J Clin Psychopharmacol 2021 Apr 8. Epub 2021 Apr 8.
From the Division of Clinical Pharmacology, Department of Medicine Division of Epidemiology and Biostatistics, Department of Global Health, Faculty of Medicine and Health Sciences, Stellenbosch University Computational Biology Division, Integrative Biomedical Sciences Wellcome Centre for Infectious Disease Research in Africa, Institute of Infectious Diseases and Molecular Medicine Centre for Infectious Disease Epidemiology Research, School of Public Health and Family Medicine, University of Cape Town Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Background: Clozapine may cause life-threatening hematological side effects (HSEs). Hematological side effect incidence data from Sub-Saharan Africa are lacking. Furthermore, clozapine reduces cellular immunity, and it is unknown whether clozapine is a risk factor for tuberculosis or whether HIV is a risk factor for developing HSEs. Read More