1,669 results match your criteria fragmentation removal

VCP/p97 cofactor UBXN1/SAKS1 regulates mitophagy by modulating MFN2 removal from mitochondria.

Autophagy 2021 May 9:1-20. Epub 2021 May 9.

Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.

Initiation of PINK1- and PRKN-dependent mitophagy is a highly regulated process involving the activity of the AAA-ATPase VCP/p97, a cofactor-guided multifunctional protein central to handling ubiquitinated client proteins. Removal of ubiquitinated substrates such as the mitofusin MFN2 from the outer mitochondrial membrane by VCP is critical for PRKN accumulation on mitochondria, which drives mitophagy. Here we characterize the role of the UBA and UBX-domain containing VCP cofactor UBXN1/SAKS1 during mitophagy. Read More

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Mechanically Coherent Zeolite 13X/Chitosan Aerogel Beads for Effective CO Capture.

ACS Appl Mater Interfaces 2021 May 26;13(17):20728-20734. Epub 2021 Apr 26.

Dipartimento di Ingegneria Chimica, dei Materiali e della Produzione Industriale (INSTM Consortium-UdR Naples), Università degli Studi di Napoli Federico II, p.le Tecchio 80, Naples 80125, Italy.

The constant increase of CO concentration in the atmosphere is recognized worldwide to severely impact the environment and human health. Zeolites possess a high adsorption capacity for CO removal, but their powdery form prevents their use in many practical applications. When binding agents are used, a partial occlusion of the porosity can severely compromise the adsorption capacity. Read More

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[Diagnosis, treatment and etiology analysis of nerve compression by bone fragment after lumbar spine surgery].

Zhongguo Gu Shang 2021 Apr;34(4):349-53

The Second Department of Orthopaedics, Lihuili Hospital of Ningbo Medical Center, Ningbo 315000, Zhejiang, China.

Objective: To explore the diagnosis, treatment, cause and prevention of nerve compression by bone fragment after lumbar spine surgery.

Methods: The clinical data of 23 patients with nerve compression by bone fragment after lumbar spine surgery from February 2012 to March 2019 were collected retrospectively, including 9 males and 14 females, aged 42 to 81 years with an average of (62.60±5. Read More

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An improved direct metamobilome approach increases the detection of larger-sized circular elements across kingdoms.

Plasmid 2021 May 17;115:102576. Epub 2021 Apr 17.

Department of Environmental Science, Aarhus University, Roskilde, Denmark; Department of Plant and Environmental Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address:

Mobile genetic elements (MGEs) are instrumental in natural prokaryotic genome editing, permitting genome plasticity and allowing microbes to accumulate genetic diversity. MGEs serve as a vast communal gene pool and include DNA elements such as plasmids and bacteriophages (phages) among others. These mobile DNA elements represent a human health risk as they can introduce new traits, such as antibiotic resistance or virulence, to a bacterial strain. Read More

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A Rare Case of Cholecystoduodenal Fistula with Rapid Distal Gallstone Migration.

Am J Case Rep 2021 Apr 19;22:e929150. Epub 2021 Apr 19.

Department of General Surgery, Ascension Michigan Genesys Hospital, Grand Blanc, MI, USA.

BACKGROUND Abnormal communicating channels or fistulas between the gallbladder or common bile duct and the intestine are rare, but have potential to result in serious complications. Further complications can arise with migration of gallstones from the gallbladder to the intestines, causing distal obstruction in the ileum, intestinal hemorrhage, or intestinal perforation. High clinical suspicion is warranted for the diagnosis of Bouveret's syndrome, with anticipation of surgery to prevent distal gallstone migration that would otherwise result in unfavorable patient outcomes. Read More

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Presence of microplastics in drinking water from freshwater sources: the investigation in Changsha, China.

Environ Sci Pollut Res Int 2021 Apr 3. Epub 2021 Apr 3.

Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, 410011, People's Republic of China.

We investigated the abundance of microplastics in freshwater, treated water, and household tap water from the drinking water supply chain in Changsha, China. The abundance was 2173-3998 (mean = 2753), 338-400 (mean = 351.9), and 267-404 (mean = 343. Read More

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A data-independent acquisition approach based on HRMS to explore the biodegradation process of organic micropollutants involved in a biological ion-exchange drinking water filter.

Chemosphere 2021 Mar 13;277:130216. Epub 2021 Mar 13.

