952,292 results match your criteria function survival

[Expression and clinical significance of CXC chemokine ligand 10 in glioma].

Zhonghua Yi Xue Za Zhi 2021 Apr;101(14):1031-1035

Department of Radiation Oncology, the Second Affiliated Hospital of Guangxi Medical University, Nanning 530000, China.

To analyze the expression of CXC chemokine ligand 10 (CXCL10) in glioma and its clinical significance through bioinformatics. The expression level of CXCL10 in glioma, and its prognostic significance, gene ontology (GO) function annotation, Kyoto Encyclopedia of Genes and Genome (KEGG) pathway enrichment and the correlation of tumor cell purity were analyzed in TCGA, CGGA, MetaScape, TIMER databases. In addition, 34 clinical glioma tissues were collected for Western Blot and immunohistochemistry to further verify the correlation between CXCL10 and glioma. Read More

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Cardio-pulmonary-renal interactions in ICU patients. Role of mechanical ventilation, venous congestion and perfusion deficit on worsening of renal function: Insights from the MIMIC-III database.

J Crit Care 2021 Mar 29;64:100-107. Epub 2021 Mar 29.

Medical Intensive Care Unit, APHP, Ambroise Paré Hospital, Boulogne-Billancourt, France; Versailles Saint Quentin University, France; INSERM UMR 1018, Team 5 Kidney-Heart, Centre de recherche en Epidémiologie et Santé des Populations, Villejuif, France; FHU SEPSIS (Saclay and Paris Seine Nord Endeavour to PerSonalize Interventions for Sepsis), France.

Background Mechanical ventilation (MV) in ICU patients may impact hemodynamics and renal function. We aimed to describe the interactions of MV settings, hemodynamic parameters and worsening of renal function (WRF). Methods We included adult patients admitted for the first time in the ICU from the MIMIC-III database. Read More

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A label-free electrochemical aptasensor for breast cancer cell detection based on a reduced graphene oxide-chitosan-gold nanoparticle composite.

Bioelectrochemistry 2021 Mar 26;140:107807. Epub 2021 Mar 26.

Department of Chemistry, University of Isfahan, Isfahan 81746-73441, Iran. Electronic address:

Regarding the cancer fatal consequences, early detection and progression monitoring are the most vital issues in patients' treatment and mortality reduction. Therefore, there is a great demand for fast, inexpensive, and selective detection methods. Herein, a graphene-based aptasensor was designed for sensitive human breast cancer cell detection. Read More

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Graft-versus-host disease prophylaxis with posttransplantation bendamustine (PTB) in patients with refractory acute leukemia: a dose-ranging study: Category of manuscript: Regular Manuscript.

Transplant Cell Ther 2021 Apr 9. Epub 2021 Apr 9.

RM Gorbacheva Research Institute, Pavlov University, Saint-Petersburg, Russian Federation. Electronic address:

Background: The prognosis of acute leukemia refractory to induction chemotherapy or immunotherapy is dismal. Salvage allogeneic hematopoietic stem cell transplantation (HSCT) is widely used option for these patients, but only 10-15% of patients are cured by the procedure. Preclinical studies indicate that substitution of posttransplantation cyclophosphomide (PTCY) with bendamustine (PTB) in a prophylaxis regimen may be associated with augmented graft-versus-leukemia (GVL) reaction. Read More

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Caspofungin pharmacokinetics and probability of target attainment in ICU patients in China.

J Glob Antimicrob Resist 2021 Apr 9. Epub 2021 Apr 9.

Department of intensive care unit, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Electronic address:

Background: Effective antifungal therapy is important for reducing the mortality of patients with invasive fungal diseases. Numerous factors affect the pharmacokinetic (PK)/pharmacodynamic (PD) parameters in critically ill patients. To guide the individualized administration of the antifungal drug caspofungin in critically ill patients, it is of great significance to investigate the population pharmacokinetics of caspofungin. Read More

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Left Ventricular Global Longitudinal Strain as a Predictor of Outcomes in Heart Failure Patients with Secondary Mitral Regurgitation: The COAPT Trial.

J Am Soc Echocardiogr 2021 Apr 9. Epub 2021 Apr 9.

Medstar Health Research Institute, Washington, DC; Georgetown University, Washington, DC. Electronic address:

Background: Left ventricular (LV) global longitudinal strain (GLS) is a sensitive marker of LV function and may help identify patients with heart failure (HF) and secondary mitral regurgitation (SMR) who would have a better prognosis and are more likely to benefit from edge-to-edge transcatheter mitral valve repair (TMVr) with the MitraClip. We sought to assess the prognostic utility of baseline LVGLS during 2-year follow-up of HF patients with SMR enrolled in the COAPT trial.

