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Cue-Based Feeding as Intervention to Achieve Full Oral Feeding in Preterm Infants Primarily Managed with Bubble CPAP.

Am J Perinatol 2021 Jun 15. Epub 2021 Jun 15.

Department of Rehabilitation, the George Washington University Hospital, Washington, District of Columbia.

Objective:  Cue-based feeding aims at matching introduction of per oral (PO) feeding with physiological readiness of preterm infants to facilitate PO intake and avoid oral aversion. It was claimed that cue-based feeding may lead to delay in the initiation or achieving full PO feeding in clinical setting primarily using bubble nasal continuous positive airway pressure (CPAP). The study aimed to examine the association of cue-based feeding with time of introduction and completing oral feeding in infants primarily managed with bubble CPAP. Read More

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Variations of antibiotic resistome in swine wastewater during full-scale anaerobic digestion treatment.

Environ Int 2021 Jun 12;155:106694. Epub 2021 Jun 12.

SCNU Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Theoretical Chemistry of Environment, South China Normal University, Guangzhou 510006, China; School of Environment, South China Normal University, University Town, Guangzhou 510006, China. Electronic address:

Anaerobic digesters have been widely used to treat wastewaters in livestock farms. With the increasing risk of antibiotic resistance originated from livestock husbandry, removal of antibiotics and antibiotic resistance genes (ARGs) via anaerobic digesters deserved more attention. Here we investigated the removal of antibiotics and ARGs in swine wastewater by three on-farm full-scale anaerobic digesters, including buried biogas digester (BBD), up-flow anaerobic sludge blanket (UASB) and high density polyethylene covered biogas digester (HDPE-BD). Read More

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Dynamic stability during stair negotiation after total knee arthroplasty.

Clin Biomech (Bristol, Avon) 2021 Jun 10;87:105410. Epub 2021 Jun 10.

Department of Biomedical Engineering, University of Strathclyde, Glasgow, Scotland, UK.

Background: The assessment of dynamic stability is crucial for the prevention of falls in the elderly and people with functional impairments. Evidence that total knee arthroplasty improves balance in patients with severe osteoarthritis is scarce and no information exists about how the surgery affects dynamic stability during stair negotiation.

Methods: This study aims to investigate if patients before and one year after surgery are less stable compared to asymptomatic controls. Read More

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Intra operative assessment of the coronal balance in spinal deformity surgery : a technical note and retrospective study.

Acta Orthop Belg 2021 Mar;87(1):175-179

Obtaining a spine that is well balanced after fusion for scoliotic deformity is primordial for the patients' quality of life. A simple T-shaped instrument combined with standard intraoperative fluoroscopy can be of great help to evaluate the coronal alignment quickly. The aim of this study was to evaluate if a T-shaped device could predict the postoperative coronal balance. Read More

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Assessment of clinical efficacy of lidocaine/tetracaine 7%/7% peel cream in fractional micro-ablative laser procedure-associated pain for facial skin ageing treatment. A randomized, controlled, single-blind trial.

J Cosmet Dermatol 2021 Jun 15. Epub 2021 Jun 15.

R&D Cantabria Labs Difa Cooper.

Background: Lidocaine/tetracaine 7%/7% peel cream (L/T-pC) is very effective in reducing pain in several dermatological procedures, such as hair or tattoo laser removal or conventional photodynamic therapy associated pain. Fractional laser resurfacing (FLR) is an effective treatment strategy for facial skin ageing. The main drawback of FLR is the procedure-associated pain. Read More

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Going Beyond the State Law: Investigating High School Sport-Related Concussion Protocols.

J Athl Train 2020 Jun 18. Epub 2020 Jun 18.

A.T. Still University, Athletic Training Programs, School of Osteopathic Medicine in Arizona, 5850 E Still Circle, Mesa, Arizona 85206, United States,

Context: State laws provide general guidelines for sport-related concussion (SRC) management, but do not comprehensively address the multiple layers of management for this complex injury. While high schools are encouraged to develop a SRC protocol that includes both state law tenets and additional management practices, the execution of this warrants examination.

Objective: To investigate state law compliance and practice components included in high school SRC protocols, and determine whether the degree of sports medicine coverage influenced protocol quality. Read More

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The recurrent urinary tract infection health and functional impact questionnaire (RUHFI-Q): design and feasibility assessment of a new evaluation scale.

Can J Urol 2021 Jun;28(3):10729-10732

Department of Urology, University Hospital Limerick, Dooradoyle, Co. Limerick, Ireland.

