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Performance up-gradation of Symbiotic Organisms Search by Backtracking Search Algorithm.

J Ambient Intell Humaniz Comput 2021 Apr 11:1-42. Epub 2021 Apr 11.

Department of Mathematics, National Institute of Technology Agartala, Agartala, Tripura 799046 India.

Symbiotic Organisms Search (SOS) algorithm is characterized based on the framework of relationships among the ecosystem species. Nevertheless, it is suffering from wasteful discovery, little productivity, and slack convergence rate. These deficiencies cause stagnation at the local optimum, which is hazardous in deciding the genuine optima of the optimization problem. Read More

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Tiliroside Ameliorates Ulcerative Colitis by Restoring the M1/M2 Macrophage Balance the HIF-1α/glycolysis Pathway.

Front Immunol 2021 31;12:649463. Epub 2021 Mar 31.

Center for Metabolic Disease Research and Department of Physiology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States.

Macrophages polarized to different phenotypes critically contribute to colitis development by coordinating inflammatory and anti-inflammatory processes. Herein, targeting the balance between the pro-inflammatory M1 and the anti-inflammatory M2 macrophage phenotypes can be a novel therapeutic approach for colitis. In the present study, we firstly demonstrated that tiliroside possessed the ability to alleviate the clinical symptoms of colitis as evidenced by decreased disease activity index (DAI) scores, longer colon length, reduced myeloperoxidase (MPO) activity, and improvement of colonic pathological damage . Read More

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HMGB1 Promotes the Release of Sonic Hedgehog From Astrocytes.

Front Immunol 2021 1;12:584097. Epub 2021 Apr 1.

Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

High mobility group box 1 protein (HMGB1) is known to be a trigger of inflammation in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). However, it may play a different role in some way. Here we investigated the effect of HMGB1 on promoting sonic hedgehog (shh) release from astrocytes as well as the possible signal pathway involved in it. Read More

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usDSM: a novel method for deleterious synonymous mutation prediction using undersampling scheme.

Brief Bioinform 2021 Apr 19. Epub 2021 Apr 19.

GMU-GIBH Joint School of Life Sciences, Guangzhou Medical University, China.

Although synonymous mutations do not alter the encoded amino acids, they may impact protein function by interfering with the regulation of RNA splicing or altering transcript splicing. New progress on next-generation sequencing technologies has put the exploration of synonymous mutations at the forefront of precision medicine. Several approaches have been proposed for predicting the deleterious synonymous mutations specifically, but their performance is limited by imbalance of the positive and negative samples. Read More

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Bioinformatic analysis identifying FGF1 gene as a new prognostic indicator in clear cell Renal Cell Carcinoma.

Cancer Cell Int 2021 Apr 17;21(1):222. Epub 2021 Apr 17.

Department of Pathology, The Second Hospital of ShanXi Medical University, ShanXi Province, No.382 WuYi Road, Tai Yuan, 030000, China.

Background: Clear cell renal cell carcinoma (ccRCC) has been the commonest renal cell carcinoma (RCC). Although the disease classification, diagnosis and targeted therapy of RCC has been increasingly evolving attributing to the rapid development of current molecular pathology, the current clinical treatment situation is still challenging considering the comprehensive and progressively developing nature of malignant cancer. The study is to identify more potential responsible genes during the development of ccRCC using bioinformatic analysis, thus aiding more precise interpretation of the disease METHODS: Firstly, different cDNA expression profiles from Gene Expression Omnibus (GEO) online database were used to screen the abnormal differently expressed genes (DEGs) between ccRCC and normal renal tissues. Read More

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Evaluation of α5β1 integrin as a candidate marker for fertility in bull sperm samples.

Theriogenology 2021 Apr 3;168:66-74. Epub 2021 Apr 3.