Methods: Symptomatic HF patients with moderate-to-severe or severe SMR who remained symptomatic despite maximally-tolerated guideline directed medical therapy (GDMT) were randomized to TMVr plus GDMT or GDMT alone. Read More

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Intracellular pathways involved in cell survival are deregulated in mouse and human spinal muscular atrophy motoneurons.

Neurobiol Dis 2021 Apr 9:105366. Epub 2021 Apr 9.

Neuronal Signaling Unit, Experimental Medicine Department, Universitat de Lleida-IRBLleida, Rovira Roure, 80, 25198 Lleida, Spain; Neuronal Signaling Unit, Experimental Medicine Department, Universitat de Lleida-IRBLleida, Rovira Roure, 80, 25198 Lleida, Spain. Electronic address:

Spinal Muscular Atrophy (SMA) is a severe neuromuscular disorder caused by loss of the Survival Motor Neuron 1 gene (SMN1). Due to this depletion of the survival motor neuron (SMN) protein, the disease is characterized by the degeneration of spinal cord motoneurons (MNs), progressive muscular atrophy, and weakness. Nevertheless, the ultimate cellular and molecular mechanisms leading to cell loss in SMN-reduced MNs are only partially known. Read More

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Renal and cardiovascular repercussions in preeclampsia and their impact on fluid management: a literature review.

Braz J Anesthesiol 2021 Apr 9. Epub 2021 Apr 9.

Universidade de São Paulo (USP), Hospital das Clínicas, Faculdade de Medicina, São Paulo, SP, Brazil.

Preeclampsia is a multifactorial condition associated with significant morbidity and mortality. Fluid therapy in these patients is challenging since volume expansion may precipitate pulmonary edema, and fluid restriction may worsen renal function. Furthermore, cardiac impairment may introduce an additional component to the hemodynamic management. Read More

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Blind spot in sepsis management - Tissue level changes in microcirculation.

Physiol Int 2021 Apr 9. Epub 2021 Apr 9.

3Department of Emergency Medicine, Clinical Centre, University of Pécs, Pécs, Hungary.

In sepsis cytokine-mediated inflammation, clotting cascade activation and glycocalyx shedding impair both function and structure of the microcirculation, compromising adequate tissue oxygenation/perfusion. Such mismatch results in "dysoxia", an imbalance in mitochondrial respiration.Microvessel injuries can be grouped into four types: cytotoxic oedema, micro-vessel heterogeneity, sluggish/absent flow, and focal anaemia. Read More

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Effect of Photobiomodulation on Restoration of Ionization Radiation-Induced Thyroid Dysfunction Through p53 and Retinoblastoma Signaling.

Photobiomodul Photomed Laser Surg 2021 Apr;39(4):254-264

Beckman Laser Institute Korea, Dankook University, Cheonan, Republic of Korea.

This study aimed to investigate whether photobiomodulation (PBM) restores normal thyroid follicular cells affected by ionizing radiation, and to determine the mechanism of PBM on thyroid function. Despite diverse applications of PBM to medical therapy, there has been no evidence of its involvement with thyroid function. A light emission diode (850 nm) array was used at 2, 5, and 10 J/cm for analysis in human thyroid N-Thy-3. Read More

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The predictive value of neurobiological measures for recidivism in delinquent male young adults.

J Psychiatry Neurosci 2021 Apr 12;46(2):E271-E280. Epub 2021 Apr 12.

From the Amsterdam University Medical Centers, Department of Child and Adolescent Psychiatry, Amsterdam, Netherlands (Zijlmans, Marhe, Bevaart, van Duin, Luijks, Popma); the Erasmus University Rotterdam, Department of Psychology, Education and Child Studies, Rotterdam, Netherlands (Marhe, Franken); the Harvard T. H. Chan School of Public Health, Department of Social and Behavioral Sciences, Boston, Massachusetts (Tiemeier); the Erasmus University Medical Center, Department of Child and Adolescent Psychiatry, Rotterdam, Netherlands (Tiemeier); and Leiden University, Department of Criminal Law and Criminology, Leiden, Netherlands (Popma).

Background: Neurobiological measures have been associated with delinquent behaviour, but little is known about the predictive power of these measures for criminal recidivism and whether they have incremental value over and above demographic and behavioural measures. This study examined whether selected measures of autonomic functioning, functional neuroimaging and electroencephalography predict overall and serious recidivism in a sample of 127 delinquent young adults.

