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Roles of chromatin remodeling factors in the formation and maintenance of heterochromatin structure.

J Biol Chem 2011 Apr 9;286(16):14659-69. Epub 2011 Mar 9.

Department of Biology, University of Rochester, Rochester, New York 14627, USA.

Heterochromatin consists of highly ordered nucleosomes with characteristic histone modifications. There is evidence implicating chromatin remodeling proteins in heterochromatin formation, but their exact roles are not clear. We demonstrate in Saccharomyces cerevisiae that the Fun30p and Isw1p chromatin remodeling factors are similarly required for transcriptional silencing at the HML locus, but they differentially contribute to the structure and stability of HML heterochromatin. Read More

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