294,613 results match your criteria framework

An Oppositional Tolerance Account for Potential Cognitive Deficits Caused by the Discontinuation of Antidepressant Drugs.

Pharmacopsychiatry 2021 Jul 22. Epub 2021 Jul 22.

Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Dresden, Germany.

Depression is the leading cause of disability worldwide, making antidepressant drugs the most used psychiatric drugs in the USA. Withdrawal effects and rebound symptoms frequently occur after the reduction and/or discontinuation of these drugs. Although these phenomena have been investigated with respect to the clinical symptomatology, no studies have systematically investigated the effects of withdrawal/rebound on general cognition. Read More

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The Management of Orbital Roof Fractures and Defects: A Review.

Ophthalmic Plast Reconstr Surg 2021 Jul 21. Epub 2021 Jul 21.

Orbital and Oculoplastics Department, Sussex Eye Hospital, Brighton and Sussex University Hospitals NHS Trust, Brighton, United Kingdom Department of Neurosurgery, Brighton and Sussex University Hospitals NHS Trust, Brighton, United Kingdom Department of Radiology, Brighton and Sussex University Hospitals NHS Trust, Brighton, United Kingdom Department of Head & Neck Prosthetics, Queen Victoria Hospital NHS Foundation Trust, East Grinstead, United Kingdom.

Purpose: To explore the anatomy, etiopathogenesis, diagnosis and classification, current evidence on intervention and the surgical management of orbital roof fractures and defects (ORFD) for oculoplastic surgeons presented with such cases.

Methods: A review of the current literature through the MEDLINE database using the following search terms: "orbital roof fracture (+treatment/management)," "orbital roof defect (+treatment/management)," "orbital roof erosion (+treatment/management)," "orbital roof repair," "orbital roof," "orbital fracture," "pediatric orbital roof (defect/fracture/erosion)," "orbital anatomy," and "orbital roof anatomy" was conducted. As relatively little has been published on this topic, inclusion criteria were broad and peer-reviewed articles judged to be of clinical importance, relevant to the aims of this review, were included. Read More

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HEDOS - a computational tool to assess radiation dose to circulating blood cells during external beam radiotherapy based on whole-body blood flow simulations.

Phys Med Biol 2021 Jul 22. Epub 2021 Jul 22.

Division of Radiation Biophysics, Department of Radiation Oncology, , Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, UNITED STATES.

We have developed a time-dependent computational framework, HEDOS (HEmatological DOSe), to estimate dose to circulating blood cells from radiation therapy treatment fields for any treatment site. Two independent dynamic models were implemented in HEDOS: one describing the spatiotemporal distribution of blood particles (BPs) in organs and the second describing the time-dependent radiation field delivery. A whole-body blood flow network based on blood volumes and flow rates from ICRP Publication 89 was simulated to produce the spatiotemporal distribution of BPs in organs across the entire body using a discrete-time Markov process. Read More

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A qualitative study exploring the career mindset of a group of early career academic nurses as they deployed 'Habits of Mind' to sustain their career journey.

Nurse Educ Pract 2021 Jul 14;55:103149. Epub 2021 Jul 14.

Vice-Chancellor and Principal, The Vice-Chancellor's Unit, Building 36, University of Wollongong, Australia. Electronic address:

Aim: This study aimed to explore the qualities that sustain a career mindset in a group of early career academics in one Australian university.

Background: Building an academic career is a lengthy, convoluted and complex journey requiring a mindset prepared to make informed and timely decisions. Success is predicated to a large extent on the ability of persons to process information effectively before actions are taken. Read More

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Identifying optimal virtual water management strategy for Kazakhstan: A factorial ecologically-extended input-output model.

J Environ Manage 2021 Jul 20;297:113303. Epub 2021 Jul 20.

School of Environmental Science and Engineering, Xiamen University of Technology, Xiamen, 361024, China. Electronic address:

Virtual water is an important indicator measuring the amount of water needed from the perspective of consumption, which can help decision makers to identify desired system design and optimal management strategy against water resources shortage. In this study, a novel model named as factorial ecologically-extended input-output model (abbreviated as FEIOM) is developed for virtual water management. FEIOM integrates techniques of input-output model (IOM), ecological network analysis (ENA) and factorial analysis (FA) into a general framework. Read More

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A residual network with attention module for hyperspectral information of recognition to trace the origin of rice.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jul 15;263:120155. Epub 2021 Jul 15.

