13,467,077 results match your criteria function gα-plc


Algogen-induced vasosensory reflexes modulate short-term heart rate variability parameters in experimental rat models.

J Basic Clin Physiol Pharmacol 2021 Apr 20. Epub 2021 Apr 20.

Department of Physiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Objectives: The present work was designed to study the modulatory effects of algogen-induced vasosensory reflex responses on short-term heart rate variability (HRV) parameters in naïve and vagotomized rat models.

Methods: In this study, vasosensory reflex responses were elicited by instilling algogens (bradykinin/histamine), a component of inflammatory mediators into a local segment of medium-sized peripheral blood vessel (femoral artery) while a continuous electrocardiogram (ECG) was recorded. Short-term (5 min) ECG segments obtained from original recordings were examined in detail and relevant data of HRV parameters were pooled. Read More

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Exposure to prolonged unpredictable light impairs spatial memory via induction of oxidative stress and tumor necrosis factor-alpha in rats.

J Basic Clin Physiol Pharmacol 2021 Apr 20. Epub 2021 Apr 20.

Neuroscience and Oral Physiology Unit, Department of Physiology, University of Ibadan, Ibadan, Nigeria.

Objectives: The human body physiology rapidly changes and adapt to several environmental stimuli, including light. Abnormal artificial light exposures have been shown to affect sleep cycle, cognition, and mood. Although studies have reported inconsistent effects of short-term or constant long-term light exposures, human exposures to artificial lights occur at varying, unpredictable times and duration daily. Read More

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Curious Objects: How Visual Complexity Guides Attention and Engagement.

Cogn Sci 2021 Apr;45(4):e12933

Department of Psychological & Brain Sciences, Johns Hopkins University.

Some things look more complex than others. For example, a crenulate and richly organized leaf may seem more complex than a plain stone. What is the nature of this experience-and why do we have it in the first place? Here, we explore how object complexity serves as an efficiently extracted visual signal that the object merits further exploration. Read More

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Predicting the neuro-cardio-haemodynamic outcomes of sepsis and its pharmacological interventions: get to the future through numerical equations.

J Physiol 2021 Apr 19. Epub 2021 Apr 19.

Department of Biomedical Engineering, CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands.

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SARS-CoV-2: pushing the E(nvelope).

Authors:
Peying Fong

J Physiol 2021 Apr 19. Epub 2021 Apr 19.

Department of Anatomy and Physiology, Kansas State University College of Veterinary Medicine, 1620 Denison Avenue, Manhattan, KS, 66506.

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Heightened respiratory-parasympathetic coupling to airways in the spontaneously hypertensive rat.

J Physiol 2021 Apr 19. Epub 2021 Apr 19.

Cardiovascular Autonomic Research Cluster, Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

Key Points: Carotid bodies (CBs) chemoreceptors are hyperactive in hypertension, and their acute activation produces bronchoconstriction. We show that the respiratory-modulated bronchiolar tone, pulmonary parasympathetic efferent activity, as well as the firing frequency and synaptic excitation of bronchoconstrictor motoneurones in the nucleus ambiguus were all enhanced in spontaneous hypertensive (SH) rats. In SH rats, CBs denervation reduced the respiratory-related parasympathetic-mediated bronchoconstrictor tone to levels seen in normotensive rats. Read More

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Agreement between the Skull Vibration-Induced Nystagmus Test and Semicircular Canal and Otolith Asymmetry.

J Am Acad Audiol 2021 Apr 19. Epub 2021 Apr 19.

Vestibular and Balance Program, Department of Otorhinolaryngology, Mayo Clinic, Rochester, Minnesota.

Background:  How significant asymmetries in otolith organ function in the presence of symmetrical and asymmetrical semicircular canal function influence skull vibration-induced nystagmus testing (SVINT) has not been well described.

