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Spotting isomer mixtures in forensic illicit drug casework with GC-VUV using automated coelution detection and spectral deconvolution.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Mar 29;1173:122675. Epub 2021 Mar 29.

Van 't Hoff Institute for Molecular Sciences, University of Amsterdam, PO Box 94157, Amsterdam 1090 GD, the Netherlands; Co van Ledden Hulsebosch Center (CLHC), Amsterdam Center for Forensic Science and Medicine, PO Box 94157, Amsterdam 1090 GD, the Netherlands.

Analysis of isomeric mixtures is a significant analytical challenge. In the forensic field, for example, over 1000 new psychoactive substances (NPSs), comprising of many closely related and often isomeric varieties, entered the drugs-of-abuse market within the last decade. Unambiguous identification of the isomeric form requires advanced spectroscopic techniques, such as GC-Vacuum Ultraviolet Spectroscopy (GC-VUV). Read More

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How to create a faculty-centered curriculum support system: Launching the Academic Support Center (ASC) to inspire excellence in curriculum change.

J Dent Educ 2021 Apr 13. Epub 2021 Apr 13.

Division of Pediatric and Public Health, UNC Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Purpose: To define faculty needs and services requested for the implementation of a faculty-centered curriculum support system (i.e., Academic Support Center [ASC]) to assist curriculum redesign. Read More

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Oral Pharmacokinetics in Beagle Dogs of the Mitragynine Metabolite, 7-Hydroxymitragynine.

Eur J Drug Metab Pharmacokinet 2021 Apr 13. Epub 2021 Apr 13.

Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL, USA.

Background And Objectives: 7-Hydroxymitragynine (7-HMG) is an oxidative metabolite of mitragynine, the most abundant alkaloid in the leaves of Mitragyna speciosa (otherwise known as kratom). While mitragynine is a weak partial µ-opioid receptor (MOR) agonist, 7-HMG is a potent and full MOR agonist. It is produced from mitragynine by cytochrome P450 (CYP) 3A, a drug-metabolizing CYP isoform predominate in the liver that is also highly expressed in the intestine. Read More

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Assessment of Studies Evaluating Spinal Manipulative Therapy and Infectious Disease and Immune System Outcomes: A Systematic Review.

JAMA Netw Open 2021 Apr 1;4(4):e215493. Epub 2021 Apr 1.

Centre for Disability Prevention and Rehabilitation, Faculty of Health Sciences, Ontario Tech University, Oshawa, Ontario, Canada.

Importance: Claims that spinal manipulative therapy (SMT) can improve immune function have increased substantially during the COVID-19 pandemic and may have contributed to the rapid spread of both accurate and inaccurate information (referred to as an infodemic by the World Health Organization).

Objective: To identify, appraise, and synthesize the scientific literature on the efficacy and effectiveness of SMT in preventing the development of infectious disease or improving disease-specific outcomes in patients with infectious disease and to examine the association between SMT and selected immunological, endocrine, and other physiological biomarkers.

Evidence Review: A literature search of MEDLINE, the Cumulative Index to Nursing and Allied Health Literature, the Index to Chiropractic Literature, the Cochrane Central Register of Controlled Trials, and Embase was conducted from inception to April 15, 2020. Read More

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A call to action for new global approaches to cardiovascular disease drug solutions.

Eur Heart J 2021 Apr 13. Epub 2021 Apr 13.

Université de Lorraine, INSERM CIC 1493, INI CRCT, CHRU Nancy, France.

Whilst we continue to wrestle with the immense challenge of implementing equitable access to established evidence-based treatments, substantial gaps remain in our pharmacotherapy armament for common forms of cardiovascular disease including coronary and peripheral arterial disease, heart failure, hypertension, and arrhythmia. We need to continue to invest in the development of new approaches for the discovery, rigorous assessment, and implementation of new therapies. Currently, the time and cost to progress from lead compound/product identification to the clinic, and the success rate in getting there reduces the incentive for industry to invest, despite the enormous burden of disease and potential size of market. Read More

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Blockchain Personal Health Records: Systematic Review.

J Med Internet Res 2021 Apr 13;23(4):e25094. Epub 2021 Apr 13.

National University Health System, Singapore, Singapore.

Background: Blockchain technology has the potential to enable more secure, transparent, and equitable data management. In the health care domain, it has been applied most frequently to electronic health records. In addition to securely managing data, blockchain has significant advantages in distributing data access, control, and ownership to end users. Read More

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Barriers to training in laparoscopic surgery in low- and middle-income countries: A systematic review.

