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Charge Carrier Mobility Improvement in Diketopyrrolopyrrole Block-Copolymers by Shear Coating.

Polymers (Basel) 2021 Apr 29;13(9). Epub 2021 Apr 29.

Leibniz-Institut für Polymerforschung Dresden e.V., Hohe Straße 6, 01069 Dresden, Germany.

Shear coating is a promising deposition method for upscaling device fabrication and enabling high throughput, and is furthermore suitable for translating to roll-to-roll processing. Although common polymer semiconductors (PSCs) are solution processible, they are still prone to mechanical failure upon stretching, limiting applications in e.g. Read More

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One-Sided Chronic Intervillositis of Unknown Etiology in Dizygotic Twins: A Description of 3 Cases.

Int J Mol Sci 2021 Apr 30;22(9). Epub 2021 Apr 30.

Department of Pathology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

Chronic intervillositis of unknown etiology (CIUE) is a rare, poorly understood, histopathological diagnosis of the placenta that is frequently accompanied by adverse pregnancy outcomes including miscarriage, fetal growth restriction, and intrauterine fetal death. CIUE is thought to have an immunologically driven pathophysiology and may be related to human leukocyte antigen mismatches between the mother and the fetus. Dizygotic twins with one-sided CIUE provide an interesting context to study the influence of immunogenetic differences in such cases. Read More

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The (new) occupational disease no. 5101: "Severe or recurrent skin diseases".

J Dtsch Dermatol Ges 2021 May 3. Epub 2021 May 3.

Klinik für Hautkrankheiten, Universitätsklinikum Jena.

Occupational dermatoses are among the most common occupational diseases, with BK 5101 accounting for the largest proportion. Historically, the latter was also the most frequently reported group of occupational diseases within the working age population. More than 80,000 suspected cases of occupational diseases were notified in 2019, of which 19,883 related to BK 5101. Read More

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The Gut-Brain-Microbiome Axis and Its Link to Autism: Emerging Insights and the Potential of Zebrafish Models.

Front Cell Dev Biol 2021 15;9:662916. Epub 2021 Apr 15.

Department of Biology, University of Miami, Coral Gables, FL, United States.

Research involving autism spectrum disorder (ASD) most frequently focuses on its key diagnostic criteria: restricted interests and repetitive behaviors, altered sensory perception, and communication impairments. These core criteria, however, are often accompanied by numerous comorbidities, many of which result in severe negative impacts on quality of life, including seizures, epilepsy, sleep disturbance, hypotonia, and GI distress. While ASD is a clinically heterogeneous disorder, gastrointestinal (GI) distress is among the most prevalent co-occurring symptom complex, manifesting in upward of 70% of all individuals with ASD. Read More

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Combination of Side-Swing Flap With Negative-Pressure Wound Therapy Is Superior to Open Excision or Flap Alone in Children With Pilonidal Sinus-But at What Cost?

Front Pediatr 2021 14;9:595684. Epub 2021 Apr 14.

Department of Pediatric Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Pilonidal sinus (PS) disease frequently occurs in adolescents and young adults, and in many cases involves wide excision or local flaps as treatment. These treatments are associated with a significant recurrence rate, a long healing time, and thus absence from school or work. The hybrid technique, which is a combination of side-swing plasty with negative-pressure wound therapy (NPWT) may improve these outcomes. Read More

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The curious incident of the dog in the nighttime: The effects of pet-human co-sleeping and bedsharing on sleep dimensions of children and adolescents.

Sleep Health 2021 Apr 29. Epub 2021 Apr 29.

Pediatric Public Health Psychology Laboratory, Concordia University, Montréal, Québec, Canada. Electronic address:

Background: Pets are often thought to be detrimental to sleep. Up to 75% of households with children have a pet, and 30-50% of adults and children regularly share their bed with their pets. Despite these high rates, few studies have examined the effect of pet-human co-sleeping on pediatric sleep. Read More

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Massive pulmonary embolism presenting with hemoptysis and S1Q3T3 ECG findings.

BMC Cardiovasc Disord 2021 May 1;21(1):224. Epub 2021 May 1.

