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Impact of sarcopenia on clinical outcomes of patients undergoing simultaneous liver and kidney transplantation: a cohort study.

Clin Res Hepatol Gastroenterol 2021 Apr 10:101692. Epub 2021 Apr 10.

APHP, Unité Médicale de Transplantation Hépatique Hôpital Pitié Salpêtrière, Boulevard de l'Hôpital 47-83, 75013 Paris, France; Sorbonne Université, INSERM, Centre de recherche Saint-Antoine (CRSA), Paris, France; Sorbonne Université, INSERM, Institute of Cardiometabolisme and Nutrition (ICAN), Paris, France.

Background: The impact of sarcopenia in patients undergoing simultaneous liver and kidney transplantation (SLKT) has not been fully delineated. The aim of this single-centre-cohort-study was to evaluate the impact of sarcopenia on the clinical outcomes.

Methods: Between 2003 and 2018, 79 patients underwent SLKT. Read More

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The mediating role of daytime sleepiness between problematic smartphone use and post-traumatic symptoms in COVID-19 home-refined adolescents.

Child Youth Serv Rev 2021 Apr 8:106012. Epub 2021 Apr 8.

Centre for Educational and Health Psychology, Sichuan University, Chengdu, China.

Background: COVID-19 was first recognized in late 2019 in China, at which time school closures forced most students to isolate at home or maintain social distance, both of which increased smartphone use, daytime sleepiness and post traumatic disorder (PTSD) risks. However, to date, no research has fully explored these behavioral risks or the consequences.

Methods: Two thousand and ninety home-confined students from two Chinese high schools participated in an online-based questionnaire battery that assessed their sociodemographic characteristics, COVID-19 related exposures, daytime sleepiness, problematic smartphone use, and PTSD. Read More

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Development and dosimetric assessment of an automatic dental artifact classification tool to guide artifact management techniques in a fully automated treatment planning workflow.

Comput Med Imaging Graph 2021 Mar 26;90:101907. Epub 2021 Mar 26.

The University of Texas MD Anderson Cancer Center Graduate School of Biomedical Sciences, Houston, TX, USA; The University of Texas MD Anderson Cancer Center, Department of Radiation Physics, Houston, TX, USA.

Purpose: We conducted our study to develop a tool capable of automatically detecting dental artifacts in a CT scan on a slice-by-slice basis and to assess the dosimetric impact of implementing the tool into the Radiation Planning Assistant (RPA), a web-based platform designed to fully automate the radiation therapy treatment planning process.

Methods: We developed an automatic dental artifact identification tool and assessed the dosimetric impact of its use in the RPA. Three users manually annotated 83,676 head-and-neck (HN) CT slices (549 patients). Read More

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Multimodal investigation of rat hepatitis E virus antigenicity: implications for infection, diagnostics, and vaccine efficacy.

J Hepatol 2021 Jan 15. Epub 2021 Jan 15.

Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong; Carol Yu Centre for Infection, The University of Hong Kong; The Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The University of Hong Kong. Electronic address:

Background & Aims: Rat hepatitis E virus (Orthohepevirus species C; HEV-C1) is an emerging cause of viral hepatitis in humans. HEV-C1 is divergent from other HEV variants infecting humans that belong to Orthohepevirus species A (HEV-A). This study assessed HEV-C1 antigenic divergence from HEV-A and investigated the impact of this divergence on infection susceptibility, serological test sensitivity, and vaccine efficacy. Read More

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January 2021

Notch-1 and Notch-3 Mediates Hypoxia-Induced Synovial Fibroblasts Activation in Rheumatoid Arthritis.

Arthritis Rheumatol 2021 Apr 12. Epub 2021 Apr 12.

Center for Translational Medicine Research and Development, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China.

Objective: To fully understand the molecular mechanism of hypoxia-induced rheumatoid arthritis synovial fibroblast cell (RASFC) activation via Notch-1 and Notch-3 signalling, and to evaluate its potential as a therapeutic target.

Methods: Notch-1 and Notch-3 intracellular domain (N1ICD), Notch-3 intracellular domain (N3ICD), and hypoxia-inducible factor-1α (HIF-1α) were detected in RA synovial tissues via immunohistology. RASFC were cultured under hypoxic and normoxic conditions with or without small interfering RNAs, and N1ICD and N3ICD were overexpressed under normoxic conditions. Read More

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The anatomical basis behind the neuromodulation effects associated with pulmonary vein isolation.