Introduction: We aim to design a tool to assess the impact of recurrent urinary tract infection (rUTI) on quality of life (QoL) in adult women, given the notable absence of an established instrument for this purpose.

Materials And Methods: Best practice guidelines in health-related survey design were reviewed. A literature review informed creation of an interview guide. Read More

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Cardiolipin Remodeling Defects Impair Mitochondrial Architecture and Function in a Murine Model of Barth Syndrome Cardiomyopathy.

Circ Heart Fail 2021 Jun 15;14(6):e008289. Epub 2021 Jun 15.

Department of Medicine (S.Z., Z.C., M.Z., S.S., C.T., Y.G., A.N., W.F., S.M.E., X.F.), University of California, San Diego, La Jolla.

Background: Cardiomyopathy is a major clinical feature in Barth syndrome (BTHS), an X-linked mitochondrial lipid disorder caused by mutations in (), encoding a mitochondrial acyltransferase required for cardiolipin remodeling. Despite recent description of a mouse model of BTHS cardiomyopathy, an in-depth analysis of specific lipid abnormalities and mitochondrial form and function in an in vivo BTHS cardiomyopathy model is lacking.

Methods: We performed in-depth assessment of cardiac function, cardiolipin species profiles, and mitochondrial structure and function in our newly generated cardiomyocyte-specific knockout mice and Cre-negative control mice (n≥3 per group). Read More

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A review of AI and Data Science support for cancer management.

Artif Intell Med 2021 Jul 24;117:102111. Epub 2021 May 24.

University of Haifa, Israel.

Introduction: Thanks to improvement of care, cancer has become a chronic condition. But due to the toxicity of treatment, the importance of supporting the quality of life (QoL) of cancer patients increases. Monitoring and managing QoL relies on data collected by the patient in his/her home environment, its integration, and its analysis, which supports personalization of cancer management recommendations. Read More

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Assessing IQ in adolescents with mild to moderate cerebral palsy using the WISC-V.

Clin Neuropsychol 2021 Jun 14:1-20. Epub 2021 Jun 14.

School of Psychology and Public Health, La Trobe University, Melbourne, Australia.

To examine the influence of subtests that require fine motor responses on measures of intellectual ability, and compare three approaches to minimizing motor demands while assessing cognitive abilities in adolescents with cerebral palsy (CP) to the traditional method of the Wechsler Intelligence Scale for Children - Fifth edition (WISC-V). Seventy adolescents with CP ( = 14 years 6 months,  = 10 months) who were able to provide either a verbal or point response were assessed using the WISC-V administered via Q-interactive. The pencil-to-paper version of Coding was also administered. Read More

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A planetary health model for reducing exposure to faecal contamination in urban informal settlements: Baseline findings from Makassar, Indonesia.

Environ Int 2021 Jun 12;155:106679. Epub 2021 Jun 12.

Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Malaysia; International Institute for Global Health, United Nations University, Kuala Lumpur, Malaysia.

Background: The intense interactions between people, animals and environmental systems in urban informal settlements compromise human and environmental health. Inadequate water and sanitation services, compounded by exposure to flooding and climate change risks, expose inhabitants to environmental contamination causing poor health and wellbeing and degrading ecosystems. However, the exact nature and full scope of risks and exposure pathways between human health and the environment in informal settlements are uncertain. Read More

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Preference-based instrumental variables in health research rely on important and underreported assumptions: a systematic review.

J Clin Epidemiol 2021 Jun 11. Epub 2021 Jun 11.

Haukeland University Hospital, Centre for Research and Education in Forensic Psychiatry, PB 1400, Sandviksleitet 1, 5036 Bergen, Norway; Division of Health Services, Norwegian Institute of Public Health, PB 222 Skøyen 0213 Oslo, Norway; Department of Community Medicine, UiT - The Artic University of Norway, PB 6050 Langnes 9037 Tromsø, Norway; Centre for Work and Mental Health, Nordland Hospital, Bodø, Norway.

Objective: Preference-based instrumental variables (PP IV) designs can identify causal effects when patients receive treatment due to variation in providers' treatment preference. We offer a systematic review and methodological assessment of PP IV applications in health research.

Study Design And Setting: We included studies that applied PP IV for evaluation of any treatment in any population in health research (PROSPERO: CRD42020165014). Read More

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Development and prognostic relevance of a histologic grading and staging system for alcohol-related liver disease.

J Hepatol 2021 Jun 11. Epub 2021 Jun 11.

