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Going Beyond the State Law: Investigating High School Sport-Related Concussion Protocols.

J Athl Train 2020 Jun 18. Epub 2020 Jun 18.

A.T. Still University, Athletic Training Programs, School of Osteopathic Medicine in Arizona, 5850 E Still Circle, Mesa, Arizona 85206, United States,

Context: State laws provide general guidelines for sport-related concussion (SRC) management, but do not comprehensively address the multiple layers of management for this complex injury. While high schools are encouraged to develop a SRC protocol that includes both state law tenets and additional management practices, the execution of this warrants examination.

Objective: To investigate state law compliance and practice components included in high school SRC protocols, and determine whether the degree of sports medicine coverage influenced protocol quality. Read More

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Upper extremity musculoskeletal disorders and work exposures among railroad maintenance-of-way workers.

Am J Ind Med 2021 Jun 14. Epub 2021 Jun 14.

Downstate School of Public Health, State University of New York (SUNY), Brooklyn, New York, USA.

Background: Our objective was to examine occupational risk factors for musculoskeletal disorders of the shoulders, elbows, wrists, and hands among railroad maintenance-of-way (MOW) workers. Little systematic research on musculoskeletal disorders has been conducted in this occupational group.

Methods: In total, 3995 active members of the Brotherhood of Maintenance of Way Employes Division (BMWED) completed a standardized survey focusing on disorders caused by hand-transmitted vibration. Read More

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IGF1 receptor inhibition amplifies the effects of cancer drugs by autophagy and immune-dependent mechanisms.

J Immunother Cancer 2021 Jun;9(6)

Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France

Background: Pharmacological autophagy enhancement constitutes a preclinically validated strategy for preventing or treating most major age-associated diseases. Driven by this consideration, we performed a high-content/high-throughput screen on 65 000 distinct compounds on a robotized fluorescence microscopy platform to identify novel autophagy inducers.

Results: Here, we report the discovery of picropodophyllin (PPP) as a potent inducer of autophagic flux that acts on-target, as an inhibitor of the tyrosine kinase activity of the insulin-like growth factor-1 receptor (IGF1R). Read More

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National Estimates of the Reserve Capacity of Registered Nurses Not Currently Employed in Nursing and Emergency Nursing Job Mobility in the United States.

Ann Emerg Med 2021 Jun 11. Epub 2021 Jun 11.

College of Nursing, University of New Mexico, Albuquerque, NM.

Study Objective: In a large-scale disaster, recruiting from all retired and nonworking registered nurses is one strategy to address surge demands in the emergency nursing workforce. The purpose of this research was to estimate the workforce capacity of all registered nurses who are not currently working in the nursing field in the United States by state of residence and to describe the job mobility of emergency nurses.

Methods: Weighted population estimates were calculated using the 2018 National Sample Survey of Registered Nurses. Read More

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Characterization and Treatment Goals of Patients on Long-Acting Injectable vs Oral Antipsychotics: Results from a Patient/Caregiver/Psychiatrist Survey.

CNS Spectr 2021 Apr;26(2):154

Otsuka Pharmaceutical Development & Commercialization, Inc., Princeton, NJ, USA.

Background: Patient preferences in schizophrenia (SCZ), including identification of key goals and outcomes for treatment and relative importance of certain treatment goals to patients, have been assessed by several studies. However, there continues to be a lack of sufficient evidence on US patient attitudes and perceptions towards treatment goals and pharmacotherapy options in SCZ, especially taking into context long-acting injectable antipsychotics (LAIs) in this disease area. This lack of evidence is further pronounced in caregivers of individuals with SCZ. Read More

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[Inpatient Psychiatric Treatment in the Corona-crisis by Psychologists and Psychiatrists in Home-office and in the Clinic].

Fortschr Neurol Psychiatr 2021 Jun 14. Epub 2021 Jun 14.

