1,043 results match your criteria frontal elevation

Ophthalmic artery occlusion due to orbital compartment syndrome after a frontotemporal craniotomy.

Indian J Ophthalmol Case Rep 2021 Apr-Jun;1(2):383-385. Epub 2021 Apr 1.

Department of Ophthalmology, New York University, New York, NY, USA.

A 32-year-old female with a right frontal lobe glioma underwent an elective frontotemporal craniotomy. One hour postoperatively, the patient developed a right orbital compartment syndrome (OCS) with unilateral acute vision loss, proptosis, afferent pupillary defect, and complete ophthalmoplegia. The patient underwent emergent lateral canthotomy and inferior cantholysis. Read More

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Modulation of Frontal Oscillatory Power during Blink Suppression in Children: Effects of Premonitory Urge and Reward.

Cereb Cortex Commun 2020 6;1(1):tgaa046. Epub 2020 Aug 6.

Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA 90095, USA.

There is a dearth of studies examining the underlying mechanisms of blink suppression and the effects of urge and reward, particularly those measuring subsecond electroencephalogram (EEG) brain dynamics. To address these issues, we designed an EEG study to ask 3 questions: 1) How does urge develop? 2) What are EEG-correlates of blink suppression? 3) How does reward change brain dynamics related to urge suppression? This study examined healthy children ( = 26, age 8-12 years) during blink suppression under 3 conditions: blink freely (i.e. Read More

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Maximizing range of motion of reverse total shoulder arthroplasty using design optimization techniques.

J Biomech 2021 Jun 29;125:110602. Epub 2021 Jun 29.

Department of Mechanical Engineering and Materials Engineering, The University of Western Ontario, London, Ontario, Canada. Electronic address:

Range of motion (ROM) obtained after reverse shoulder arthroplasty (RSA) is an important factor in patient satisfaction and success of the procedure. The optimum RSA design that maximizes ROM is currently unknown. Furthermore, it is unknown if the envelope of motion the RSA is optimized for (overall versus forward elevation planes only) will determine its design. Read More

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Alterations of Brain Metabolites in Adults With HIV: A Systematic Meta-analysis of Magnetic Resonance Spectroscopy Studies.

Neurology 2021 Jul 12. Epub 2021 Jul 12.

Department of Neuroscience, Georgetown University Medical Center, Washington, DC 200571;

Objective: A meta-analysis of proton magnetic resonance spectroscopy (MRS) studies to investigate alterations in brain metabolites in people with HIV (PWH), as well as their relationship with combination antiretroviral therapy (cART) and cognitive impairment.

Methods: The PubMed database was searched for studies published from 1997 to 2020. Twenty-seven studies were identified, which included 1255 PWH and 633 controls. Read More

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Neurofilament Light Chain as Biomarker for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.

Front Neurosci 2021 21;15:679199. Epub 2021 Jun 21.

Department of Neurology-Stroke Unit and Laboratory of Neuroscience, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, Italy.

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two related currently incurable neurodegenerative diseases. ALS is characterized by degeneration of upper and lower motor neurons causing relentless paralysis of voluntary muscles, whereas in FTD, progressive atrophy of the frontal and temporal lobes of the brain results in deterioration of cognitive functions, language, personality, and behavior. In contrast to Alzheimer's disease (AD), ALS and FTD still lack a specific neurochemical biomarker reflecting neuropathology . Read More

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Comparing Ictal Cardiac Autonomic Changes in Patients with Frontal Lobe Epilepsy and Temporal Lobe Epilepsy by Ultra-Short-Term Heart Rate Variability Analysis.

Medicina (Kaunas) 2021 Jun 28;57(7). Epub 2021 Jun 28.

Department of Biomedical Engineering, Hanyang University, 222, Wangsimni-ro, Seongdong-gu, Seoul 04763, Korea.

: Abnormal epileptic discharges in the brain can affect the central brain regions that regulate autonomic activity and produce cardiac symptoms, either at onset or during propagation of a seizure. These autonomic alterations are related to cardiorespiratory disturbances, such as sudden unexpected death in epilepsy. This study aims to investigate the differences in cardiac autonomic function between patients with temporal lobe epilepsy (TLE) and frontal lobe epilepsy (FLE) using ultra-short-term heart rate variability (HRV) analysis around seizures. Read More

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Temporal instability in brain activation: a novel paradigm for evaluating the maintenance of attention among substance dependent patients.

