials Science, Ludong University, Key Laboratory of High Performance and Functional Polymer in the Universities of Shandong Province, Collaborative Innovation Center of Shandong Province for High Performance Fibers and Their Composites, Yantai 264025, China.

Janus nanomaterials possess remarkable prospects in the design of a series of smart materials with unique asymmetric properties. In this work, surface functionalized Janus cellulose nanocrystalline-type (CNCs-type) nanomaterials were manufactured by Pickering emulsion template and the construction of self-healing nanocomposite hydrogels has been realized. During emulsification, the mussel-inspired chemistry was employed to develop Janus nanocomposites. Read More

View Article and Full-Text PDF

Chitosan-based microneedles as a potential platform for drug delivery through the skin: Trends and regulatory aspects.

Int J Biol Macromol 2021 Jun 11. Epub 2021 Jun 11.

Industrial Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Science (BITS), Pilani, Pilani Campus, Rajasthan, India. Electronic address:

Microneedles (MNs) fabrication using chitosan has gained significant interest due to its ability of film-forming, biodegradability, and biocompatibility, making it suitable for topical and transdermal drug delivery. The presence of amine and hydroxyl functional groups on chitosan permits the modification with tunable properties and functionalities. In this regard, chitosan is the preferred material for fabrication of MNs because it does not produce an immune response in the body and can be tailored as per required strength and functionalities. Read More

View Article and Full-Text PDF

In silico analysis of deleterious SNPs of human MTUS1 gene and their impacts on subsequent protein structure and function.

PLoS One 2021 14;16(6):e0252932. Epub 2021 Jun 14.

Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, Bangladesh.

The mitochondrial tumor suppressor 1 (MTUS1) gene acts as a crucial tumor suppressor by inhibiting growth and proliferation of eukaryotic cells including tumor cell lines. Down regulation of MTUS1 gene has been implicated in a wide range of cancers as well as various human diseases. Alteration through nsSNPs can potentially damage the structure and/or function of the protein. Read More

View Article and Full-Text PDF

Six-minute walk distance, ECOG Performance Status, and Modified Borg Scale scores in a cohort of Pakistani patients with noncancerous end-stage liver disease selected for liver transplant.

J Pak Med Assoc 2021 Apr;71(4):1162-1166

Department of Rehabilitation Medicine, Fauji Foundation Hospital Rawalpindi, Punjab, Pakistan.

Objective: To evaluate the functional status of Pakistani patients with non-cancerous end-stage liver disease selected for liver transplant and to compare results acquired through various assessment tools.

Methods: The study was conducted at the Rehabilitation Medicine Department, Shifa International Hospital Islamabad, Pakistan, from August 2017 to November 2019 and comprised end-stage liver disease patients of either gender who had been selected for liver transplant. Assessment tools included the Six-Minute Walk Distance, Eastern Cooperative Oncology Group Performance Status and Modified Borg Dyspnoea Scale across age, gender, ethnicity, primary aetiology, and Model for end-stage liver disease score. Read More

View Article and Full-Text PDF

An excitation-reception collinear probe for ultrasonic, photoacoustic, and thermoacoustic tri-modal volumetric imaging.

IEEE Trans Med Imaging 2021 Jun 14;PP. Epub 2021 Jun 14.

Imaging systems that integrate multiple modalities can reveal complementary anatomic and functional information as they exploit different contrast mechanisms, which have shown great application potential and advantages in preclinical studies. A portable and easy-to-use imaging probe will be more conducive to transfer to clinical practice. Here, we present a tri-modal ultrasonic (US), photoacoustic (PA), and thermoacoustic (TA) imaging system with an excitation-reception collinear probe. Read More

View Article and Full-Text PDF

Parent rating of intelligibility: A discussion of the construct validity of the Intelligibility in Context Scale (ICS) and normative data of the Swedish version of the ICS.

Int J Lang Commun Disord 2021 Jun 14. Epub 2021 Jun 14.

Division of Speech and Language Pathology, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet (KI), Stockholm, Sweden.

Background: Intelligibility can be defined as the speakers' ability to convey a message to the listener and it is considered the key functional measure of speech. The Intelligibility in Context Scale (ICS) is a parent rating scale used to assess intelligibility in children.

Aims: To describe normative and validation data on the ICS in Swedish and to investigate how these are related to age, gender and multilingualism. Read More

View Article and Full-Text PDF

Vaccination in Older Adults: An Underutilized Opportunity to Promote Healthy Aging in India.

Drugs Aging 2021 Jun 14;38(6):469-479. Epub 2021 Jun 14.

Medical Affairs Department, GlaxoSmithKline Pharmaceuticals Ltd., 205, 2nd Floor, 62 Navketan Building, Secunderabad, Hyderabad, 500003, India.

Over the last 50 years, the Indian population aged 50 years and above (older adults) has quadrupled and is expected to comprise 404 million people in 2036, representing 27% of the country's projected population. Consequently, the contribution of chronic disease to older adults' total burden of diseases in India is likely to escalate. Disease burden is notably amplified by immunosenescence, a deterioration of the immune system that develops with age, leading to increasing susceptibility to infectious diseases and other comorbidities. Read More

View Article and Full-Text PDF

Selection of lactic acid bacteria with promising probiotic aptitudes from fruit and ability to survive in different food matrices.

Braz J Microbiol 2021 Jun 14. Epub 2021 Jun 14.

Laboratório de Microbiologia de Alimentos, Departamento de Nutrição, Centro de Ciências da Saúde, Universidade Federal da Paraíba, Campus I, João Pessoa, Paraíba, Brazil.

Lactic acid bacteria (LAB) are among the most prevalent microorganisms forming the autochthonous microbiota of fruit. This study aimed to select LAB isolates with probiotic aptitudes from apple, banana, grape, and orange through evaluation of in vitro safety, technological, and functional-related properties. The ability of most promising selected isolates to survive in commercial apple and orange juice, meat stew, vegetable puree, and UHT milk during 28 days of refrigeration storage was evaluated. Read More

View Article and Full-Text PDF