Psychiatrie und Psychotherapie, LMU Klinikum der Universität München Medizinische Klinik und Poliklinik IV, München, Germany.

Since the emergence of the new coronavirus (COVID-19) pandemic in March 2020, many people in Germany have become ill. This meant a challenge for the care of mentally ill hospitalized patients. There was a social shut-down in Bavaria with a decrease in social contacts. Read More

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Energy intake as a short-term biomarker for weight loss in adults with obesity receiving liraglutide: A randomized trial.

Obes Sci Pract 2021 Jun 9;7(3):281-290. Epub 2021 Mar 9.

AdventHealth Translational Research Institute Orlando Florida USA.

Background And Objective: Obesity is a chronic disease associated with many serious comorbidities. Pharmacologic therapies are approved for the treatment of obesity; however, short-term biomarkers to predict weight loss are not well understood. This study aimed to determine the ability of single-meal energy intake (EI) to predict weight loss in participants with obesity treated with liraglutide. Read More

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Pyrazolone ligation-mediated versatile sequential bioconjugations.

Chem Sci 2020 Jun 24;11(27):7252-7259. Epub 2020 Jun 24.

Novo Nordisk Research Center 530 Fairview Avenue North Seattle WA 98109 USA

Bioconjugation chemistries are critical tools in biotherapeutics discovery. The past efforts have been exclusively focused on two-segment conjugations. However, emerging research directions, such as polypharmacy biotherapeutics, desire multiple-component bioconjugations where more than two pharmacologically related biomolecules can be assembled into a single construct in high efficiency. Read More

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Prulifloxacin Effectiveness in Moderate-to-Severe Acute Exacerbations of Chronic Bronchitis: Α Noninterventional, Multicentre, Prospective Study in Real-Life Clinical Practice-The "AIOLOS" Study.

Can Respir J 2021 25;2021:6620585. Epub 2021 May 25.

University Respiratory Clinic, University General Hospital of Heraklion (PE.PA.GNI), Heraklion 71110, Greece.

Real-world evidence regarding the effectiveness of prulifloxacin in the treatment of acute exacerbations of chronic bronchitis (AECB) is limited. Therefore, this study aimed to assess the rates and time to symptom improvement and resolution in patients with moderate-to-severe AECB who were given prulifloxacin in the routine care in Greece. This observational, prospective study, conducted in 15 hospital-based clinics across Greece, enrolled outpatients >40 years old, with moderate-to-severe AECB, for whom the physician had decided to initiate treatment with prulifloxacin. Read More

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Dual Effects of Cyclooxygenase Inhibitors in Combination With CD19.CAR-T Cell Immunotherapy.

Front Immunol 2021 26;12:670088. Epub 2021 May 26.

Department of Internal Medicine V, University Clinic Heidelberg, Heidelberg University, Heidelberg, Germany.

Chimeric antigen receptor T (CAR-T) cells targeting CD19 came into clinical practice for the treatment of B cell lymphoma in 2018. However, patients being treated for B cell lymphoma often suffer from comorbidities such as chronic pain, cardiovascular diseases and arthritis. Thus, these patients frequently receive concomitant medications that include nonsteroidal anti-inflammatory drugs (NSAIDs) like cyclooxygenase (COX) inhibitors. Read More

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Adverse Events due to Lack of Precision in Total Hip Arthroplasty: The Potential of Provocation-Based CT for Diagnosis of Implant Loosening.

ScientificWorldJournal 2021 2;2021:8836687. Epub 2021 Jun 2.

Landstingens Ömsesidiga Försäkringsbolag, Stockholm, Sweden.

Adverse events in total hip replacement (THR) may have several origins, one being lack of precision in diagnosis and/or during surgery. This study describes the pattern and frequency of avoidable injuries in THR and the potential value of a new tool for early diagnosis of implant loosening. This retrospective study was based on all ( = 1 456) settled claims regarding THR in the Swedish National Patient Insurance database from 2010 to 2017. Read More

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The Effect of the COVID-19 Pandemic on the Economics of United States Emergency Care.

