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Occurrence of parabens in outdoor environments: Implications for human exposure assessment.

Environ Pollut 2021 Apr 1;282:117058. Epub 2021 Apr 1.

International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, 150090, China; Heilongjiang Provincial Key Laboratory of Polar Environment and Ecosystem (HPKL-PEE), Harbin, 150090, China. Electronic address:

Parabens (PBs) are widely used as preservatives in food, pharmaceuticals and personal care products (PCPs). Due to their potential characteristics, similar to endocrine-disrupting compounds, their safety in our daily products and frequent exposure to human health have become public concerns. Nevertheless, little information is available about the occurrence of PBs in outdoor environments and their implications for human exposure. Read More

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Iron deficiency is associated with impaired biventricular reserve and reduced exercise capacity in patients with unexplained dyspnea.

J Card Fail 2021 Apr 7. Epub 2021 Apr 7.

Department of Cardiology, Hartcentrum, Jessa Hospital, Hasselt, Belgium; Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium.

Background: Iron deficiency (ID) is frequent and associated with diminished exercise capacity in heart failure (HF), but its contribution to unexplained dyspnea without a HF diagnosis at rest remains unclear.

Methods: Consecutive patients with unexplained dyspnea and normal echocardiography and pulmonary function tests at rest underwent prospective standardized cardiopulmonary exercise testing with echocardiography (CPETecho) in a tertiary care dyspnea clinic. ID was defined as ferritin <300µg/l and transferrin saturation (TSAT)<20% and its impact on peak oxygen uptake (peakVO), biventricular response to exercise, and peripheral oxygen extraction was assessed. Read More

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A long-term follow-up study of minimally invasive Ivor Lewis esophagectomy with linear stapled anastomosis.

Surg Endosc 2021 Apr 9. Epub 2021 Apr 9.

Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Background: Minimally invasive esophagectomy (MIE) is increasingly performed to expect lower complication rate compared to open esophagectomy. Studies of minimally invasive Ivor Lewis esophagectomy (MIILE) with circular staplers have reported better outcomes compared to MIE with cervical anastomosis, but frequent anastomotic complications have also been reported. MIILE with linear staplers is a promising alternative, but the long-term functional and oncological outcomes are uncertain. Read More

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Successful transition from insulin to sulfonylurea, on second attempt, in a 24-year-old female with neonatal diabetes secondary to KCNJ11 gene mutation.

BMJ Case Rep 2021 Apr 9;14(4). Epub 2021 Apr 9.

Endocrinology, Mater Misericordiae University Hospital, Dublin, Ireland.

Neonatal diabetes (NDM) is defined as diabetes that occurs in the first 6 months of life, the majority of cases are due to sporadic mutations. ATP-sensitive potassium channels located in the beta cells of the pancreas play a major role in insulin secretion and blood glucose homeostasis. Mutations that alter the function of these channels may lead to NDM. Read More

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"Hyperglycemia aversiveness": Investigating an overlooked problem among adults with type 1 diabetes.

J Diabetes Complications 2021 Mar 29:107925. Epub 2021 Mar 29.

Department of Family and Community Medicine, University of California, San Francisco, CA, United States of America.

Aims: To investigate the problem of adults with type 1 diabetes (T1D) who purposefully keep their glucose levels low, and to explore contributors to, and possible impact of, this potentially dangerous phenomenon.

Methods: We developed three self-report items as a means to identify individuals who endorse a consistent preference for hypoglycemia over hyperglycemia ("Hyperglycemia Aversives"). In a large T1D survey (n = 219), validated measures of well-being, emotional distress and hypoglycemic awareness, and glycemic metrics derived from the past 14-day period, were used to examine whether Hyperglycemia Aversives could be characterized as a distinct group. Read More

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Longitudinal study of prosthesis use in veterans with upper limb amputation.

Prosthet Orthot Int 2021 Feb;45(1):26-35

1Research Department, Providence VA Medical Center, Providence, RI, USA 2Health Services, Policy and Practice, Brown University, Providence, RI, USA 3University of Massachusetts Medical School, Worcester, MA, USA.

