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The Incidence of Hip Arthroscopy in Patients with Femoroacetabular Impingement Syndrome and Labral Pathology Increased by 85% Between 2011 and 2018 in the United States.

Arthroscopy 2021 May 5. Epub 2021 May 5.

Cedars Sinai-Kerlan Jobe Institute.

Purpose: The purpose of this study was to investigate the incidence of hip arthroscopy in patients with labral pathology in the United States from the year 2011-2018 using a large national database.

Methods: Patients who underwent hip arthroscopy from 2011-2018 were identified using CPT (Current Procedural Terminology) codes in the PearlDiver Patients Records Database (Colorado Springs, CO), which is a national database of orthopedic insurance records, including Medicare patients. The incidence of surgeries, age, gender, and geographical location (by region) were all recorded. Read More

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The presence of an additional ventricular chamber does not change the outcome of Fontan circulation: a comparative study.

Eur J Cardiothorac Surg 2021 May 8. Epub 2021 May 8.

Pediatric and Congenital Cardiac Surgery, Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padova, Padova, Italy.

Objectives: The role of an additional ventricle in patients with a functional single ventricle undergoing the Fontan operation has been debated due to conflicting data. Our goal was to report our experience with Fontan circulation for complex congenital heart disease, with a focus on the influence that an additional ventricular chamber may have on early and long-term clinical outcomes.

Methods: We performed a retrospective clinical study including all patients undergoing the Fontan procedure between 1978 and 2019. Read More

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Predicting QT interval prolongation in patients diagnosed with the 2019 novel coronavirus infection.

Ann Noninvasive Electrocardiol 2021 May 7:e12853. Epub 2021 May 7.

Department of Internal Medicine, Ascension St. John Hospital, Detroit, MI, USA.

Introduction: 2019 novel coronavirus (COVID-19) patients frequently develop QT interval prolongation that predisposes them to Torsades de Pointes and sudden cardiac death. Continuous cardiac monitoring has been recommended for any COVID-19 patient with a Tisdale Score of seven or more. This recommendation, however, has not been validated. Read More

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SSX C-Terminus is a Useful Diagnostic Biomarker for Spermatocytic Tumour.

Histopathology 2021 May 7. Epub 2021 May 7.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.

Aims: Spermatocytic tumour (ST) is a rare testicular germ cell neoplasm that can be challenging to diagnose and for which there are few confirmatory biomarkers. Like normal spermatogonia, STs are known to express SSX proteins. Recently, a novel SSX antibody directed against the C-terminus (SSX_CT) of SSX1, SSX2 and SSX4, has emerged as a reliable biomarker for these SSX proteins and synovial sarcoma. Read More

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Evaluation of Dosing Strategies and Trough Concentrations of Vancomycin in Patients Undergoing Continuous Venovenous Hemofiltration.

Pharmacotherapy 2021 May 8. Epub 2021 May 8.

Harper University Hospital, Detroit, Michigan, USA.

Background: Recommendations regarding vancomycin dosing in critically ill patients on continuous venovenous hemofiltration (CVVH) are limited. The purpose of this study was to evaluate current dosing practices of pharmacists for patients treated with CVVH, develop guidelines for optimal dosing and monitoring of vancomycin to improve target trough attainment, and reduce pharmacist workload.

Methods: A retrospective cohort study was performed of critically ill adult patients at an academic medical center in Detroit, Michigan, from January 2015 to December 2018. Read More

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Impact of the Affordable Care Act Medicaid Expansion on Reimbursement in Emergency General Surgery.

J Gastrointest Surg 2021 May 7. Epub 2021 May 7.

Department of Surgery, University of Kentucky, Lexington, KY, USA.

Background: Kentucky had one of the nation's largest increases in insurance coverage with the Affordable Care Act's (ACA) Medicaid expansion, quadrupling the proportion of Kentuckians with insurance coverage. This study compares reimbursement rates for surgical procedures performed by emergency general surgery (EGS) services at the University of Kentucky (UK) before and after Medicaid expansion in January 2014.

Methods: This IRB-approved, single-institution study retrospectively evaluated all patients undergoing surgical treatment by our EGS team from 1/1/2011 to 12/31/2016. Read More

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Assessment of suspected adverse drug reactions in elderly patients with diabetes mellitus based on a Portuguese spontaneous reporting database: analysis of reporting from 2008 to 2018.

