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Identifying Opportunities for Workflow Automation in Health Care: Lessons Learned from Other Industries.

Appl Clin Inform 2021 May 28;12(3):686-697. Epub 2021 Jul 28.

Clinovations Government + Health, Washington, District of Columbia, United States.

Background:  Workflow automation, which involves identifying sequences of tasks that can be streamlined by using technology and modern computing, offers opportunities to address the United States health care system's challenges with quality, safety, and efficiency. Other industries have successfully implemented workflow automation to address these concerns, and lessons learned from those experiences may inform its application in health care.

Objective:  Our aim was to identify and synthesize (1) current approaches in workflow automation across industries, (2) opportunities for applying workflow automation in health care, and (3) considerations for designing and implementing workflow automation that may be relevant to health care. Read More

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Effect of intrapulmonary percussive ventilation on intensive care unit length of stay, the incidence of pneumonia and gas exchange in critically ill patients: A systematic review.

PLoS One 2021 28;16(7):e0255005. Epub 2021 Jul 28.

Sydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia.

Background: Pulmonary complications such as pneumonia, pulmonary atelectasis, and subsequent respiratory failure leading to ventilatory support are a common occurrence in critically ill patients. Intrapulmonary percussive ventilation (IPV) is used to improve gas exchange and promote airway clearance in these patients. The current evidence regarding the effectiveness of intrapulmonary percussive ventilation in critical care settings remains unclear. Read More

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Impact of human papillomavirus in sinonasal cancer-a systematic review.

Acta Oncol 2021 Jul 28:1-17. Epub 2021 Jul 28.

Department of Otorhinolaryngology, Head and Neck Surgery, and Audiology, Copenhagen University Hospital, Copenhagen, Denmark.

Background: Human papillomavirus (HPV) is an established prognostic marker in oropharyngeal squamous cell carcinoma. Currently, the role of HPV in sinonasal carcinoma is being explored.

Objectives: This systematic review addresses the role of HPV in sinonasal cancer, establishing the occurrence of HPV-positive cancers and the influence of HPV-positivity on prognosis in sinonasal cancer as well as the utility of the putative surrogate marker of HPV (p16) in sinonasal cancer. Read More

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Can exposure to panoramic radiographs induce genotoxic effects on the oral epithelium? A systematic review with meta-analysis.

Dentomaxillofac Radiol 2021 Jul 28:20210149. Epub 2021 Jul 28.

PRODONTO, Dentistry Department, Federal University of Sergipe, Prodonto, Brazil.

Objective: To evaluate, through a systematic review (SR) with meta-analysis, the occurrence of genotoxic effects in the oral epithelium after the exposure of patients to panoramic radiographs.

Methods: An SR was performed with the PICOS (Population, Intervention, Comparison, Outcome, and Study design) strategy, aiming to answer the following question: "Can panoramic radiographs induce genotoxic effects on the oral epithelium?" The study was registered in the PROSPERO (International prospective register of systematic reviews) platform. A systematic search was performed in the following electronic databases: PubMed (including MedLine), Scopus, Embase, LILACS, Medline EbscoHost, and Google Scholar. Read More

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Association between Atopic Dermatitis and Hypertension: A Systematic Review and Meta-Analysis.

Br J Dermatol 2021 Jul 28. Epub 2021 Jul 28.

The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.

Background: Previous studies found conflicting results about the association of atopic dermatitis (AD) with hypertension.

Objectives: Determine whether AD and AD severity are associated with hypertension.

Methods: A systematic review was performed of published studies in MEDLINE, EMBASE, Scopus, Web of Science, and GREAT databases. Read More

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Integration of Arts and Humanities in Medical Education: a Narrative Review.

J Cancer Educ 2021 Jul 28. Epub 2021 Jul 28.

Department of Foundational Medical Studies, Oakland University William Beaumont School of Medicine, Rochester, MI, 48309, USA.

This narrative review aims to identify and review the extant literature describing methods and outcomes of embedding the arts and humanities (AH) into medical school curricula. The Association of American Medical Colleges changed the Medical College Admission Test (MCAT) in 2015 to place new emphasis on the role of liberal arts in the process of developing well-rounded physicians. Consequently, medical schools have been implementing more connections to creative writing, literature, theater, movies, music, and the visual arts into their curricula. Read More

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Delayed hemorrhage after pediatric stereo-electroencephalography: delayed occurrence or delayed diagnosis?

