Neurobiol Learn Mem 2021 May 18;183:107458. Epub 2021 May 18.
Texas A&M University Institute for Neuroscience, Texas A&M University, College Station, TX 77843-4235, United States; Department of Psychological & Brain Sciences, Texas A&M University, College Station, TX 77843-4235, United States. Electronic address:
Considerable work indicates that instrumental responding is context-dependent, but the neural mechanisms underlying this phenomenon are poorly understood. Given the important role for the hippocampal formation in contextual processing, we hypothesized that reversible inactivation of the hippocampus would impair the context-dependence of active avoidance. To test this hypothesis, we used a two-way signaled active avoidance (SAA) task that requires rats to shuttle across a divided chamber during a tone CS in order to avoid a footshock US. Read More