Laboratorio de Biología de la Reproducción en Mamíferos (CEFYBO-UBA/CONICET, Buenos Aires, Argentina. Electronic address:

With the progressive increase in the use of reproductive biotechnologies in the cattle industry, like artificial insemination and in vitro embryo production, the accurate determination of fertilizing competence of cryopreserved sperm samples is an essential issue. The routine methodology to assess bull sperm quality relies primarily on count, viability and motility of spermatozoa. However, these parameters do not tightly predict the reproductive success of samples. Read More

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KLF7/VPS35 axis contributes to hepatocellular carcinoma progression through CCDC85C-activated β-catenin pathway.

Cell Biosci 2021 Apr 15;11(1):73. Epub 2021 Apr 15.

Department of Surgery, The First Affiliated Hospital of Shanxi Medical University, 85 South Jiefang Road, Taiyuan, 030001, Shanxi, China.

Objective: Dysregulation of KLF7 participates in the development of various cancers, but it is unclear whether there is a link between HCC and aberrant expression of KLF7. The aim of this study was to investigate the role of KLF7 in proliferation and migration of hepatocellular carcinoma (HCC) cells.

Methods: CCK8, colony growth, transwell, cell cycle analysis and apoptosis detection were performed to explore the effect of KLF7, VPS35 and Ccdc85c on cell function in vitro. Read More

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Robust Face Alignment via Deep Progressive Reinitialization and Adaptive Error-driven Learning.

IEEE Trans Pattern Anal Mach Intell 2021 Apr 15;PP. Epub 2021 Apr 15.

Regression-based face alignment involves learning a series of mapping functions to predict the true landmark from an initial estimation of the alignment. Most existing approaches focus on learning efficacious mapping functions from some feature representations to improve performance. The issues related to the initial alignment estimation and the final learning objective, however, receive less attention. Read More

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[Retrograde muscle release method in treatment of mild to moderate ischemic muscle contracture of forearm].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Apr;35(4):483-487

Department of Orthopedics, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, 102218, P.R.China.

Objective: To investigate the effectiveness of retrograde muscle release in treatment of mild to moderate type ischemic muscle contracture of forearm classified by Tsuge.

Methods: Between March 2010 and September 2018, 11 patients with mild to moderate ischemic muscle contracture of forearm were treated with retrograde muscle release. There were 6 males and 5 females with an average age of 24 years (range, 16-29 years). Read More

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Health and Disease Are Dynamic Complex-Adaptive States Implications for Practice and Research.

Front Psychiatry 2021 29;12:595124. Epub 2021 Mar 29.

Faculty of Health and Medicine, School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia.

Interoception, the ability to convey one's overall physiological state, allows people to describe their health along an experiential continuum, from excellent, very good, good, fair to poor. Each health state reflects a distinct pattern of one's overall function. This assay provides a new frame of understanding health and disease as complex-adaptive system states of the person as-a-whole. Read More

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CircPTPRA blocks the recognition of RNA N-methyladenosine through interacting with IGF2BP1 to suppress bladder cancer progression.

Mol Cancer 2021 Apr 14;20(1):68. Epub 2021 Apr 14.

Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Background: Circular RNAs (circRNAs) have been found to have significant impacts on bladder cancer (BC) progression through various mechanisms. In this study, we aimed to identify novel circRNAs that regulate the function of IGF2BP1, a key mA reader, and explore the regulatory mechanisms and clinical significances in BC.

Methods: Firstly, the clinical role of IGF2BP1 in BC was studied. Read More

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Phosphorylated LASS2 inhibits prostate carcinogenesis via negative regulation of Wnt/β-catenin signaling.

J Cell Biochem 2021 Apr 14. Epub 2021 Apr 14.

Department of Pathology, Peking University Third Hospital, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.

LASS2 is a novel tumor-suppressor gene and has been characterized as a ceramide synthase, which synthesizes very-long acyl chain ceramides. However, LASS2 function and pathway-related activity in prostate carcinogenesis are still largely unexplored. Here, we firstly report that LASS2 promotes β-catenin degradation through physical interaction with STK38, SCYL2, and ATP6V0C via the ubiquitin-proteasome pathway, phosphorylation of LASS2 is essential for β-catenin degradation, and serine residue 248 of LASS2 is illustrated to be a key phosphorylation site. Read More

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The treatment of integrated traditional Chinese and Western medicine to cure severe immune thrombocytopenia in a patient in a minimally conscious state: a case report.