Expert Opin Drug Saf 2021 May 7. Epub 2021 May 7.

UFBI - Pharmacovigilance Unit of Beira Interior, University of Beira Interior, Covilhã, Portugal.

Background: Age is one of the most important risk factors in the development of diabetes mellitus and certain drug classes indicated for this condition may be associated with clinically important adverse drug reactions (ADRs). The aim of this study was to analyse the suspected ADRs in older patients with diabetes mellitus, reported to the Portuguese Pharmacovigilance System from 2008 to 2018.

Research Design And Methods: A retrospective analysis of suspected ADRs reports was performed, involving patients aged ≥65 years. Read More

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International consensus on methodological issues in standardization of fecal calprotectin measurement in inflammatory bowel diseases.

United European Gastroenterol J 2021 May 7. Epub 2021 May 7.

Department of Gastroenterology and Inserm U1256, Nutrition - Genetics and Exposure to Environmental Risks, University Hospital of Nancy, University of Lorraine, Vandoeuvre-lès-Nancy, France.

Background: Fecal calprotectin (FC) is a non-invasive marker of gut inflammation which is frequently used to guide therapeutic decisions in patients with inflammatory bowel diseases (IBD). Each step of FC measurement can influence the results, leading to misinterpretations and potentially impacting the management of IBD patients. To date, there is high heterogeneity between FC measurements and no current method is universally accepted as a standard. Read More

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Graft-versus-host disease after liver transplantation is associated with bone marrow failure, hemophagocytosis, and DNMT3A mutations.

Am J Transplant 2021 May 7. Epub 2021 May 7.

Department of Surgery, Division of Abdominal Organ Transplantation, Oregon Health & Science University, Portland.

Graft-versus-host disease after liver transplantation (LT-GVHD) is rare, frequently fatal, and associated with bone marrow failure (BMF), cytopenias, and hyperferritinemia. Given hyperferritinemia and cytopenias are present in hemophagocytic lymphohistiocytosis (HLH), and somatic mutations in hematopoietic cells are associated with hyperinflammatory responses (clonal hematopoiesis of indeterminate potential, CHIP), we identified the frequency of hemophagocytosis and CHIP mutations in LT-GVHD. We reviewed bone marrow aspirates and biopsies, quantified blood/marrow chimerism, and performed next-generation sequencing (NGS) with a targeted panel of genes relevant to myeloid malignancies, CHIP, and BMF. Read More

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[Diagnosis, Treatment and Complications of Knee Dislocation: a Retrospective Study].

Acta Chir Orthop Traumatol Cech 2021 ;88(2):107-116

Klinika ortopedie a traumatologie pohybového ústrojí a Lékařské fakulty Univerzity Karlovy a Fakultní nemocnice, Plzeň.

PURPOSE OF THE STUDY Acute knee dislocation is a less common injury of the knee joint. It is, however, a serious injury with a high rate of nerve and vascular damage and it is considered a limb threatening injury with long-term functional disability, which can ultimately lead to amputation. Knee dislocations constitute less than 0. Read More

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January 2021

Socioscientific Issues in Science Education: An opportunity to Incorporate Education about Risk and Risk Analysis?

Risk Anal 2021 May 7. Epub 2021 May 7.

Tumba Gymnasium, Botkyrka kommun, Sweden.

Socioscientific issues (SSI) concern social issues, often lacking simple solutions, that relate to science and often also risk controversies. SSIs have become an established part of science education, aiming to teach students not only about content knowledge but also about the nature of science and to offer them practice in argumentation and decision making. We performed a scoping review of the literature on SSI in science education research, in order to investigate if the topics covered would lean themselves to education about risk, and if risk is raised in these works. Read More

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Objective measurements for upper airway obstruction in infants with Robin sequence: what are we measuring? A systematic review.

J Clin Sleep Med 2021 May 7. Epub 2021 May 7.

Department of Plastic and Reconstructive Surgery, Amsterdam University Medical Centre, location AMC & VU, Emma Children's Hospital, Amsterdam, The Netherlands.