Trop Doct 2021 Apr 13:49475521998186. Epub 2021 Apr 13.

Leeds Institute of Medical Research at St. James's, 4468University of Leeds, Leeds, UK.

Laparoscopic surgery has the potential to improve care in resource-deprived low- and-middle-income countries (LMICs). This study aims to analyse the barriers to training in laparoscopic surgery in LMICs. Medline, Embase, Global Health and Web of Science were searched using 'LMIC', 'Laparoscopy' and 'Training'. Read More

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Nanopore long-read RNA-seq and absolute quantification delineate transcription dynamics in early embryo development of an insect pest.

Sci Rep 2021 Apr 12;11(1):7878. Epub 2021 Apr 12.

McGill Genome Centre, Department of Human Genetics, McGill University, Montréal, Québec, Canada.

The olive fruit fly, Bactrocera oleae, is the most important pest for the olive fruit but lacks adequate transcriptomic characterization that could aid in molecular control approaches. We apply nanopore long-read RNA-seq with internal RNA standards allowing absolute transcript quantification to analyze transcription dynamics during early embryo development for the first time in this organism. Sequencing on the MinION platform generated over 31 million reads. Read More

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Adiabatic quantum state transfer in a semiconductor quantum-dot spin chain.

Nat Commun 2021 Apr 12;12(1):2156. Epub 2021 Apr 12.

Department of Physics and Astronomy, University of Rochester, Rochester, NY, USA.

Semiconductor quantum-dot spin qubits are a promising platform for quantum computation, because they are scalable and possess long coherence times. In order to realize this full potential, however, high-fidelity information transfer mechanisms are required for quantum error correction and efficient algorithms. Here, we present evidence of adiabatic quantum-state transfer in a chain of semiconductor quantum-dot electron spins. Read More

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The efficacy of N-Acetylcysteine in severe COVID-19 patients: A structured summary of a study protocol for a randomised controlled trial.

Trials 2021 Apr 12;22(1):271. Epub 2021 Apr 12.

Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

Objectives: Severe acute respiratory infection (SARI) caused by the SARS-CoV-2 virus may cause lung failure and the need for mechanical ventilation. Infection with SARS-COV-2 can lead to activation of inflammatory factors, increased reactive oxygen species, and cell damage. In addition to mucolytic effects, N-Acetylcysteine has antioxidant effects that we believe can help patients recover. Read More

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Society of Thoracic Surgeons 2021 Adult Cardiac Surgery Risk Models for Multiple Valve Operations.

Ann Thorac Surg 2021 Apr 9. Epub 2021 Apr 9.

Duke University, Durham, North Carolina.

Background: The STS Quality Measurement Task Force has developed risk models and composite performance measures for isolated coronary artery bypass grafting surgery (CABG), isolated aortic valve replacement (AVR), isolated mitral valve replacement or repair (MVRR), AVR+CABG, and MVRR+CABG. To further enhance its portfolio of risk-adjusted performance metrics, STS has developed new risk models for multiple valve operations +/- CABG procedures.

Methods: Using July 2011 to June 2019 STS Adult Cardiac Surgery Database (ACSD) data, risk models for AVR+MVRR (n=31,968) and AVR+MVRR+CABG (n=12,650) were developed with the following endpoints: operative mortality, major morbidity (any one or more of the following: cardiac reoperation; deep sternal wound infection/mediastinitis; stroke; prolonged ventilation; and renal failure), and combined mortality and/or major morbidity. Read More

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Can Coupling Multiple Complementary Methods Improve the Spectroscopic Based Diagnosis of Gastrointestinal Illnesses? A Proof of Principle Study Using Celiac Disease as the Model Illness.

Anal Chem 2021 Apr 12. Epub 2021 Apr 12.

Gastroenterology Research Unit, Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin 9054, New Zealand.

Spectroscopic methods are a promising approach for providing a point-of-care diagnostic method for gastrointestinal mucosa associated illnesses. Such a tool is desired to aid immediate decision making and to provide a faster pathway to appropriate treatment. In this pilot study, Raman, near-infrared, low frequency Raman, and autofluoresence spectroscopic methods were explored alone and in combination for the diagnosis of celiac disease. Read More

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An International Continence Society (ICS) report on the terminology for pelvic floor muscle assessment.