NSERC Industrial Chair on Drinking Water, Department of Civil Engineering, Polytechnique School of Montreal, Montreal, QC, Canada.

Drinking water producers continuously develop innovative treatment processes to effectively remove organic micropollutants from raw water. Biological ion-exchange (BIEX) water treatment is one of these new techniques under development and showing great potential. In order to investigate if biodegradation is highly involved in such a removal technique, cultures were prepared with microorganisms sampled on the resins of a BIEX filter. Read More

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The Impacts of Age and Sex in a Mouse Model of Childhood Narcolepsy.

Front Neurosci 2021 4;15:644757. Epub 2021 Mar 4.

Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States.

Narcolepsy is a sleep disorder caused by selective death of the orexin neurons that often begins in childhood. Orexin neuron loss disinhibits REM sleep during the active period and produces cataplexy, episodes of paralysis during wakefulness. Cataplexy is often worse when narcolepsy develops in children compared to adults, but the reason for this difference remains unknown. Read More

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Femtosecond Laser-Assisted Cataract Surgery in Soft and Hard Nuclear Cataracts: A Comparison of Effective Phacoemulsification Time.

Clin Ophthalmol 2021 10;15:1095-1100. Epub 2021 Mar 10.

Ain Shams University, Faculty of Medicine, Ophthalmology Department, Cairo, Egypt.

Purpose: To compare effective phacoemulsification time (EFX) in femtosecond laser-assisted cataract surgery (FLACS) versus traditional quick chop phacoemulsification (QCP) in senile nuclear cataracts with different densities focusing on soft and hard ones.

Patients And Methods: A prospective non-randomized comparative study was carried out in Al Watany Eye Hospital and Ain Shams University Hospital, Cairo, Egypt; 250 eyes with senile nuclear cataract (NC) were included and classified into two main groups, FLACS and QCP groups. Each of them was stratified according to nuclear density into three subgroups, subgroups I (Soft NC), II (Medium NC), and III (Hard NC). Read More

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Management of a Fragmented Angiocatheter During Central Venous Cannulation: A Case Report and Important Lessons.

A A Pract 2021 Mar 17;15(3):e01423. Epub 2021 Mar 17.

From the Department of Anesthesiology, University of Minnesota, Minneapolis, Minnesota.

Complications during central venous catheter (CVC) insertion are infrequent with an incidence of 0.1%-1%. We experienced a rare CVC complication with fragmentation of the angiocatheter at its hub during central venous cannulation while utilizing the modified Seldinger technique (ie, wire through the catheter technique). Read More

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Saltmarsh resilience controlled by patch size and plant density of habitat-forming species that trap shells.

Sci Total Environ 2021 Mar 1;778:146119. Epub 2021 Mar 1.

Department of Coastal Systems, NIOZ Royal Netherlands Institute for Sea Research, Utrecht University, Den Burg, Texel, the Netherlands; Conservation Ecology Group, Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, the Netherlands.

Habitat fragmentaion into small patches is regarded as a vital cause of biodiversity loss. Fragmentationof habitat-forming species is especially harmful, as patchiness of such species often controls ecosystem stability and resilience by density and patch size-dependent self-reinforcing feedbacks. Although fragmentation are expected to weaken or even break such feedbacks, it remains unclear how the resulting patchiness of habitat-forming species affect ecosystem resilience to environmental stresses. Read More

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Modelling the impact of clot fragmentation on the microcirculation after thrombectomy.

PLoS Comput Biol 2021 Mar 12;17(3):e1008515. Epub 2021 Mar 12.

Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, United Kingdom.

Many ischaemic stroke patients who have a mechanical removal of their clot (thrombectomy) do not get reperfusion of tissue despite the thrombus being removed. One hypothesis for this 'no-reperfusion' phenomenon is micro-emboli fragmenting off the large clot during thrombectomy and occluding smaller blood vessels downstream of the clot location. This is impossible to observe in-vivo and so we here develop an in-silico model based on in-vitro experiments to model the effect of micro-emboli on brain tissue. Read More

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Single-use microfluidic device for purification and concentration of environmental DNA from river water.

Talanta 2021 May 21;226:122109. Epub 2021 Jan 21.