Purpose:  The aim of the study is to examine the agreement between SVINT and caloric testing, ocular vestibular-evoked myogenic potentials (oVEMP), and cervical vestibular-evoked myogenic potentials (cVEMP) for detecting asymmetric vestibular function.

Research Design:  This is a retrospective study of patients presenting with the chief complaint of vertigo, dizziness, or imbalance. Read More

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The Relationship between Psychoacoustic and Electrophysiological Assessments of Temporal Resolution.

J Am Acad Audiol 2021 Apr 19. Epub 2021 Apr 19.

Department of Audiology, School of Rehabilitation Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background:  Temporal resolution is essential to speech acoustic perception. However, it may alter in individuals with auditory disorders, impairing the development of spoken and written language. The envelope of speech signals contains amplitude modulation (AM) that has critical information. Read More

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R-Ras Deficiency in Pericytes Causes Frequent Microphthalmia and Perturbs Retinal Vascular Development.

J Vasc Res 2021 Apr 19:1-15. Epub 2021 Apr 19.

Cancer and Blood Disorders Institute, Institute for Fundamental Biomedical Research, and Department of Surgery, Johns Hopkins All Children's Hospital, and Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, St. Petersburg, Florida, USA.

Purpose: The retinal vasculature is heavily invested by pericytes. Small GTPase R-Ras is highly expressed in endothelial cells and pericytes, suggesting importance of this Ras homolog for the regulation of the blood vessel wall. We investigated the specific contribution of pericyte-expressed R-Ras to the development of the retinal vasculature. Read More

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The Role of Serum Chloride in Acute and Chronic Heart Failure: A Narrative Review.

Cardiorenal Med 2021 Apr 19:1-12. Epub 2021 Apr 19.

Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, Florida, USA.

Clinical guidelines include diuretics for the treatment of heart failure (HF), not to decrease mortality but to decrease symptoms and hospitalizations. More attention has been paid to the worse outcomes, including mortality, associated with continual diuretic therapy due to hypochloremia. Studies have revealed a pivotal role for serum chloride in the pathophysiology of HF and is now a target of treatment to decrease mortality. Read More

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Baseline Characteristics and Survival of an Australian Interstitial Pneumonia with Autoimmune Features Cohort.

Respiration 2021 Apr 19:1-12. Epub 2021 Apr 19.

Department of Respiratory, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.

Background And Objective: The research term "interstitial pneumonia with autoimmune features" (IPAF) encompasses interstitial lung disease (ILD) patients with autoimmune features not meeting diagnostic criteria for a defined connective tissue disease (CTD). It remains unclear if IPAF is a distinct disease entity with implications for management and prognosis. We describe an Australian IPAF population and compare their baseline characteristics and outcomes with distinct cohorts of idiopathic interstitial pneumonia (IIP), CTD-ILD, and unclassifiable ILD. Read More

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Spin correlations and spin-density wave phase in a finite-temperature quasi-one-dimensional electron gas.

J Phys Condens Matter 2021 Apr 19. Epub 2021 Apr 19.

Physics, Kurukshetra University Faculty of Science, Department of Physics, Kurukshetra University Kurukshetra, Haryana, INDIA, Kurukshetra, Haryana, 136119, INDIA.

In this paper, we theoretically investigate the effect of temperature on spin correlations in an unpolarized quasi-one-dimensional electron gas (Q1DEG). The correlations are treated dynamically within quantum version of the self-consistent mean-field approach of Singwi {\it et al}. Numerical results for the $\uparrow\uparrow$ and $\uparrow\downarrow$ components of static structure factor and pair-correlation function, and the wave vector dependent static spin and charge susceptibilities are presented over a wide range of temperature $T$ and electron coupling $r_s$. Read More

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The Relationship Between Neuromuscular Function and the W' in Elite Cyclists.

Int J Sports Physiol Perform 2021 Apr 19:1-7. Epub 2021 Apr 19.

Purpose: To assess the association between the W' and measures of neuromuscular function relating to the capacity of skeletal muscle to produce force in a group of elite cyclists.