Lance O Bauer

Psychopharmacology (Berl) 2021 Jul 1. Epub 2021 Jul 1.

Department of Psychiatry, University of Connecticut School of Medicine, 263 Farmington Ave, Farmington, CT, 06030, USA.

Rationale: Prior studies have demonstrated statistically significant but subtle differences in brain function between patients with a history of substance dependence (SD) and control groups.

Objectives: The goal of the present study was to show that variability in brain activation over the trials of a cognitive task is more useful for revealing the putative impact of SD than analyses focusing on the amplitude of activation averaged over trials. The study also tested the additional contribution of antisocial personality disorder (ASPD)-a prevalent comorbidity that promotes both an early onset and more severe course of SD. Read More

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Characteristics of Regional Cerebral Blood Flow in Alzheimer Disease and Amnestic Mild Cognitive Impairment by Single-Photon Emission Computerized Tomography: A Cross-Sectional Study.

Dement Geriatr Cogn Dis Extra 2021 May-Aug;11(2):91-98. Epub 2021 May 6.

Dementia-Related Disease Medical Center, Tokyo Saiseikai Central Hospital, Tokyo, Japan.

Introduction: The regional cerebral blood flow (rCBF) distribution can affect brain functioning, leading to amnestic mild cognitive impairment (aMCI) and mild Alzheimer disease (AD). This study aimed to clarify the detailed characteristics of rCBF distribution in patients with mild AD and aMCI.

Methods: This cross-sectional study from April 2015 to March 2018 included 103 older adults (mean age 78. Read More

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Neuroprotective Effects of Rhynchophylline Against Aβ-Induced Oxidative Stress, Neurodegeneration, and Memory Impairment Via Nrf2-ARE Activation.

Neurochem Res 2021 Sep 25;46(9):2439-2450. Epub 2021 Jun 25.

Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, 211198, People's Republic of China.

Extensive studies have shown that oxidative stress is a crucial pathogenic factor in Alzheimer's disease (AD). Nuclear factor E2-related factor 2 (Nrf2) is a master cytoprotective regulator against oxidative stress, and thus represents an attractive therapeutic target in AD. The goal of our study is to investigate the contribution of Nrf2 in Rhynchophylline (Rhy)-induced neuroprotection in AD. Read More

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September 2021

Antidepressant-like effects of water extract of Cordyceps militaris (Linn.) Link by modulation of ROCK2/PTEN/Akt signaling in an unpredictable chronic mild stress-induced animal model.

J Ethnopharmacol 2021 Aug 8;276:114194. Epub 2021 May 8.

Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan; Center for Food and Biomolecules, National Taiwan University, Taipei, Taiwan; National Center for Food Safety Education and Research, National Taiwan University, Taipei, Taiwan. Electronic address:

Ethnopharmacology Relevance: Cordyceps militaris (Linn.) Link (CM) is a medicinal mushroom traditionally used in tonics for treating several neurological disorders, including epilepsy and anxiety, in Asia. Reports have shown that CM has anti-inflammatory and anti-oxidative effects and may be beneficial for depression management. Read More

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Brain-Heart Interaction During Transcutaneous Auricular Vagus Nerve Stimulation.

Front Neurosci 2021 15;15:632697. Epub 2021 Mar 15.

Institute for Neuromodulation and Neurotechnology, University of Tübingen, Tübingen, Germany.

Objectives: Transcutaneous auricular vagus nerve stimulation (taVNS) modulates brain activity and heart function. The induced parasympathetic predominance leads to an increase of heart rate variability (HRV). Knowledge on the corresponding cortical activation pattern is, however, scarce. Read More

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Short lingual frenum in infants, children and adolescents. Part 2: Lingual frenum release. Functional surgical approach.

Eur J Paediatr Dent 2021 ;22(1):47-54

Head and Neck Department, "Fondazione Policlinico Universitario A. Gemelli - IRCCS" School of Dentistry, Università Cattolica del Sacro Cuore - Master Laser Dentistry, Rome, Italy.

Aim: The aim of this study was to review the craniofacial growth impairment and different malfunctions associated with short lingual frenum and to assess the validity of lingual frenum surgery based on minimally invasive laser release with a myofunctional approach.