Background: Little is known about the patterns of prosthesis use and satisfaction of those who cease use or begin to use upper limb prostheses.

Objectives: Among a longitudinal sample of Veterans with upper limb amputation, (1) describe changes in prosthesis use over 1 year, (2) examine rates of receipt of new prostheses, and (3) compare prosthesis satisfaction in respondents who received a new prosthesis to those who did not.

Study Design: Longitudinal survey. Read More

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February 2021

Ambulatory Patients with Cardiometabolic Disease and Without Evidence of COVID-19 During the Pandemic. The CorCOVID LATAM Study.

Glob Heart 2021 Feb 17;16(1):15. Epub 2021 Feb 17.

Queen's University, CA.

Background: SARS-CoV-2 pandemic has modified the cardiovascular care of ambulatory patients. The aim of this survey was to study changes in lifestyle habits, treatment adherence, and mental health status in patients with cardiometabolic disease, but no clinical evidence of COVID-19.

Methods: A cross-sectional survey was conducted in ambulatory patients with cardiometabolic disease using paper/digital surveys. Read More

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February 2021

Clinical Features and Prognostic Factors of 245 Portuguese Patients Hospitalized With COVID-19.

Cureus 2021 Mar 4;13(3):e13687. Epub 2021 Mar 4.

Infectious Diseases Department, Centro Hospitalar Vila Nova De Gaia, Vila Nova De Gaia, PRT.

Introduction Since the declaration of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in March 2020, Portugal was considered a role model with regards to the first COVID-19 wave. However, a third wave started in 2021 started, turning the country into the worst in the world regarding new infections and death rate per capita in the last weeks of January 2021. No significant data regarding the country's first wave of hospitalized patients have been published. Read More

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How Can a Multidisciplinary Approach Improve Prognosis of Soft-Tissue Sarcomas of Extremities?

Int J Surg Oncol 2021 24;2021:8871557. Epub 2021 Mar 24.

Department of Pathology, Hassan II University Hospital, Fez, Morocco.

Soft-tissue sarcomas are malignant tumors that require good management within specialized centers. Our study aims to assess the benefit of handling these kinds of tumors using the Multidisciplinary Meeting (MDM) approach. The current paper details this approach through a prospective study that has lasted for 42 months in the HASSAN II University Hospital Center, Fez, Morocco. Read More

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A 4-year epidemiological injury analysis in a Japanese male professional basketball team in terms of racial differences in injury patterns.

J Rural Med 2021 Apr 1;16(2):67-71. Epub 2021 Apr 1.

Department of Orthopaedic Surgery, Ibaraki Prefectural University of Health Sciences, Japan.

To analyze injury patterns in a male Japanese professional basketball team of this new league, with a particular focus on the difference between injuries of Asian and non-Asian players. During four basketball seasons, we analyzed all injuries in a B2 league team. We investigated the injury rate (IR), game injury rate (GIR), practice injury rate (PIR), pathology, and body area of each injury. Read More

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Favorable Response to Long-Term Azithromycin Therapy in Bronchiectasis Patients with Chronic Airflow Obstruction Compared to Chronic Obstructive Pulmonary Disease Patients without Bronchiectasis.

Int J Chron Obstruct Pulmon Dis 2021 30;16:855-863. Epub 2021 Mar 30.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Purpose: Long-term macrolide treatment is recommended for patients with chronic obstructive pulmonary disease (COPD) with frequent exacerbations. Bronchiectasis is a common comorbid condition in patients with COPD, for which long-term azithromycin is effective in preventing exacerbation. This study aimed to compare the effect of long-term azithromycin between bronchiectasis patients with chronic airflow obstruction (CAO) and COPD patients without bronchiectasis. Read More

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The effect of cellphone position on driving and gaze behaviour.

Sci Rep 2021 Apr 8;11(1):7692. Epub 2021 Apr 8.

University of Auckland, 85 Park Rd., Grafton, Auckland, 1023, New Zealand.

Legislation frequently restricts the use of cellphones while driving. Despite this, many people continue to interact with cellphones covertly while driving, typically by concealing their device in their lap. This strategy leads to frequent diversion of the drivers' gaze from the road ahead, potentially reducing their driving performance. Read More

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Tobacco mythbusting-tobacco is not a major driver of foot traffic in low socio-economic small retail stores.