Transitional and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK; Department of Pathology, Aretaieio Hospital, Medical School, National & Kapodistrian University of Athens, Athens 11528, Greece.

Background & Aims: The SALVE Histopathology Group (SHG) developed and validated a grading and staging system for the clinical and full histological spectrum of alcohol-related liver disease (ALD) and evaluated its prognostic utility in a multinational cohort of 445 patients.

Methods: SALVE grade was described by semiquantitative scores for steatosis, activity (hepatocellular injury and lobular neutrophils) and cholestasis. The histological diagnosis of steatohepatitis due to ALD (histological ASH, hASH) was based on the presence of hepatocellular ballooning and lobular neutrophils. Read More

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Longitudinal assessment of cardiac function in extremely low birth weight children at 7 and 11 years of age: implications for adult medicine.

Kardiol Pol 2021 ;79(5):539-545

Department of Pediatrics, Jagiellonian University Medical College, Kraków, Poland.

Background: The long-term impact of extreme prematurity on cardiac structure and function has not been fully evaluated.

Aims: The aim of the study was to assess cardiac condition at 11 years of age in a local cohort of extremely low birth weight (ELBW) children born between 2002 and 2004 and to compare it to a previous study in the same group at 7 years of age.

Methods: Sixty-four children with ELBW (median birth weight of 890 g) and 36 children born at full term underwent echocardiography and physical examination. Read More

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Should We Scan Hidradenitis Suppurativa Patients? A Systematic Review of Radiologic Findings.

Adv Skin Wound Care 2021 Jul;34(7):1-10

At the Universidade Federal do Rio de Janeiro, Brazil, Gabriel Gutfilen-Schlesinger, MSc, is PhD Student, Postgraduate Program of Medicine; Sergio Augusto Lopes de Souza, PhD, is Associate Professor, Department of Radiology; and Bianca Gutfilen, PhD, is Full Professor, Department of Radiology. Acknowledgments: The authors thank José Marcos Telles da Cunha, MD, PhD, for his thoughtful insights during various stages of manuscript preparation. This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Brasil (Finance Code 001) and the Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro. The authors have disclosed no other financial relationships related to this article. Submitted October 23, 2020; accepted in revised form January 7, 2021.

Objective: To bring awareness and close gaps between dermatologists and radiologists about the contribution of imaging techniques for diagnosis, treatment, and follow-up of hidradenitis suppurativa (HS).

Data Sources: Investigators searched the PubMed database for articles on HS and radiology techniques.

Study Selection: Databases were searched up to December 2018. Read More

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Effect of Local Delivery of Vancomycin and Tobramycin on Bone Regeneration.

Orthop Surg 2021 Jun 14. Epub 2021 Jun 14.

Department of Traumatology, Beijing Jishuitan Hospital, Beijing, China.

Objective: A bone defect rat model was established to investigate the osteogenic effect of local delivery two antibiotics (vancomycin and tobramycin powder) on bone regeneration.

Methods: Twenty-four Sprague-Dawley (SD) male rats (6 to 8 weeks, 200 to 250 g) were used in this study. All these rats were randomly divided into four groups. Read More

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Education and training to support physiotherapists working in dementia care: a scoping review protocol.

HRB Open Res 2021 10;4:27. Epub 2021 Mar 10.

Centre for Gerontology and Rehabilitation, School of Medicine, University College Cork and Mercy University Hospital, Cork, Ireland.

The care of people with dementia is of global concern. Physiotherapeutic intervention can be of benefit to patients with dementia. Physiotherapists can play a role in assessment, falls prevention, pain management and gait re-education. Read More

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Lower Urinary Tract Symptoms and Sexual Dysfunction in Male: A Systematic Review and Meta-Analysis.

Front Med (Lausanne) 2021 28;8:653510. Epub 2021 May 28.

Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

An association between lower urinary tract symptoms (LUTS) and risk of sexual dysfunction in male remains controversial in recent decades. PubMed and Web of Science were searched up to October 28, 2020, for articles reporting the prevalence of sexual dysfunction in men with LUTS. The main outcomes were results from sexual dysfunction assessments. Read More

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A lymphodepleted non-human primate model for the assessment of acute on-target and off-tumor toxicity of human chimeric antigen receptor-T cells.

Clin Transl Immunology 2021 3;10(6):e1291. Epub 2021 Jun 3.

Center for Advanced Research of Gene and Cell Therapy in Shinshu University (CARS) Shinshu University School of Medicine Matsumoto Japan.