Department of Radiodiagnostic, Biruni University of Medical Faculty, Istanbul, Turkey.

Background: Venous thromboembolism clinically presenting with a deep vein thrombosis or pulmonary embolism is among the most commonly seen cardiovascular syndromes. The aim of this case presentation is to emphasise the typical electrocardiographic findings that are detected with massive pulmonary embolism along with the electrocardiographic S1Q3 and S1Q3T3 accompanied by T negativity at the D3 derivation based on prevalent T negativity.

Case Presentation: We present the case of an adult male who presented with a massive pulmonary embolism that was associated with tachycardia, haemoptysis and typical S1Q3T3 electrocardiographic findings. Read More

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Causal judgments about atypical actions are influenced by agents' epistemic states.

Cognition 2021 Apr 27;212:104721. Epub 2021 Apr 27.

Department of Experimental Psychology, University College London, United Kingdom.

A prominent finding in causal cognition research is people's tendency to attribute increased causality to atypical actions. If two agents jointly cause an outcome (conjunctive causation), but differ in how frequently they have performed the causal action before, people judge the atypically acting agent to have caused the outcome to a greater extent. In this paper, we argue that it is the epistemic state of an abnormally acting agent, rather than the abnormality of their action, that is driving people's causal judgments. Read More

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Migrant children in transit: health profile and social needs of unaccompanied and accompanied children visiting the MSF clinic in Belgrade, Serbia.

Confl Health 2021 Apr 29;15(1):32. Epub 2021 Apr 29.

Adventist Development and Relief Agency, Belgrade, Serbia.

Background: Thousands of children migrate to Europe each year in search of safety and the promise of a better life. Many of them transited through Serbia in 2018. Children journey alone or along with their family members or caregivers. Read More

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Immunohistochemical Analysis of the Expression of Adhesion Proteins: TNS1, TNS2 and TNS3 in Correlation with Clinicopathological Parameters in Gastric Cancer.

Biomolecules 2021 Apr 26;11(5). Epub 2021 Apr 26.

Department of General Pathomorphology, Medical University of Białystok, Kilińskiego 1, 15-089 Białystok, Poland.

Tensins belong to the group of adhesion proteins that are involved in cell adhesion and migration, actin cytoskeleton maintenance and intercellular communication. TNS1, TNS2 and TNS3 proteins expression was evaluated in 90 patients with gastric cancer by immunohistochemistry method. TNS1 was more frequently present in non-differentiated tumors compared to poorly and moderately differentiated tumors ( = 0. Read More

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Combining Mass Spectrometry-Based Phosphoproteomics with a Network-Based Approach to Reveal FLT3-Dependent Mechanisms of Chemoresistance.

Proteomes 2021 Apr 27;9(2). Epub 2021 Apr 27.

Department of Biology, University of Rome Tor Vergata, Via delle Ricerca Scientifica 1, 00133 Rome, Italy.

FLT3 mutations are the most frequently identified genetic alterations in acute myeloid leukemia (AML) and are associated with poor clinical outcome, relapse and chemotherapeutic resistance. Elucidating the molecular mechanisms underlying FLT3-dependent pathogenesis and drug resistance is a crucial goal of biomedical research. Given the complexity and intricacy of protein signaling networks, deciphering the molecular basis of FLT3-driven drug resistance requires a systems approach. Read More

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Syndecan-1 (CD138), Carcinomas and EMT.

Authors:
John R Couchman

Int J Mol Sci 2021 Apr 19;22(8). Epub 2021 Apr 19.

Biotech Research & Innovation Centre, University of Copenhagen, 2200 Copenhagen, Denmark.

Cell surface proteoglycans are known to be important regulators of many aspects of cell behavior. The principal family of transmembrane proteoglycans is the syndecans, of which there are four in mammals. Syndecan-1 is mostly restricted to epithelia, and bears heparan sulfate chains that are capable of interacting with a large array of polypeptides, including extracellular matrix components and potent mediators of proliferation, adhesion and migration. Read More

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Pregnancy and Dentistry: A Literature Review on Risk Management during Dental Surgical Procedures.