Neurourol Urodyn 2021 Apr 12. Epub 2021 Apr 12.

Urology Department, University Hospital Fundación Sante Fé de Bogotá, Bogotá, Colombia.

Introduction: The terminology for female and male pelvic floor muscle (PFM) assessment has expanded considerably since the first PFM function and dysfunction standardization of terminology document in 2005. New terms have entered assessment reports, and new investigations to measure PFM function and dysfunction have been developed. An update of this terminology was required to comprehensively document the terms and their definitions, and to describe the assessment method and interpretation of the finding, to standardize assessment procedures and aid diagnostic decision making. Read More

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Factors influencing emergency department observation time following anaphylaxis: a systematic review.

CJEM 2021 Apr 12. Epub 2021 Apr 12.

Université de Sherbrooke, Sherbrooke, QC, Canada.

Objective: Anaphylaxis is a condition that warrants an observation period after symptoms resolution to detect rare but life-threatening delayed complications. There is a need for evidence to identify patients who would benefit from prolonged observation time. The purpose of this review was to identify factors that may influence the need for longer observation in the emergency department. Read More

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Autonomic Nervous System Maturation and Emotional Coordination in Interactions of Preterm and Full-Term Infants With Their Parents: Protocol for a Multimethod Study.

JMIR Res Protoc 2021 Apr 12;10(4):e28089. Epub 2021 Apr 12.

Department of Neonatology, Neonatal Intensive Care Unit, School of Medicine, University of Crete, Heraklion, Greece.

Background: There is limited knowledge on the physiological and behavioral pathways that may affect the developmental outcomes of preterm infants and particularly on the link between autonomic nervous system maturation and early social human behavior. Thus, this study attempts to investigate the way heart rate variability (HRV) parameters are related to emotional coordination in interactions of preterm and full-term infants with their parents in the first year of life and the possible correlation with the developmental outcomes of infants at 18 months.

Objective: The first objective is to investigate the relationship between emotional coordination and HRV in dyadic full-term infant-parent (group 1) and preterm infant-parent (group 2) interactions during the first postpartum year. Read More

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Requirements for Unobtrusive Monitoring to Support Home-Based Dementia Care: Qualitative Study Among Formal and Informal Caregivers.

JMIR Aging 2021 Apr 12;4(2):e26875. Epub 2021 Apr 12.

Centre for eHealth and Wellbeing Research, Department of Psychology, Health & Technology, University of Twente, Enschede, Netherlands.

Background: Due to a growing shortage in residential care, people with dementia will increasingly be encouraged to live at home for longer. Although people with dementia prefer extended independent living, this also puts more pressure on both their informal and formal care networks. To support (in)formal caregivers of people with dementia, there is growing interest in unobtrusive contactless in-home monitoring technologies that allow caregivers to remotely monitor the lifestyle, health, and safety of their care recipients. Read More

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Call for More Effective Regulation of Clinical Trials with Advanced Therapy Medicinal Products Consisting of or Containing Genetically Modified Organisms in the European Union.

Hum Gene Ther 2021 Apr 11. Epub 2021 Apr 11.

Biogen Idec Inc, 2191, Regulatory Chemistry, Manufacturing and Controls, Maidenhead, Berkshire, United Kingdom of Great Britain and Northern Ireland;

Advanced Therapy Medicinal Products (ATMPs), such as gene therapies that consist of or contain Genetically Modified Organisms (GMOs) need to comply with the European Union (EU) GMO legislation, as implemented in each EU Member State, before a clinical trial can commence. Complying with GMO requirements is complex, varies significantly across EU Member States and is leading to delays to clinical trials with ATMPs (see Supplemental materials). Such delays and varying implementation of the GMO legislation makes the EU less attractive as a region to conduct clinical trials with investigational gene therapies. Read More

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On the function and relevance of alternative 3'-UTRs in gene expression regulation.

Wiley Interdiscip Rev RNA 2021 Apr 12:e1653. Epub 2021 Apr 12.

Gene Regulation, i3S, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.

Messanger RNA (mRNA) isoforms with alternative 3'-untranslated regions (3'-UTRs) are produced by alternative polyadenylation (APA), which occurs during transcription in most eukaryotic genes. APA fine-tunes gene expression in a cell-type- and cellular state-dependent manner. Selection of an APA site entails the binding of core cleavage and polyadenylation factors to a particular polyadenylation site localized in the pre-mRNA and is controlled by multiple regulatory determinants, including transcription, pre-mRNA cis-regulatory sequences, and protein factors. Read More

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ThermoScan: Semi-automatic Identification of Protein Stability Data From PubMed.