Methods: Twenty-two athletes specializing in a range of disciplines and competing internationally volunteered to participate. Athletes completed assessments of maximum voluntary torque (MVT), voluntary activation, and isometric maximum voluntary contraction to measure rate of torque development (RTD). Read More

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Origin of post-ictal and post-anesthesia adverse effects and possibly of SUDEP.

Med Hypotheses 2021 Apr 9;151:110591. Epub 2021 Apr 9.

Physics Dept., Sami Shamoon College of Engineering, Beer-Sheva, Israel.

The origin of post-ictal malfunctions is debatable. We want to propose a novel idea of a cause of these adverse results occurring following epileptic seizures and anesthesia. Previously we have put forward the idea that epileptic seizures termination is caused by the function of the glymphatic system in the brain. Read More

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Bidirectional sensory neuron-immune interactions: a new vision in the understanding of allergic inflammation.

Curr Opin Immunol 2021 Apr 16;72:79-86. Epub 2021 Apr 16.

Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), Inserm UMR1291 CNRS UMR5051, University of Toulouse III, Toulouse, France. Electronic address:

Peripheral neurons (including sensory neurons) are ubiquitously distributed in all tissues, particularly at the interface with the environment. The primary function of sensory neurons is the transmission of sensations of temperature, pain and itch to elicit appropriate behavioral responses. More recently, sensory neurons have emerged as potent regulators of type 2 immune responses and allergic inflammation. Read More

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Levodopa facilitates improvements in gait kinetics at the hip, not the ankle, in individuals with Parkinson's disease.

J Biomech 2021 Mar 24;121:110366. Epub 2021 Mar 24.

Applied Neuromechanics Laboratory, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, USA.

Parkinson's disease symptoms impair gait, limit mobility, and reduce independence. Levodopa improves muscle activation, strength, and coordination; thus, facilitating increased step length, but few studies have evaluated the underlying forces associated with medication-induced gait improvements. Here, we assess the effects of levodopa on gait kinetics in persons with Parkinson's disease. Read More

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Cyclic mechanical stimulation inhibits rheumatoid arthritis fibroblast-like synoviocytes proliferation via cell cycle arrest.

J Biomech 2021 Apr 8;121:110424. Epub 2021 Apr 8.

Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400030, PR China. Electronic address:

The imbalance between proliferation and apoptosis of fibroblast-like synoviocytes (FLSs) has been the main cause of rheumatoid arthritis (RA) synovial hyperplasia. Our previous study confirmed that the cyclic mechanical stimulation (CMS) inhibited the proliferation of RA FLSs, but the underlying mechanisms are still unclear. This study aimed to investigate these underlying mechanisms. Read More

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Lower extremity muscle contributions to ACL loading during a stop-jump task.

J Biomech 2021 Apr 9;121:110426. Epub 2021 Apr 9.

Department of Kinesiology, Recreation, and Sport Studies, The University of Tennessee, Knoxville, TN, USA. Electronic address:

Landing is considered a high-risk movement, especially landings from a stop-jump task, as they are often associated with lower extremity injuries, such as anterior cruciate ligament injuries (ACL). Females demonstrate lower extremity landing mechanics that often place them at a larger risk of injury compared to their male counterparts. While efforts have been made to understand lower extremity mechanics during stop-jump landings, little is known regarding the musculature function during these tasks and how they may influence ACL loading. Read More

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Relationship between forward propulsion and foot motion during gait in healthy young adults.

J Biomech 2021 Apr 8;121:110431. Epub 2021 Apr 8.

Department of Rehabilitation, Faculty of Rehabilitation, Hiroshima International University, 555-36, Gakuendai, Kurose, Higashihiroshima-shi, Hiroshima 739-0295, Japan. Electronic address:

The foot contributes to propulsion and postural stability function by changing its morphology during walking through the truss/windlass mechanisms. We quantified the truss mechanism regarding foot stiffness and the windlass mechanism regarding the movement coordination between the foot arch and metatarsophalangeal (MTP) joint. We aimed to clarify the relationship of these mechanisms with propulsive force and static foot alignment. Read More

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Applicability of GLI 2012 spirometry equation among preschool aged Jordanian.

