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Comparison of patient- and clinician-reported outcome measures in lower back rehabilitation: introducing a new integrated performance measure (t2D).

Qual Life Res 2021 Jun 15. Epub 2021 Jun 15.

Ludwig Boltzmann Institute for Rehabilitation Research, Reizenpfenninggasse 1, 1140, Vienna, Austria.

Purpose: Patient- and clinician-reported outcome measures (PROMs, CROMs) are used in rehabilitation to evaluate and track the patient's health status and recovery. However, controversy still exists regarding their relevance and validity when assessing a change in health status.

Methods: We retrospectively analyzed the changes in a CROM (Fingertip-To-Floor Test - FTF) and PROMs (ODI, HAQ-DI, NPRS, EQ5D) and the associations between these outcomes in 395 patients with lower back pain (57. Read More

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Personal responsibility for health? A phenomenographic analysis of general practitioners' conceptions.

Scand J Prim Health Care 2021 Jun 15:1-10. Epub 2021 Jun 15.

Department of Research and Development, Region Kronoberg, Växjö, Sweden.

Objective: To analyse and describe general practitioners' perceptions of the notion of a 'personal responsibility for health'.

Design: Interview study, phenomenographic analysis.

Setting: Swedish primary health care. Read More

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Daratumumab provides a survival benefit in relapsed and refractory Multiple Myeloma, independent of baseline clinical characteristics: A meta-analysis.

Pharmacol Res Perspect 2021 Aug;9(4):e00797

Radiology Department, The People's Hospital of Pingyi County, Linyi, China.

Daratumumab was approved in patients with relapsed or refractory multiple myeloma (MM) who previously received proteasome inhibitors or immunomodulatory drugs. However, the efficacy and safety of the addition of daratumumab in subpopulations of patients with relapsed or refractory MM is still unknown. We systematically searched MEDLINE, EMBASE, and Cochrane for randomized controlled trials (inception to September 2020). Read More

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Psychosocial factors affecting quality of life in patients with anorectal malformation and Hirschsprung disease-a qualitative systematic review.

J Pediatr Surg 2021 May 21. Epub 2021 May 21.

Comprehensive Colorectal Center, Children's Mercy-Kansas City, Kansas City, MO, United States; Department of Surgery, Children's Mercy Hospital Kansas City, MO, United States; University of Missouri-Kansas City School of Medicine, United States. Electronic address:

Introduction: Little is known about psychosocial and behavioral factors that impact the quality of life of patient's with anorectal malformations (ARM) and Hirschsprung disease (HSCR). We aimed to highlight the psychosocial, emotional, and behavioral themes that affect these patients.

Methods: A qualitative literature review of articles published between 1980 and 2019 was performed. Read More

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The Dilemma, Conversion Disorder or Stiff Person Syndrome, a Case Report.

Sultana Jahan

CNS Spectr 2021 Apr;26(2):145-146

University of Missouri, Department of Psychiatry, Columbia, MO, USA.

Study Objectives: The main objectives of this case study are 1. Clinicians facing symptoms that are difficult to interpret should exercise caution in diagnosing conversion disorder. 2. Read More

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Anti-neutrophil cytoplasmic antibody-associated vasculitis accompanied by type II heparin-induced thrombocytopenia resulting in asymptomatic cerebral infarction: a case report.

BMC Nephrol 2021 Jun 14;22(1):220. Epub 2021 Jun 14.

Department of Hypertension and Nephrology, NTT Medical Centre, 5-9-22, Higasi- Gotanda, Shinagawa-ku, 141-8625, Tokyo, Japan.

Background: Heparin-induced thrombocytopenia (HIT) involves platelet activation and aggregation caused by heparin or HIT antibodies associated with poor survival outcomes. We report a case of HIT that occurred after hemodialysis was started for rapidly progressive glomerulonephritis (RPGN), which was caused by anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV), and ultimately resulted in asymptomatic cerebral infarction.

Case Presentation: A 76-year-old Japanese man was urgently admitted to our hospital for weight loss and acute kidney injury (serum creatinine: 12 mg/dL). Read More

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Dynamic Assessment of Femoroacetabular Impingement Syndrome Hips.