Front Mol Biosci 2021 25;8:620475. Epub 2021 Mar 25.

Department of Pharmacy and Biotechnology (FaBiT), University of Bologna, Bologna, Italy.

During the last years, the increasing number of DNA sequencing and protein mutagenesis studies has generated a large amount of variation data published in the biomedical literature. The collection of such data has been essential for the development and assessment of tools predicting the impact of protein variants at functional and structural levels. Nevertheless, the collection of manually curated data from literature is a highly time consuming and costly process that requires domain experts. Read More

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From less invasive to minimal invasive extracorporeal circulation.

J Thorac Dis 2021 Mar;13(3):1909-1921

Cardiothoracic Department, AHEPA University Hospital, Thessaloniki, Greece.

Development of minimally invasive cardiac surgery (MICS) served the purpose of performing surgery while avoiding the surgical stress triggered by a full median sternotomy. Minimizing surgical trauma is associated with improved cosmesis and enhanced recovery leading to reduced morbidity. However, it has to be primarily appreciated that the extracorporeal circulation (ECC) stands for the basis of nearly all MICS procedures. Read More

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Comparative Analyses of Full-Length Transcriptomes Reveal e Stem Developmental Dynamics.

Front Genet 2021 25;12:615284. Epub 2021 Mar 25.

Guangdong Provincial Key Laboratory of Silviculture, Protection and Utilization, Guangdong Academy of Forestry, Guangzhou, China.

Genus , of which the majority species are pantropical liana, have broad industrial uses including for string, nets, and paper production. Although numerous studies have investigated anatomical structures during stem development, the underlying molecular mechanisms that regulate this developmental trajectory in species remain poorly understood. A total of 12 full-length transcriptomes were generated from four stem developmental stages of an arborescent representative of this genus, , using Oxford Nanopore Technologies. Read More

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Direct and Indirect Somatic Embryogenesis Induction in Abel.

Front Plant Sci 2021 26;12:644389. Epub 2021 Mar 26.

Key Laboratory of Forest Silviculture and Conservation of the Ministry of Education, The College of Forestry, Beijing Forestry University, Beijing, China.

Abel. is an important woody oil species; however, the shortage of rapid and industrialized seedling culture is a large constraint on the development of the tea oil industry. Somatic embryogenesis (SE) is one of the main powerful biotechnological tools for plant mass regeneration, but the largely unknown SE in limits the scale production of clonal plants. Read More

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Team Emotional Intelligence: Emotional Processes as a Link Between Managers and Workers.

Front Psychol 2021 24;12:619999. Epub 2021 Mar 24.

Department of Clinical and Health Psychology and Research Methodology, Faculty of Psychology, University of the Basque Country, Donostia-San Sebastian, Spain.

Research has shown that transformational leaders are able, through emotional contagion mechanisms, to transmit their emotions and boost positive feelings among their followers. Although research on leadership and team processes have shown a positive relation between transformational leadership and workers' well-being, there is a lack of studies examining the "black box" of this association. The present study aimed to assess the mediation effect of team emotional intelligence (TEI) of the management team on the relationship between management's transformational behaviors and employees' responses. Read More

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Financial forecasting for self-sufficiency and food security in poultry meat.

Environ Dev Sustain 2021 Apr 5:1-20. Epub 2021 Apr 5.

Department of Agricultural Economics, College of Food and Agricultural Sciences, King Saud University, P. O. Box 2460, Riyadh, 11451 Saudi Arabia.

This study estimates the need for financing and water to achieve self-sufficiency and food security in the poultry meat industry in Saudi Arabia. This study was based on secondary data and economic and statistical equations. The indexes related to the food security applied and the need for financing and water for poultry meat were calculated. Read More

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Impact of patient access to their electronic health record: systematic review.

Inform Health Soc Care 2021 Apr 10:1-13. Epub 2021 Apr 10.

King's College London, London, United Kingdom of Great Britain and Northern Ireland.

Patient access to their own electronic health records (EHRs) is likely to become an integral part of healthcare systems worldwide. It has the potential to decrease the healthcare provision costs, improve access to healthcare data, self-care, quality of care, and health and patient-centered outcomes. This systematic literature review is aimed at identifying the impact in terms of benefits and issues that have so far been demonstrated by providing patients access to their own EHRs, via providers' secure patient portals from primary healthcare centers and hospitals. Read More

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Recent advances in partial denitrification-anaerobic ammonium oxidation process for mainstream municipal wastewater treatment.

