285 results match your criteria fukang granule


A randomized clinical trial using cyclopentolate and tropicamide to compare cycloplegic refraction in Chinese young adults with dark irises.

BMC Ophthalmol 2021 Jun 10;21(1):256. Epub 2021 Jun 10.

Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, 251 Fukang Road, Nankai District, Tianjin, China.

Background: To evaluate the necessity of cycloplegia for epidemiological studies of refraction in Chinese young adults (aged 17-22 years) with dark irises, and to compare the cycloplegic effects of 1% cyclopentolate and 0.5% tropicamide in them.

Methods: A total of 300 young adults (108 males and 192 females) aged 17 to 22 years (mean 19. Read More

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Real-Time Tissue Elastography to Evaluate Hepatic Hypoxic-Ischemic Injury Caused by Brain Death.

Ultrasound Q 2021 Jun;37(2):138-143

Department of Ultrasound, Tianjin First Central Hospital, No. 24 Fukang Road, Nankai District, Tianjin, 300192, China.

Abstract: This study aimed to explore the potential of real-time tissue elastography (RTE) in evaluating hepatic hypoxic-ischemic injury caused by brain death. We performed RTE and biopsy for 50 donated liver. Hematoxylin-eosin staining was used to observe hepatocyte acidophilic change. Read More

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A GLUT1 inhibitor-based fluorogenic probe for Warburg effect-targeted drug screening and diagnostic imaging of hyperglycolytic cancers.

Anal Chim Acta 2021 Jul 30;1167:338593. Epub 2021 Apr 30.

Institute of Molecular Plus, Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin, 300072, PR China. Electronic address:

Increased expression of glucose transporters, especially GLUT1 has been proven to be involved in the Warburg effect. Therefore, GLUT1-targeted oncological approaches are being successfully employed for clinical tumor diagnostic imaging (e.g. Read More

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Prognostic value of late gadolinium enhancement in arrhythmogenic right ventricular cardiomyopathy: a meta-analysis.

Clin Radiol 2021 May 20. Epub 2021 May 20.

Department of Radiology, Tianjin First Central Hospital, No. 24, Fukang Road, Nankai District, Tianjin, 300000, China. Electronic address:

Aim: To assess systematically the prognostic value of cardiac magnetic resonance imaging (CMRI) in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC).

Materials And Methods: The full text of studies of the clinical efficacy of late gadolinium enhancement (LGE) in ARVC was retrieved in multiple databases. Stata 14 was adopted for meta-analysis and bias analysis. Read More

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Divergent vertical distributions of microbial biomass with soil depth among groups and land uses.

J Environ Manage 2021 Aug 13;292:112755. Epub 2021 May 13.

Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences, Beijing, 100081, China. Electronic address:

Soil microbial biomass is key to improving the prediction of soil organic carbon (SOC) dynamics by modeling. However, the driving mechanism of microbial biomass of different groups with soil depth is poorly understood across sites. Here, we compiled the biomass of different microbial groups (i. Read More

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Oxidation process of lead sulfide nanoparticle in the atmosphere or natural water and influence on toxicity toward Chlorella vulgaris.

J Hazard Mater 2021 May 8;417:126016. Epub 2021 May 8.

School of Resources and Civil Engineering, Northeastern University, Shenyang 110819, China. Electronic address:

Lead sulfide nanoparticle (nano-PbS) released into environment can cause hazards to human or ecosystem. Nano-PbS potentially undergoes oxidation in the environment, but oxidation mechanism is not understood yet. Herein, oxidation kinetics and products of nano-PbS by ozone (O), hydrogen peroxide (HO) and hydroxyl radical (HO·) in the atmosphere or natural water were investigated. Read More

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Recurrent dislocation of binocular crystal lenses in a patient with cystathionine beta-synthase deficiency.

BMC Ophthalmol 2021 May 13;21(1):212. Epub 2021 May 13.

SUNY College of Optometry, New York, NY, USA.

Background: Ectopia lentis is the common ocular manifestation of homocystinuria resulting from cystathionine beta-synthase (CBS) deficiency which has a high risk of thromboembolic complications.

Case Presentation: The present study reports the case of a teenager with recurrent lens dislocation and glaucoma. He was diagnosed with CBS deficiency according to a high level of serum homocysteine and compound heterozygous mutations at two different positions on the CBS gene. Read More

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A GLUT1 inhibitor-based probe significantly ameliorates the sensitivity of tumor detection and diagnostic imaging.