Arthroscopy 2021 Jun 11. Epub 2021 Jun 11.

Department of Orthopedic Surgery, Hospital for Special Surgery, New York, NY, USA.

Purpose: The purpose of our study was to compare lower extremity rotational kinematics and kinetics (angles, torques, and powers) and hip muscle EMG activity between cam-type FAIS and age-sex matched controls during walking, fast walking, stair ascent, stair descent, and sit-to-stand.

Methods: This study included ten males with unilateral FAIS and ten control males with no FAIS. We measured kinematics, kinetics and electromyographic signals during stair ascent/descent, sit-to-stand, self-selected and fast walk. Read More

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Hedgehog transcriptional effector GLI mediates mTOR-Induced PD-L1 expression in gastric cancer organoids.

Cancer Lett 2021 Jun 11. Epub 2021 Jun 11.

Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA. Electronic address:

Tumors evade immune surveillance by expressing Programmed Death-Ligand 1 (PD-L1), subsequently inhibiting CD8 cytotoxic T lymphocyte function. Response of gastric cancer to immunotherapy is relatively low. Our laboratory has reported that Helicobacter pylori-induced PD-L1 expression within the gastric epithelium is mediated by the Hedgehog (Hh) signaling pathway. Read More

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A case of Philadelphia chromosome-positive acute lymphocytic leukaemia with type I CD36 deficiency.

Vox Sang 2021 Jun 14. Epub 2021 Jun 14.

Department of Transfusion Medicine, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan.

Background: CD36 is a glycoprotein expressed on platelets and monocytes of the blood. There are two types of CD36 deficiency, type I and type II. Individuals with type I-deficiency do not express CD36 in any cell type and can produce the CD36 antibody, which causes pathological conditions, such as fetal/neonatal alloimmune thrombocytopenia (FNAIT) and platelet transfusion refractory (PTR), through antigenic exposure via transfusion or pregnancy. Read More

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Assessment of Volume Status and Fluid Responsiveness in Small Animals.

Front Vet Sci 2021 28;8:630643. Epub 2021 May 28.

Department of Companion Animals, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.

Intravenous fluids are an essential component of shock management in human and veterinary emergency and critical care to increase cardiac output and improve tissue perfusion. Unfortunately, there are very few evidence-based guidelines to help direct fluid therapy in the clinical setting. Giving insufficient fluids and/or administering fluids too slowly to hypotensive patients with hypovolemia can contribute to continued hypoperfusion and increased morbidity and mortality. Read More

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Cardiac Arrest and Inverted Takotsubo Cardiomyopathy Following Intramyometrial Vasopressin Injection During Myomectomy.

Eur J Case Rep Intern Med 2021 21;8(5):002504. Epub 2021 May 21.

Department for Intensive Internal Medicine, University Medical Center Ljubljana, Slovenia.

Vasopressin is involved in cardiovascular homeostasis that can influence coronary perfusion. It is commonly used as a local vasoconstricting agent during gynaecological procedures. We present a case of cardiac arrest and inverse Takotsubo features following intramyometrial vasopressin administration during myomectomy. Read More

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Nivolumab for Metastatic Urothelial Cancer in a Renal Allograft Recipient With Subsequent Graft Rejection and Treatment Complete Remission: A Case Report.

Front Oncol 2021 26;11:646322. Epub 2021 May 26.

Department of Radiation and Medical Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Immune checkpoint inhibitors (ICIs) expanded the therapeutic options for several cancers. However, whether some special groups of patients including those with organ transplantation can receive ICIs remains unclear. In this report we presented an interesting case. Read More

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Profound Metabolic Acidosis due to Metformin Intoxication Requiring Dialysis.

Case Rep Nephrol 2021 24;2021:9914982. Epub 2021 May 24.

Ingham Nephrology and Hypertension, 405 W Greenlawn Ave # 230, Lansing, MI 48910, USA.