Study Objectives: Identifying optimal treatment for infants with Robin sequence (RS) is challenging due to substantial variability in the presentation of upper airway obstruction (UAO) in this population. Objective assessments of UAO and treatments are not standardized. A systematic review of objective measures of UAO was conducted as step towards evidence based clinical decision making for RS. Read More

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Intracranial Angioplasty with Enterprise Stent for Intracranial Atherosclerotic Stenosis: A Single-Center Experience and a Systematic Review.

Biomed Res Int 2021 17;2021:6645500. Epub 2021 Apr 17.

Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.

Background: The high rate of periprocedural complications for the endovascular stent procedure in the Stenting Versus Aggressive Medical Management Therapy for Intracranial Arterial Stenosis (SAMMPRIS) trial resulted in it being less recommended than medical therapy to treat intracranial atherosclerotic stenosis (ICAS). Because Enterprise stent use might reduce the incidence of complications in ICAS treatment compared to other frequently used stents, this paper evaluated the safety and effectiveness of the Enterprise stent for the treatment of ICAS.

Methods: We performed a comprehensive literature search for reports on intracranial angioplasty using the Enterprise stent for ICAS treatment from the earliest date available from each database to May 2020 for PubMed, EMBASE, Web of Science, Cochrane, and Clinical Trials databases. Read More

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CXCL1 Clone Evolution Induced by the HDAC Inhibitor Belinostat Might Be a Favorable Prognostic Indicator in Triple-Negative Breast Cancer.

Biomed Res Int 2021 17;2021:5089371. Epub 2021 Apr 17.

Biomedical Research Institute, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong 518036, China.

Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer due to its lack of treatment options. Patients with TNBC frequently develop resistance to chemotherapy. As epigenetic-based antineoplastic drugs, histone deacetylase inhibitors (HDACis) have achieved particular efficacy in lymphoma but are less efficacious in solid tumors, and the resistance mechanism remains poorly understood. Read More

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Efficacy, Safety, and Cost-Minimization Analysis of Continuous Infusion of Low-Dose Gemcitabine Plus Cisplatin in Patients With Unresectable Malignant Pleural Mesothelioma.

Front Oncol 2021 20;11:641975. Epub 2021 Apr 20.

Foundation for Clinical and Applied Cancer Research (FICMAC), Bogotá, Colombia.

Background: Malignant pleural mesothelioma (MPM) is rare and aggressive neoplasia, with a poor prognosis; furthermore, the monetary cost of its treatment represents a major challenge for many patients. The economic burden this malignancy imposes is underscored by the fact that asbestos exposure, which is the most frequent risk factor, is much more prevalent in the lower socioeconomic population of developing countries. The aims of the present study were to evaluate the efficacy, safety, and cost of continuous infusion of low-dose Gemcitabine plus Cisplatin (CIGC) as a treatment strategy for patients with unresectable MPM. Read More

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TP53 mutation and MET amplification in circulating tumor DNA analysis predict disease progression in patients with advanced gastric cancer.

PeerJ 2021 16;9:e11146. Epub 2021 Apr 16.

Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine (TCM), Shanghai, China.

Background: Gastric cancer (GC) is a heterogeneous disease that encompasses various molecular subtypes. The molecular mutation characteristics of circulating tumor DNA (ctDNA) in advanced gastric cancer (AGC), especially the clinical utility of TP53 mutation and MET amplification in ctDNA need to be further explored.

Objectives: The aim of this study was mainly to assess the clinical utility of TP53 mutation and MET amplification in ctDNA as biomarkers for monitoring disease progression of AGC. Read More

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Association Between ApoA1 Gene Polymorphisms and Antipsychotic Drug-Induced Dyslipidemia in Schizophrenia.

Neuropsychiatr Dis Treat 2021 30;17:1289-1297. Epub 2021 Apr 30.

Department of Medical Laboratory, Huai'an Third People's Hospital, Huai'an, People's Republic of China.

Purpose: Dyslipidemia frequently occurs in schizophrenia patients treated with antipsychotic drugs (APDs), especially atypical APDs. Apolipoprotein A1 (ApoA1) plays a key role in lipid metabolism. The aim of this study was to investigate whether ApoA1 gene polymorphisms are associated with APD-induced dyslipidemia in schizophrenia patients. Read More

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Canadian national electrophysiology ablation registry report 2011-2016.