Methods: We assessed demographics; education and intelligence; previous delinquency and drug use; behavioural traits, including aggression and psychopathy; and neurobiological measures, including heart rate, heart rate variability, functional brain activity during an inhibition task and 2 electroencephalographic measures of error-processing. Read More

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Prognostic evidence of LEF1 isoforms in childhood acute lymphoblastic leukemia.

Int J Lab Hematol 2021 Apr 12. Epub 2021 Apr 12.

Department of Genetics, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey.

Introduction: The lymphoid enhancer factor 1 (LEF1) is a DNA-binding transcription factor that functions in the Wnt signaling pathway. Increased LEF1 activity is associated with progression of several types of cancer including leukemia. Here, we investigated LEF1 isoform expression and genomic variations in acute lymphoblastic leukemia (ALL). Read More

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Trans-ovo permethrin exposure affects growth, brain morphology and cardiac development in quail.

Environ Toxicol 2021 Apr 12. Epub 2021 Apr 12.

School of Biological Sciences and Center for Reproductive Biology, Washington State University, Pullman, Washington, USA.

Permethrin is a commonly used, highly effective pesticide in poultry agriculture, and has recently been trialed in conservation efforts to protect Galápagos finch hatchlings from an invasive ectoparasite. Although permethrin is considered safe for adults, pesticides can have health consequences when animals are exposed during early life stages. The few studies that have examined permethrin's effects in embryonic chicks and rats have shown hydrocephaly, anencephaly, reduced cellular energy conversion, and disruption of developing heart muscle. Read More

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Morbidly adherent placenta and cesarean section methods. A retrospective comparative multicentric study on two different skin and uterine incision.

Ginekol Pol 2021 Apr 12. Epub 2021 Apr 12.

Department of Obstetrics and Gynecology, "Veris delli Ponti" Hospital, Scorrano, Lecce, Italy.

Objectives: Morbidly adherent placenta (MAP) is one of leading causes of maternal mortality, with an increasing rate because of repeated cesarean sections (CS). The primary objective of this study is to compare two techniques of skin and uterine incisions in patients with MAP, evaluating the maternal fetal impact of the two methods. Retrospective multicentric cohort study. Read More

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Predictors of poor neonatal outcomes in fetuses diagnosed with congenital urinary tract anomalie.

Ginekol Pol 2021 Apr 12. Epub 2021 Apr 12.

Clinic for Gynecology and Obstetrics, Clinical Center of Niš, Serbia.

Objectives: Urinary tract anomalies account for approximately one-quarter of all antenatally detected anomalies. The aim of this study was to identify factors associated with severe adverse neonatal outcomes of a prenatally diagnosed urinary tract anomaly.

Material And Methods: A retrospective-prospective study included 101 pregnant women with prenatally diagnosed fetal urinary tract anomalies presented to the Council for Fetal Anomalies. Read More

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Prognosis and Risk Factors of Sepsis Patients in Chinese Icus: A Retrospective Analysis of A Cohort Database.

Shock 2021 Mar 31. Epub 2021 Mar 31.

Department of Critical Care Medicine, Fuxing Hospital, Capital Medical University. 20A Fuxingmenwai Street, Xicheng District, Beijing 100038, China Department of Statistics, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China. Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University. 10 Xitoutiao, Youanmenwai, Fengtai District, Beijing 100069, China Department of Critical Care Medicine, Xuanwu Hospital, Capital Medical University. 45 Changchun Road, Xicheng District, Beijing 100045, China.

Background: Sepsis-3 proposed a new definition of septic shock that excluded patients without hyperlactacidemia. The data from China might help to elucidate the prognosis of this special patient group.

Objective: To study the clinical prognosis and factors affecting patients with sepsis based on data from Chinese intensive care units (ICUs). Read More

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Calcineurin-mediated intracellular organelle calcium homeostasis is required for the survival of fungal pathogens upon extracellular calcium stimuli.

Virulence 2021 Dec;12(1):1091-1110

Jiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Centre for Microbiology, College of Life Sciences, Nanjing Normal University, Nanjing, China.