School of Automation Engineering, Northeast Electric Power University, Jilin 132012, China. Electronic address:

In this work, a neural network framework for hyperspectral information recognition was proposed, combined with residual block and convolutional block attention module (CBAM) to enhance the detection performance of hyperspectral for tracing the rice quality. Firstly, the hyperspectral image system was used to obtain the hyperspectral information of the rice. Secondly, due to the small data set, the structure of the residual network was designed based on the characteristics of the hyperspectral information to prevent overfitting the model. Read More

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Leveraging unsupervised image registration for discovery of landmark shape descriptor.

Med Image Anal 2021 Jul 9;73:102157. Epub 2021 Jul 9.

Scientific Computing and Imaging Institute, 72 Central Campus Dr, University of Utah, Salt Lake City, Utah-84112, USA; School of Computing, 50 Central Campus Dr, University of Utah, Salt Lake City, Utah-84112, USA.

In current biological and medical research, statistical shape modeling (SSM) provides an essential framework for the characterization of anatomy/morphology. Such analysis is often driven by the identification of a relatively small number of geometrically consistent features found across the samples of a population. These features can subsequently provide information about the population shape variation. Read More

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A distributed optimisation framework combining natural gradient with Hessian-free for discriminative sequence training.

Neural Netw 2021 May 29;143:537-549. Epub 2021 May 29.

Cambridge University Engineering Department, Trumpington Street, Cambridge, CB2 1PZ, UK. Electronic address:

This paper presents a novel natural gradient and Hessian-free (NGHF) optimisation framework for neural network training that can operate efficiently in a distributed manner. It relies on the linear conjugate gradient (CG) algorithm to combine the natural gradient (NG) method with local curvature information from Hessian-free (HF). A solution to a numerical issue in CG allows effective parameter updates to be generated with far fewer CG iterations than usually used (e. Read More

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Reporting quality of TMS studies in neurological conditions: A critical appraisal of the main gaps, challenges and clinical implications.

J Neurosci Methods 2021 Jul 20;362:109293. Epub 2021 Jul 20.

Department of Biomedical Sciences, University of Sassari, Sassari, Italy.

Transparent reporting of study methods and findings can dramatically expand the reliability and impact of health research. Evidence-based reporting checklists and guidelines, such as those hosted by the EQUATOR network, provide a framework for summarizing statistics, methods and data presentation. While being increasingly used in several research fields, such trend toward better control seems in its infancy in the field of transcranial magnetic stimulation (TMS). Read More

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Timing, duration, and differential susceptibility to early life adversities and cardiovascular disease risk across the lifespan: Implications for future research.

Prev Med 2021 Jul 19:106736. Epub 2021 Jul 19.

Department of Psychology, University of Denver, Denver, CO, United States of America.

Early life adversities (ELA), include experiences such as child maltreatment, household dysfunction, bullying, exposure to crime, discrimination, bias, and victimization, and are recognized as social determinants of cardiovascular disease (CVD). Strong evidence shows exposure to ELA directly impacts cardiometabolic risk in adulthood and emerging evidence suggests there may be continuity in ELA's prediction of cardiometabolic risk over the life course. Extant research has primarily relied on a cumulative risk framework to evaluate the relationship between ELA and CVD. Read More

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NH-MIL-125(Ti) doped CdS/Graphene composite as electro and photo catalyst in basic medium under light irradiation.

Environ Res 2021 Jul 20;200:111719. Epub 2021 Jul 20.

Centre for Nanotechnology Research, Vellore Institute of Technology, Vellore, Tamil Nadu, India. Electronic address:

The development of active electrocatalysts and photocatalysts for hydrogen evolution reaction (HER) and for environmental remediation is a huge challenge. Research is still underway on the development of low-cost catalytic materials with appreciable efficiency for HER. In the present study, a composite of metal organic framework (MOF) with CdS and graphene (NH-MIL-125(Ti)/CdS-graphene) composites were developed with different loadings of graphene material via solvothermal technique. Read More

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A Novel Hierarchical Framework for Measuring the Complexity and Irregularity of Multimodal Speech Signals and Its Application in the Assessment of Speech Impairment in Amyotrophic Lateral Sclerosis.