J Cardiovasc Electrophysiol 2021 Apr 12. Epub 2021 Apr 12.

Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool, UK.

The anatomical basis underlying the neuromodulation effects seen with pulmonary vein (PV) isolation (PVI) is not fully understood. Left atrial (LA) electro-anatomical maps of 38 patients who underwent catheter cardioneuroablation for vagally mediated bradycarrhythmias (VMB) were studied. During the procedure, LA ganglionic plexi (GPs) were systematically identified and ablated. Read More

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Effect of Short-Term Homebased Pre- and Postoperative Exercise on Recovery after Colorectal Cancer Surgery (PHYSSURG-C): A Randomized Clinical Trial.

Ann Surg 2021 Apr 9. Epub 2021 Apr 9.

Scandinavian Surgical Outcomes Research Group (SSORG), Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Region Västra Götaland, Sahlgrenska University Hospital, Department of Pediatric Oncology, Gothenburg, Sweden Region Västra Götaland, Alingsås Hospital, Department of Surgery, Alingsås, Sweden Region Västra Götaland, Sahlgrenska University Hospital, Department of Surgery, Gothenburg, Sweden Center for Health and Performance, Dept of molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Region Västra Götaland, Sahlgrenska University Hospital, Department of Medicine, Gothenburg, Sweden Department of Health and Rehabilitation/Physiotherapy, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Department of Surgery, Skaraborgs hospital, Skövde, Sweden.

Objective: To determine the effect of a short-term, unsupervised exercise intervention before and after colorectal cancer surgery on self-assessed physical recovery.

Summary Background Data: Preoperative exercise interventions could help improve recovery after colorectal cancer surgery and is currently recommended.

Methods: A randomized, parallel, open-label trial in six university or regional hospitals in Sweden. Read More

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RESEARCH OF THE ACTUAL ENERGY CONSUMPTION OF THE MILITARY PERSONNEL OF THE ARMED FORCES OF UKRAINE TO SUBSTANTIATE THE CORRECTION OF THEIR DAILY DIET.

Wiad Lek 2021 ;74(3 cz 2):684-689

BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE.

Objective: The aim: Is to determine the actual energy costs of servicemen on the qualification course of special operations of the Armed Forces of Ukraine to substantiate the adequate nutritional and energy value of their diet.

Patients And Methods: Materials and methods: The actual average daily energy consumption of 85 servicemen of the qualification course (hereinafter - Q-course) of special operations of AF of Ukraine was determined by time-table and instrumental methods. By laboratory, calculation and questionnaire methods, the compensatory possibilities of their actual nutrition were assessed. Read More

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January 2021

A Novel Behavioral Intervention for Rural Appalachian Cancer Survivors (weSurvive): Participatory Development and Proof-of-Concept Testing.

JMIR Cancer 2021 Apr 12;7(2):e26010. Epub 2021 Apr 12.

Department of Public Health Sciences, School of Medicine, University of Virginia, Christiansburg, VA, United States.

Background: Addressing the modifiable health behaviors of cancer survivors is important in rural communities that are disproportionately impacted by cancer (eg, those in Central Appalachia). However, such efforts are limited, and existing interventions may not meet the needs of rural communities.

Objective: This study describes the development and proof-of-concept testing of weSurvive, a behavioral intervention for rural Appalachian cancer survivors. Read More

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The infectivity of progeny adenovirus in the presence of neutralizing antibody.

J Gen Virol 2021 Apr;102(4)

Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University, Tokyo, Japan.

Human adenoviruses (Ads), common pathogens that cause upper respiratory and gastrointestinal infections, are blocked by neutralizing antibodies (nAbs). However, Ads are not fully eliminated even in hosts with nAbs. In this study, we assessed the infectivity of progeny Ad serotype 5 (Ad5) in the presence of nAb. Read More

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Role of Frailty in Prediction of Hospitalized Older Adult Patients Outcomes: A Prospective Study.

Turk J Med Sci 2021 Apr 12. Epub 2021 Apr 12.

Background/aim: Frailty is associated with an increased risk of negative short-term and long-term hospital outcomes. This study aimed to evaluate the role of frailty in predicting readmission, length of stay, and quality of life in the hospitalized older adults.

Materials And Methods: This observational study was conducted at Ziaiyan Hospital, Tehran, Iran. Read More

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Concurrent Validation and Reference Values of Gluteus Medius Clinical Test.