Tob Control 2021 Apr 8. Epub 2021 Apr 8.

School of Population and Global Health, The University of Western Australia, Perth, Western Australia, Australia.

Background: One of the opposing arguments to restricting or banning the sale of tobacco products stem from a perception that this would adversely impact on small retail stores that rely on tobacco sales for viability. It has also been argued that purchases of tobacco leads to unplanned purchasing of other items that yield income for small store owners. This study tested the veracity of these arguments in the Australian context. Read More

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Comparison and clinical characteristics of COVID-19 between January and February 2020 in Wuhan, China.

Ann Palliat Med 2021 Mar 23. Epub 2021 Mar 23.

Department of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, China.

Background: Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) continues to make a deadly impact on human life all over the world. Therefore, we aimed to analyze the changes in clinical characteristics of coronavirus disease 2019 (COVID-19) patients over time.

Methods: We recruited 896 patients who were admitted to the Renmin Hospital of Wuhan University between 30th January 2020 and 16st March 2020. Read More

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[Assessment of Computed Tomography Sagittal Images for Early Diagnosis of Pulmonary Torsion after Lung Resection].

Kyobu Geka 2021 Mar;74(3):191-195

Department of Thoracic Surgery Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.

The incidence of postoperative pulmonary torsion is not frequent but it has a high mortality rate once it occurs, and prompt diagnosis and treatment are required. From past reports, it is considered effective to point out disruption of pulmonary blood flow by contrast-enhanced computed tomography (CT) examination for diagnosis. However, the comparison of pre- and post-operative plain CT images is considered to be useful in diagnosing lung torsion, and postoperative CT lung window setting sagittal images were examined in three cases of postoperative lung torsion. Read More

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Sick building syndrome among healthcare workers and healthcare associates at observed general hospital in Slovenia.

Cent Eur J Public Health 2021 Mar;29(1):28-37

Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Objective: The aim of this study was to assess the possible associations between self-perceived sick building syndrome (SBS) symptoms among healthcare workers and healthcare associates and self-perceived parameters of indoor work environment quality.

Methods: The cross-sectional study was conducted from February to April 2019. Validated standardized evaluation tools (MM 040 NA Hospital 2007 and MM 040 NA Office 2007) were used for estimating the prevalence of SBS among observed populations. Read More

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Elevated serum calprotectin (S100A8/A9) in patients with severe asthma.

J Asthma 2021 Apr 8:1-9. Epub 2021 Apr 8.

Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium.

Asthma is a heterogeneous disease consisting of several inflammatory phenotypes of which neutrophilic asthma is associated with poorer responses to classic therapies, namely (inhaled) corticosteroids. The development of targeted therapies requires the identification of biomarkers to distinguish these phenotypes. Currently, we lack validated biomarkers for non-eosinophilic asthma. Read More

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Association of Obesity with Worse Operative and Oncologic Outcomes for Patients Undergoing Gastric Cancer Resection.

Ann Surg Oncol 2021 Apr 8. Epub 2021 Apr 8.

Gastric and Mixed Tumor Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Background: How obesity has an impact on operative and oncologic outcomes for gastric cancer patients is unclear, and the influence of obesity on response to neoadjuvant chemotherapy (NAC) has not been evaluated.

Methods: Patients who underwent curative gastrectomy for primary gastric cancer between 2000 and 2018 were retrospectively identified. After stratification for NAC, operative morbidity, mortality, overall survival (OS), and disease-specific survival (DSS) were compared among three body mass index (BMI) categories: normal BMI (< 25 kg/m), mild obesity (25-35 kg/m), and severe obesity (≥ 35 kg/m). Read More

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Evaluation of Change of Peak Expiratory Flow Rate (PEFR) in Male Chronic Obstructive Pulmonary Diseased (COPD) Patients.