International Iberian Nanotechnology Laboratory (INL), Avenida Mestre José Veiga, 4715-310, Braga, Portugal. Electronic address:

Purification and concentration of DNA is a critical step on DNA-based analysis, which should ensure efficient DNA isolation and effective removal of contaminants that may interfere with downstream DNA amplification. Complexity of samples, minute content of target analyte, or high DNA fragmentation greatly entangles the success of this step. To overcome this issue, we designed and fabricated a novel miniaturized disposable device for a highly efficient DNA purification. Read More

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Systematic comparison for effects of different scale mechanical-NaOH coupling treatments on lignocellulosic components, micromorphology and cellulose crystal structure of wheat straw.

Bioresour Technol 2021 Apr 1;326:124786. Epub 2021 Feb 1.

College of Engineering, China Agricultural University, Box 191, Beijing 100083, China. Electronic address:

In order to compare the effect of different mechanical-chemical coupling treatment on wheat straw and provide guidance for the subsequent preparation of cellulose nanomaterials, this paper systematically explored the impact of different scale mechanical fragmentation coupling various NaOH concentration treatment on the lignocellulosic components, micromorphology and cellulose crystal structure of wheat straw. The results showed that the relationship between hemicellulose and lignin removal with NaOH concentration can be expressed as exponential function Y = a(1-exp(-bX)), and micro-nano-scale ball-milling coupling NaOH treatment can facilitate the removal of hemicellulose and lignin. Micromorphology analysis found that wet ball milling coupling NaOH one-step treatment can disintegrate cellulose fiber into crosslinked network structure of cellulose microfibrils. Read More

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Is it safe to remove a dam at the risk of a sprawl by exotic fish species?

Sci Total Environ 2021 Jun 11;771:144768. Epub 2021 Jan 11.

Centro de Investigação e Tecnologias Agroambientais e Biológicas, Universidade de Trás-os-Montes e Alto Douro, Ap 1013, 5001-801 Vila Real, Portugal.

The longitudinal dimension of river connectivity has been significantly disrupted by barriers to compensate for water demand in the long periods of water scarcity in the Iberian Peninsula. The scale of this modification is widespread in the Portuguese part of Douro River network where, side to side with agriculture water demand, there is a constant increase in hydropower production. Thus, native species in Iberian freshwater systems, performing reproductive migrations along the rivers, are strongly affected by the amplification of fragmentation caused by the tremendous density of transversal obstacles in this river basin. Read More

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A neglected double J ureteral stent for 10 years: A rare case report.

Hamdy Aboutaleb

Urol Case Rep 2021 May 13;36:101570. Epub 2021 Jan 13.

Urology Department, 1. Burjeel Hospital, Abu Dhabi, United Arab Emirates.

Complications of Double J stenting (DJS) include migration, fragmentation, and encrustation. In addition, forgotten stents with encrustations and stone formations are difficult to remove. We report the case of a stent "forgotten" for 10 years, concomitant with multiple ureteral stones and bladder calculus. Read More

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Anti-biofouling properties of poly(dimethyl siloxane) with RAFT photopolymerized acrylate/methacrylate surface grafts against model marine organisms.

Biofouling 2021 01 24;37(1):78-95. Epub 2021 Jan 24.

Department of Materials Science and Engineering, University of Florida, Gainesville, FL, USA.

Biofouling of man-made surfaces by marine organisms is a global problem with both financial and environmental consequences. However, the development of non-toxic anti-biofouling coatings is challenged by the diversity of fouling organisms. One possible solution leverages coatings composed of diverse chemical constituents. Read More

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January 2021

Sperm Cryopreservation in American Flamingo (): Influence of Cryoprotectants and Seminal Plasma Removal.

Animals (Basel) 2021 Jan 15;11(1). Epub 2021 Jan 15.

Department of Animal Reproduction, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, (INIA) 28040 Madrid, Spain.

The American flamingo is a useful model for the development of successful semen cryopreservation procedures to be applied to threatened related species from the family Phoenicopteridae, and to permit genetic material banking. Current study sought to develop effective sperm cryopreservation protocols through examining the influences of two permeating cryoprotectants and the seminal plasma removal. During two consecutive years (April), semen samples were collected and frozen from American flamingos. Read More

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January 2021

Removal of acetaminophen through direct electron transfer by reactive MnO: Efficiency, mechanism and pathway.

Sci Total Environ 2021 May 26;769:144377. Epub 2020 Dec 26.