Metformin-associated lactic acidosis (MALA) is a rare but life-threatening condition with often high mortality rates. Despite this, metformin continues to be one of the most commonly prescribed antihyperglycemic agents in the market. We present a unique case of a 61-year-old female with severe acidosis of pH = 6. Read More

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Case Report: Deep Brain Stimulation of the Nucleus Basalis of Meynert for Advanced Alzheimer's Disease.

Front Hum Neurosci 2021 26;15:645584. Epub 2021 May 26.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Patients with advanced Alzheimer's disease (AD) experience cognitive impairment and physical disabilities in daily life. Currently, there are no treatments available to slow down the course of the disease, and limited treatments exist only to treat symptoms. However, deep brain stimulation of the nucleus basalis of Meynert (NBM-DBS) has been reported to improve cognitive function in individuals with AD. Read More

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Bacillus Calmette-Guérin-induced perinuclear antineutrophil cytoplasmic antibodies associated vasculitis in bladder cancer.

J Cancer Res Ther 2021 Apr-Jun;17(2):609-612

Department of Nephrology, University of Health Sciences Bakırkoy Dr. Sadi Konuk Research and Educational Hospital, Istanbul, Turkey.

Intravesical instillation of Bacillus Calmette-Guérin (BCG) immunotherapy remains the most effective adjuvant treatment for noninvasive bladder cancer. Systemic BCG-related complications are rare and usually related to infective agent or an immune-mediated reaction. We discussed a case with perinuclear antineutrophil cytoplasmic antibodies (p-ANCA) vasculitis, developing after instillation of BCG for non-invasive bladder cancer. Read More

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Enhanced recovery after surgery for sleeve gastrectomies: improved patient outcomes.

Surg Obes Relat Dis 2021 May 3. Epub 2021 May 3.

Department of Surgery, Saint Barnabas Medical Center, RWJ Barnabas Health, Livingston, New Jersey. Electronic address:

Background: Enhanced Recovery After Surgery (ERAS) is a paradigm shift in perioperative care and incorporates patient-centered, evidence-based, and multidisciplinary team-developed pathways for a surgical specialty. ERAS pathways aim to reduce the patient's surgical stress response, optimize their physiologic function, facilitate recovery, and reduce the length of stay. The bariatric program at our institution was previously managed by many surgeons with anecdotal preferences, resulting in increased costs, lengths of stay, and opioid prescribing. Read More

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Total femur replacement in a patient with chronic persistence osteomyelitis - A case report.

Int J Surg Case Rep 2021 Jun 9;84:106067. Epub 2021 Jun 9.

E Hospital, Hanoi, Viet Nam; University of Medicine and Pharmacy, Vietnam National University, Hanoi, Viet Nam. Electronic address:

Introduction And Importance: Total femoral replacement (TFR) is a salvage surgical procedure that has been indicated mainly for oncologic indication to avoid lower limb amputation but has recently been indicated for non-oncological disorders.

Case Presentation: We report the case of a 63-year-old male with chronic osteomyelitis of the left femur, severe pain and bone deformation, the risk of amputation in this patient was very high. The patient underwent total femur replacement (TFR) with a modular mega-prosthesis. Read More

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Quality of life in patients with soft palate resection: The relationship between reported functional prosthetic outcomes and the patient's psychological adjustment.

J Prosthet Dent 2021 Jun 10. Epub 2021 Jun 10.

Professor and Chief, Department of Prosthodontics, National and Kapodistrian University of Athens, School of Dentistry, Athens, Greece.

Statement Of Problem: Tumors of the soft palate and the adjacent tissues often create considerable soft palate defects that are challenging for the maxillofacial prosthodontist. Soft palate obturator prostheses can usually address functional and esthetic concerns; however, the effectiveness of the prosthetic rehabilitation in improving the patient's well-being and overall quality of life (QOL) has not been extensively researched.

Purpose: The purpose of the present research was to evaluate the function of the prosthesis, to review the interrelation between sociodemographic, medical, and treatment (SMT) characteristics, QOL, and prosthesis functioning, and to analyze the role of the prosthesis in how the patient represents the illness and the psychological coping response. Read More

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Determining the approximate factor VIII level of patients with severe haemophilia A on emicizumab using in vivo global haemostasis assays.