Mymensingh Med J 2021 Apr;30(2):351-354

Dr Afroza Sharmin, Lecturer, Department of Physiology, Mymensingh Medical College (MMC), Mymensingh, Bangladesh; E-mail:

Chronic obstructive pulmonary disease (COPD) is a major public health problem which causes high health care utilizations, poor health-related quality of life, and substantial cost burden and deaths in worldwide. This study was done to evaluate the changes of peak expiratory flow rate (PEFR) in COPD patients in comparison to healthy person. This analytical type of cross sectional study was carried out in the Department of Physiology, Mymensingh Medical College, Mymensingh, Bangladesh from July 2018 to June 2019. Read More

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Characteristics and outcomes of COVID-19 pneumonia in pregnancy compared with infected nonpregnant women.

Int J Gynaecol Obstet 2021 Apr 8. Epub 2021 Apr 8.

Department of Obstetrics and Gynecology, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Objective: To compare the clinical and paraclinical features and outcomes of pregnant and nonpregnant women with COVID-19.

Methods: A multicenter retrospective cohort study of pregnant and nonpregnant women of reproductive age hospitalized between March and October 2020 in Tehran, Iran. Medical records were reviewed and women who tested positive for SARS-CoV-2 on RT-PCR were included. Read More

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Molecular Characterization of "True" Low-Grade IDH-Wildtype Astrocytomas.

J Neuropathol Exp Neurol 2021 Apr 7. Epub 2021 Apr 7.

From the Department of Pathology and Laboratory Medicine and Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health San Antonio, San Antonio, Texas, USA (TER, JMW); Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA (KJH).

Numerous recent studies have demonstrated that the vast majority of IDH-wildtype astrocytomas with WHO grade II/III histology have clinical outcomes equivalent to IDH-wildtype glioblastomas. This has called into question the existence of an IDH-wildtype lower-grade astrocytoma (LGA) category, and the cIMPACT-NOW study group has suggested 3 molecular features which, if present, warrant upgrading IDH-wildtype LGA to glioblastoma: EGFR amplification, 7+/10-, and TERT promoter mutation. Herein, we evaluate the clinical, histologic, and molecular features of IDH-wildtype low-grade astrocytomas, defined here as infiltrative adult astrocytoma lacking histologic features of glioblastoma (microvascular proliferation and/or necrosis), IDH1/2 mutation, and all 3 of the cIMPACT-NOW update 3 factors. Read More

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CBCT-Based Adaptive Assessment Workflow for Intensity Modulated Proton Therapy for Head and Neck Cancer.

Int J Part Ther 2021 15;7(4):29-41. Epub 2021 Mar 15.

Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, FL, USA.

Purpose: Anatomical changes and patient setup uncertainties during intensity modulated proton therapy (IMPT) of head and neck (HN) cancers demand frequent evaluation of delivered dose. This work investigated a cone-beam computed tomography (CBCT) and deformable image registration based therapy workflow to demonstrate the feasibility of proton dose calculation on synthetic computed tomography (sCT) for adaptive IMPT treatment of HN cancer.

Materials And Methods: Twenty-one patients with HN cancer were enrolled in this study, a retrospective institutional review board protocol. Read More

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Evolution of Pathology Patterns in Persons Who Died From COVID-19 in Italy: A National Study Based on Death Certificates.

Front Med (Lausanne) 2021 22;8:645543. Epub 2021 Mar 22.

Statistical Service, Istituto Superiore di Sanità, Rome, Italy.

In Italy, during the first epidemic wave of 2020, the peak of coronavirus disease 2019 (COVID-19) mortality was reached at the end of March. Afterward, a progressive reduction was observed until much lower figures were reached during the summer, resulting from the contained circulation of SARS-CoV-2. This study aimed to determine if and how the pathological patterns of the individuals deceased from COVID-19 changed during the phases of epidemic waves in terms of: (i) main cause of death, (ii) comorbidities, and (iii) complications related to death. Read More

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Rhinovirus: A Narrative Review on Its Genetic Characteristics, Pediatric Clinical Presentations, and Pathogenesis.

Front Pediatr 2021 22;9:643219. Epub 2021 Mar 22.

Departement of Emergency and Pediatrics, Louis-Mourier Hospital, APHP, Colombes, France.