BMC Health Serv Res 2021 May 6;21(1):435. Epub 2021 May 6.

Sunnybrook Health Sciences Centre, University of Toronto, 890 Sheppard Avenue West, Ontario, M4N 3M5, Toronto, Canada.

Background/purpose: Interventional cardiac electrophysiology (EP) is a rapidly evolving field in Canada; a nationwide registry was established in 2011 to conduct a periodic review of resource allocation.

Methods: The registry collects annual data on EP lab infrastructure, imaging, tools, human resources, procedural volumes, success rates, and wait times. Leading physicians from each EP lab were contacted electronically; participation was voluntary. Read More

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Clinical Characteristics and Outcomes of a Cohort of Pediatric Oncohematologic Patients With COVID-19 Infection in the City of Bogotá, Colombia.

Pediatr Infect Dis J 2021 Jun;40(6):499-502

Bone Marrow Transplant Unit, HOMI, Fundación Hospital pediátrico la Misericordia, Bogotá, Colombia.

Background: In children, the complications of severe acute respiratory syndrome coronavirus 2 infection occur less frequently than in adults but the characteristics of this disease in oncology patients are not well characterized.

Methods: This was a retrospective study in patients younger than 18 years of age with coronavirus disease 2019 (COVID-19) and cancer diagnoses between April and September 2020. Demographic variables, laboratory, and radiologic findings and complications of each case were identified. Read More

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Assessment of captive rearing conditions on loggerhead hatchlings: Effect of handling frequency and stocking density.

J Exp Zool A Ecol Integr Physiol 2021 May 6. Epub 2021 May 6.

ECOAQUA UI, University of Las Palmas de Gran Canaria. Parque Científico Tecnológico Marino, Las Palmas, Spain.

Frequently, stranded sea turtles require rehabilitation under controlled conditions. Currently, few publications have described the conditions under which rehabilitation is to take place, particularly with respect to the hatchling life stage. To address this paucity of data, we conducted some experiments to assist rehabilitating facilities assess their handling of hatchlings. Read More

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Locomotion of an adult female and juvenile male aye-aye (Daubentonia madagascariensis) in Torotorofotsy, Madagascar.

Am J Primatol 2021 May 6:e23267. Epub 2021 May 6.

Center for Conservation and Research, Omaha's Henry Doorly Zoo and Aquarium, Omaha, Nebraska, USA.

Aye-ayes (Daubentonia madagascariensis) locate and acquire invertebrates from within woody substrates at all levels of the rainforest; yet how their locomotion helps them accommodate this diet has not been explored in detail. We studied the locomotor behavior of an adult female (N = 1,085) and juvenile male (N = 708) aye-aye in the undisturbed forest of Torotorofotsy, Madagascar from May to December 2017. We used bout sampling to record locomotion during foraging and travel of the two radio-collared individuals. Read More

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Intubation-Related Laryngeal Deficiency and Vocal Fold Immobility in Pediatric Premature Patients.

Laryngoscope 2021 May 6. Epub 2021 May 6.

Division of Pediatric Otolaryngology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, U.S.A.

Objectives/hypothesis: We report a posterior laryngeal rating system and measures of voice disability in pediatric patients undergoing phonosurgery for vocal fold paralysis. Posterior glottic deficiency may account for persistent voice disability.

Study Design: Retrospective Study. Read More

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The Inferto-Sex Syndrome (ISS): sexual dysfunction in fertility care setting and assisted reproduction.

J Endocrinol Invest 2021 May 6. Epub 2021 May 6.

Chair of Endocrinology and Medical Sexology (ENDOSEX), Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier, 1, E Tower South. Floor 4, Room E413, 00133, Rome, Italy.

Purpose: Infertility represents a peculiar social burden affecting more than 15% of couples, provoking it a real threat to the general quality of life and to the sexual health. The medicalization (diagnosis, therapy and follow up) of the lack of fertility is frequently a challenge in term of personal and couple's involvement. In particular, while the Assisted Reproductive Technology (ART) has allowed many infertile couples to achieve pregnancy, the therapeutic process faced by the couple bears a strong psychological stress that can affect the couple's quality of life, relationship and sexuality. Read More

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Diagnostic Yield of Whole Exome Sequencing for Adults with Ataxia: a Brazilian Perspective.