Int J Sports Phys Ther 2021 Apr 1;16(2):335-341. Epub 2021 Apr 1.

Head of the Physical Therapy Department, Minas Tenis Clube.

Context: The hip abductor muscles, mainly the gluteus medius, are responsible for controlling hip adduction in a closed kinetic chain. Frontal plane knee alignment, assessed during functional activities such squatting, jumping and running, may overload joint structures, like the anterior cruciate ligament and patellofemoral joint. The hand-held dynamometer is reliable and effective for testing the muscular strength of the hip abductors. Read More

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Nuciferine Inhibited the Differentiation and Lipid Accumulation of 3T3-L1 Preadipocytes by Regulating the Expression of Lipogenic Genes and Adipokines.

Front Pharmacol 2021 22;12:632236. Epub 2021 Mar 22.

Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Nuciferine, a main aporphine alkaloid component found in lotus leaf (), has been demonstrated to possess the property of reducing fat mass and alleviating dyslipidemia . The purpose of this study is to explore the effects of nuciferine on the proliferation and differentiation of 3T3-L1 cells and further investigate the possible underlying molecular mechanisms. 3T3-L1 preadipocytes were treated with 0∼20 μM nuciferine for 24∼120 h, the cell viability was assessed using CCK8. Read More

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Substance use among refugees in three Lebanese camps: A cross-sectional study.

Int J Drug Policy 2021 Apr 8;94:103204. Epub 2021 Apr 8.

Montpellier University, INSERM U 1058, Pathogenesis and Control of Chronic Infections (PCCI), Montpellier-France; Medical Pharmacology, and toxicology department Montpellier University, School of Pharmacy Montpellier- France. Electronic address:

Background: There is a strong link between conflict exposure and ill health, including substance use. However, this widely acknowledged problem has not been studied yet in refugee camps in Lebanon.

Aim: To investigate substance use among civilians following war or displacement, and to assess its association with socio-demographic characteristics. Read More

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Self-regulation task in young school age children born preterm: Correlation with early academic achievement.

Early Hum Dev 2021 Mar 26;157:105362. Epub 2021 Mar 26.

Center for Human Development, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0115, United States of America; Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0603, United States of America. Electronic address:

Background: Children born preterm are at risk for difficulties in executive function (EF), however there are limited tools to assess EF in young children and it is not fully understood how these early deficits are related to emerging academic skills.

Aims: To examine (a) early EF differences in young children born preterm, (b) how a measure of behavioral self-regulation correlates with other measures of EF in children born preterm, and (c) how this measure relates to academic outcomes in children born preterm.

Study Design: Longitudinal cohort study. Read More

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Relationship of physical function with quality of life in older patients with acute heart failure.

J Am Geriatr Soc 2021 Apr 10. Epub 2021 Apr 10.

Section of Cardiovascular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States.

Background: Older patients with acute decompensated heart failure (ADHF) have severely impaired physical function (PF) and quality of life (QOL). However, relationships between impairments in PF and QOL are unknown but are relevant to clinical practice and trial design.

Methods: We assessed 202 consecutive patients hospitalized with ADHF in the multicenter Rehabilitation Therapy in Older Acute HF Patients (REHAB-HF) Trial. Read More

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Impact of lockdown on key workers: findings from the COVID-19 survey in four UK national longitudinal studies.

J Epidemiol Community Health 2021 Apr 9. Epub 2021 Apr 9.

MRC Unit for Lifelong Health and Ageing, University College London, London, UK

Background: Key workers played a pivotal role during the national lockdown in the UK's response to the COVID-19 pandemic. Although protective measures have been taken, the impact of the pandemic on key workers is yet to be fully elucidated.

Methods: Participants were from four longitudinal age-homogeneous British cohorts (born in 2001, 1990, 1970 and 1958). Read More

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Dura promotes metastatic potential in prostate cancer through the CXCR2 pathway.

J Neurooncol 2021 Apr 9. Epub 2021 Apr 9.

Department of Neurosurgery, University of Michigan, 3552 Taubman Center, 1500 E. Medical Center Dr., Ann Arbor, MI, 48109, USA.

Purpose: Spinal metastases are common in cancer. This preferential migration/growth in the spine is not fully understood. Dura has been shown to affect the surrounding microenvironment and promote cancer growth. Read More

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Periostin promotes arterial calcification through PPARγ-related glucose metabolism reprogramming.

Am J Physiol Heart Circ Physiol 2021 Apr 9. Epub 2021 Apr 9.

Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, P.R., China.

Extracellular matrix (ECM) exerts a list of biological functions, contributing to almost 30% of the osteogenic process. Periostin is a secreted protein that can alter ECM remodeling in response to vascular injury. However, the functional role of periostin in vascular calcification has yet to be fully described. Read More

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Greater Scores for Dietary Fat and Grain Quality Components Underlie Higher Total Healthy Eating Index-2015 Scores, While Whole Fruits, Seafood, and Plant Proteins Are Most Favorably Associated with Cardiometabolic Health in US Adults.

Curr Dev Nutr 2021 Mar 26;5(3):nzab015. Epub 2021 Feb 26.

Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA.

Background: High-quality diets reduce the risk of cardiometabolic and other chronic diseases. The dietary components that distinguish higher from lower quality diets, and their associations with health, have not been fully investigated.

Objectives: This study aimed to assess the component scores that underlie differences in total Healthy Eating Index (HEI)-2015 scores, quantify fatty acid (saturated, monounsaturated, polyunsaturated) intakes that comprise Fatty Acids component scores, and assess associations between component scores and cardiometabolic risk factors. Read More

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Spinal surgery during the COVID-19 pandemic: the experience in a tertiary referral centre.

J Spine Surg 2021 Mar;7(1):62-67

Department of Spinal Surgery, Salford Royal NHS Foundation Trust, Salford, UK.

Background: The COVID-19 pandemic first came to prominence in December 2019, and since then has swept the globe, causing one of the largest public health problems seen. It has had a wide-ranging impact on healthcare provision, with a cessation of elective operating. We aimed to assess the impact of COVID-19 on a tertiary referral centre for spinal surgery in England. Read More

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Prognostic value of thrombin generation parameters in hospitalized COVID-19 patients.

Sci Rep 2021 04 8;11(1):7792. Epub 2021 Apr 8.

Servicio de Hematología y Oncología Médica, Hospital General Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Arrixaca, CIBERER, Avda. Marqués de Los Vélez, s/n, 30008, Murcia, Spain.

SARS-CoV-2 infection increases the risk of thrombosis by different mechanisms not fully characterized. Although still debated, an increase in D-dimer has been proposed as a first-line hemostasis test associated with thromboembolic risk and unfavorable prognosis. We aim to systematically and comprehensively evaluate the association between thrombin generation parameters and the inflammatory and hypercoagulable state, as well as their prognostic value in COVID-19 patients. Read More

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Efficacy and safety of methylprednisolone against acute respiratory distress syndrome: A systematic review and meta-analysis.

Medicine (Baltimore) 2021 Apr;100(14):e25408

Intensive Care Unit, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.

Background: Acute respiratory distress syndrome (ARDS) is caused by an inflammatory injury to the lung. Dysregulated inflammation is the cardinal feature of ARDS. Methylprednisolone is an option for treating ARDS. Read More

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The Rhino-Lip-Lifting: A Novel Proposal for Midface Profileplasty Performed as a Single Surgical Procedure.

Facial Plast Surg 2021 Apr 8. Epub 2021 Apr 8.

Department of Facial Plastic Surgery, Rigeneralab Center for Regenerative Medicine, Torino, Italy.

As facial aging occurs, aesthetic changes of the nasal tip and the senile upper lip include tip ptosis, increase in skin length, loss of vermillion height and Cupid's bow, and vertical wrinkles.Regardless of the rejuvenation procedure, the lips are not to be considered as a single anatomical entity, instead they should be placed in a strong correlation with the nose. The aim of this study is therefore to demonstrate the effectiveness of the association of primary closed rhinoplasty together with indirect subnasal lip-lifting technique. Read More

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Higher colorectal tissue HIV infectivity in cisgender women compared with MSM before and during oral preexposure prophylaxis.

AIDS 2021 Apr 6. Epub 2021 Apr 6.

Baylor College of Medicine Children's Foundation Uganda, Kampala, Uganda University of Pittsburgh Medical School, Pittsburgh, Pennsylvania, USA Orion Biotechnology, Ottawa, Ontario, Canada Fred Hutchinson Cancer Research Center, Medical School, Pittsburgh, Pennsylvania Johns Hopkins University School of Medicine, Baltimore, Maryland University of Pennsylvania, Infectious Disease Division, Philadelphia, Pennsylvania University of North Carolina at Chapel Hill, Chapel Hill, North Carolina University of California Los Angeles, Center for Clinical AIDS Research and Education, Los Angeles, California, USA University of Barcelona, Barcelona, Spain University of Colorado, Denver, Colorado Fenway Health/Harvard Medical School, Boston, Massachusetts University of Michigan, School of Public Health, Ann Arbor, Michigan Weill Cornell Medicine, New York, New York, USA Prevention Sciences Program, Division of AIDS, National Institute of Allergy and Infectious Diseases FHI360.