Department of Environmental Science and Engineering, Hubei Environmental Remediation Material Engineering Technology Research Center, School of Resource and Environmental Sciences, Wuhan University, Wuhan 430079, China. Electronic address:

MnO with certain oxidative reactivity, was fabricated via sol-gel method and applied for the removal of acetaminophen (APAP). The mechanism of APAP oxidation was revealed in depth through electrochemical tests and X-ray photoelectron spectroscopy (XPS). Moreover, the selective abatement of various organic contaminants contained different functional groups by MnO was investigated through linear free energy relationship (LFER) estimated with peak potentials (E) of these organic contaminants. Read More

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Ureteral Stent Fracture After Irreversible Electroporation for Treatment of Metastatic Rectal Adenocarcinoma.

J Endourol Case Rep 2020 29;6(4):548-550. Epub 2020 Dec 29.

Beaumont Health, Royal Oak, Michigan, USA.

Irreversible electroporation (IRE) is a soft tissue ablation technique using electrical pulses without thermal energy to create pores in the cell membrane, resulting in death from apoptosis rather than necrosis. Advantages include protection of blood vessels, nerves, and surrounding structures. Documented complications include periprocedure nausea/vomiting, infection, and severe pain. Read More

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December 2020

Simultaneous Holmium Laser Enucleation of Prostate with Removal of the Permanent Prostatic Urethral Stent Using the High-Power Holmium Laser: Technique in Two Cases and Review of the Literature.

J Endourol Case Rep 2020 29;6(4):438-441. Epub 2020 Dec 29.

Department of Urology, Miller School of Medicine, University of Miami, Coral Gables, Florida, USA.

Although the prostatic urethral stents are no longer used in the United States for treatment of prostatomegaly, urologists will encounter patients with complications of previously placed permanent prostatic stents. We report two cases of persistent bothersome lower urinary tract symptoms (LUTS) after prostatic stent placement treated with simultaneous holmium laser enucleation of prostate (HoLEP) with endoscopic removal of the prostatic urethral stent using high-power holmium laser. We also reviewed the literature regarding the removal of prostatic stents with holmium laser combined with surgical management of benign prostatic hyperplasia. Read More

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December 2020

A Rare Complication of Amplatz Sheath: Amplatz Sheath Rupture During Percutaneous Nephrolithotomy.

J Endourol Case Rep 2020 29;6(4):399-401. Epub 2020 Dec 29.

Department of Urology, Yozgat City Hospital, Yozgat, Turkey.

Amplatz sheaths are hollow tubes that serve as the portal for the insertion of the nephroscope during percutaneous nephrolithotomy (PCNL). Breakage of this tube during the procedure is rare, but when it does occur it should be recognized and addressed promptly. A 46-year-old Caucasian male patient was scheduled for PCNL. Read More

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December 2020

Endourologic Treatment of Late Migration of Embolization Causing Nephrolithiasis in Two Patients.

J Endourol Case Rep 2020 29;6(4):278-282. Epub 2020 Dec 29.

Ville Turro Division, Department of Urology, IRCCS San Raffaele Hospital, Milan, Italy.

Selective renal artery angioembolization is the first treatment option in case of significant bleeding after percutaneous nephrolithotomy. Migration of embolization material into the collecting system is extremely rare. The treatment of this condition is not standardized, but manual extraction, ultrasound fragmentation, and holmium laser lithotripsy have been described. Read More

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December 2020

Animal movement in a pastoralist population in the Maasai Mara Ecosystem in Kenya and implications for pathogen spread and control.

Prev Vet Med 2021 Mar 5;188:105259. Epub 2021 Jan 5.

Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, MN, United States.

Livestock movements are important drivers for infectious disease transmission. However, paucity of such data in pastoralist communities in rangeland ecosystems limits our understanding of their dynamics and hampers disease surveillance and control. The aim of this study was to investigate animal movement networks in a pastoralist community in Kenya, and assess network-based strategies for disease control. Read More

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The Impacts of Dam Construction and Removal on the Genetics of Recovering Steelhead () Populations across the Elwha River Watershed.

Genes (Basel) 2021 Jan 13;12(1). Epub 2021 Jan 13.

Northwest Fisheries Science Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, 2725 Montlake Boulevard East, Seattle, WA 98112, USA.