Ann Palliat Med 2021 Mar;10(3):3483-3490

Panzhihua University, Affiliated Hospital of Panzhihua University, Panzhihua, China.

Immune thrombocytopenia is a common complication in patients in a minimally conscious state (MCS). MCS patients are prone to pulmonary infection for the reasons of long-term bed rest and tracheotomy etc., which leads to frequent immune thrombocytopenia. Read More

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Particle tracking and beam optics analysis on a toroidal gantry for proton therapy.

Phys Med Biol 2021 Apr 13. Epub 2021 Apr 13.

SCI-IC-BD, Ecole Polytechnique Fédérale de Lausanne, Station 14, Lausanne, 1015, SWITZERLAND.

GaToroid is a concept of toroidal gantry for hadron therapy under investigation at CERN. It makes use of the toroidal magnetic field between each pair of coils to steer and focus the particle beams down to the patient. This peculiar concept requires detailed studies on particle tracking and beam optics to optimize the winding geometry and explore the properties of the system. Read More

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Exploring Chromatic Aberration and Defocus Blur for Relative Depth Estimation from Monocular Hyperspectral Image.

IEEE Trans Image Process 2021 Apr 13;PP. Epub 2021 Apr 13.

This article investigates spectral chromatic and spatial defocus aberration in a monocular hyperspectral image (HSI) and proposes methods on how these cues can be utilized for relative depth estimation. The main aim of this work is to develop a framework by exploring intrinsic and extrinsic reflectance properties in HSI that can be useful for depth estimation. Depth estimation from a monocular image is a challenging task. Read More

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Difficulty in articulation following left progressive blurred vision.

Eur J Ophthalmol 2021 Apr 10:11206721211008037. Epub 2021 Apr 10.

College of Medicine, Chang Gung University, Taoyuan.

Purpose: To report a case of Paracentral acute middle maculopathy (PAMM) caused by severe internal carotid artery (ICA) stenosis and discuss the correlation between PAMM and ICA stenosis.

Case Description: A 67-year-old male patient presented with left acute blurred vision for 1 week. The best-corrected visual acuity of the left eye was 0. Read More

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Endogenous sulfur dioxide is a novel inhibitor of hypoxia-induced mast cell degranulation.

J Adv Res 2021 Mar 8;29:55-65. Epub 2020 Sep 8.

Department of Pediatrics, Peking University First Hospital, Beijing, China.

Introduction: Mast cell (MC) degranulation is an important step in the pathogenesis of inflammatory reactions and allergies; however, the mechanism of stabilizing MC membranes to reduce their degranulation is unclear.

Methods: SO content in MC culture supernatant was measured by HPLC-FD. The protein and mRNA expressions of the key enzymes aspartate aminotransferase 1 (AAT1) and AAT2 and intracellular AAT activity were detected. Read More

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Melatonin as a therapy in cardiac ischemia-reperfusion injury: Potential mechanisms by which MT2 activation mediates cardioprotection.

J Adv Res 2021 Mar 28;29:33-44. Epub 2020 Sep 28.

Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.

Introduction: Previous studies reported the beneficial effects of pretreatment with melatonin on the heart during cardiac ischemia/reperfusion (I/R) injury. However, the effects of melatonin given after cardiac ischemia, as well as its comparative temporal effects are unknown. These include pretreatment, during ischemia, and at the onset of reperfusion. Read More

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High temperature stress induces expression of CYP450 genes and contributes to insecticide tolerance in Liriomyza trifolii.

Pestic Biochem Physiol 2021 May 10;174:104826. Epub 2021 Mar 10.