Materials And Methods: Thirty patients, children and adolescents whose ages ranged from 8 years to 18 years, diagnosed with a short lingual frenum and concomitant orthodontic problems and/or presence of associated muscular or postural problems, were treated in this study. Pre-operative tongue assessment was performed following morphological and functional criteria, consisting of measurement of the free tongue, and of visual assessment of tongue protrusion out of the mouth and elevation to the incisive palatal papilla. Read More

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Contemporary management of pediatric open skull fractures: a multicenter pediatric trauma center study.

J Neurosurg Pediatr 2021 Mar 12:1-5. Epub 2021 Mar 12.

8Pediatric Surgery, Rady Children's Hospital, San Diego, California.

Objective: The authors sought to evaluate the contemporary management of pediatric open skull fractures and assess the impact of variations in antibiotic and operative management on the incidence of infectious complications.

Methods: The records of children who presented from 2009 to 2017 to 6 pediatric trauma centers with an open calvarial skull fracture were reviewed. Data collected included mechanism and anatomical site of injury; presence and depth of fracture depression; antibiotic choice, route, and duration; operative management; and infectious complications. Read More

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The Influence of Acute SSRI Administration on White Matter Microstructure in Patients Suffering From Major Depressive Disorder and Healthy Controls.

Int J Neuropsychopharmacol 2021 Jul;24(7):542-550

Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.

Background: Selective serotonin reuptake inhibitors (SSRIs) are predominantly prescribed for people suffering from major depressive disorder. These antidepressants exert their effects by blocking the serotonin transporter (SERT), leading to increased levels of serotonin in the synaptic cleft and subsequently to an attenuation of depressive symptoms and elevation in mood. Although long-term studies investigating white matter (WM) alterations after exposure to antidepressant treatment exist, results on the acute effects on the brain's WM microstructure are lacking. Read More

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Exploiting lamina terminalis appearance and motion in prediction of hydrocephalus using convolutional LSTM network.

J Neuroradiol 2021 Feb 12. Epub 2021 Feb 12.

Department of Radiology, City Hospital, Bilkent, Ankara, Turkey; Department of Radiology, Yildirim Beyazit University, Ankara, Turkey; National MR Research Center (UMRAM), City Hospital, Bilkent University, Ankara, Turkey.

Background: Evaluation of the lamina terminalis (LT) is crucial for non-invasive evaluation of the CSF diversion for the treatment of hydrocephalus. Together with deep learning algorithms, morphological and physiological analyses of the LT may play an important role in the management of hydrocephalus.

Aim: We aim to show that exploiting the motion of LT can contribute to the evaluation of hydrocephalus using deep learning algorithms. Read More

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February 2021

T Cells Limit Accumulation of Aggregate Pathology Following Intrastriatal Injection of α-Synuclein Fibrils.

J Parkinsons Dis 2021 ;11(2):585-603

Center for Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, USA.

Background: α-Synuclein (α-syn) is the predominant protein in Lewy-body inclusions, which are pathological hallmarks of α-synucleinopathies, such as Parkinson's disease (PD) and multiple system atrophy (MSA). Other hallmarks include activation of microglia, elevation of pro-inflammatory cytokines, as well as the activation of T and B cells. These immune changes point towards a dysregulation of both the innate and the adaptive immune system. Read More

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January 2021

Relation between frontal plane center of mass position stability and foot elevation during obstacle crossing.

J Biomech 2021 02 12;116:110219. Epub 2021 Jan 12.

Human Health Sciences, Graduate School of Medicine, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo, Kyoto 606-8507, Japan.

High foot elevation during obstacle crossing is viewed as a conservative strategy in older adults, but excessive foot elevation may result in large mediolateral center of mass (CoM) displacement. Since an incorrect transfer of CoM can lead to balance loss during locomotion, both appropriate foot elevation and CoM position must be controlled and coordinated by adjusting body segment positions. However, no studies have revealed time profiles of CoM position by coordinated segment movements and the relation of foot elevation with CoM position during obstacle crossing. Read More

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February 2021

Clinico-radiological Profile of Posterior Reversible Encephalopathy Syndrome and Its Associated Risk Factors in PICU: A Single-center Experience from a Tertiary Care Hospital in Bhubaneswar, Odisha.

Indian J Crit Care Med 2020 Dec;24(12):1223-1229

Department of Radio Diagnosis, Sum Ultimate Medicare, Bhubaneswar, Odisha, India.

