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Regional Ictal Hyperperfusion in the Contralateral Occipital Area May Be a Poor Prognostic Marker of Anterior Temporal Lobectomy: A SISCOM Analysis of MTLE Cases.

Neuropsychiatr Dis Treat 2021 22;17:2421-2427. Epub 2021 Jul 22.

Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background And Objective: Subtraction of ictal SPECT coregistered to MRI (SISCOM) provides complementary information for detecting the ictal onset zone, especially in patients with MRI-negative focal epilepsy, and provides additional useful information for predicting long-term postresection outcomes. This study sought to investigate the relationship between surgical failure and increased cerebral blood flow (CBF) pattern using SPECT in patients with mesial temporal lobe epilepsy with unilateral hippocampal sclerosis (MTLE-HS).

Methods: Among 42 subjects who underwent anterior temporal lobectomy with amygdalohippocampectomy (ATL-AH) for MTLE-HS, 29 (69. Read More

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Photocurable bioresorbable adhesives as functional interfaces between flexible bioelectronic devices and soft biological tissues.

Nat Mater 2021 Jul 29. Epub 2021 Jul 29.

Chemistry Life Processes Institute, Northwestern University, Evanston, IL, USA.

Flexible electronic/optoelectronic systems that can intimately integrate onto the surfaces of vital organ systems have the potential to offer revolutionary diagnostic and therapeutic capabilities relevant to a wide spectrum of diseases and disorders. The critical interfaces between such technologies and living tissues must provide soft mechanical coupling and efficient optical/electrical/chemical exchange. Here, we introduce a functional adhesive bioelectronic-tissue interface material, in the forms of mechanically compliant, electrically conductive, and optically transparent encapsulating coatings, interfacial layers or supporting matrices. Read More

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Highly efficient and robust noble-metal free bifunctional water electrolysis catalyst achieved via complementary charge transfer.

Nat Commun 2021 Jul 29;12(1):4606. Epub 2021 Jul 29.

Department of Materials Science and Engineering, Perovtronics Research Center, Low Dimensional Carbon Materials Center, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea.

The operating principle of conventional water electrolysis using heterogenous catalysts has been primarily focused on the unidirectional charge transfer within the heterostructure. Herein, multidirectional charge transfer concept has been adopted within heterostructured catalysts to develop an efficient and robust bifunctional water electrolysis catalyst, which comprises perovskite oxides (LaSrCoO, LSC) and potassium ion-bonded MoSe (K-MoSe). The complementary charge transfer from LSC and K to MoSe endows MoSe with the electron-rich surface and increased electrical conductivity, which improves the hydrogen evolution reaction (HER) kinetics. Read More

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Identifying Patients Who May Benefit from Liver Resection Compared to Living Donor Liver Transplantation for Hepatocellular Carcinoma Using F-FDG PET.

World J Surg 2021 Jul 17. Epub 2021 Jul 17.

Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.

Background: This study aimed to assess an oncologic setting where patients with hepatocellular carcinoma (HCC) could benefit from liver resection (LR) compared to living donor liver transplantation (LDLT) using F-fluorodeoxyglucose (FDG) positron emission tomography.

Methods: The consecutive data of patients with HCC who underwent F-FDG PET before LR (LR group, n = 314) and LDLT (LDLT group, n = 65) between 2003 and 2015 were retrospectively analyzed. Tumor F-FDG avidity was quantified as the tumor to liver standardized uptake value ratio (TLR, cut-off value was defined at 2). Read More

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Heteroepitaxial van der Waals semiconductor superlattices.

Nat Nanotechnol 2021 Jul 15. Epub 2021 Jul 15.

Center for Artificial Low Dimensional Electronic Systems, Institute for Basic Science (IBS), Pohang, Korea.

A broad range of transition metal dichalcogenide (TMDC) semiconductors are available as monolayer (ML) crystals, so the precise integration of each kind into van der Waals (vdW) superlattices (SLs) could enable the realization of novel structures with previously unexplored functionalities. Here we report the atomic layer-by-layer epitaxial growth of vdW SLs with programmable stacking periodicities, composed of more than two kinds of dissimilar TMDC MLs, such as MoS, WS and WSe. Using kinetics-controlled vdW epitaxy in the near-equilibrium limit by metal-organic chemical vapour depositions, we achieved precise ML-by-ML stacking, free of interlayer atomic mixing, which resulted in tunable two-dimensional vdW electronic systems. Read More

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Final results of the double-blind placebo-controlled randomized phase 2 LOTUS trial of first-line ipatasertib plus paclitaxel for inoperable locally advanced/metastatic triple-negative breast cancer.