Ann Emerg Med 2021 Apr 27. Epub 2021 Apr 27.

US Acute Care Solutions, Canton, OH; Department of Emergency Medicine, Allegheny Health Network, Pittsburgh, PA.

Study Objective: We describe how the coronavirus disease 2019 (COVID-19) pandemic affected the economics of emergency department care (ED).

Methods: We conducted an observational study of 136 EDs from January 2019 to September 2020, using 2020-to-2019 3-week moving ratios for ED visits, complexity, revenue, and staffing expenses. We tabulated 2020-to-2019 staffing ratios and calculated hour and full-time-equivalent changes. Read More

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Social connectedness and self-perceived health of older adults in New Zealand.

Health Soc Care Community 2021 Jun 11. Epub 2021 Jun 11.

School of Nursing, Midwifery and Health Practice, Faculty of Health, Victoria University of Wellington, Wellington, New Zealand.

The objective of this research was to explore social connectedness and associations with self-perceived health amongst older adults in New Zealand at a population level. The data for this analysis were derived from the 2016 Health and Lifestyle Survey, a nationally representative survey administered via face-to-face interviews. The findings from this analysis of 1,374 respondents, all of whom were over the age of 55 years, highlight that being female, belonging to older age groups (above 70 years), being employed full-time or part-time, connecting online with known people, considering cultural connections to be important and not feeling isolated from others are significantly and positively associated with positive self-perceived health. Read More

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Paid sick leave benefits among essential frontline workers serving people experiencing homelessness in Canada during the COVID-19 pandemic.

Public Health 2021 Jun 7;195:142-144. Epub 2021 Jun 7.

Department of Psychiatry, University of Toronto, 1051 Queen Street West, Toronto, Ontario, Canada, M6J 1H4. Electronic address:

Objectives: This study examined the prevalence and factors associated with paid sick leave benefits among direct service providers who work with people experiencing homelessness.

Study Design: Cross-sectional study using an online survey disseminated during the second wave of the COVID-19 pandemic in Canada.

Methods: Survey data from 572 direct service providers working in the homeless, supportive housing, and harm reduction service sectors were analyzed for this study. Read More

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Opalescence Measurements: Improvements in Fundamental Knowledge, Identifying Sources of Analytical Biases, and Advanced Applications for the Development of Therapeutic Proteins.

J Pharm Sci 2021 Jun 7. Epub 2021 Jun 7.

Drug Product Development, Bristol Myers Squibb Company, New Brunswick, New Jersey, USA 08903.

Opalescence of biopharmaceutical solutions can indicate suboptimal colloidal stability and is therefore a generally undesirable attribute that requires investigation and potentially remediation. While there are numerous instrumentation options available for measuring opalescence, cross-instrument comparisons and detailed knowledge of analytical biases have been limited.  Here, we highlight key findings from a multi-instrument investigation where differences in reported opalescence values are explained with particular emphasis on how the optical configuration and detector properties of each instrument affect the response of the sample and the primary formazin standards required for instrument calibration. Read More

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Seroprevalence of anti-SARS-CoV-2 IgG antibodies in the staff of a public school system in the midwestern United States.

PLoS One 2021 10;16(6):e0243676. Epub 2021 Jun 10.

Harvard Medical School, Boston, MA, United States of America.

Since March 2020, the United States has lost over 580,000 lives to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19. A growing body of literature describes population-level SARS-CoV-2 exposure, but studies of antibody seroprevalence within school systems are critically lacking, hampering evidence-based discussions on school reopenings. The Lake Central School Corporation (LCSC), a public school system in suburban Indiana, USA, assessed SARS-CoV-2 seroprevalence in its staff and identified correlations between seropositivity and subjective histories and demographics. Read More

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From zero to hero and back to zero: The consequences of status inconsistency between the work roles of multiple jobholders.