Childs Nerv Syst 2021 Jul 28. Epub 2021 Jul 28.

Department of Pediatric Neurosurgery, Sant Joan de Déu Barcelona Children's Hospital, Universitat de Barcelona, Barcelona, Spain.

Background: Stereo-electroencephalography (SEEG) is a well-known invasive diagnostic method for drug-resistant epilepsy (DRE). Its rate of complications is relatively low, being the intracranial hemorrhage (ICH) the most relevant. Most centers perform immediate imaging studies after SEEG to rule out complications. Read More

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New developments in rare vulvar and vaginal cancers.

Curr Opin Oncol 2021 Jul 27. Epub 2021 Jul 27.

Gynecology and Breast Care Center, Mater Olbia Hospital, Olbia Dipartimento Scienze della Vita e Sanità Pubblica, Università Cattolica del Sacro Cuore Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy.

Purpose Of Review: To provide the latest insight on the rare vulvar and vaginal malignancies, able to impact on clinical practice, and to outline new potential research developments.

Recent Findings: Many efforts are being made to produce technical and scientific advances in the fields of vulvar and vaginal carcinoma, including imaging work-up, interventional procedures and minimally invasive surgical approach, as well as molecular profiling and identification of new target treatments.

Summary: In the evaluation of lymph node status, ultrasound has demonstrated promising results because of high predictive value, low risk and low cost. Read More

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Cranial Nerve Noninvasive Neuromodulation in Adults With Neurological Conditions: Protocol for a Scoping Review.

JMIR Res Protoc 2021 Jul 28;10(7):e29965. Epub 2021 Jul 28.

Department of Physical Therapy, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Background: Cranial nerve noninvasive neuromodulation (CN-NINM) via translingual nerve stimulation (TLNS) is a promising new intervention combined with neurological rehabilitation to improve outcomes for persons with neurological conditions. A portable neuromodulation stimulation (PoNS) device rests on the tongue and stimulates cranial nerves V and VII (trigeminal and facial nerves, respectively). Emerging evidence suggests that CN-NINM using the PoNS device, combined with targeted physical therapy, improves balance and gait outcomes but has not yet been comprehensively reviewed. Read More

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Sámi traditional medicine: practices, usage, benefit, accessibility and relation to conventional medicine, a scoping review study.

Int J Circumpolar Health 2021 Dec;80(1):1924993

Centre for Sami Research (Várdduo), Umeå University, Umeå, Sweden.

The Sámi Indigenous populations, who live in the arctic Sápmi area across four countries - Norway, Sweden, Finland and the Kola Peninsula of Russia - have practiced traditional medicine (TM) for millennia. However, today Sámi TM is unknown within the Swedish health care services (HCS). The aim of this study is to describe the nature and scope of research conducted on Sámi TM among the four Sápmi countries. Read More

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December 2021

Coaching Caregivers of Children who are Deaf or Hard of Hearing: A Scoping Review.

J Deaf Stud Deaf Educ 2021 Jul 28. Epub 2021 Jul 28.

Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada.

Caregiver coaching is an expected practice in early intervention. However, little is known about coaching with caregivers of children who are deaf or hard of hearing, receiving services for listening and spoken language (LSL). A systematic review of 7 databases, the gray literature, and consultation with 7 expert LSL practitioners yielded 506 records for full-text review, 22 of which were ultimately included in the review. Read More

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Role of anaesthesia in endoscopic and external dacryocystorhinostomy: A meta-analysis of 3282 cases.

Eur J Ophthalmol 2021 Jul 28:11206721211035616. Epub 2021 Jul 28.

Division of Head and Neck Department, Otorhinolaryngology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Distal acquired lacrimal obstruction is a common adulthood pathology whose primary treatment is represented by EXT-DCR and END-DCR. When considering their influencing factors, the role of the type of anaesthesia applied during these surgeries has a major role. The aim of this study is to systematically analyse the influence of general and local/regional anaesthesia on the final success rates of EXT-DCR and END-DCR. Read More

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COMP Report: An updated algorithm to estimate medical physics staffing levels for radiation oncology.