College of Horticulture and Plant Protection & Institute of Applied Entomology, Yangzhou University, Yangzhou, China; Joint International Research Laboratory of Agriculture and Agri-Product Safety, Yangzhou University, Yangzhou, China. Electronic address:

Liriomyza trifolii is an invasive leafminer fly that inflicts damage on many horticultural and vegetable crops. In this study, the effects of elevated temperatures on L. trifolii tolerance to insecticides abamectin (AB), monosultap (MO) and a mixture of abamectin and monosultap (AM) were firstly investigated, then five CYP450 genes (LtCYPs) were cloned, and expression patterns and NADPH cytochrome C reductase (NCR) activity in L. Read More

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A community-supported metaproteomic pipeline for improving peptide identifications in hydrothermal vent microbiota.

Brief Bioinform 2021 Apr 8. Epub 2021 Apr 8.

School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.

Microorganisms in deep-sea hydrothermal vents provide valuable insights into life under extreme conditions. Mass spectrometry-based proteomics has been widely used to identify protein expression and function. However, the metaproteomic studies in deep-sea microbiota have been constrained largely by the low identification rates of protein or peptide. Read More

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Adaptive fractional-order non-singular terminal sliding mode control based on fuzzy wavelet neural networks for omnidirectional mobile robot manipulator.

ISA Trans 2021 Mar 29. Epub 2021 Mar 29.

College of Electronic Engineering and Automation, Guilin University of Electronic Technology, Guilin, Guangxi, 541004, PR China. Electronic address:

This paper studies a novel adaptive fractional-order non-singular terminal sliding mode (FO-NTSM) control strategy for omnidirectional mobile robot manipulator (OMRM) with unknown parameters and external disturbances. Firstly, we adopt the fuzzy wavelet neural networks (FWNNs) to estimate the dynamic uncertainty of the OMRM because it has superior function approximation capability. Secondly, we design the adaptive NTSM controller to attenuate external disturbances by virtue of adjusting the weights of the FWNNs online. Read More

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Hypoxia-dependent expression of MAP17 coordinates the Warburg effect to tumor growth in hepatocellular carcinoma.

J Exp Clin Cancer Res 2021 Apr 8;40(1):121. Epub 2021 Apr 8.

Department of Gastroenterology, Huadong Hospital, Shanghai Medical College, Fudan University, No.221 Yan'an West Road, Shanghai, 200040, P.R. China.

Background: Reprogrammed glucose metabolism, also known as the Warburg effect, which is essential for tumor progression, is regarded as a hallmark of cancer. MAP17, a small 17-kDa non-glycosylated membrane protein, is frequently dysregulated in human cancers. However, its role in hepatocellular carcinoma (HCC) remains largely unknown. Read More

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Design of a multifunction novel flexible fault current limiter for AC distribution network.

PLoS One 2021 8;16(4):e0245956. Epub 2021 Apr 8.

School of Electrical Engineering and Automation, Fuzhou University, Fuzhou, Fujian, China.

Based on the separation voltage type of cascaded H bridge-modular multilevel converters (CHB-MMC) and current predictive model control (CPMC) technology, a novel flexible fault-current limiter (NFFCL) is firstly proposed for restraining the negative impact of the distribution network's disturbance in this paper. When a disturbance occurs, the inner-loop CPMC of the multilevel converters establish the value function to offer the specific current, thus increasing the voltage deviation at both ends of the series capacitor or generating reverse harmonic compensation voltage. In that case, three single-phase MNFFCLs can be regarded as variable voltage sources to eliminate the negative effects of faults or harmonics. Read More

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African Swine Fever Virus Protein E199L Promotes Cell Autophagy through the Interaction of PYCR2.

Virol Sin 2021 Apr 8. Epub 2021 Apr 8.

College of Animal Science, South China Agricultural University & Lingnan Guangdong Laboratory of Modern Agriculture & Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Guangzhou, 510642, China.