Respir Med 2021 Apr 16;182:106397. Epub 2021 Apr 16.

Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan. Electronic address:

Objectives: The Validation of Global Lung Initiative (GLI 2012) equations is required prior to their application in clinical practice in different regions. This study validated the GLI 2012 equations in Middle Eastern preschool aged children, which was not previously conducted.

Study Design: Spirometry measures were collected from 765 (54% males) healthy 3 to 5-year-old Jordanian children. Read More

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Effects of cigarette smoke on the aggravation of ovalbumin-induced asthma and the expressions of TRPA1 and tight junctions in mice.

Mol Immunol 2021 Apr 16;135:62-72. Epub 2021 Apr 16.

School of Traditional Chinese Medicine & Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, Jiangsu Province, China.

The occurrence of asthma is closely related to environmental factors such as cigarette smoke (CS), one of the common risk factors. Environmental stimuli have the potential to activate transient receptor potential ankyrin 1 (TRPA1) and cause or aggravate asthma. The destruction of tight junctions (TJs) between airway epithelial cells by environmental stimuli in asthma has been researched. Read More

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Analytical models of probe dynamics effects on NMR measurements.

J Magn Reson 2021 Mar 27;327:106975. Epub 2021 Mar 27.

University of Florida, 1064 Center Drive, Gainesville, FL 32611, USA. Electronic address:

This paper provides a detailed analysis of three common NMR probe circuits (untuned, tuned, and impedance-matched) and studies their effects on multi-pulse experiments, such as those based on the Carr-Purcell-Meiboom-Gill (CPMG) pulse sequence. The magnitude of probe dynamics effects on broadband refocusing pulses are studied as a function of normalized RF bandwidth. Finally, the probe circuit models are integrated with spin dynamics simulations to design hardware-specific RF excitation and refocusing pulses for optimizing user-specified metrics such as signal-to-noise ratio (SNR) in grossly inhomogeneous fields. Read More

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External rotation of the tibial component should be avoided in lateral unicompartmental knee arthroplasty.

Knee 2021 Apr 16;30:70-77. Epub 2021 Apr 16.

Department of Orthopedic Surgery, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.

Background: Lateral unicompartmental knee arthroplasty (UKA) leads to good clinical outcomes for isolated lateral osteoarthritis. However, the impact of the tibial component position on postoperative outcomes in lateral UKA is yet to be determined.

Purpose: This study investigated the influence of tibial component malposition on clinical outcomes in lateral UKA. Read More

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Excessive ammonia inhalation causes liver damage and dysfunction by altering gene networks associated with oxidative stress and immune function.

Ecotoxicol Environ Saf 2021 Apr 16;217:112203. Epub 2021 Apr 16.

College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, People's Republic of China; Key Laboratory of Swine Facilities Engineering, Ministry of Agriculture and Rural Affairs, Harbin, People's Republic of China. Electronic address:

Ammonia (NH) is a major gaseous pollutant in livestock production and has adverse effects on production, health and welfare of animals. The liver is one of the target organs of NH, and excessive NH inhalation can induce liver damage. However, the toxicity assessment of NH on pig liver and its mechanism have not been reported yet. Read More

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Investigation of the therapeutic effect of Yinchen Wuling Powder on CCl-induced hepatic fibrosis in rats by H NMR and MS-based metabolomics analysis.

J Pharm Biomed Anal 2021 Apr 16;200:114073. Epub 2021 Apr 16.