Dent J (Basel) 2021 Apr 19;9(4). Epub 2021 Apr 19.

Dental Clinic, Department of Neuroscience, University of Padua, 35129 Padua, Italy.

Pregnancy is a unique moment in a woman's life, accompanied with several physiologic changes that have an impact on oral health. The purpose of the present study was to conduct a critical review of published literature regarding pregnancy and dentistry, the most frequent oral diseases that are encountered during pregnancy, their correlation to adverse pregnancy events, and safe dental treatments that can be performed during pregnancy. A Medline/COCHRANE search was carried using specific keywords and MeSH terms, combined with the boolean operators "OR" and "AND". Read More

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Hospitalization for Short-Term Diabetes-Related Complications: Focus on Patients Aged over 85 Years.

Healthcare (Basel) 2021 Apr 14;9(4). Epub 2021 Apr 14.

Department of Medicine and Ageing Sciences, "G. d'Annunzio" University of Chieti-Pescara, 66100 Chieti, Italy.

(1) : The prevalence of diabetes in elderly people is frequently high. When occurring in the elderly, diabetes is often accompanied by complications and comorbidities, at least one in 60% and four or more in 40% of older people with diabetes. As far as short-term complications among the elderly are concerned, hypoglycemia and hyperglycemic crises prove to be frequent. Read More

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Affect across adulthood: Evidence from English, Dutch, and Spanish.

J Exp Psychol Gen 2021 Apr;150(4):792-812

McMaster University.

Emotions play a fundamental role in language learning, use, and processing. Words denoting positivity account for a larger part of the lexicon than words denoting negativity, and they also tend to be used more frequently, a phenomenon known as positivity bias. However, language experience changes over an individual's lifetime, making the examination of the emotion-laden lexicon an important topic not only across the life span but also across languages. Read More

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Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic hepatotoxicity.

Front Med 2021 Apr 28. Epub 2021 Apr 28.

China Military Institute of Chinese Materia, the Fifth Medical Centre, Chinese PLA General Hospital, Beijing, 100039, China.

Psoraleae Fructus (PF) is a well-known traditional herbal medicine in China, and it is widely used for osteoporosis, vitiligo, and other diseases in clinical settings. However, liver injury caused by PF and its preparations has been frequently reported in recent years. Our previous studies have demonstrated that PF could cause idiosyncratic drug-induced liver injury (IDILI), but the mechanism underlying its hepatotoxicity remains unclear. Read More

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Anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor encephalitis: A case report.

Medicine (Baltimore) 2021 Apr;100(17):e25694

Aerospace Clinic Academy, Peking University Health Science Centre, Beijing, China.

Introduction: : Anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) is a subtype of glutamate receptor that mediates most of the fast excitatory neurotransmission in the brain. Anti-AMPAR encephalitis is an autoimmune-mediated neurological disorder, frequently accompanied by the presence of neoplasms, comprising a spectrum of paraneoplastic syndrome.

Patient Concerns: A 56-year-old man was admitted for deterioration in memory and aberrant psychological behaviors, which lasted for at least 20 days. Read More

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Production in Escherichia coli of recombinant COVID-19 spike protein fragments fused to CRM197.

Biochem Biophys Res Commun 2021 Apr 20;558:79-85. Epub 2021 Apr 20.

Department of Pharmacy and Biotechnology, University of Bologna, Viale Risorgimento 4, 40136, Bologna, Italy; CSGI, University of Firenze, Via della Lastruccia 3, 50019, Sesto Fiorentino, FI, Italy. Electronic address:

During 2020, the COVID-19 pandemic affected almost 10 individuals. Quite a number of vaccines against COVID-19 were therefore developed, and a few recently received authorization for emergency use. Overall, these vaccines target specific viral proteins by antibodies whose synthesis is directly elicited or indirectly triggered by nucleic acids coding for the desired targets. Read More

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Weight Gain After Smoking Cessation and Risk of Major Chronic Diseases and Mortality.

JAMA Netw Open 2021 Apr 1;4(4):e217044. Epub 2021 Apr 1.