J Appl Psychol 2021 Jun 10. Epub 2021 Jun 10.

W. P. Carey School of Business, Arizona State University.

The surge of opportunities available through the gig economy has increased the sizeable population of people who hold multiple jobs. Many of these multiple jobholders are full-time employees who have adopted side-hustles-income-generating work performed alongside full-time work. A core and ubiquitous feature of both full-time work and side-hustles is status, or membership in a social hierarchy. Read More

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Distributed education enables distributed economic impact: the economic contribution of the Northern Ontario School of Medicine to communities in Canada.

Health Econ Rev 2021 Jun 9;11(1):20. Epub 2021 Jun 9.

Professor of Rural Health, and Founding Dean Emeritus, Northern Ontario School of Medicine, 935 Ramsey Lake Road, Greater Sudbury, Ontario, P3E 2C6, Canada.

Background: Medical schools with distributed or regional programs encourage people to live, work, and learn in communities that may be economically challenged. Local spending by the program, staff, teachers, and students has a local economic impact. Although the economic impact of DME has been estimated for nations and sub-national regions, the community-specific impact is often unknown. Read More

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Reference equations for tidal breathing parameters using structured light plethysmography.

ERJ Open Res 2021 Apr 7;7(2). Epub 2021 Jun 7.

Lung Function and Sleep, Queen Elizabeth Hospital, Birmingham, UK.

Tidal breathing measurements can be used to identify changes in respiratory status. Structured light plethysmography (SLP) is a non-contact tidal breathing measurement technique. Lack of reference equations for SLP parameters makes clinical decision-making difficult. Read More

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The impact of organizational culture on professional fulfillment and burnout in an academic department of medicine.

PLoS One 2021 9;16(6):e0252778. Epub 2021 Jun 9.

Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

Physician wellness is vital to career satisfaction, provision of high quality patient care, and the successful education of the next generation of physicians. Despite this, the number of physicians experience symptoms of burnout is rising. To assess the impact of organizational culture on physicians' professional fulfillment and burnout, we surveyed full-time Department of Medicine members at the University of Toronto. Read More

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Underrepresented Women Leaders: Lasting Impact of Gender Homophily in Surgical Faculty Networks.

Laryngoscope 2021 Jun 9. Epub 2021 Jun 9.

Department of Economics, Monash University, Clayton, Victoria, Australia.

Objective: Despite the increase of women in surgical fields and resources toward advancing women, there is no corresponding increased representation of women in higher academic ranks and leadership. The following hypotheses are explored: 1) men and women build/maintain different relationship networks and 2) women are not similarly included within the organization and do not receive the same sponsorship as male counterparts.

Study Design: Prospective observational study. Read More

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A Survey of Tranexamic Acid Use by US Tactical Emergency Medical Support Providers.

J Spec Oper Med 2021 ;21(2):72-76

Background: Tactical Emergency Medical Support (TEMS) providers may encounter severe traumatic injuries, with associated hemorrhagic shock, coagulopathy, and hyperfibrinolysis. Tranexamic acid (TXA) administration represents a potential intervention in this operational environment. This study evaluated TXA availability and use among US tactical medical personnel supporting law enforcement tactical teams. Read More

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Best Practices in Specialized Amyloidosis Centers in the United States: A Survey of Cardiologists, Nurses, Patients, and Patient Advocates.

Clin Med Insights Cardiol 2021 29;15:11795468211015230. Epub 2021 May 29.

Pfizer, New York, NY, USA.

Background: Because transthyretin amyloid cardiomyopathy (ATTR-CM) poses unique diagnostic and therapeutic challenges, referral of patients with known or suspected disease to specialized amyloidosis centers is recommended. These centers have developed strategic practices to provide multidisciplinary comprehensive care, but their best practices have not yet been well studied as a group.