Breast Cancer Res Treat 2021 Jul 15. Epub 2021 Jul 15.

Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Purpose: In LOTUS (NCT02162719), adding the oral AKT inhibitor ipatasertib to first-line paclitaxel for locally advanced/metastatic triple-negative breast cancer (aTNBC) improved progression-free survival (PFS; primary endpoint), with an enhanced effect in patients with PIK3CA/AKT1/PTEN-altered tumors (FoundationOne next-generation sequencing [NGS] assay). We report final overall survival (OS) results.

Methods: Eligible patients had measurable previously untreated aTNBC. Read More

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The impact of preoperative EUS-FNA for distal resectable pancreatic cancer: Is it really effective enough to take risks?

Surg Endosc 2021 Jul 12. Epub 2021 Jul 12.

Division of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.

Background And Aims: Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is frequently used for the preoperative histologic diagnosis of pancreatic cancer. However, debate continues regarding the clinical merits of preoperative EUS-FNA for the management of resectable pancreatic cancer. We aimed to evaluate the benefits and safety of preoperative EUS-FNA for resectable distal pancreatic cancer. Read More

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Electrochemical behaviors of a pincer-type NNN-Fe complex and catalytic H evolution activity.

Chem Commun (Camb) 2021 Jul;57(61):7497-7500

Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.

We describe electrochemical reactivity of a pincer-type [NNN-Fe(tBuNC)3](ClO4)2 complex. Upon electron reduction, the Fe(i) species experienced disproportionation to Fe(0) and Fe(ii). An electron-reduced Fe center dissociated a tBuNC ligand to make an open coordination site, where a proton could be transferred. Read More

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The origin of waste activated sludge affects the enhancement of anaerobic digestion by free nitrous acid pre-treatment.

Sci Total Environ 2021 Jul 3;795:148831. Epub 2021 Jul 3.

Advanced Water Management Centre, The University of Queensland, St Lucia, QLD 4072, Australia.

Anaerobic digestion is a common stabilization method for treating primary sludge (PS) and waste activated sludge (WAS). However, its application is often limited by the degradation of WAS. Recent studies have demonstrated FNA to be an effective pre-treatment for enhancing WAS degradability, while having limited effect on PS degradability. Read More

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In-depth characterization of non-human sialic acid (Neu5Gc) in human serum using label-free ZIC-HILIC/MRM-MS.

Anal Bioanal Chem 2021 Jul 7. Epub 2021 Jul 7.

Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon, 34134, Republic of Korea.

Sialic acid Neu5Gc, a non-human glycan, is recognized as a new harmful substance that can cause vascular disease and cancer. Humans are unable to synthesize Neu5Gc due to a genetic defect that converts Neu5Ac to Neu5Gc, but Neu5Gc is often observed in human biological samples. Therefore, the demand for accurately measuring the amount of Neu5Gc present in human blood or tissues is rapidly increasing, but there is still no method to reliably quantify trace amounts of a non-human sugar. Read More

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Microvascular invasion may be the determining factor in selecting TACE as the initial treatment in patients with hepatocellular carcinoma.

Medicine (Baltimore) 2021 Jul;100(27):e26584

Department of Radiology.

Abstract: The aim of this study was to investigate factors affecting tumor necrosis with transcatheter arterial chemoembolization (TACE). Factors associated with early hepatocellular carcinoma recurrence after curative hepatectomy were also evaluated.Data of 51 patients who underwent surgery after a single session of TACE at a single university hospital were retrospectively analyzed. Read More

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Defined serum-free culture of human infant small intestinal organoids with predetermined doses of Wnt3a and R-spondin1 from surgical specimens.

Pediatr Surg Int 2021 Jul 3. Epub 2021 Jul 3.

Department of Research and Development for Organoids, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

Purpose: Refinement of organoid technology is important for studying physiology and disease of the intestine. We aimed to optimize defined serum-free conditions for human infant small intestinal (SI) organoid culture with predetermined doses of Wnt3a and Rspo1 from surgical specimens. We further assessed whether intestinal specimens could be stored before use as a source of organoids. Read More

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Cytotoxicity, metabolic enzyme inhibitory, and anti-inflammatory effect of Lentinula edodes fermented using probiotic lactobacteria.