Cerebellum 2021 May 6. Epub 2021 May 6.

Department of Neurology, School of Medical Sciences, University of Campinas (UNICAMP), Rua Tessália Vieira de Camargo, 126. Cidade Universitária "Zeferino Vaz", Campinas, SP, 13083-887, Brazil.

Previous studies using whole exome sequencing (WES) have shown that a significant proportion of adult patients with undiagnosed ataxia in European and North American cohorts have a known genetic cause. Little is known about the diagnostic yield of WES in non-Caucasian ataxic populations. Herein, we used WES to investigate a Brazilian cohort of 76 adult patients with idiopathic ataxia previously screened for trinucleotide expansions in known ataxia genes. Read More

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Health-related quality of life, workability, and return to work of patients after liver transplantation.

Langenbecks Arch Surg 2021 May 6. Epub 2021 May 6.

Transplant Center Graz, Graz, Austria.

Background: Health-related quality of life (HrQoL) and workability are related parameters to measure success of therapy. Both have been insufficiently explored in patients after liver transplantation (LT). Particularly little is known about patients' attitude to return to work, employment status before LT, and how frequently there is any employment at any time after LT. Read More

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SETBP1 overexpression acts in the place of class-defining mutations to drive FLT3-ITD-mutant AML.

Blood Adv 2021 May;5(9):2412-2425

Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, United Kingdom.

Advances in cancer genomics have revealed genomic classes of acute myeloid leukemia (AML) characterized by class-defining mutations, such as chimeric fusion genes or in genes such as NPM1, MLL, and CEBPA. These class-defining mutations frequently synergize with internal tandem duplications in FLT3 (FLT3-ITDs) to drive leukemogenesis. However, ∼20% of FLT3-ITD-positive AMLs bare no class-defining mutations, and mechanisms of leukemic transformation in these cases are unknown. Read More

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Pathology of cryptosporidiosis in raccoons: case series and retrospective analysis, 1990-2019.

J Vet Diagn Invest 2021 May 6:10406387211011949. Epub 2021 May 6.

California Animal Health and Food Safety Laboratory (CAHFS), University of California-Davis, San Bernardino, CA, USA.

Cryptosporidiosis is an intestinal protozoal disease of public health importance caused by spp. Despite the high synanthropism of raccoons, studies describing the pathology of spp. infections in this species are lacking. Read More

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Evaluation of the Association of Polymorphisms With Palbociclib-Induced Neutropenia: Pharmacogenetic Analysis of PALOMA-2/-3.

Oncologist 2021 May 5. Epub 2021 May 5.

Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Background: The most frequently reported treatment-related adverse event in clinical trials with the cyclin-dependent kinase 4/6 (CDK4/6) inhibitor palbociclib is neutropenia. Allelic variants in ABCB1 and ERCC1 might be associated with early occurrence (ie, end of Week 2 treatment) of grade 3/4 neutropenia. Pharmacogenetic analyses were performed to uncover associations between single nucleotide polymorphisms (SNPs) in these genes, patient baseline characteristics, and early occurrence of grade 3/4 neutropenia. Read More

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The impact of basic atrial rhythm during catheter ablation of atrial fibrillation on clinical outcomes: Lessons from the German Ablation Registry.

J Cardiovasc Electrophysiol 2021 May 5. Epub 2021 May 5.

Universitäres Herz- und Gefäßzentrum Hamburg-Eppendorf, Department of Cardiology, Hamburg, Germany.

Background: The impact of basic atrial rhythm (sinus rhythm (SR) vs atrial fibrillation (AF)) during AF ablation on efficacy and safety is unknown.

Methods: 3375 patients from the German Ablation Registry undergoing first-time AF ablation were divided according to the type of AF and the basic atrial rhythm during the ablation procedure: paroxysmal AF (PAF) and SR [group Ia], PAF and AF [group Ib]), persistent AF and SR (IIa) and persistent AF and AF (IIb).

Results: Patients in SR (n=2312 (67%)) underwent cryoballoon ablation more often (Ia vs Ib p=0. Read More

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