Dam construction and longitudinal river habitat fragmentation disrupt important life histories and movement of aquatic species. This is especially true for that exhibits both migratory (steelhead) and non-migratory (resident rainbow) forms. While the negative effects of dams on salmonids have been extensively documented, few studies have had the opportunity to compare population genetic diversity and structure prior to and following dam removal. Read More

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January 2021

The historical range and drivers of decline of the Tapanuli orangutan.

PLoS One 2021 4;16(1):e0238087. Epub 2021 Jan 4.

Liverpool John Moores University, Liverpool, United Kingdom.

The Tapanuli Orangutan (Pongo tapanuliensis) is the most threatened great ape species in the world. It is restricted to an area of about 1,000 km2 of upland forest where fewer than 800 animals survive in three declining subpopulations. Through a historical ecology approach involving analysis of newspaper, journals, books and museum records from the early 1800s to 2009, we demonstrate that historically Pongo tapanuliensis inhabited a much larger area, and occurred across a much wider range of habitat types and at lower elevations than now. Read More

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Endoscopic holmium laser fragmentation and retrieval of migrated intravesical prolene mesh.

BMJ Case Rep 2020 Dec 22;13(12). Epub 2020 Dec 22.

Urology, All India Institute of Medical Sciences, New Delhi, Delhi, India.

A 52-year-old man presented with lower urinary tract symptoms and intermittent haematuria for the last 6 months. He had undergone totally extraperitoneal right inguinal hernia repair a decade ago. The ultrasonography and an X-ray of the pelvis suggested a large radio-opaque shadow in the bladder. Read More

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December 2020

Structural and compositional characteristics of Fukushima release particulate material from Units 1 and 3 elucidates release mechanisms, accident chronology and future decommissioning strategy.

Sci Rep 2020 12 16;10(1):22056. Epub 2020 Dec 16.

Interface Analysis Centre, School of Physics, University of Bristol, Bristol, BS8 1TL, UK.

The structural form and elemental distribution of material originating from different Fukushima Daiichi Nuclear Power Plant reactors (Units 1 and 3) is hereby examined to elucidate their contrasting release dynamics and the current in-reactor conditions to influence future decommissioning challenges. Complimentary computed X-ray absorption tomography and X-ray fluorescence data show that the two suites of Si-based material sourced from the different reactor Units have contrasting internal structure and compositional distribution. The known event and condition chronology correlate with the observed internal and external structures of the particulates examined, which suggest that Unit 1 ejecta material sustained a greater degree of melting than that likely derived from reactor Unit 3. Read More

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December 2020

Antegrade Therapy for Management of Choledocholithiasis through Endoscopic Ultrasound-Guided Hepaticogastrostomy in a Patient with Surgically Altered Gastrointestinal Anatomy.

Case Rep Gastrointest Med 2020 12;2020:8866899. Epub 2020 Nov 12.

Department of Medicine, Section on Gastroenterology, Wake Forest School of Medicine, Winston-Salem, USA.

Endoscopic ultrasound-guided hepaticogastrostomy (EUS-HG) is a technique used to access the biliary tree in patients with surgically altered anatomy. Additionally, development of EUS-HG fistula permits intraductal therapy, thereby preventing patients from requiring surgery or percutaneous transhepatic biliary drainage (PTBD), thus decreasing morbidity. This clinical vignette describes an 83-year-old man with a history of gangrenous cholecystitis requiring cholecystectomy, partial gastrectomy, and Roux-en-Y gastrojejunostomy who presented to an outside hospital with abdominal pain and fever and found to have cholangitis and choledocholithiasis. Read More

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November 2020

Abundance and characteristics of microplastics in soils with different agricultural practices: Importance of sources with internal origin and environmental fate.

J Hazard Mater 2021 02 18;403:123997. Epub 2020 Sep 18.

Department of Marine Science, College of Natural Sciences, Incheon National University, Academy-ro 119, Yeounsu-gu, Incheon 22012, Republic of Korea.

Despite intensive use of plastics in agriculture, little is known about the occurrence of microplastics (MPs) in agro-environment. To identify the effect of internal sources and environmental fate on MP appearance in farmland, we examined four soil types with different agricultural practices representing either direct application of polyethylene (PE) film-the inside (GS-in) and outside (GS-out) soils of greenhouse and mulch-film use soils (MS)-or rare use of plastics (rice-paddy soils; RS). MP abundance was 10-7630 items kg, with the order of GS-in, GS-out, RS, and MS. Read More

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February 2021