Haemophilia 2021 Jun 11. Epub 2021 Jun 11.

Children's Hospital Los Angeles, Hemostasis and Thrombosis Center, Los Angeles, California, USA.

Introduction: Emicizumab is a recombinant, humanized bispecific monoclonal antibody that mimics the function of factor VIII (FVIII) which results in a significant reduction in the annualized bleeding rate in patients with haemophilia A (HA), however, the degree with which emicizumab corrects the coagulation defect remains unclear. The objective of this study was to predict the approximate FVIII level in severe haemophilia A patients with inhibitors on emicizumab using global haemostasis assays.

Materials And Methods: Patients with moderate and mild HA in the non-bleeding state and healthy controls had FVIII levels and thrombin generation assessed. Read More

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GABAA receptor encephalitis associated with human parvovirus B19 virus infection: Case report.

Medicine (Baltimore) 2021 Jun;100(23):e26324

Faculdades Pequeno Principe.

Rationale: Human parvovirus B19 (B19) infection can produce a spectrum of clinical syndromes, including neurological manifestations, most notably encephalitis. Although symptoms suggestive of autoimmune disease in patients with B19 infection have been previously described, a clear association of autoimmune encephalitis with B19 infection has yet to be established.

Patient Concerns: We describe the case of a 6-year-old boy who was hospitalized due to status epilepticus, which evolved to super-refractory status epilepticus that was only mildly responsive to anticonvulsant drugs. Read More

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Can the Knee Outcome and Osteoarthritis Score (KOOS) Function Subscale Be Linked to the PROMIS Physical Function to Crosswalk Equivalent Scores?

Clin Orthop Relat Res 2021 Jun 11. Epub 2021 Jun 11.

Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Background: An increased focus on patient-reported outcome measures (PROMs) has led to a proliferation of these measures in orthopaedic surgery. Mandating a single PROM in clinical and research orthopaedics is not feasible given the breadth of data already collected with older measures and the emergence of psychometrically superior measures. Creating crosswalk tables for scores between measures allows providers to maintain control of measure choice. Read More

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Dietary recommendations during the Covid-19 pandemic. Statement of the Committee of Human Nutrition Science of the Polish Academy of Sciences.

Rocz Panstw Zakl Hig 2021 ;72(2):209-220

Department of Dietetics, Warsaw University of Life Sciences, Warsaw, Poland.

During the COVID-19 pandemic, care for an adequate diet, well adapted to the body's needs and the current level of physical activity, becomes of particular importance. Many dietary compounds participate in the functioning of the immune system, while vitamins D, C, A (including beta-carotene), E, B6, B12, folic acid, zinc, copper, selenium, iron, amino acids, n-3 and n-6 polyunsaturated fatty acids and intestinal microbiota are crucial in various types of defence processes. There has been no evidence that consumed food and its compounds, including those with pro-/prebiotic properties, play a significant role in preventing SARS-CoV-2 infection or alleviating its course. Read More

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January 2021

Zhengyuan capsule for the treatment of cancer-related fatigue in lung cancer patients undergoing operation: a study protocol for a randomized controlled trial.

J Tradit Chin Med 2021 Jun;41(3):486-491

Department of Integrated Chinese and Western Medicine, Shanghai Chest Hospital Shanghai JiaoTong University, Shanghai 200030, China.

Objective: To evaluate the efficacy and safety of Zhengyuan capsule () when treating Cancer-related fatigue (CRF) in lung cancer patients undergoing surgical operation.

Methods/design: This is a single-center, double-blinded, prospective, and randomized controlled trial in the Department of Integrated Chinese and Western Medicine, Shanghai Chest Hospital Shanghai JiaoTong University, Shanghai. Eligible participants will be randomly allocated into two groups: a treatment group receiving an 8-week Zhengyuan capsule regimen therapy and a control group receiving an 8-week placebo capsule regimen therapy. Read More

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Efficiency of an Optimized Care Organization in Fibromyalgia Patients: The From Intent to Move (FIMOUV) Study Protocol of a Randomized Controlled Trial.