School of Social Sciences and Psychology, Western Sydney University, Sydney, Australia.

Importance: Smoking cessation is frequently followed by weight gain; however, whether weight gain after quitting reduces the health benefits of quitting is unclear.

Objective: To examine the association between weight change after smoking cessation and the risk of cardiovascular diseases (CVD), type 2 diabetes, cancer, chronic obstructive pulmonary disease (COPD), and all-cause mortality.

Design, Setting, And Participants: This cohort study analyzed data from a nationally representative sample of Australian adults aged 18 years or older who were studied between 2006 and 2014. Read More

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Analysis of local habitat selection and large-scale attraction/avoidance based on animal tracking data: is there a single best method?

Mov Ecol 2021 Apr 23;9(1):20. Epub 2021 Apr 23.

Institute of Applied Mathematics (IAM) Heidelberg University, Im Neuenheimer Feld 205, Heidelberg, 69120, Germany.

Background: New wildlife telemetry and tracking technologies have become available in the last decade, leading to a large increase in the volume and resolution of animal tracking data. These technical developments have been accompanied by various statistical tools aimed at analysing the data obtained by these methods.

Methods: We used simulated habitat and tracking data to compare some of the different statistical methods frequently used to infer local resource selection and large-scale attraction/avoidance from tracking data. Read More

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Features of Various Bladder Lesions and Their Impact on Clinical Symptoms and Recurrence in Interstitial Cystitis.

J Urol 2021 Apr 23:101097JU0000000000001811. Epub 2021 Apr 23.

Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: We aimed to investigate the impact of various bladder lesions on the clinical symptoms and recurrence of interstitial cystitis (IC).

Materials And Methods: IC patients who underwent transurethral resection and cauterization (TURC) for Hunner lesions (HLs) were enrolled. Features of HLs-non-inflamed, inflamed, and gradually inflamed-and associated cystoscopic findings, including waterfall bleeding (none, focal, or extensive), submucosal hemorrhage, and mucosal streak, were analyzed to investigate their association with preoperative symptoms and recurrence. Read More

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Generalized morphoea in the setting of combined immune checkpoint inhibitor therapy for metastatic melanoma: A case report.

Medicine (Baltimore) 2021 Apr;100(16):e25513

Department of Dermatology, University of Lübeck, Lübeck, Germany.

Rationale: Immune checkpoint inhibition has dramatically altered the therapeutic landscape in the treatment of a range of locally advanced and metastatic skin cancers. In particular, the treatment of metastatic melanoma with combined anti-programmed cell death protein 1 (anti-PD1) and anti-cytotoxic T-lymphocyte-associated protein 4 (anti-CTLA4) antagonists has resulted in median 5-year survival rates of over 50%. However, combined immune checkpoint inhibitor therapy frequently results in the development of immune-related adverse events (irAE) which can be severe and life-threatening. Read More

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Chemotherapy-induced CDA expression renders resistant non-small cell lung cancer cells sensitive to 5'-deoxy-5-fluorocytidine (5'-DFCR).

J Exp Clin Cancer Res 2021 Apr 19;40(1):138. Epub 2021 Apr 19.

Department of General Thoracic Surgery, Inselspital, Bern University Hospital, Murtenstrasse 50, 3008, Bern, Switzerland.

Background: Pemetrexed (MTA) plus cisplatin combination therapy is considered the standard of care for patients with advanced non-small-cell lung cancer (NSCLC). However, in advanced NSCLC, the 5-year survival rate is below 10%, mainly due to resistance to therapy. We have previously shown that the fraction of mesenchymal-like, chemotherapy-resistant paraclone cells increased after MTA and cisplatin combination therapy in the NSCLC cell line A549. Read More

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Similar EEG Activity Patterns During Experimentally-Induced Auditory Illusions and Veridical Perceptions.

Front Neurosci 2021 1;15:602437. Epub 2021 Apr 1.

Experimental Psychology Lab, Department of Psychology, European Medical School, Cluster of Excellence "Hearing4All," Carl von Ossietzky University, Oldenburg, Germany.