School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang, Liaoning, China. Electronic address:

Hepatic fibrosis (HF) is a typical consequence of various chronic liver diseases, and there is still no ideal drug for its treatment. Yinchen Wuling Powder (YCWLP), a famous traditional Chinese medicine prescription, is effective for the treatment of icteric hepatitis, hepatic fibrosis, non-alcoholic fatty liver disease and other liver diseases in clinical practices, however, the underlying mechanisms of YCWLP on HF is still unclear. In this study, H NMR and MS-based metabolomics analysis along with body weight change, serum liver function indexes, serum liver fibrosis index and histopathological observations of liver were applied to evaluate the therapeutic effect of YCWLP on hepatic fibrosis and the mechanism associated with this. Read More

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Calibration of silicone for passive sampling of semivolatile organic contaminants in indoor air.

Chemosphere 2021 Apr 8;279:130536. Epub 2021 Apr 8.

RECETOX, Masaryk University, Kamenice 753/5, 625 00, Brno, Czech Republic. Electronic address:

Semivolatile organic compounds (SVOCs) are mostly man-made chemicals that distribute between the gas and solid phase in the environment. Many of them could pose harm to people and therefore it is important to know their concentrations in the indoor environment to evaluate the related risks. Inhalation exposure can be assessed using passive sampling. Read More

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Dynamic interplay between GABAergic networks and developing neurons in the adult hippocampus.

Curr Opin Neurobiol 2021 Apr 16;69:124-130. Epub 2021 Apr 16.

Laboratory of Neuronal Plasticity, Leloir Institute (IIBBA - CONICET), Av. Patricias Argentinas 435, Buenos Aires, C1405BWE, Argentina. Electronic address:

Neurogenesis is a powerful mechanism for structural and functional remodeling that occurs in restricted areas of the adult brain. Although different neurotransmitters regulate various aspects of the progression from neural stem cell quiescence to neuronal maturation, GABA is the main player. The developmental switch from excitation to inhibition combined with a heterogeneous population of GABAergic interneurons that target different subcellular compartments provides multiple points for the regulation of development and function of new neurons. Read More

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The synaptic life of microtubules.

Curr Opin Neurobiol 2021 Apr 16;69:113-123. Epub 2021 Apr 16.

Department of Pathology & Cell Biology, Columbia University Medical Center, 630 W. 168th Street, New York, NY 10032, USA. Electronic address:

In neurons, control of microtubule dynamics is required for multiple homeostatic and regulated activities. Over the past few decades, a great deal has been learned about the role of the microtubule cytoskeleton in axonal and dendritic transport, with a broad impact on neuronal health and disease. However, significantly less attention has been paid to the importance of microtubule dynamics in directly regulating synaptic function. Read More

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Placing covered self-expanding metal stents by suspension laryngoscope in benign tracheal stenosis.

Am J Otolaryngol 2021 Apr 13;42(5):103040. Epub 2021 Apr 13.

Department of Thoracic Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China. Electronic address:

Background: Tracheobronchial stent placement for malignant airway strictures has been proved to improve respiratory function, but experience for benign tracheobronchial stenoses is limited. The purpose of our study is to investigate the efficacy of covered expandable metallic stents, inserted through a suspension laryngoscope, treating tracheal stenosis following intubation or tracheostomy.

Methods: From 2010 to 2018, 67 adult patients with the benign tracheal stenosis, underwent stent placement, using a suspension laryngoscope. Read More

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Feedback mechanisms of periphytic biofilms to ZnO nanoparticles toxicity at different phosphorus levels.

J Hazard Mater 2021 Apr 8;416:125834. Epub 2021 Apr 8.

State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Sciences, Chinese Academy of Sciences, Nanjing 210008, China; College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.

The increasing use of nanoparticles (NPs) has raised concerns about their potential environmental risks. Many researches on NPs focused on the toxicity mechanism to microorganisms, but neglect the toxicity effects in relation to nutritional conditions. Here, we evaluated the interactive effects of zinc oxide (ZnO) NPs and phosphorus (P) levels on the bacterial community and functioning of periphytic biofilms. Read More

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