Human rhinoviruses (HRVs) are the leading cause of common colds. With the development of new molecular methods since the 2000s, HRVs have been increasingly involved among severe clinical infections. Recent knowledge of the HRV genetic characteristics has also improved the understanding of their pathogenesis. Read More

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Microsaccade generation requires a foveal anchor.

J Eye Mov Res 2020 May 16;12(6). Epub 2020 May 16.

State University of New York, Downstate Brooklyn, NY, USA.

Visual scene characteristics can affect various aspects of saccade and microsaccade dynamics. For example, blank visual scenes are known to elicit diminished saccade and microsaccade production, compared to natural scenes. Similarly, microsaccades are less frequent in the dark. Read More

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Coping Behaviors and Psychological Disturbances in Youth Affected by the COVID-19 Health Crisis.

Front Psychol 2021 22;12:565657. Epub 2021 Mar 22.

Health Psychology Department, Universidad Miguel Hernández, Elche, Spain.

The COVID-19 pandemic and the quarantine undergone by children in many countries is a stressful situation about which little is known to date. Children and adolescents' behaviors to cope with home confinement may be associated with their emotional welfare. The objectives of this study were: (1) to examine the coping strategies used out by children and adolescents during the COVID-19 health crisis, (2) to analyze the differences in these behaviors in three countries, and (3) to examine the relationship between different coping modalities and adaptation. Read More

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Evaluation of adding the Erector spinae plane block to standard anesthetic care in patients undergoing posterior lumbar interbody fusion surgery.

Sci Rep 2021 Apr 7;11(1):7631. Epub 2021 Apr 7.

Department of Anesthesiology, Intensive Care and Pain Medicine, Catharina Hospital, Michelangelolaan 2, 5623 EJ, Eindhoven, The Netherlands.

Postoperative analgesia in patients undergoing spinal fusion surgery is challenging due to the invasiveness of the surgical procedure and the frequent use of opioids preoperatively by many patients. Recently, the erector spinae plane (ESP) block has been introduced in our clinical practice as part of a multimodal pain strategy after posterior lumbar interbody fusion surgery. This is a retrospective case-control study evaluating the analgesic efficacy of the ESP block when added to our standard analgesic regimen for posterior lumbar interbody fusion surgery. Read More

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Different Zn loading in Urea-Formaldehyde influences the N controlled release by structure modification.

Sci Rep 2021 Apr 7;11(1):7621. Epub 2021 Apr 7.

National Nanotechnology Laboratory for Agribusiness (LNNA), Embrapa Instrumentação, XV Novembro Street, CP: 741, São Carlos, SP, 13560-206, Brazil.

Nitrogen fertilization has been a critical factor for high crop productivity, where urea is currently the most used N source due to its high concentration and affordability. Nevertheless, urea fast solubilization leads to frequent losses and lower agronomic efficiency. The modification of urea structure by condensation with formaldehyde has been proposed to improve nutrient uptake by plants and to reduce environmental losses. Read More

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Topical ophthalmic atropine in horses, pharmacokinetics and effect on intestinal motility.

BMC Vet Res 2021 Apr 7;17(1):149. Epub 2021 Apr 7.

Department of Biomedicine and Veterinary Public Health, Division of Pharmacology and Toxicology, Swedish University of Agricultural Sciences, P.O. Box 7028, SE-750 07, Uppsala, Sweden.

Background: Topical ophthalmic atropine sulfate is an important part of the treatment protocol in equine uveitis. Frequent administration of topical atropine may cause decreased intestinal motility and colic in horses due to systemic exposure. Atropine pharmacokinetics are unknown in horses and this knowledge gap could impede the use of atropine because of the presumed risk of unwanted effects. Read More

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Cerebral embolic protection devices during transcatheter aortic valve implantation, the current state of the art.

Acta Cardiol 2021 Apr 8:1-8. Epub 2021 Apr 8.

Department of Cardiology, Memorial Ankara Hospital, Ankara, Turkey.

Stroke after transcatheter aortic valve (TAVI) is a devastating adverse event. The majority of these occur in the acute phase following TAVI where cerebral embolic events are frequent. Cerebral embolic protection devices (CEPD) have been developed to minimise the risk of peri-procedural ischaemic stroke during TAVI. Read More

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