Chemosphere 2021 Apr 1;278:130436. Epub 2021 Apr 1.

School of Energy Science and Engineering, Central South University, Changsha, 410083, China. Electronic address:

To solve the bottleneck of the unstable accumulation of nitrite in the partial nitrification (PN)-anammox (AMX) in municipal wastewater treatment, a novel process called partial denitrification (PD)-AMX has been developed. PD-AMX, which is known for cost-efficiency and environmental friendliness, has currently exhibited a promising potential for the removal of biological nitrogen from municipal wastewater and has attracted much research interest regarding its process mechanisms, as well as its practical applications. Here, we review the recent advances in the PD process and its coupling to the anammox process, including the development, basic principles, main characteristics, and critical process parameters of the stable operation of the PD-AMX process. Read More

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Design and identification of a new farnesoid X receptor (FXR) partial agonist by computational structure-activity analysis: Ligand-induced H8 helix fluctuation in the ligand-binding domain of FXR may lead to partial agonism.

Bioorg Med Chem Lett 2021 Apr 8:128026. Epub 2021 Apr 8.

Graduate School of Pharmaceutical Sciences, Hiroshima International University, 5-1-1 Hirokoshingai, Kure, Hiroshima, 737-0112, Japan; Faculty of Clinical Nutrition, Hiroshima International University, 5-1-1 Hirokoshingai, Kure, Hiroshima, 737-0112, Japan.

Farnesoid X receptor (FXR) controls gene-expression relevant to various diseases including nonalcoholic steatohepatitis and has become a drug target to regulate metabolic aberrations. However, some side effects of FXR agonists reported in clinical development such as an increase in blood cholesterol levels, incentivize the development of partial agonists to minimize side effects. In this study, to identify a new partial agonist, we analyzed the computational structure-activity relationship (SAR) of FXR agonists previously developed in our laboratories using molecular dynamics simulations. Read More

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Benchtop NIR Method Development for Continuous Manufacturing Scale to Enable Efficient PAT Application for Solid Oral Dosage Form.

Int J Pharm 2021 Apr 8:120581. Epub 2021 Apr 8.

Worldwide Research and Development, Pfizer Inc. Groton CT USA 06340.

A Near Infrared (NIR) method was developed using a small benchtop feed frame system to quantify Saccharin potency in a powder blend during continuous manufacturing process. A 15-point Design of Experiments (DoE) was created based on the NIR spectral response and compositions of the formulation to develop a calibration set. The calibration set was designed to create compositional and raw material lots variation using minimum resources. Read More

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Self-regulation task in young school age children born preterm: Correlation with early academic achievement.

Early Hum Dev 2021 Mar 26;157:105362. Epub 2021 Mar 26.

Center for Human Development, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0115, United States of America; Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0603, United States of America. Electronic address:

Background: Children born preterm are at risk for difficulties in executive function (EF), however there are limited tools to assess EF in young children and it is not fully understood how these early deficits are related to emerging academic skills.

Aims: To examine (a) early EF differences in young children born preterm, (b) how a measure of behavioral self-regulation correlates with other measures of EF in children born preterm, and (c) how this measure relates to academic outcomes in children born preterm.

Study Design: Longitudinal cohort study. Read More

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Comparative study on anticancer drug access times between FDA, EMA and the French temporary authorisation for use program over 13 years.

Eur J Cancer 2021 Apr 7;149:82-90. Epub 2021 Apr 7.

ANSM Agence Nationale de Sécurité des Médicaments Direction Onco-hématologie et Thérapie Cellulaire, 147 Boulevard Anatole France, Saint-Denis, France; Avec Groupe Hospitalier Mutualiste de Grenoble - Institut Daniel Hollard, 8, Rue Docteur Calmette, 38028 Grenoble cedex 1, France. Electronic address:

Introduction: The cancer incidence continues to rise worldwide. Medical innovation has a major impact on patient survival, but within drug development, it can take more than 10 years to obtain marketing authorisation (MA). The time required for access to therapeutic innovation remains critical, so France has developed a specific expanded access program named ATU, which allows the administration of drugs before the European Medicines Agency (EMA) approval. Read More

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