Methods: A qualitative survey was conducted by telephone/email from October 2019 to February 2020 among eligible healthcare providers with experience in the management of ATTR-CM at US amyloidosis centers, patients with ATTR-CM treated at amyloidosis centers, and patient advocates from amyloidosis patient support groups. Read More

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Platform Trials to Expedite Drug Development in Alzheimer's Disease: A Report from the EU/US CTAD Task Force.

J Prev Alzheimers Dis 2021 ;8(3):306-312

P.S. Aisen, University of Southern California Alzheimer's Therapeutic Research Institute, San Diego, CA, USA,

A diverse range of platforms has been established to increase the efficiency and speed of clinical trials for Alzheimer's disease (AD). These platforms enable parallel assessment of multiple therapeutics, treatment regimens, or participant groups; use uniform protocols and outcome measures; and may allow treatment arms to be added or dropped based on interim analyses of outcomes. The EU/US CTAD Task Force discussed the lessons learned from the Dominantly Inherited Alzheimer's Network Trials Unit (DIAN-TU) platform trial and the challenges addressed by other platform trials that have launched or are in the planning stages. Read More

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January 2021

Large scale meta-analysis of preclinical toxicity data for target characterisation and hypotheses generation.

PLoS One 2021 8;16(6):e0252533. Epub 2021 Jun 8.

Computational Toxicology, Data and Computational Sciences, GlaxoSmithKline, London, United Kingdom.

Recent technological advances in the field of big data have increased our capabilities to query large databases and combine information from different domains and disciplines. In the area of preclinical studies, initiatives like SEND (Standard for Exchange of Nonclinical Data) will also contribute to collect and present nonclinical data in a consistent manner and increase analytical possibilities. With facilitated access to preclinical data and improvements in analytical algorithms there will surely be an expectation for organisations to ensure all the historical data available to them is leveraged to build new hypotheses. Read More

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Understanding providers' attitudes and key concerns toward incorporating CVD risk prediction into clinical practice: a qualitative study.

BMC Health Serv Res 2021 Jun 7;21(1):561. Epub 2021 Jun 7.

Center for Clinical Management Research, VA Ann Arbor Healthcare System, 2215 Fuller Rd, Ann Arbor, MI, 48105, USA.

Background: Although risk prediction has become an integral part of clinical practice guidelines for cardiovascular disease (CVD) prevention, multiple studies have shown that patients' risk still plays almost no role in clinical decision-making. Because little is known about why this is so, we sought to understand providers' views on the opportunities, barriers, and facilitators of incorporating risk prediction to guide their use of cardiovascular preventive medicines.

Methods: We conducted semi-structured interviews with primary care providers (n = 33) at VA facilities in the Midwest. Read More

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Pharmacokinetic and pharmacodynamic interactions between daridorexant, a dual orexin receptor antagonist, and citalopram in healthy subjects.

Eur Neuropsychopharmacol 2021 Jun 4;51:90-104. Epub 2021 Jun 4.

Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.

Daridorexant (ACT-541468) is a new dual orexin receptor antagonist being evaluated for the treatment of insomnia, which is a common comorbidity of depression and anxiety. Therefore, daridorexant is likely to be administered concomitantly with agents (e.g. Read More

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Reproductive and menstrual factors for papillary thyroid cancer risk: A case-control study in Chinese women.

Cancer Epidemiol 2021 Jun 5;73:101964. Epub 2021 Jun 5.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, PR China. Electronic address:

Background: Thyroid cancer (TC) is threefold more common in women than men. Reproductive and menstrual factors may be related to the onset of papillary thyroid cancer (PTC). This study aims to determine the association of reproductive and menstrual factors with PTC in Chinese females. Read More

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Passing the Test: A Model-Based Analysis of Safe School-Reopening Strategies.

Ann Intern Med 2021 Jun 8. Epub 2021 Jun 8.

Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland (M.C.F.).

Background: The COVID-19 pandemic has induced historic educational disruptions. In April 2021, about 40% of U.S. Read More

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