J Food Biochem 2021 Jul 1:e13838. Epub 2021 Jul 1.

Department of Food Science and Biotechnology, Gwangju University, Gwangju, Republic of Korea.

We found that the fermented Lentinula edodes (FLE) products exhibited various differences in terms of proximate composition, free sugar, and amino acid. In particular, there were higher levels of ergosterol, and ergothioneine in FLE-Pediococcus pentosaceus (PP) and -Lactobacillus acidophilus (LA) than in the L. edodes (LE) products. Read More

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Chloroplast and mitochondrial DNA editing in plants.

Nat Plants 2021 Jul 1;7(7):899-905. Epub 2021 Jul 1.

Center for Genome Engineering, Institute for Basic Science, Daejeon, Republic of Korea.

Plant organelles including mitochondria and chloroplasts contain their own genomes, which encode many genes essential for respiration and photosynthesis, respectively. Gene editing in plant organelles, an unmet need for plant genetics and biotechnology, has been hampered by the lack of appropriate tools for targeting DNA in these organelles. In this study, we developed a Golden Gate cloning system, composed of 16 expression plasmids (8 for the delivery of the resulting protein to mitochondria and the other 8 for delivery to chloroplasts) and 424 transcription activator-like effector subarray plasmids, to assemble DddA-derived cytosine base editor (DdCBE) plasmids and used the resulting DdCBEs to efficiently promote point mutagenesis in mitochondria and chloroplasts. Read More

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A Planar Millimeter-Wave Resonator-Array to Sense the Permittivity of COP Film with the 5G Handset Back-Cover.

Sensors (Basel) 2021 Jun 24;21(13). Epub 2021 Jun 24.

Department of Information & Telecommunication Engineering, Incheon National University, Incheon 22012, Korea.

In this paper, a new sensor is developed to estimate the dielectric constant of Cyclo Olefin Polymer (COP) film utilizable for 5G mobile phones' multi-layered back-cover. It is featured by the electrical characterization of the thin layer of the COP film at 28 GHz as the material under test (MUT) directly contacting the planar probe (which is an array of resonating patches) and a new meta-surface as metal patterned on the COP film inserted between the planar probe and the 5G multi-layered back-cover for enhanced physical interpretation of the data by way of impedance matching. In this approach to delving into the material, a thin and small meta-surface film with an area of 25. Read More

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Nickelocene as an Air- and Moisture-Tolerant Precatalyst in the Regioselective Synthesis of Multisubstituted Pyridines.

J Org Chem 2021 Jul 30;86(14):9328-9343. Epub 2021 Jun 30.

Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea.

Ni(COD)-catalyzed cycloaddition reactions to access pyridines have been extensively studied. However, this catalyst typically requires drying procedures and inert-atmosphere techniques for the reactions. Herein, we report operationally simple nickel(0) catalysis to access substituted pyridines from various nitriles and 1,6-diynes without the aid of air-free techniques. Read More

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Algorithmic Prediction of Delayed Radiology Turn-Around-Time during Non-Business Hours.

Acad Radiol 2021 Jun 27. Epub 2021 Jun 27.

Radiology and Biomedical Imaging, University of California, San Francisco (UCSF), San Francisco, California 94143. Electronic address:

Rationale And Objectives: Radiology turnaround time is an important quality measure that can impact hospital workflow and patient outcomes. We aimed to develop a machine learning model to predict delayed turnaround time during non-business hours and identify factors that contribute to this delay.

Materials And Methods: This retrospective study consisted of 15,117 CT cases from May 2018 to May 2019 during non-business hours at two hospital campuses after applying exclusion criteria. Read More

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Defect-Free Mechanical Graphene Transfer Using Doping Adhesive Gel Buffer.

ACS Nano 2021 Jun 29. Epub 2021 Jun 29.

School of Advanced Materials Science and Engineering, Sungkyunkwan University (SKKU), 2066 Seobu-ro, Jangan-gu, Suwon-si 16419, Republic of Korea.

The synthesis of uniform low-defect graphene on a catalytic metal substrate is getting closer to the industrial level. However, its practical application is still challenging due to the lack of an appropriate method for its scalable damage-free transfer to a device substrate. Here, an efficient approach for a defect-free, etchant-free, wrinkle-free, and large-area graphene transfer is demonstrated by exploiting a multifunctional viscoelastic polymer gel as a simultaneous shock-free adhesive and dopant layer. Read More

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Protective effects of krill oil on high fat diet-induced cognitive impairment by regulation of oxidative stress.