J Appl Clin Med Phys 2021 Jul 28. Epub 2021 Jul 28.

Departments of Oncology and Medical Biophysics, Western University, London, ON, Canada.

Purpose: Medical physics staffing models require periodic review due to the rapid evolution of technology and clinical techniques in radiation oncology. We present an update to a grid-based physics staffing algorithm for radiation oncology (originally published in 2012) that has been widely used in Canada over the last decade.

Materials And Methods: The physics staffing algorithm structure was modified to improve the clarity and consistency of input data. Read More

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Predictive Accuracy of Prenatal Ultrasound Findings for Lower Urinary Tract Obstruction: A systematic review and Bayesian meta-analysis.

Prenat Diagn 2021 Jul 27. Epub 2021 Jul 27.

Division of Urology, The Hospital for Sick Children (SickKids), Toronto, Ontario, Canada.

Lower urinary tract obstruction (LUTO) is a rare but critical fetal diagnosis. Different ultrasound markers have been reported with varying sensitivity and specificity. The objective of this systematic review and meta-analysis was to identify the diagnostic accuracy of ultrasound markers for LUTO. Read More

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A Review of Utility Measurement Methods Used in Pharmacoeconomic Submissions to HIRA in South Korea: Methodological Consistency and Areas for Improvement.

Pharmacoeconomics 2021 Jul 28. Epub 2021 Jul 28.

College of Pharmacy, Gyeongsang National University, Jinju, South Korea.

Pharmacoeconomic (PE) guidelines, first published in 2006 and later updated in 2011, were developed to guide the preparation and submission of PE data to the Health Insurance Review and Assessment Service (HIRA) for drug reimbursement decision making in South Korea. This study, which was conducted as part of a project for revision of the PE guideline, reviewed utility values used in the PE submissions processed at HIRA during 2014-2018 to identify aspects of the current guidelines that may need to be revisited. A total of 50 PE submissions were processed at HIRA over the 5 years. Read More

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Case-Based Review of the Current Global Evidence Supporting Impella-Facilitated Complex and Complete Revascularization.

JACC Case Rep 2019 Dec 18;1(5):869-872. Epub 2019 Dec 18.

Bristol Heart Institute, University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom.

A 74-year-old male patient who was admitted with non-ST-segment elevation myocardial infarction, severe left ventricular impairment, severe mitral regurgitation, and full viability who was turned down for surgery underwent high-risk and indicated multivessel stenting with Impella (Abiomed) support. At 6-month follow-up he was angina free, with complete resolution of the mitral regurgitation. (). Read More

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December 2019

Therapeutic management of patients with COVID-19: a systematic review.

Infect Prev Pract 2020 Sep 17;2(3):100061. Epub 2020 Apr 17.

Department of Biochemistry, College of Science (Faculty of Science), University of Jeddah, Jeddah, Saudi Arabia.

Background: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which was declared a global pandemic by the World Health Organization on 11 March 2020. The treatment guidelines for COVID-19 vary between countries, yet there is no approved treatment to date.

Aim: To report any evidence of therapeutics used for the management of patients with COVID-19 in clinical practice since emergence of the virus. Read More

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September 2020

Can omalizumab be used effectively to treat severe conjunctivitis in children with asthma? A case example and review of the literature.

World J Clin Pediatr 2021 Jul 9;10(4):48-52. Epub 2021 Jul 9.

Centre of Medical Education, Queens University Belfast, School of Medicine, Belfast BT9 7BL, United Kingdom.

A 14-year-old girl with poorly controlled asthma attended the difficult-to-treat asthma clinic for review. Although she has eosinophilia and significantly raised immunoglobulin E levels, she is not currently a candidate for omalizumab (Xolair). She also suffers from chronic urticaria, eosinophilic eosophagitis and severe conjunctivitis. Read More

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Vector control for malaria prevention during humanitarian emergencies: protocol for a systematic review and meta-analysis.

BMJ Open 2021 Jul 27;11(7):e046325. Epub 2021 Jul 27.