Objective: Posterior reversible encephalopathy syndrome (PRES) is a clinico-radiographic entity of heterogeneous etiologies having similar clinical and neuroimaging features. Pediatric data are sparse, making early diagnosis challenging, which needs a high index of suspicion. So, we conducted this study to evaluate clinico-radiological features, associated risk factors, etiology, and outcome in children. Read More

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December 2020

A variant Nishida's technique for surgical correction of monocular elevation deficiency syndrome.

Arch Soc Esp Oftalmol (Engl Ed) 2020 Dec 17. Epub 2020 Dec 17.

Servicio de Oftalmología, Hospital Universitario 12 de Octubre, Madrid, España.

Monocular elevation deficiency (MED) is characterized by unilateral limitation of supraductions, similar in adduction and abduction, in addition to hypotropia and ptosis. We describe a case of a 62-year-old woman with long-standing left ptosis who was initially operated with a frontal suspension technique. On subsequent examinations, a MED of that eye was found. Read More

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December 2020

The repeatability of 3-dimensional scapular kinematic analysis during bilateral upper extremity movements.

J Bodyw Mov Ther 2020 Oct 11;24(4):37-42. Epub 2020 Jul 11.

Department of Physiotherapy and Rehabilitation, Hacettepe University, Turkey.

Although three-dimensional electromagnetic systems are widely used to evaluate the 3-dimensional scapular kinematics their reliability when testing bilateral upper extremity tasks is unknown. The purpose of this study was to investigate the repeatability of the scapular kinematic analyses using the Flock of Birds (FOB) system during bilateral upper extremity movements. Twenty-one volunteers without shoulder problems were included (aged 24. Read More

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October 2020

Arm mobilization provokes deformity of long-term indwelling ports implanted via the jugular vein.

J Vasc Surg Venous Lymphat Disord 2021 Jul 31;9(4):998-1006. Epub 2020 Oct 31.

Vascular Surgery Department, Hospital Israelita Albert Einstein, São Paulo, Brazil.

Background: The incidence of totally implantable catheter fracture ranges from 0.48% to 5.00%, and these fractures represent a potentially fatal complication. Read More

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Determining Trendelenburg test validity and reliability using 3-dimensional motion analysis and muscle dynamometry.

Chiropr Man Therap 2020 10 19;28(1):53. Epub 2020 Oct 19.

Chiropractic, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, 3083, Australia.

Background: The hip abductor muscle group stabilises the pelvis during gait to prevent excessive pelvic drop. Hip abductor weakness has been linked to musculoskeletal conditions such as chronic low-back pain. As such, it is important that practitioners can correctly diagnose hip abductor weakness in a clinical setting. Read More

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October 2020

Alterations of Metabolites in the Frontal Cortex and Amygdala Are Associated With Cognitive Impairment in Alcohol Dependent Patients With Aggressive Behavior.

Front Psychiatry 2020 11;11:00694. Epub 2020 Sep 11.

Department of Psychiatrics, Brains Hospital of Hunan Province, Changsha, China.

Background: Alcohol dependence (AD) patients have a high prevalence of aggressive behavior (AB). The frontal cortex and amygdala contains various neurotransmitter systems and plays an important role in AB, which is also associated with cognitive deficits. However, to date, no study has addressed the association of metabolites in the frontal cortex and amygdala with cognitive deficits in Chinese aggressive behavior-alcohol dependent patients(AB-ADs). Read More

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September 2020

Early Life Stress Preceding Mild Pediatric Traumatic Brain Injury Increases Neuroinflammation but Does Not Exacerbate Impairment of Cognitive Flexibility during Adolescence.

J Neurotrauma 2021 02 6;38(4):411-421. Epub 2020 Nov 6.

Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Early life stress (ELS) followed by pediatric mild traumatic brain injury (mTBI) negatively impacts spatial learning and memory and increases microglial activation in adolescent rats, but whether the same paradigm negatively affects higher order executive function is not known. Hence, we utilized the attentional set-shifting test (AST) to evaluate executive function (cognitive flexibility) and to determine its relationship with neuroinflammation and hypothalamic-pituitary-adrenal (HPA) axis activity after pediatric mTBI in male rats. ELS was induced via maternal separation for 180 min per day (MS180) during the first 21 post-natal (P) days, while controls (CONT) were undisturbed. Read More

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February 2021

Tissue-specific analysis of Fgf18 gene function in palate development.