Front Public Health 2021 25;9:554291. Epub 2021 May 25.

University Lyon, UJM-Saint-Etienne Sainbiose Laboratory, INSERM U1059, Saint-Étienne, France.

Fibromyalgia (FM) is characterized by multiple symptoms including pain, fatigue, and sleep disorders, altering patient's quality of life. In the absence of effective pharmacological therapy, the last European guidelines recommend a multidisciplinary management based on exercise and education. Thus, our main objective was to measure the effectiveness of a healthcare organization offering a specific program of adapted physical activity combined with a therapeutic education program for FM patients. Read More

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Recurrent uncomplicated urinary tract infections: definitions and risk factors.

Tommaso Cai

GMS Infect Dis 2021 27;9:Doc03. Epub 2021 May 27.

Department of Urology, Santa Chiara Hospital, Trento, Italy.

Recurrent uncomplicated urinary tract infections (UTI) have a high impact on patients' quality of life and high direct and indirect costs for public health. Therefore, optimal management should be of high priority. Current international guidelines were reviewed, and a systematic literature search was performed in Medline, Cochrane, and Embase. Read More

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Triage and resuscitation tools for low and middle income countries: how to catch the killer?

Arch Dis Child Educ Pract Ed 2021 Jun 10. Epub 2021 Jun 10.

Emergency Department, Gold Coast University Hospital, Southport, Queensland, Australia

Under-5 mortality rates in low and middle-income countries (LMIC) remain high. One major contributing factor is the failure to recognise critically unwell children when they first present to hospital. This leads to delayed or inadequate resuscitation and an increased risk of death. Read More

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[Application progress of ultrasound monitoring of diaphragm function in clinic].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 May;33(5):638-640

Department of Anesthesiology, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, China.

In recent years, point of care ultrasound (POCUS) has developed rapidly in the fields of anesthesia and critical care. POCUS is widely used in clinic to monitor the function of human tissues and organs such as the heart, lungs, and diaphragm due to its visual, non-invasive, portable, and repeatable characters at the bedside. Diaphragm is an important structure to maintain respiratory function. Read More

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Wrist fracture management and the role of surgical care practitioner through the patient's journey.

J Perioper Pract 2021 Jun 10:1750458920976070. Epub 2021 Jun 10.

School of Allied Health, Faculty of HEMS, Anglia Ruskin University, Essex, UK.

The presentation of this case study involves an exploration of the patient's journey in detail after having a traumatic wrist fracture, which is recognised as one of the most common fractures encountered daily in emergency services by junior doctors and practitioners. However, this article not only analyses the medical guidance for this type of case, but also the importance of the surgical care practitioner role in trauma and orthopaedics. All practitioners attending patients in emergency services are required to develop a good knowledge of anatomy, physiology, patient's examination technique, classifications and consequently being aware of the possible surgical options for treatment of the fracture. Read More

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Mechano-regulation of Vascular Network Formation without Branches in 3D Bioprinted Cell-laden Hydrogel Constructs.

Biotechnol Bioeng 2021 Jun 10. Epub 2021 Jun 10.

Ruihua Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215104, China.

Restoration of a wound is a common surgical procedure in clinic. Currently, the skin required for clinical use is taken from the patient's own body. However, it can be difficult to obtain enough skin sources for large-sized wounds and thus surgeons have started using commercial skin substitutes. Read More

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Staggered Dual Kidney Transplantation.

Prog Transplant 2021 Jun 10:15269248211024606. Epub 2021 Jun 10.

Department of Renal and Pancreas Transplantation, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester, United Kingdom.

We describe a case where a patient received a successful dual kidney transplantation in a staggered fashion. Two kidneys from a deceased donor were accepted for 2 separate primary intended recipients, however, due to unforeseen circumstances, both kidneys were eventually transplanted in a staggered fashion into an alternate single recipient. The intention behind this method was to enhance the patient's renal function and to prevent the wastage of a kidney. Read More

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