In eukaryotes, calcium not only is an essential mineral nutrient but also serves as an intracellular second messenger that is necessary for many physiological processes. Previous studies showed that the protein phosphatase-calcineurin protects fungi from toxicity caused by the extracellular calcium; however, little is known about how calcineurin mediates the cellular physiology process for this function. In this study, by monitoring intracellular calcium, particularly by tracking vacuolar calcium dynamics in living cells through a novel procedure using modified aequorin, we found that calcineurin dysfunction systematically caused abnormal intracellular calcium homeostasis in cytosol, mitochondria, and vacuole, leading to drastic autophagy, global organelle fragmentation accompanied with the increased expression of cell death-related enzymes, and cell death upon extracellular calcium stimuli. Read More

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December 2021

An implantable cardioverter-defibrillator for primary prevention in non-ischemic cardiomyopathy: A systematic review and meta-analysis.

Cardiol J 2021 Apr 12. Epub 2021 Apr 12.

3rd Department of Cardiology, Silesian Center for Heart Diseases, Medical University of Silesia, Zabrze, Poland.

Background: Recent data regarding the comparison of implantable cardioverter-defibrillator (ICD) therapy and optimal medical treatment in patients with non-ischemic cardiomyopathy has indicated no mortality benefit as a result of ICD therapy. Although the recommendations for ICD implantation did not change, it is worth noting that these findings significantly affected the daily practice of ICD implantation in Europe.

Methods: To assess the effect of ICD implantation in comparison to pharmacotherapy in the non-ischemic cardiomyopathy heart failure population through a systematic review and meta-analysis of the available carefully designed prospective randomized controlled trials. Read More

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Machine learning approach to gene essentiality prediction: a review.

Brief Bioinform 2021 Apr 10. Epub 2021 Apr 10.

Department of Computer and Information Sciences, Covenant University, Ota, Ogun State, Nigeria.

 : Essential genes are critical for the growth and survival of any organism. The machine learning approach complements the experimental methods to minimize the resources required for essentiality assays. Previous studies revealed the need to discover relevant features that significantly classify essential genes, improve on the generalizability of prediction models across organisms, and construct a robust gold standard as the class label for the train data to enhance prediction. Read More

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Neuroendocrine cells of the prostate: Histology, biological functions, and molecular mechanisms.

Precis Clin Med 2021 Mar 28;4(1):25-34. Epub 2021 Jan 28.

Department of Pathology, Duke University School of Medicine, Durham, NC 27710, USA.

Prostate cancer (PCa) is a common cause of cancer-related mortality in men worldwide. Although most men are diagnosed with low grade, indolent tumors that are potentially curable, a significant subset develops advanced disease where hormone therapy is required to target the androgen receptor (AR). Despite its initial effect, hormone therapy eventually fails and the tumor progresses to lethal stages even through continued inhibition of AR. Read More

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Distinct prognostic values of programmed death-ligand 1 and programmed cell death protein 1 in lung adenocarcinoma and squamous cell carcinoma patients.

Ann Transl Med 2021 Mar;9(5):397

Department of Medical Oncology, the First Hospital of China Medical University, Shenyang, China.

Background: Although immunotherapy has demonstrated similar clinical activities in the treatment of lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC), several studies have shown programmed death-ligand 1 (PD-L1) to have different predictive roles in ADC and SCC. This study was conducted to compare the different functions of PD-L1/programmed cell death protein 1 (PD-1) pathway in these malignancies.

Methods: A multi-dimensional analysis based on public databases and 2 independent cohorts including 262 patients with lung cancer was performed. Read More

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In-hospital mortality of liver transplantation and risk factors: a single-center experience.

Ann Transl Med 2021 Mar;9(5):369

Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Background: Liver transplantation (LT) is a life-saving treatment for patients with end-stage liver disease and acute liver failure. However, in-hospital death cannot be avoided. We designed this study to analyze patients' in-hospital mortality rate after LT and the factors correlated with in-hospital death. Read More

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Comparison of Clinical Outcomes Between Chinese Patients Receiving Hepatectomy With or Without Enhanced Recovery After Surgery Strategy.

Front Surg 2021 26;8:645935. Epub 2021 Mar 26.

Department of Hepatobiliary Surgery, Inner Mongolia Xing'an Meng People's Hospital, Ulanhot, China.

For the first time in China, the current study was designed to compare the clinical outcomes between Chinese patients receiving hepatectomy with or without the enhanced recovery after surgery (ERAS) strategy. The current study enrolled 250 patients who would receive hepatectomy. Patients were randomized into two groups: ERAS group ( = 125, ERAS strategy) and control ( = 125, conventional care). Read More

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Metallic Ions Encapsulated in Electrospun Nanofiber for Antibacterial and Angiogenesis Function to Promote Wound Repair.