Dev Dyn 2021 Apr 21;250(4):562-573. Epub 2020 Oct 21.

Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Background: Previous studies showed that mice lacking Fgf18 function had cleft palate defects and that the FGF18 locus was associated with cleft lip and palate in humans, but what specific roles Fgf18 plays during palatogenesis are unclear.

Results: We show that Fgf18 exhibits regionally restricted expression in developing palatal shelves, mandible, and tongue, during palatal outgrowth and fusion in mouse embryos. Tissue-specific inactivation of Fgf18 throughout neural crest-derived craniofacial mesenchyme caused shortened mandible and reduction in ossification of the frontal, nasal, and anterior cranial base skeletal elements in Fgf18 ;Wnt1-Cre mutant mice. Read More

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Dehydrozingerone protects temozolomide-induced cognitive impairment in normal and C6 glioma rats besides enhancing its anticancer potential.

3 Biotech 2020 Oct 17;10(10):438. Epub 2020 Sep 17.

Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104 India.

Considering the cognitive impairment induced by temozolomide (TMZ) in glioblastoma survivors, the present study was aimed to evaluate the protective effect of dehydrozingerone (DHZ) against TMZ-induced cognitive impairment (chemobrain) and C6 cell line-induced glioma in male Wistar rats. In both chemobrain and glioma models, TMZ was administered at a dose of 18 mg/kg i.v every 5th day and DHZ at a dose of 100 mg/kg p. Read More

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October 2020

Kurtosis and skewness of high-frequency brain signals are altered in paediatric epilepsy.

Brain Commun 2020 31;2(1):fcaa036. Epub 2020 Mar 31.

MEG Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

Intracranial studies provide solid evidence that high-frequency brain signals are a new biomarker for epilepsy. Unfortunately, epileptic (pathological) high-frequency signals can be intermingled with physiological high-frequency signals making these signals difficult to differentiate. Recent success in non-invasive detection of high-frequency brain signals opens a new avenue for distinguishing pathological from physiological high-frequency signals. Read More

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Effective stretching positions for the posterior shoulder capsule as determined by shear wave elastography.

J Shoulder Elbow Surg 2021 May 9;30(5):1186-1195. Epub 2020 Sep 9.

Second Division of Physical Therapy, School of Health Sciences, Sapporo Medical University, Sapporo, Japan.

Background: Stretching is often used to prevent and treat posterior shoulder capsule tightness; however, the most effective stretching positions are not clearly defined. The purpose of this study was to identify the stretching positions that specifically applied the greatest passive tension on the posterior shoulder capsule by evaluating the elastic characteristics of posterior capsules and muscles in various stretching positions using ultrasound shear wave elastography (SWE).

Methods: We evaluated 9 fresh-frozen shoulders (mean age 86. Read More

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Scapulohumeral rhythm in patients after total shoulder arthroplasty compared to age-matched healthy individuals.

Gait Posture 2020 10 11;82:38-44. Epub 2020 Aug 11.

Clinic for Orthopedics and Trauma Surgery, Heidelberg University Hospital, Schlierbacher Landstraße 200a, 69118 Heidelberg, Germany; Swabian Joint Centre, ATOS Clinic Stuttgart, Hohenheimer Straße 91, 70184 Stuttgart, Germany. Electronic address:

Purpose: The coordination of the glenohumeral joint and the shoulder girdle has been known as scapulohumeral rhythm. The effects of anatomical total shoulder arthroplasty (aTSA) are still subject to research. Former studies showed a higher amount of scapula lateral rotation to compensate for reduced glenohumeral elevation. Read More

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October 2020

Revisiting the Direct Brow Lift in Patients With Facial Palsy: 4 Key Modifications.

Ophthalmic Plast Reconstr Surg 2021 Mar-Apr 01;37(2):179-182

Corneoplastic Unit, Queen Victoria Hospital, East Grinstead, RH19 3DZ, United Kingdom.

Purpose: The direct brow lift is a simple and popular technique, particularly in patients with brow ptosis secondary to facial palsy. It provides a high degree of control in determining the degree of brow elevation and shape achieved. However, it is arguably the least debated in terms of addressing some of its sequelae, namely the risks of a visible or indrawn scar and forehead paraesthesia. Read More

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