African swine fever virus (ASFV), as a member of the large DNA viruses, may regulate autophagy and apoptosis by inhibiting programmed cell death. However, the function of ASFV proteins has not been fully elucidated, especially the role of autophagy in ASFV infection. One of three Pyrroline-5-carboxylate reductases (PYCR), is primarily involved in conversion of glutamate to proline. Read More

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Overexpression of DSCR1 prevents proliferation and predicts favorable prognosis in colorectal cancer patients.

World J Surg Oncol 2021 Apr 7;19(1):100. Epub 2021 Apr 7.

Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Objectives: Down syndrome critical region 1 (DSCR1) is associated with carcinogenesis and tumor growth in several types of malignancy. However, little is known about the role of DSCR1 in CRC progression. The present study aimed to elucidate the clinicopathological significance, prognostic, and function roles of DSCR1 in CRC. Read More

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An improved multi-variable grey model for forecasting China's finished products from comprehensive waste utilization.

Environ Sci Pollut Res Int 2021 Apr 7. Epub 2021 Apr 7.

College of Management Science and Engineering, Chongqing Technology and Business University, Chongqing, 400067, People's Republic of China.

A reasonable prediction of the finished products from waste recycling and reprocessing is of great significance to the sustainable use of limited resources, the reduced pollution caused by waste, and the reflected comprehensive waste utilization (CWU) creativity. To this end, an improved multi-variable grey model was employed to forecast the finished products in China's CWU. Firstly, the degree of grey incidence was applied to select explanatory variables and eliminate multicollinearity between them. Read More

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C1q-like 1 is frequently up-regulated in lung adenocarcinoma and contributes to the proliferation and invasion of tumor cells.

J Chemother 2021 Apr 7:1-10. Epub 2021 Apr 7.

Jinan Evidence Medicine Technology Development Center, Jinan, Shandong, China.

This study aims to investigate the effects of C1q-like 1 (C1QL1) on the growth and migration of lung adenocarcinoma (LUAD) cells and the underlying mechanism. The expression of C1QL1 in LUAD tissues and its prognostic value were analyzed using the data from The Cancer Genome Atlas (TCGA) database. To investigate the function of C1QL1, loss-of-function and gain-of-function assays were conducted in Calu-3 cells and LTEP-a-2 cells, respectively. Read More

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A cut above the rest: oxidative stress in chronic wounds and the potential role of polyphenols as therapeutics.

J Pharm Pharmacol 2021 Apr 3. Epub 2021 Apr 3.

School of Health, Medical and Applied Science, CQUniversity, Bruce Hwy, North Rockhampton, Queensland, Australia.

Objectives: The pathophysiology of chronic wounds typically involves redox imbalance and inflammation pathway dysregulation, often with concomitant microbial infection. Endogenous antioxidants such as glutathione and tocopherols are notably reduced or absent, indicative of significant oxidative imbalance. However, emerging evidence suggests that polyphenols could be effective agents for the amelioration of this condition. Read More

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A clinical study on bone defect reconstruction and functional recovery in benign bone tumors of the lower extremity, treated by bone marrow mesenchymal stem cell rapid screening-enrichment-composite system.

World J Surg Oncol 2021 Apr 5;19(1):98. Epub 2021 Apr 5.

Department of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, 639 Zhizaoju Road, Shanghai, 200011, People's Republic of China.

Background: With the development of medical technology, credible options for defect reconstructions after the resection of benign bone tumors of the lower extremities have become a high priority. As the current reconstructive methods commonly used in clinical practice have some flaws, new methods of reconstruction need to be explored. We aimed to prepare a new kind of bioactive scaffold for the repair of bone defects through a stem cell rapid screening-enrichment-composite technology system developed by our team. Read More

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Single-shot fringe projection profilometry based on deep learning and computer graphics.

Opt Express 2021 Mar;29(6):8024-8040

Multiple works have applied deep learning to fringe projection profilometry (FPP) in recent years. However, to obtain a large amount of data from actual systems for training is still a tricky problem, and moreover, the network design and optimization is still worth exploring. In this paper, we introduce graphic software to build virtual FPP systems in order to generate the desired datasets conveniently and simply. Read More

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