Front Cell Dev Biol 2021 25;9:660571. Epub 2021 Mar 25.

Department of Breast Surgery, Hainan General Hospital, Hainan Medical University, Haikou, China.

Electrospun nanofiber is an attractive biomaterial for skin tissue engineering because it mimics the natural fibrous extracellular matrix structure and creates a physical structure suitable for skin tissue regeneration. However, endowing the nanofibrous membranes with antibacterial and angiogenesis functions needs to be explored. In the current study, we aimed to fabricate gelatin/polycaprolactone (GT/PCL) (GT/PCL-Ag-Mg) nanofibers loaded with silver (Ag) and magnesium (Mg) ions for antibacterial activity and pro-angiogenesis function for wound repair. Read More

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3-Deoxysappanchalcone Inhibits Skin Cancer Proliferation by Regulating T-Lymphokine-Activated Killer Cell-Originated Protein Kinase and .

Front Cell Dev Biol 2021 25;9:638174. Epub 2021 Mar 25.

Department of Pathophysiology, School of Basic Medical Sciences, College of Medicine, Zhengzhou University, Zhengzhou, China.

Background: Skin cancer is one of the most commonly diagnosed cancers worldwide. The 5-year survival rate of the most aggressive late-stage skin cancer ranges between 20 and 30%. Thus, the discovery and investigation of novel target therapeutic agents that can effectively treat skin cancer is of the utmost importance. Read More

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The Collective Effect of MIP-3α and FL Promotes Dendritic Cell Function Within the Immune Microenvironment of Murine Liver Cancer.

Front Oncol 2021 26;11:646527. Epub 2021 Mar 26.

Graduate School, Shanxi Medical University, Taiyuan, China.

Hepatocellular carcinoma is a highly malignant and lethal tumor. In addition to surgery, immunotherapy is currently a more effective treatment for hepatocellular carcinoma. The tumor immune microenvironment (TIME) largely determines the efficacy of cancer immunotherapy. Read More

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LncRNA SNHG19 Promotes the Development of Non-Small Cell Lung Cancer Mediating miR-137/E2F7 Axis.

Front Oncol 2021 25;11:630241. Epub 2021 Mar 25.

Department of Thoracic Surgery, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Objective: Non-small cell lung cancer (NSCLC) is a common malignant tumor, which has high incidence and low the 5-year survival rate. Long non-coding RNAs (lncRNAs) play critical roles in carcinoma occurrence and metastasis. Herein, our aim was to investigate the effects of lncRNA SNHG19 in NSCLC progression. Read More

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Continuous-flow left ventricular assist device versus orthotopic heart transplantation in adults with heart failure: a systematic review and meta-analysis.

Ann Cardiothorac Surg 2021 Mar;10(2):209-220

Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Cardiovascular Clinical College of Tianjin Medical University, Tianjin, China.

Background: Due to the lack of donor hearts, many studies have assessed the prognosis of heart failure (HF) patients treated with a continuous-flow left ventricular assist device (CF-LVAD). However, previous results have not been consistent and minimal data is available regarding long-term outcomes. There is no consensus on whether CF-LVAD as a bridge or destination therapy (DT) can equal orthotopic heart transplantation (HTx). Read More

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Expression and clinical implications of estrogen receptors in thoracic malignancies: a narrative review.

J Thorac Dis 2021 Mar;13(3):1851-1863

Department of Pharmaceutical Sciences, University of Piemonte Orientale, 28100 Novara, Italy.

Thoracic malignancies represent a significant global health burden with incidence and mortality increasing year by year. Thoracic cancer prognosis and treatment options depend on several factors, including the type and size of the tumor, its location, and the overall health status of patients. Gender represents an important prognostic variable in thoracic malignancies. Read More

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A propensity-matched analysis of stereotactic body radiotherapy and sublobar resection for stage I non-small cell lung cancer in patients at high risk for lobectomy: the results in a Chinese population.

J Thorac Dis 2021 Mar;13(3):1822-1832

Department of Radiation Oncology, Shanghai Pulmonary Hospital Tongji University, Shanghai, China.

Background: To investigate the comparative effectiveness of stereotactic body radiotherapy (SBRT) and sublobar resection (SLR) in patients with stage I non-small cell lung cancer (NSCLC) considered to be high-risk lobectomy patients.

Methods: From January 2012 to December 2015, patients who underwent SBRT or SLR for clinical stage I NSCLC were examined retrospectively. Propensity score matching (PSM) was performed to reduce selection bias in SBRT and SLR patients. Read More

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