Free Radic Res 2021 Jun 28:1-11. Epub 2021 Jun 28.

Department of Food Science and Nutrition, Pusan National University, Busan, Republic of Korea.

Consumption of high fat diet (HFD) increases risk of cognitive impairment and memory deficit by elevation of oxidative stress in the brain. In this study, we investigated the protective effects of krill oil (KO) against HFD-induced cognitive impairment in mice. The mice were fed with HFD for 10 weeks, and then KO was orally administered at doses of 100, 200, or 500 mg/kg/d for 4 weeks. Read More

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Stabilization of Chemical-Vapor-Deposition-Grown WS Monolayers at Elevated Temperature with Hexagonal Boron Nitride Encapsulation.

ACS Appl Mater Interfaces 2021 Jul 25;13(26):31271-31278. Epub 2021 Jun 25.

Department of Applied Physics and Applied Mathematics, Columbia University, New York, New York 10027, United States.

Chemical vapor deposition (CVD)-grown flakes of high-quality monolayers of WS can be stabilized at elevated temperatures by encapsulation with several layer hexagonal boron nitride (BN), but to different degrees in the presence of ambient air, flowing N, and flowing forming gas (95% N, 5% H). The best passivation of WS at elevated temperature occurs for -BN-covered samples with flowing N (after heating to 873 K), as judged by optical microscopy and photoluminescence (PL) intensity after a heating/cooling cycle. Stability is worse for uncovered samples, but best with flowing forming gas. Read More

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Effect of capsaicinoids in hot pepper powder on microbial community and free sugar during kimchi fermentation.

J Food Sci 2021 Jul 19;86(7):3195-3204. Epub 2021 Jun 19.

Department of Integrated Biomedical and Life Science, Graduate School, Korea University, Seoul, Republic of Korea.

Effect of capsaicinoids in hot pepper powder (HP) contains various chemical compounds, including capsaicin and dihydrocapsaicin, which are the main ingredients of the spicy taste. To evaluate the effect of HP on the microbial community in kimchi fermentation, kimchi [kimchi-HP, kimchi-HPE and kimchi-HPER made by adding HP, HP alcohol extract (HPE) and HPE residues (HPER)] was fermented at 4°C for 28 days. The pH and titratable acidity of the samples and the number of bacteria changed with fermentation time. Read More

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6-Gingerol Ameliorates Hepatic Steatosis via HNF4α/miR-467b-3p/GPAT1 Cascade.

Cell Mol Gastroenterol Hepatol 2021 Jun 15. Epub 2021 Jun 15.

Metabolism and Nutrition Research Group, Korea Food Research Institute, Wanju-gun, Korea; Division of Food Biotechnology, University of Science and Technology, Daejeon, Korea. Electronic address:

Background & Aims: The development of nonalcoholic fatty liver disease (NAFLD) can be modulated by microRNAs (miRNA). Dietary polyphenols modulate the expression of miRNA such as miR-467b-3p in the liver. In addition, 6-gingerol (6-G), the functional polyphenol of ginger, has been reported to ameliorate hepatic steatosis; however, the exact mechanism involved and the role of miRNA remain elusive. Read More

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An anesthetic management of head and neck cancer reconstructive surgery in a patient having hemophilia A: a case report.

J Dent Anesth Pain Med 2021 Jun 1;21(3):261-268. Epub 2021 Jun 1.

Department of Dental Anesthesiology, School of Dentistry, Seoul National University, Seoul, Republic of Korea.

Hemophilia A is a hemorrhagic disease caused by coagulation factor VIII deficiency. In head and neck cancer surgery, especially during a reconstructive one, complications can occur. These include hematomas due to bleeding which can then lead to flap ischemia, necrosis, and impaired wound healing. Read More

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The Prognosis and Oncological Predictor of Urachal Carcinoma of the Bladder: A Large Scale Multicenter Cohort Study Analyzed 203 Patients With Long Term Follow-Up.

Front Oncol 2021 31;11:683190. Epub 2021 May 31.

Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea.

Aim: This study evaluated the prognosis and survival predictors for bladder urachal carcinoma (UC), based on large scale multicenter cohort with long term follow-up database.