Objectives: Chimeric antigen receptor (CAR)-T cell therapy possesses the potential to cause unexpected on-target toxicities that may be life-threatening. Non-human primates (NHPs) share considerable structural homology and expression profiles of most proteins with humans and are therefore utilised as an animal model for non-clinical safety studies. We have developed a lymphodepleted NHP model by conditioning the animals with immunosuppressive chemotherapy designed to simulate clinical practice conditions, to induce transient mixed chimerism before the administration of human CAR-T cells redirected to target Ephrin type-B receptor 4 (EPHB4-CAR-T cells) to evaluate the toxicity of these cells. Read More

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Diagnostic accuracy of Raman spectroscopy for the diagnosis of bladder cancer: A systematic review and meta-analysis.

J Cancer Res Ther 2021 Apr-Jun;17(2):426-433

Department of Urology, Soonchunhyang University Seoul Hospital, Soonchunhyang University Medical College, Seoul, Korea.

Introduction: Although several studies have been conducted to evaluate the feasibility of Raman spectroscopy (RS) for the diagnosis of bladder cancer (BCa), it is difficult to use RS in real clinical settings based on the current limited evidence. Therefore, we performed a systematic review and meta-analysis to assess the diagnostic accuracy of RS in BCa.

Materials And Methods: Comprehensive literature searches were performed in the PubMed/Medline, Embase, and Cochrane Library databases up to March 2019. Read More

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Simplifying Computer Aided Ergonomics: A User-Product Interaction-Modeling Framework in CAD based on a Taxonomy of Elementary Affordances.

IISE Trans Occup Ergon Hum Factors 2021 Jun 13:1-16. Epub 2021 Jun 13.

Engineering Design (KTmfk), Friedrich-Alexander-Universität Erlangen-Nürnberg.

Occupational ApplicationsThis contribution provides a framework for modeling user-product interactions (in CAD) for in-depth ergonomic analysis of product design, using digital human models. The framework aims to be applicable to a wide range of different products while being suitable for designers - especially those who do not have specialized ergonomic expertise or training in human behavior - by providing an intuitive, standardized, and time-efficient modeling procedure. The framework contains 31 elementary affordances, which describe mechanical dependencies between product geometries and human end effectors. Read More

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Application of DoE-Based Analytical QRM to Development of the Multipurpose RP-HPLC Method for Estimation of Multiple FDC Products of Telmisartan Using Enhanced AQbD Approach.

J Chromatogr Sci 2021 Jun 14. Epub 2021 Jun 14.

Department of Quality Assurance, Maliba Pharmacy College, Maliba Campus, Bardoli-Mahuva Road, Tarsadi, Mahuva, Surat 394350, Gujarat, India.

Telmisartan is an antihypertensive drug and several FDC products of telmisartan are available in the market for the treatment of hypertension. The multipurpose reverse-phase high-performance liquid chromatography (RP-HPLC) method has been developed and validated as economical and eco-friendly alternative to numerous published chromatography methods for synchronous estimation of FDC of telmisartan to save time, cost and solvent for analysis. The analytical quality risk management was initiated with identification of potential method parameters using cause-effect diagram followed by assessment of their risk by risk priority number ranking and filtering method. Read More

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Gait kinematic alterations in subjects with adult spinal deformity and their radiological determinants.

Gait Posture 2021 Jun 4;88:203-209. Epub 2021 Jun 4.

Faculty of Medicine, University of Saint-Joseph in Beirut, Lebanon; Institut de Biomécanique Humaine Georges Charpak, Arts et Métiers ParisTech, Paris, France. Electronic address:

Background: Adults with spinal deformity (ASD) are known to have postural malalignment affecting their quality of life. Classical evaluation and follow-up are usually based on full-body static radiographs and health related quality of life questionnaires. Despite being an essential daily life activity, formal gait assessment lacks in clinical practice. Read More

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Pathological findings in horses with lumbosacral region pain.

Equine Vet J 2021 Jun 12. Epub 2021 Jun 12.

Centre for Equine Studies, Animal Health Trust, Lanwades Park, Newmarket, Suffolk, CB8 7UU, UK.

Background: There is a lack of understanding of the pathological and/or physiological nature of lumbosacral region pain.

Objectives: To describe the gross variations of the osseous and soft tissues of the lumbosacral region and report the histological findings of sections of nerve tissue in affected and control horses.

Study Design: Descriptive post-mortem case series. Read More

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Assessment of a complete and classified platelet proteome from genome-wide transcripts of human platelets and megakaryocytes covering platelet functions.