Chem Commun (Camb) 2021 Jun;57(45):5530-5533

Institute of Molecular Plus, Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Rd, Nankai, Tianjin 300072, P. R. China.

We report a non-antibody GLUT1 inhibitor probe NBDQ that is 30 times more sensitive than the traditional GLUT1 transportable tracer for cancer cell imaging and Warburg effect-based tumor detection. NBDQ reveals significant advantages in terms of tumor selectivity, fluorescence stability and in vivo biocompatibility in xenograft tumor imaging, including triple-negative breast cancer. Read More

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The plasminogen protein is associated with high myopia as revealed by the iTRAQ-based proteomic analysis of the aqueous humor.

Sci Rep 2021 Apr 22;11(1):8789. Epub 2021 Apr 22.

Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, No. 251, Fukang Road, Nankai District, Tianjin, 300110, China.

To explore the pathogenesis of high myopia (HM) using quantitative proteomics. The aqueous humor of patients with simple nuclear cataract and nuclear cataract complicated with HM (hereinafter referred to as "C" and "HM" groups, respectively) were collected. The isobaric tags for relative and absolute quantitation (iTRAQ)-based liquid chromatography-tandem mass spectrometry (LC-MS/MS) proteomics approach was employed to explore differentially expressed proteins (DEPs). Read More

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Exploring the Potential Mechanism of Costunolide-Induced MCF-7 Cells Apoptosis by Multi-Spectroscopy, Molecular Docking and Cell Experiments.

Chem Biodivers 2021 May 14;18(5):e2001069. Epub 2021 Apr 14.

School of life Science, Liaoning University, 66 Chongshan Middle Road, Shenyang, 110036, P. R. China.

Breast cancer is one of the most common cancer with high morbidity and mortality in women. This study aimed to explore the potential mechanism of costunolide inducing MCF-7 cells apoptosis by multi-spectroscopy, molecular docking, and cell experiments. The results manifested that costunolide interacted with calf thymus DNA (ct-DNA) in a spontaneous manner, and the minor groove as the preferential binding mode. Read More

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MicroRNA-431-5p encapsulated in serum extracellular vesicles as a biomarker for proliferative diabetic retinopathy.

Int J Biochem Cell Biol 2021 Jun 7;135:105975. Epub 2021 Apr 7.

Tianjin International Joint Research and Development Center of Ophthalmology and Vision Science, Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, No. 251, Fukang Road, Nankai District, Tianjin, 300384, China. Electronic address:

Early diagnosis and precise monitoring of the development of proliferative diabetic retinopathy (PDR) can significantly improve therapeutic strategies and help decrease blindness caused by it. Extracellular vesicles (EVs) were recently found to be involved in intercellular communications and are a potential source for the discovery of novel biomarkers. The current study aims to investigate the effectiveness of microRNAs (miRNAs) encapsulated in small EVs (sEVs) as minimally invasive biomarkers for PDR. Read More

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Spatio-temporal dynamics and eco-hydrological controls of water and salt migration within and among different land uses in an oasis-desert system.

Sci Total Environ 2021 Jun 4;772:145572. Epub 2021 Feb 4.

State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou 311300, China. Electronic address:

Identifying the eco-hydrological processes associated with water-salt dynamics is important for the sustainable management of water resources and eco-environmental systems in groundwater-dependent ecosystems, especially across different land use types in salt-affected oasis-desert ecosystems. In this study, a typical cropland-shelterbelt-desert site at the oasis-desert system in the Sangong River watershed of northwestern China was selected to investigate the spatio-temporal variations of water-salt dynamics using the Spearman rank correlation analysis and water/mass balance analysis, and to identify the response of vegetation dynamics to water-salt variations based on a model framework for vegetation-salinity-groundwater interactions, within and among these land uses during crop growth period (CGP: April 1-June 28, 2018) and non-crop-growth period (Non-CGP: June 29-October 31, 2018). Results showed that the soil water content (SWC) and soil electrical conductivity (SEC) had clear vertical stratification, horizontal transition and seasonal fluctuation characteristics during both CGP and Non-CGP. Read More

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Antioxidative effects of polypyrimidine tract-binding protein-associated splicing factor against pathological retinal angiogenesis through promotion of mitochondrial function.