Panying Rong

J Speech Lang Hear Res 2021 Jul 22:1-19. Epub 2021 Jul 22.

Department of Speech-Language-Hearing: Sciences & Disorders, University of Kansas, Lawrence.

Purpose The purposes of this study are to develop a novel multimodal framework for measuring variability at the muscular, kinematic, and acoustic levels of the motor speech hierarchy and evaluate the utility of this framework in detecting speech impairment in amyotrophic lateral sclerosis (ALS). Method The myoelectric activities of three bilateral jaw muscle pairs (masseter, anterior temporalis, and anterior belly of digastric), jaw kinematics, and speech acoustics were recorded in 13 individuals with ALS and 10 neurologically healthy controls during sentence reading. Thirteen novel measures (six muscular, three kinematic, four acoustic), which characterized two different but interrelated aspects of variability-complexity and irregularity-were derived using linear and nonlinear methods. Read More

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A framework to support the integration of priority setting in the preparedness, alert, control and evaluation stages of a disease pandemic.

Glob Public Health 2021 Jul 22:1-13. Epub 2021 Jul 22.

Reeleder & Associate, Toronto, Canada.

The COVID-19 pandemic, where the need-resource gap has necessitated decision makers in some contexts to ration access to life-saving interventions, has demonstrated the critical need for systematic and fair priority setting and resource allocation mechanisms. Disease outbreaks are becoming increasingly common and priority setting lessons from previous disease outbreaks could be better harnessed to inform decision making and planning for future disease outbreaks. The purpose of this paper is to discuss how priority setting and resource allocation could, ideally, be integrated into the WHO pandemic planning and preparedness framework and used to inform the COVID-19 pandemic recovery plans and plans for future outbreaks. Read More

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Personalized 0D-1D multiscale hemodynamic modeling and wave dynamics analysis of cerebral circulation for an elderly patient with dementia.

Int J Numer Method Biomed Eng 2021 Jul 22:e3510. Epub 2021 Jul 22.

Graduate School of Engineering, Chiba University, Chiba, Japan.

Senile dementia is associated with pronounced alterations in cerebral circulation. A fundamental understanding of intracranial hemodynamics and wave dynamics is essential for assessing dementia risk. Recent findings suggest that higher carotid artery wave intensity (WI) can predict future cognitive impairments in the elderly. Read More

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Canopy Catalysts for Alkyne Metathesis: Investigations into a Bimolecular Decomposition Pathway and the Stability of the Podand Cap.

Chemistry 2021 Jul 22. Epub 2021 Jul 22.

Max-Planck-Institut fur Kohlenforschung, Organometallic Chemistry, GERMANY.

Molybdenum alkylidyne complexes with a trisilanolate podand ligand framework ("canopy catalysts") are the arguably most selective catalysts for alkyne metathesis known to date. Among them, complex 1a endowed with a fence of lateral methyl substituents on the silicon linkers is most reactive, although fairly high loadings are required in certain applications. It is now shown that this catalyst decomposes readily via a bimolecular pathway, which engages the MoºCR entities in a stoichiometric triple bond metathesis event to furnish RCºCR and the corresponding dinuclear complex 8 with a MoºMo core. Read More

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Exploring the factors in information seeking behavior: a perspective from multinational COPD online forums.

Health Promot Int 2021 Jul 19. Epub 2021 Jul 19.

Department of Information Technology and Decision Sciences, G. Brint Ryan College of Business, University of North Texas, Denton, TX, USA.

This research establishes a theoretical framework for evaluating antecedents of the information seeking behaviors of online forum participants with chronic obstructive pulmonary disease (COPD). We evaluated the proposed framework using partial least squares structural equation modeling (PLS-SEM) after gathering data using a cross-sectional survey. We subsequently assessed the framework using importance-performance map analysis (IPMA). Read More

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Grandmothers' care practices in areas of high deprivation of Scotland: the potential for health promotion.

Health Promot Int 2021 Jul 22. Epub 2021 Jul 22.

Usher Institute, University of Edinburgh, Edinburgh EH8 9AG, UK.