Hallucinations and illusions are two instances of perceptual experiences illustrating how perception might diverge from external sensory stimulations and be generated or altered based on internal brain states. The occurrence of these phenomena is not constrained to patient populations. Similar experiences can be elicited in healthy subjects by means of suitable experimental procedures. Read More

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Dietary-challenged mice with Alzheimer-like pathology show increased energy expenditure and reduced adipocyte hypertrophy and steatosis.

Aging (Albany NY) 2021 Apr 16;13. Epub 2021 Apr 16.

Department of Endocrinology and Metabolism, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 10117, Germany.

Alzheimer's disease (AD) is frequently accompanied by progressing weight loss, correlating with mortality. Counter-intuitively, weight loss in old age might predict AD onset but obesity in midlife increases AD risk. Furthermore, AD is associated with diabetes-like alterations in glucose metabolism. Read More

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Does Tc-tilmanocept, as next generation radiotracer, meet with the requirements for improved sentinel node imaging?

Rev Esp Med Nucl Imagen Mol 2021 Apr 13. Epub 2021 Apr 13.

Sección de Medicina Nuclear & Laboratorio de Imagen Molecular Intervencionista, Departamento de Radiología, Centro Médico Universidad de Leiden, Leiden, Países Bajos; Departamento de Radiología y Medicina Nuclear, Hospital Onze Lieve Vrouwe Gasthuis, Ámsterdam, Países Bajos.

Introduction And Objectives: To evaluate the migration of Tc-tilmanocept from the injection site (IS) as well as the uptake in sentinel nodes (SNs) and non-SNs for lymphatic mapping in patients with breast cancer and melanoma, scheduled for SN biopsy after interstitial tracer administration.

Materials And Methods: For 29 primary tumours in 28 patients (mean age: 62y, range: 45-81y) scheduled for SN biopsy planar images were acquired 10 and 120 min after administration of 74 MBq Tc-tilmanocept, in order to evaluate lymphatic drainage as well as uptake ratios between injection site (IS), SN and non-SN. SPECT/CT was performed immediately after delayed planar images to enable anatomical lymph node localization. Read More

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Selenium alleviates the negative effect of heat stress on myogenic differentiation of C2C12 cells with the response of selenogenome.

J Therm Biol 2021 Apr 12;97:102874. Epub 2021 Feb 12.

Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, Sichuan, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Chengdu, Sichuan, China. Electronic address:

With the globe warming, heat stress (HS) has frequently affected animal production. Selenium (Se) is an essential trace element for animals and exerts most of its biological functions through selenoproteins. We previously demonstrated that the damage to C2C12 cells by HS accompanied with the response of selenoprotein encoding genes and proteins. Read More

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[Childhood Cancer Patients in a Family-Oriented Rehabilitation Program: Goals and Change in Physical Functioning].

Rehabilitation (Stuttg) 2021 Apr 15;60(2):124-131. Epub 2021 Apr 15.

Institut und Poliklinik für Medizinische Psychologie, Universitätsklinikum Hamburg-Eppendorf, Deutschland.

Purpose: Childhood cancer often leads to physical and psychosocial burdens that can persist beyond the end of treatment. Family-oriented rehabilitation programs (FOR) focus on long-term consequences and support families in returning to daily life. The objectives of this study were to describe rehabilitation goals and goal attainment, to analyze the relationship between physical functioning and physical well-being and to examine predictors of changes in physical functioning during the FOR. Read More

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Anti-neutrophil cytoplasmic antibody associated glomerulonephritis complicating treatment with hydralazine.

Kidney Int 2021 Apr 20. Epub 2021 Apr 20.

Department of Pathology, Columbia University Irving Medical Center, New York, New York, USA.

Hydralazine, a widely used therapy for hypertension and heart failure, can elicit autoimmune disease, including anti-neutrophil cytoplasmic antibody associated glomerulonephritis (ANCA-GN). We identified 80 cases of ANCA-GN complicating treatment with hydralazine, accounting for 4.3% (80/1858 biopsies) of ANCA-GN diagnosed between 2006 and 2019. Read More

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