J Mol Med (Berl) 2021 Mar 26. Epub 2021 Mar 26.

Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin, People's Republic of China.

Reactive oxygen species (ROS), a by-product of oxygen metabolism mainly originating from mitochondria, participate in many pathological processes related to ophthalmopathy. Excessive production of ROS leads to oxidative stress, which influences the permeability, proliferation, migration, and tube formation of human retinal microcapillary endothelial cells (HRMECs). The molecular mechanisms underlying the effects of ROS are not clear. Read More

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Increased frequency of β cells with abnormal NKX6.1 expression in type 2 diabetes but not in subjects with higher risk for type 2 diabetes.

BMC Endocr Disord 2021 Mar 12;21(1):47. Epub 2021 Mar 12.

NHC Key Laboratory for Critical Care Medicine, Tianjin First Central Hospital, Tianjin, 300384, China.

Background: NKX6.1 is a transcription factor for insulin, as well as a marker for β cell maturity. Abnormal NKX6. Read More

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Genesis, controls and risk prediction of HS in coal mine gas.

Sci Rep 2021 Mar 11;11(1):5712. Epub 2021 Mar 11.

School of Resources and Earth Geosciences, China University of Mining and Technology, Jiangsu, Xuzhou, 221116, China.

Abnormal HS concentration in coal mine gas is a serious threat to normal mining activities, which has caused serious loss of life and property in many coal mines. This study explores the genesis and influencing factors of abnormal HS concentration in coal mine gas, taking the Xishan coal mine in the Fukang mining area as a case study. The HS formation by bacterial sulfate reduction (BSR) is simulated with a bacterial culture experiment and that by thermochemical sulfate reduction (TSR) is simulated with a thermal reduction experiment. Read More

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A Study on Three-Phase Gas Content in Coal Reservoirs and Coalbed Methane-Water Differential Distribution in the Western Fukang Mining Area, Xinjiang, China.

ACS Omega 2021 Feb 29;6(5):3999-4012. Epub 2021 Jan 29.

School of Resources and Geosciences, China University of Mining and Technology, Xuzhou 221116, China.

The daily gas production of a single well (coalbed methane (CBM) vertical well) in the western Fukang mining area in the southern margin of the Junggar Basin, Xinjiang, China is relatively high. However, there are significant differences between gas and water production of CBM wells at different locations in the area, and the reason has not been adequately explained. To explore the distribution characteristic of coalbed methane and water in the Fukang mining area, the three-phase CBM gas (adsorption gas, free gas, and water-soluble gas) content was determined based on theoretical analysis and simulation. Read More

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February 2021

Population Dynamics and Life History Response to Precipitation Changes for a Desert Ephemeral Plant With Biseasonal Germination.

Front Plant Sci 2021 3;12:625475. Epub 2021 Feb 3.

State Key Laboratory of Desert and Oasis Ecology/Fukang Station of Desert Ecology, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi, China.

The changing availability of water resources and frequent extreme drought events in the context of global change will have a profound impact on desert vegetation, especially on herbaceous populations such as ephemerals. is the dominant species in the Gurbantunggut Desert. It can germinate both in spring and autumn, which is important for herbaceous layer coverage and productivity. Read More

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February 2021

Proteomic Analysis of Plasma sEVs Reveals That TNFAIP8 Is a New Biomarker of Cell Proliferation in Diabetic Retinopathy.

J Proteome Res 2021 03 17;20(3):1770-1782. Epub 2021 Feb 17.

Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin International Joint Research and Development Centre of Ophthalmology and Vision Science, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, 251 Fukang Road, Tianjin 300384, China.

Small extracellular vesicles (sEVs) derived from the plasma have been increasingly recognized as important vehicles of intercellular communication and potential sources of new biomarkers for multiple diseases. In this study, proteomic profiles of plasma sEVs from normal subjects and diabetic patients with or without diabetic retinopathy (DR) were systematically compared using iTRAQ-based quantitative proteomics. Among a total of 901 identified proteins in plasma sEVs (false discovery rate (FDR) < 1%), 90 proteins were found to have significantly changed levels in DR. Read More

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Correction to: Human embryonic stem cell-derived extracellular vesicles alleviate retinal degeneration by upregulating Oct4 to promote retinal Müller cell retrodifferentiation via HSP90.

Stem Cell Res Ther 2021 Feb 15;12(1):134. Epub 2021 Feb 15.

Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin International Joint Research and Development Centre of Ophthalmology and Vision Science, Eye Institute and School of Optometry, Tianjin Medica lUniversity Eye Hospital, No 251, Fukang Road, Nankai District, Tianjin, 300384, People's Republic of China.

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February 2021

Evaluation of cesarean delivery rates in different levels of hospitals in Jiangsu Province, China, using the 10-Group classification system.

J Matern Fetal Neonatal Med 2021 Feb 15:1-7. Epub 2021 Feb 15.

Department of Obstetrics and Gynecology, Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital, Nanjing, China.

Objective: To compare cesarean delivery (CD) rates in referral and non-referral hospitals in Maternal Safety Collaboration in Jiangsu province, China.

Methods: Sixteen participants (4 referral hospitals, 12 non-referral hospitals) from Drum Tower Hospital Collaboration for Maternal Safety reported CD rates in 2019 using ten-group classification system and maternal/neonatal morbidity and mortality.

Results: A total of 22,676 CDs were performed among 52,499 deliveries and the average CD rate was 43. Read More

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February 2021

PSF functions as a repressor of hypoxia-induced angiogenesis by promoting mitochondrial function.

Cell Commun Signal 2021 Feb 11;19(1):14. Epub 2021 Feb 11.

Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin, People's Republic of China.

Background: Abnormal neovascularization is the most common cause of blindness, and hypoxia alters tissue metabolism, function, and morphology. HIF-1α, the transcriptional activator of VEGF, has intricate mechanisms of nuclear translocation and activation, but its signal termination mechanisms remain unclear.

Methods: We investigated the role of polypyrimidine tract-binding protein-associated splicing factor (PSF) in cellular energy production, migration, and proliferation by targeting HIF-1α in vivo and in vitro PSF plasmids were transfected with liposome 2000 transfection reagent. Read More

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February 2021

Visualization of lenticulostriate artery by intracranial dark-blood vessel wall imaging and its relationships with lacunar infarction in basal ganglia: a retrospective study.

Eur Radiol 2021 Feb 10. Epub 2021 Feb 10.

Department of Radiology, Tianjin First Central Clinical College, Medical University of Tianjin, Tianjin, China.

Objectives: There is close relationship between lenticulostriate arteries (LSAs) and lacunar infarctions (LIs) of the basal ganglia. The study aims to visualize the LSAs using high-resolution vessel wall imaging (VWI) on 3T system and explore the correlation between LSAs and LIs.

Methods: Fifty-six patients with LIs in basal ganglia, and 44 age-matched control patients were enrolled and analyzed retrospectively. Read More

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February 2021

miR-496/MMP10 Is Involved in the Proliferation of IL-1β-Induced Fibroblast-Like Synoviocytes Via Mediating the NF-κB Signaling Pathway.

Inflammation 2021 Feb 6. Epub 2021 Feb 6.

Department of Rheumatology, Tianjin First Central Hospital, No.24 FuKang Road, Nankai District, Tianjin, 300192, China.

Rheumatoid arthritis (RA) is a common chronic autoimmune disease featured by synovial inflammation. miR-496 is closely involved in various pathologic conditions. However, its role in RA has not yet been elucidated. Read More

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February 2021

Quantitative susceptibility-weighted imaging may be an accurate method for determining stroke hypoperfusion and hypoxia of penumbra.

Eur Radiol 2021 Jan 29. Epub 2021 Jan 29.

Department of Radiology, Tianjin First Central Hospital, School of Medicine, Nankai University, Number 24 of Fukang Road, Nankai District, Tianjin, China.

Objectives: To quantitatively evaluate the volume of the ischemic penumbra using susceptibility-weighted imaging and mapping (SWIM) of asymmetrical prominent cortical veins (APCVs) in patients with acute ischemic stroke.

Methods: Eighty-five eligible patients with acute ischemic stroke on admission within 12 h from symptom onset were studied. The APCVs on SWIM were quantitatively (SWI-volume) and semi-quantitatively (SWI-Alberta Stroke Program Early CT Score, SWI-ASPECTS) evaluated to calculate mismatch. Read More

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January 2021

Two new species of (Hymenoptera, Eulophidae) from China, with first report on a host association for the genus.

Zookeys 2021 4;1009:67-79. Epub 2021 Jan 4.