In many families grandparents play an essential role by providing secondary care for grandchildren. The family is a key setting for promoting children's health; however, studies describing health initiatives with grandparents are rare. Grandparents could play an important role in promoting health for their grandchildren within their families and communities. Read More

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A face recognition software framework based on principal component analysis.

PLoS One 2021 22;16(7):e0254965. Epub 2021 Jul 22.

University of Waterloo, Waterloo, ON, Canada.

Face recognition, as one of the major biometrics identification methods, has been applied in different fields involving economics, military, e-commerce, and security. Its touchless identification process and non-compulsory rule to users are irreplaceable by other approaches, such as iris recognition or fingerprint recognition. Among all face recognition techniques, principal component analysis (PCA), proposed in the earliest stage, still attracts researchers because of its property of reducing data dimensionality without losing important information. Read More

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The influence of the crowding assumptions in biofilm simulations.

PLoS Comput Biol 2021 Jul 22;17(7):e1009158. Epub 2021 Jul 22.

Laboratory of Computational Systems Biotechnology, École Polytechnique Fédérale de Lausanne, EPFL, Lausanne, Switzerland.

Microorganisms are frequently organized into crowded structures that affect the nutrients diffusion. This reduction in metabolite diffusion could modify the microbial dynamics, meaning that computational methods for studying microbial systems need accurate ways to model the crowding conditions. We previously developed a computational framework, termed CROMICS, that incorporates the effect of the (time-dependent) crowding conditions on the spatio-temporal modeling of microbial communities, and we used it to demonstrate the crowding influence on the community dynamics. Read More

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Spatio-temporal modeling of the crowding conditions and metabolic variability in microbial communities.

PLoS Comput Biol 2021 Jul 22;17(7):e1009140. Epub 2021 Jul 22.

Laboratory of Computational Systems Biotechnology, École Polytechnique Fédérale de Lausanne, EPFL, Lausanne, Switzerland.

The metabolic capabilities of the species and the local environment shape the microbial interactions in a community either through the exchange of metabolic products or the competition for the resources. Cells are often arranged in close proximity to each other, creating a crowded environment that unevenly reduce the diffusion of nutrients. Herein, we investigated how the crowding conditions and metabolic variability among cells shape the dynamics of microbial communities. Read More

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Addressing antimicrobial resistance by improving access and quality of care-A review of the literature from East Africa.

PLoS Negl Trop Dis 2021 Jul 22;15(7):e0009529. Epub 2021 Jul 22.

The Boyd Orr Centre for Population and Ecosystem Health, Institute of Biodiversity, Animal Health & Comparative Medicine, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, United Kingdom.

Universal access to healthcare, including quality medicines, is a fundamental human right but is still out of reach for many in low- and middle-income countries (LMICs). An existing framework capturing variability of access to healthcare in low-resource settings includes the 5 dimensions: availability, accessibility, affordability, adequacy, and acceptability. This framework encompasses key components, including health infrastructure and means to access it as well as service organisation, costs, and factors that influence users' satisfaction. Read More

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ChIP-GSM: Inferring active transcription factor modules to predict functional regulatory elements.

PLoS Comput Biol 2021 Jul 22;17(7):e1009203. Epub 2021 Jul 22.

Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, Virginia, United States of America.

Transcription factors (TFs) often function as a module including both master factors and mediators binding at cis-regulatory regions to modulate nearby gene transcription. ChIP-seq profiling of multiple TFs makes it feasible to infer functional TF modules. However, when inferring TF modules based on co-localization of ChIP-seq peaks, often many weak binding events are missed, especially for mediators, resulting in incomplete identification of modules. Read More

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Evaluating the impact of COVID-19 on the adoption of virtual care in general practice in 20 countries (inSIGHT): rationale and study protocol.

JMIR Res Protoc 2021 Jul 19. Epub 2021 Jul 19.

Institute of Global Health Innovation, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, Institute of Global Health Innovation, Room 1035/7, QEQM Wing, St Mary's Hospital Campus, London, GB.

Background: In recent decades, virtual care has emerged as a promising option to support primary care delivery. However, despite the potential, adoption rates remained low. With the outbreak of COVID-19, it has suddenly been pushed to the forefront of care delivery. Read More

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Evaluating the Feasibility of Continuing Medical Education for Disseminating Emerging Science on the Breast Cancer and Environment Connection.