Objective: The objective of this study was to compare HIV-negative cisgender women (CGW) with MSM for mucosal tissue differences in pharmacokinetics, HIV infectivity and cell phenotype.

Design: A substudy of HPTN 069/ACTG A5305, 48-week study of three oral candidate preexposure prophylaxis regimens: maraviroc, maraviroc/emtricitabine and maraviroc/tenofovir disoproxil fumarate (TDF) compared with a TDF/emtricitabine control group.

Methods: Plasma, peripheral blood mononuclear cells and cervical and colorectal tissue biopsies were collected at Baseline (no drug), Week 24 and 48 (on drug), and Week 49 (1-week postdrug). Read More

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RF shielding materials for highly-integrated PET/MRI systems.

Phys Med Biol 2021 Apr 8. Epub 2021 Apr 8.

Institute for Experimental Molecular Imaging, Department of Physics of Molecular Imaging Systems, RWTH Aachen University, Aachen, Nordrhein-Westfalen, GERMANY.

Integration of magnetic resonance imaging (MRI) and positron emission tomography (PET) into a simultaneous device calls for adaptations of the radio frequency (RF) shielding concept. Conventional PET module housings fully encase the entire PET detector to reduce mutual interference. Excluding passive components, i. Read More

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Sex-stratified genome-wide association study of multisite chronic pain in UK Biobank.

PLoS Genet 2021 Apr 8;17(4):e1009428. Epub 2021 Apr 8.

School of Life Sciences, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.

Chronic pain is highly prevalent worldwide and imparts a significant socioeconomic and public health burden. Factors influencing susceptibility to, and mechanisms of, chronic pain development, are not fully understood, but sex is thought to play a significant role, and chronic pain is more prevalent in women than in men. To investigate sex differences in chronic pain, we carried out a sex-stratified genome-wide association study of Multisite Chronic Pain (MCP), a derived chronic pain phenotype, in UK Biobank on 178,556 men and 209,093 women, as well as investigating sex-specific genetic correlations with a range of psychiatric, autoimmune and anthropometric phenotypes and the relationship between sex-specific polygenic risk scores for MCP and chronic widespread pain. Read More

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A framework to account for the effects of visual loss on human auditory abilities.

Psychol Rev 2021 Apr 8. Epub 2021 Apr 8.

Vision and Eye Research Institute.

Until recently, a commonly held view was that blindness resulted in enhanced auditory abilities, underpinned by the beneficial effects of cross-modal neuroplasticity. This viewpoint has been challenged by studies showing that blindness results in poorer performance for some auditory spatial tasks. It is now clear that visual loss does not result in a general increase or decrease in all auditory abilities. Read More

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Microleakage of pit and fissure sealings placed after enamel conditioning with phosphoric acid or with self-etching primers/adhesives.

Clin Exp Dent Res 2021 Apr 7. Epub 2021 Apr 7.

Department of Pediatric Dentistry, Dental School, University of Marburg and University Medical Center Giessen and Marburg, Campus Giessen, Giessen, Germany.

Background: It is still not fully understood what pretreatment is best for achieving maximum tightness for pit and fissure sealings (PFS).

Aim: This study investigated microleakage of PFS placed after etching with phosphoric acid or after the application of self-etching primers/adhesives (SEPA).

Design: 131 third molars were assigned to ten groups. Read More

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Longitudinal trajectories of diet quality and subsequent mortality among Chinese adults: results from the China health and nutrition survey 1997-2015.

Int J Behav Nutr Phys Act 2021 Apr 7;18(1):51. Epub 2021 Apr 7.

Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, 221 Burwood Highway, Burwood, Victoria, 3125, Australia.

Background: China has witnessed a significant nutritional transition. However, there is a gap in the literature investigating the association between change of diet and mortality among Chinese. Thus, we aimed to explore the longitudinal trajectories of diet quality over 10 years (from 1997 to 2006) and the subsequent risk of death till 2015 among Chinese adults. Read More

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