BMC Bioinformatics 2021 Apr 20;22(1):203. Epub 2021 Apr 20.
Institute of Quantitative and Theoretical Biology, Heinrich Heine University, Universitätsstr. 1, 40225, Düsseldorf, Germany.
Background: Computational mathematical models of biological and biomedical systems have been successfully applied to advance our understanding of various regulatory processes, metabolic fluxes, effects of drug therapies, and disease evolution and transmission. Unfortunately, despite community efforts leading to the development of SBML and the BioModels database, many published models have not been fully exploited, largely due to a lack of proper documentation or the dependence on proprietary software. To facilitate the reuse and further development of systems biology and systems medicine models, an open-source toolbox that makes the overall process of model construction more consistent, understandable, transparent, and reproducible is desired. Read More