Best Pract Res Clin Obstet Gynaecol 2019 Feb 28;55:49-58. Epub 2018 Jun 28.
Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia; Sir Peter MacCallum Dept of Oncology, The University of Melbourne, Parkville, Victoria, Australia. Electronic address:
Globally, breast cancer is the most common female reproductive cancer. Although alkylating chemotherapy is not part of initial curative-intent treatment in women with other reproductive cancers, it is often used to treat women with curable breast cancer. Chemotherapy-associated ovarian failure (COF) is a potential consequence of this treatment and can cause infertility and increase the risk of cognitive impairment, cardiovascular disease and fractures from reduced bone mineral density. Read More