College of Life Science and Technology, Xinjiang University, 666 Shengli Road, Tianshan District, Urumqi, Xinjiang, 830046, China Xinjiang University Urumqi China.

Two new species of Kostjukov (Hymenoptera: Eulophidae: Tetrastichinae), Li, Wang & Hu, and Li, Wang & Hu, , are described and illustrated from Xinjiang Uyghur Autonomous Region, China. was reared from stem-galls made by sp. (Diptera: Cecidomyiidae) on black saxaul, (Chenopodiaceae); was collected by sweeping from both black saxaul and white saxaul, , in Beishawo Desert near Fukang. Read More

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January 2021

Acute ischemic stroke versus transient ischemic attack: Differential plaque morphological features in symptomatic intracranial atherosclerotic lesions.

Atherosclerosis 2021 02 11;319:72-78. Epub 2021 Jan 11.

Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd., PACT 400, Los Angeles, CA, USA; Department of Radiology, University of Southern California, Los Angeles, CA, USA; Department of Radiation Oncology, University of Southern California, Los Angeles, CA, USA. Electronic address:

Background And Aims: Intracranial atherosclerotic disease (ICAD) is a major etiologic cause for acute ischemic stroke (AIS) and transient ischemic attack (TIA). The study was designed to investigate if differential morphological features exist in symptomatic atherosclerotic lesions between AIS and TIA patients.

Methods: The culprit plaques from 45 AIS patients and 42 TIA patients were analyzed for the degree of stenosis, vessel wall irregularity, normalized wall index (NWI), remodeling index, plaque-wall contrast ratio (CR), high signal intensity on T1-weighted images, plaque enhancement ratio and enhancement grade. Read More

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February 2021

Oxaliplatin derived monofunctional triazole-containing platinum(II) complex counteracts oxaliplatin-induced drug resistance in colorectal cancer.

Bioorg Chem 2021 Feb 8;107:104636. Epub 2021 Jan 8.

School of Pharmaceutical Science and Technology and Institute of Molecular Plus, Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, Tianjin University, 92 Weijin Road, Nankai District, Tianjin 300072, PR China; Department of Biology, Gudui BioPharma Technology Inc, 5 Lanyuan Road, Huayuan Industrial Park, Tianjin 300384, PR China. Electronic address:

Oxaliplatin-based chemotherapy is the current standard of care in adjuvant therapy for advanced colorectal cancer (CRC). But acquired resistance to oxaliplatin eventually occurs and becoming a major cause of treatment failure. Thus, there is an unmet need for developing new chemical entities (NCE) as new therapeutic candidates to target chemotherapy-resistant CRC. Read More

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February 2021

An unexpected cause of pulmonary hypertension.

Eur Heart J Case Rep 2020 Dec 24;4(6):1-2. Epub 2020 Nov 24.

Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin International Joint Research and Development Centre of Ophthalmology and Vision Science, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, 251 Fukang Road, Nankai District, Tianjin 300384, China.

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December 2020

Identification of circ-FAM169A sponges miR-583 involved in the regulation of intervertebral disc degeneration.

J Orthop Translat 2021 Jan 6;26:121-131. Epub 2020 Nov 6.

Department of Orthopaedics, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin, 300052, China.

Objective: Low back pain (LBP) is the predominant cause of disc degeneration in patients, which brings serious social problems and economic burdens. Increasing evidence has indicated that intervertebral disc degeneration (IDD) is one of the most common causes triggering LBP. Accumulating evidence has shown that circRNAs are involved in the pathological process of IDD. Read More

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January 2021

Human embryonic stem cell-derived extracellular vesicles alleviate retinal degeneration by upregulating Oct4 to promote retinal Müller cell retrodifferentiation via HSP90.

Stem Cell Res Ther 2021 Jan 7;12(1):21. Epub 2021 Jan 7.

Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin International Joint Research and Development Centre of Ophthalmology and Vision Science, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, No 251, Fukang Road, Nankai District, Tianjin, 300384, People's Republic of China.

Objective: Retinal degenerative diseases remain the dominant causes of blindness worldwide, and cell replacement is viewed as a promising therapeutic direction. However, the resources of seed cells are hard to obtain. To further explore this therapeutic approach, human embryonic stem extracellular vesicles (hESEVs) were extracted from human embryonic stem cells (hESCs) to inspect its effect and the possible mechanism on retinal Müller cells and retinal function. Read More

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January 2021