Sci Rep 2021 Jun 11;11(1):12358. Epub 2021 Jun 11.

Department of Biochemistry, CARIM, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.

Novel platelet and megakaryocyte transcriptome analysis allows prediction of the full or theoretical proteome of a representative human platelet. Here, we integrated the established platelet proteomes from six cohorts of healthy subjects, encompassing 5.2 k proteins, with two novel genome-wide transcriptomes (57. Read More

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Autoimmune Disease and Breast Implants: Systematic Review of Outcomes.

Ann Plast Surg 2021 Jun 10. Epub 2021 Jun 10.

From the Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY Division of Plastic and Reconstructive Surgery, NorthShore University HealthSystem, Chicago, IL Section of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI Medical Library, Memorial Sloan Kettering Cancer Center, New York, NY.

Abstract: Given that the use of breast implants for both cosmetic and reconstructive purposes is growing in the United States, an evaluation of factors that may affect the outcome of breast implant surgery is needed. A systematic review was conducted to evaluate the question: Does a personal or family history of autoimmune disease affect outcomes in breast implant surgery? The literature search yielded 2425 records, but after removal of duplicates, abstract screening, and full-text assessment, only 2 studies met the inclusion criteria for the final review. Both studies provided level III evidence and the average Methodological Index for Non-Randomized Studies score was 16. Read More

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Screening for more with less: Validation of the Global Appraisal of Individual Needs Quick v3 (GAIN-Q3) screeners.

J Subst Abuse Treat 2021 Jul 15;126:108414. Epub 2021 Apr 15.

Suzanne Dworak-Peck School of Social Work, USC Center for Artificial Intelligence in Society, USC Center for Mindfulness Science, USC Institute for Addiction Science, University of Southern California, United States of America.

Multi-morbidity is the norm among adolescents and adults with substance use and other mental disorders and warrants a multi-pronged screening approach. However, the time constraints on assessment inherent in clinical practice often temper the desire for a full understanding of multi-morbidity problems. The 15- to 25-minute Global Appraisal of Individual Needs Quick version 3 (GAIN-Q3) includes screeners for 9 common clinical problems that are short (4 to 10 items) and provide dimensional measures of problem severity in each area that are also categorized to guide clinical decision making. Read More

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Does the evidence support brief (≤30-mins), moderate (31-60-mins), or long duration naps (61+ mins) on the night shift? A systematic review.

Sleep Med Rev 2021 May 19;59:101509. Epub 2021 May 19.

University of Pittsburgh, School of Medicine, Department of Emergency Medicine, Pittsburgh, PA, 15261, USA.

We performed a systematic review of four databases to determine if the evidence supports a short or long duration nap during night shifts to mitigate fatigue, and/or improve health, safety, or performance for emergency services and public safety personnel (PROSPERO CRD42020156780). We focused on experimental research and evaluated the quality of evidence with the grading of recommendations, assessment, development, and evaluation (GRADE) framework. We used the Cochrane Collaboration's risk of bias tool to assess bias and reported findings using the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement. Read More

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Projecting palliative and end-of-life care needs in Central Lancashire up to 2040: an integrated palliative care and public health approach.

Public Health 2021 Jun 8;195:145-151. Epub 2021 Jun 8.

Consultant in Palliative Medicine, Lancashire Teaching Hospitals Foundation Trust, Preston, England, UK.

Objectives: A collaborative study was undertaken by palliative care and public health on behalf of Chorley & South Ribble and Greater Preston Clinical Commissioning Groups. Going beyond a traditional needs assessment by providing projections of local palliative and end-of-life care needs in all conditions over 20 years, the study will support locality commissioning and development of appropriate health care services.

Study Design: Population-based needs assessment involving secondary analysis of routinely available regional mortality and population data for Central Lancashire (2017). Read More

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Autoantibodies in Neuropsychiatric Systemic Lupus Erythematosus (NPSLE): Can They Be Used as Biomarkers for the Differential Diagnosis of This Disease?

Elias Manca

Clin Rev Allergy Immunol 2021 Jun 11. Epub 2021 Jun 11.

Department of Biomedical Sciences, University of Cagliari, 09042, Monserrato, Cagliari, Italy.

Systemic lupus erythematosus is a complex immunological disease where both environmental factors and genetic predisposition lead to the dysregulation of important immune mechanisms. Eventually, the combination of these factors leads to the production of self-reactive antibodies that can target any organ or tissue of the human body. Autoantibodies can form immune complexes responsible for both the organ damage and the most severe complications. Read More

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