J Health Commun 2021 Jul 22:1-11. Epub 2021 Jul 22.

Department of Communication, Michigan State University, East Lansing, United States.

Developing continuing medical education (CME) training programs is a strategy for communicating emerging science to health practitioners. This research tests the feasibility of using CME modules for translating and disseminating research findings from the Breast Cancer and Environment Research Program. Recent findings have identified certain windows of susceptibility, like during puberty, in which exposure to endocrine-disrupting chemicals can increase breast cancer risk later in life. Read More

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Outpatient Practice Reactivation in an Integrated Community Practice During the COVID-19 Pandemic.

Telemed J E Health 2021 Jul 22. Epub 2021 Jul 22.

Department of Management Engineering and Consulting, Mayo Clinic, Rochester, Minnesota, USA.

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Ferroptosis-Strengthened Metabolic and Inflammatory Regulation of Tumor-Associated Macrophages Provokes Potent Tumoricidal Activities.

Nano Lett 2021 Jul 22. Epub 2021 Jul 22.

School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, People's Republic of China.

Modulation of tumor-associated macrophages (TAMs) holds promise for cancer treatment, mainly relying on M1 signaling activation and pro-inflammatory promotion. Nevertheless, the antitumor activity is often limited by the anti-inflammatory factors in the tumor microenvironment. Moreover, the metabolic function of TAMs is also critical to tumor progression. Read More

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Extraction of Au(III) by Microbially Reduced Metal-Organic Frameworks.

Langmuir 2021 Jul 22. Epub 2021 Jul 22.

McKetta Department of Chemical Engineering, University of Texas at Austin, Austin, Texas 78712, United States.

Gold is a critical resource in the jewelry and electronics industries and is facing increased consumer demand. Accordingly, methods for its extraction from waste effluents and environmental water sources have been sought to supplement existing mining infrastructure. Redox-mediated treatments, such as Fe(II)-based platforms, offer promise for precipitating soluble Au(III). Read More

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Interplay between Kinetics and Dynamics of Liquid-Liquid Phase Separation in a Protein Solution Revealed by Coherent X-ray Spectroscopy.

J Phys Chem Lett 2021 Jul 22:7085-7090. Epub 2021 Jul 22.

Institut für Angewandte Physik, Universität Tübingen, Auf der Morgenstelle 10, 72076 Tübingen, Germany.

Microscopic dynamics of complex fluids in the early stage of spinodal decomposition (SD) is strongly intertwined with the kinetics of structural evolution, which makes a quantitative characterization challenging. In this work, we use X-ray photon correlation spectroscopy to study the dynamics and kinetics of a protein solution undergoing liquid-liquid phase separation (LLPS). We demonstrate that in the early stage of SD, the kinetics relaxation is up to 40 times slower than the dynamics and thus can be decoupled. Read More

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Emerging Technologies for In Vitro Inhalation Toxicology.

Adv Healthc Mater 2021 Jul 22:e2100633. Epub 2021 Jul 22.

Department of Chemical Engineering, Rayen School of Engineering, Youngstown State University, Youngstown, OH, 44555, USA.

Respiratory toxicology remains a major research area in the 21st century since current scenario of airborne viral infection transmission and pollutant inhalation is expected to raise the annual morbidity beyond 2 million. Clinical and epidemiological research connecting human exposure to air contaminants to understand adverse pulmonary health outcomes is, therefore, an immediate subject of human health assessment. Important observations in defining systemic effects of environmental contaminants on inhalation metabolic dysfunction, liver health, and gastrointestinal tract have been well explored with in vivo models. Read More

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A Framework for the Use of Biological Medicines in the Free State Province, South Africa.

Pharmacoepidemiol Drug Saf 2021 Jul 22. Epub 2021 Jul 22.

Department of Biostatistics, University of the Free State, Bloemfontein, South Africa.

Purpose: The use of biological medicines (BM) has increased worldwide owing to their effectiveness in the treatment of many chronic diseases. However, in South Africa, access to BM remains limited, hence, there is a need to develop strategies that will enable timely access to BM by all patients who need them.

Objective: To develop a framework for the use of BM in South Africa. Read More

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