Methods: A total 203 patients with bladder UC treated at 19 hospitals were enrolled. Clinical parameters on carcinoma presentation, diagnosis, and therapeutic methods were reviewed for the primary cancer and for all subsequent recurrences. Read More

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Metabolic signatures of cholesterol biosynthesis and absorption in patients with coronary artery disease.

J Steroid Biochem Mol Biol 2021 Jun 10;212:105940. Epub 2021 Jun 10.

Molecular Recognition Research Center, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea. Electronic address:

Due to the biochemical importance of cholesterol homeostasis in cardiovascular disease (CVD), this study was aimed to identify metabolic signatures of serum sterols according to atherosclerotic CVD severity. Biogically active free cholesterol and its 11 analogues in serum samples obtained from subjects who underwent cardiovascular intervention were quantitatively evaluated by gas chromatography-mass spectrometry (GCMS). Study groups were divided by 29 patients with stable angina (SA), 35 patients with acute coronary syndrome (ACS), and 41 controls. Read More

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Extra disulfide and ionic salt bridge improves the thermostability of lignin peroxidase H8 under acidic condition.

Enzyme Microb Technol 2021 Aug 22;148:109803. Epub 2021 Apr 22.

Department of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST), UNIST-gil 50, Ulsan, 44919, Republic of Korea. Electronic address:

The development of a lignin peroxidase (LiP) that is thermostable even under acidic pH conditions is a main issue for efficient enzymatic lignin degradation due to reduced repolymerization of free phenolic products at acidic pH (< 3). Native LiP under mild conditions (half-life (t) of 8.2 days at pH 6) exhibits a marked decline in thermostability under acidic conditions (t of only 14 min at pH 2. Read More

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Varying undersampling directions for accelerating multiple acquisition magnetic resonance imaging.

NMR Biomed 2021 Jun 10:e4572. Epub 2021 Jun 10.

Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.

In this study, we propose a new sampling strategy for efficiently accelerating multiple acquisition MRI. The new sampling strategy is to obtain data along different phase-encoding directions across multiple acquisitions. The proposed sampling strategy was evaluated in multicontrast MR imaging (T1, T2, proton density) and multiple phase-cycled (PC) balanced steady-state free precession (bSSFP) imaging by using convolutional neural networks with central and random sampling patterns. Read More

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Nanoscale Terahertz Monitoring on Multiphase Dynamic Assembly of Nanoparticles under Aqueous Environment.

Adv Sci (Weinh) 2021 06 24;8(11):e2004826. Epub 2021 Mar 24.

Sensor System Research Centre, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea.

Probing the kinetic evolution of nanoparticle (NP) growth in liquids is essential for understanding complex nano-phases and their corresponding functions. Terahertz (THz) sensing, an emerging technology for next-generation laser photonics, has been developed with unique photonic features, including label-free, non-destructive, and molecular-specific spectral characteristics. Recently, metasurface-based sensing platforms have helped trace biomolecules by overcoming low THz absorption cross-sectional limits. Read More

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How Cerebral Vessel Tortuosity Affects Development and Recurrence of Aneurysm: Outer Curvature versus Bifurcation Type.

J Stroke 2021 May 31;23(2):213-222. Epub 2021 May 31.

Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background And Purpose: Previous studies have assessed the relationship between cerebral vessel tortuosity and intracranial aneurysm (IA) based on two-dimensional brain image analysis. We evaluated the relationship between cerebral vessel tortuosity and IA according to the hemodynamic location using three-dimensional (3D) analysis and studied the effect of tortuosity on the recurrence of treated IA.

Methods: We collected clinical and imaging data from patients with IA and disease-free controls. Read More

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Expression of phosphorylated p21-activated kinase 4 is associated with aggressive histologic characteristics and poor prognosis in patients with surgically treated renal cell carcinoma.

Investig Clin Urol 2021 Jul 17;62(4):399-407. Epub 2021 May 17.

Department of Urology, Chungbuk National University Hospital, College of Medicine, Chungbuk National University, Cheongju, Korea.

Purpose: P21-activated kinase 4 (PAK4), a serine/threonine kinase that regulates a number of fundamental cellular processes, has been suggested as a prognostic factor for various human tumors. The aim of the present study was to evaluate the clinical implications of phospho-Ser474 PAK4 (pPAK4), an activated form of PAK4, in surgically treated renal cell carcinoma (RCC).

Materials And Methods: Samples from 131 patients with surgically treated RCC were immunostained to detect PAK4 and pPAK4. Read More

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