Disease Control, London School of Hygiene & Tropical Medicine, London, UK.

Introduction: Humanitarian emergencies, of either natural or anthropogenic origins, are equivalent to major disasters, which can lead to population displacement, food insecurity and health system disruptions. Almost two-thirds of people affected by humanitarian emergencies inhabit malaria endemic regions, particularly the WHO African Region, which currently accounts for 93% and 94% of malaria cases and deaths, respectively. As of late 2020, the United Nations Refugee Agency estimates that there are globally 79. Read More

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Review of control strategies for lower-limb exoskeletons to assist gait.

J Neuroeng Rehabil 2021 Jul 27;18(1):119. Epub 2021 Jul 27.

Biorobotics laboratory (BioRob), EPFL, Lausanne, Switzerland.

Background: Many lower-limb exoskeletons have been developed to assist gait, exhibiting a large range of control methods. The goal of this paper is to review and classify these control strategies, that determine how these devices interact with the user.

Methods: In addition to covering the recent publications on the control of lower-limb exoskeletons for gait assistance, an effort has been made to review the controllers independently of the hardware and implementation aspects. Read More

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Are birth outcomes in low risk birth cohorts related to hospital birth volumes? A systematic review.

BMC Pregnancy Childbirth 2021 Jul 27;21(1):531. Epub 2021 Jul 27.

Center for Evidence-Based Healthcare, Medical Faculty Carl Gustav Carus, TU Dresden, Fetscherstraße 74, 01307, Dresden, Germany.

Background: There is convincing evidence that birth in hospitals with high birth volumes increases the chance of healthy survival in high-risk infants. However, it is unclear whether this is true also for low risk infants. The aim of this systematic review was to analyze effects of hospital's birth volume on mortality, mode of delivery, readmissions, complications and subsequent developmental delays in all births or predefined low risk birth cohorts. Read More

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Current state of knowledge on immunotherapy in ECOG PS 2 patients. A systematic review.

Adv Med Sci 2021 Jul 24;66(2):381-387. Epub 2021 Jul 24.

2nd Department of Lung Diseases and Tuberculosis, Medical University of Bialystok, Bialystok, Poland.

Background: Patients with Eastern Cooperative Oncology Group Performance Status 2 (ECOG PS 2) are not included in most randomized clinical trials and registry studies. Nevertheless, immune checkpoint inhibitors are registered in the USA and Europe regardless of the performance status. Evidence regarding the effectiveness and safety of such treatment in this cohort is sparse. Read More

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Global sagittal balance of spine in asymptomatic controls: A systematic review and meta-analysis.

World Neurosurg 2021 Jul 24. Epub 2021 Jul 24.

Mental Health Research Group, Health Metrics Research Centre, Iranian Institute for Health Sciences Research, ACECR, Tehran, Iran.

Objective: The purpose of this study was to assess the global sagittal balance of spine (GSBS) in asymptomatic controls.

Methods: PubMed, Scopus, Cochrane library, and Web of Science searched up to July 2020. Studies were screened for the GSB parameters including T1 pelvic angle (TPA), spinosacral angle (SSA), sagittal vertical axis (SVA), C7/ sacrofemoral distance ratio (Barrey index), odontoid hip axis (OD-HA) and Full Balance Index (FBI) as measured in asymptomatic participants. Read More

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Traditional uses, phytochemistry, pharmacology, toxicology and formulation aspects of Glycosmis species: A systematic review.

Phytochemistry 2021 Jul 23;190:112865. Epub 2021 Jul 23.

National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A), An Institute of National Importance, Government of India, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Opp. Air Force Station, Palaj, Gandhinagar, 382355, Gujarat, India. Electronic address:

The present article is a systematic and constructive review of the traditional medicinal uses, chemistry, pharmacology, toxicology, and formulation aspects of Glycosmis species. The genus Glycosmis comprise 51 accepted species broadly distributed in Australia, China, India, and South-East Asia. Traditionally, Glycosmis species are used in folk medicines to treat cancer, anaemia, rheumatism, fever, cough, liver-related problems, skin ailments, intestinal worm infections, wounds, and facial inflammation. Read More

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Public Health Effects of Travel-Related Policies on the COVID-19 Pandemic: A Mixed-Methods Systematic Review.

J Infect 2021 Jul 24. Epub 2021 Jul 24.

Evidence-Based Public Health Unit, Center for International Health Protection, Robert Koch Institute, Nordufer. 20 13353 Berlin, Germany. Electronic address:

Objectives: To map travel policies implemented due to COVID-19 during 2020, and conduct a mixed-methods systematic review of health effects of such policies, and related contextual factors.

Design: Policy mapping and systematic review DATA SOURCES AND ELIGIBILITY CRITERIA: for the policy mapping, we searched websites of relevant government bodies and used data from the Oxford COVID-19 Government Response Tracker for a convenient sample of 31 countries across different regions. For the systematic review, we searched Medline (Ovid), PubMed, EMBASE, the Cochrane Central Register of Controlled Trials and COVID-19 specific databases. Read More

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CAPABLE program improves disability in multiple randomized trials.

J Am Geriatr Soc 2021 Jul 27. Epub 2021 Jul 27.

Johns Hopkins School of Nursing, Baltimore, Maryland, USA.

Background: Programs to reduce disability are crucial to the quality of life for older adults with disabilities. Reducing disability is also important to avert unnecessary and costly hospitalizations, relocation, or nursing home placements. Few programs reduce disability and few have been replicated and scaled beyond initial research settings. Read More

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Subsyndromal generalised anxiety disorder: operationalisation and epidemiology - a systematic literature survey.

Int J Psychiatry Clin Pract 2021 Jul 27:1-10. Epub 2021 Jul 27.

Department of Psychiatry, Psychotherapy, and Psychosomatics, Psychiatric Hospital, University of Zürich, Zürich, Switzerland.

The diagnosis of anxiety disorders, like other psychiatric disorders also, is operationalised since the introduction of diagnostic manuals. The diagnostic criteria of Generalised Anxiety Disorder (GAD) have been tightened in the last decades. This leads to the exclusion of patients with a high level of anxiety, but not fulfilling certain of the GAD-criteria, from effective treatment. Read More

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Post-concussion symptoms three months after mild-to-moderate TBI: characteristics of sick-listed patients referred to specialized treatment and consequences of intracranial injury.

Brain Inj 2021 Jul 27:1-11. Epub 2021 Jul 27.

Department of Research, Sunnaas Rehabilitation Hospital Trust, Nesoddtangen, Norway.

: To present pre-injury, injury-related, work-related and post-injury characteristics, and to compare patients with and without traumatic intracranial abnormalities, in a treatment-seeking sample with persistent post-concussion symptoms (PPCS) after mild-to-moderate TBI.: Cross-sectional design in the context of a specialized TBI outpatient clinic. Eligible patients were aged 18-60 years, employed ≥ 50% at time of injury, and sick listed ≥ 50% at inclusion due to PPCS. Read More

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Effect of Oral Motor Intervention on Oral Feeding in Preterm Infants: A Systematic Review and Meta-Analysis.

Am J Speech Lang Pathol 2021 Jul 27:1-11. Epub 2021 Jul 27.

Department of Rehabilitation Medicine, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.

Objective This review article aimed to explore the effect of oral motor intervention on oral feeding in preterm infants through a meta-analysis. Method Eligible studies were retrieved from four databases (PubMed, Embase, Cochrane Library, and Web of Science) up to July 2020 and screened based on established selection criteria. Thereafter, relevant data were extracted and heterogeneity tests were conducted to select appropriate effect models according to the chi-square test and statistics. Read More

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Decision-support tools via mobile devices to improve quality of care in primary healthcare settings.

Cochrane Database Syst Rev 2021 Jul 27;7:CD012944. Epub 2021 Jul 27.

Norwegian Institute of Public Health, Oslo, Norway.

Background: The ubiquity of mobile devices has made it possible for clinical decision-support systems (CDSS) to become available to healthcare providers on handheld devices at the point-of-care, including in low- and middle-income countries. The use of CDSS by providers can potentially improve adherence to treatment protocols and patient outcomes. However, the evidence on the effect of the use of CDSS on mobile devices needs to be synthesized. Read More

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