248 results match your criteria fractures ovarian


Does Compression Sensory Axonopathy in the Proximal Tibia Contribute to Noncontact Anterior Cruciate Ligament Injury in a Causative Way?-A New Theory for the Injury Mechanism.

Life (Basel) 2021 May 14;11(5). Epub 2021 May 14.

Department of Health Sciences and Sport Medicine, University of Physical Education, 1123 Budapest, Hungary.

Anterior cruciate ligament injury occurs when the ligament fibers are stretched, partially torn, or completely torn. The authors propose a new injury mechanism for non-contact anterior cruciate ligament injury of the knee. Accordingly, non-contact anterior cruciate ligament injury could not happen without the acute compression microinjury of the entrapped peripheral proprioceptive sensory axons of the proximal tibia. Read More

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Bone-modifying Agents (BMAs) in Breast Cancer.

Clin Breast Cancer 2021 Apr 26. Epub 2021 Apr 26.

Icahn School of Medicine at Mt Sinai, New York, NY. Electronic address:

Bone-modifying agents (BMAs) are mainstays in breast cancer and prevent and treat osteoporosis in early-stage disease and reduce skeletal metastases complications in advanced disease. There is some evidence to support that BMA also prevents skeletal metastases and improves overall survival. Bone loss occurs with chemotherapy-induced ovarian failure, gonadotrophin-releasing hormone (GnRH) agonists, and aromatase inhibitors. Read More

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New insights into the diagnosis and management of bone health in premature ovarian insufficiency.

Climacteric 2021 May 6:1-10. Epub 2021 May 6.

Department of Endocrinology, Monash Health, Clayton, VIC, Australia.

Premature ovarian insufficiency (POI), defined as a loss of ovarian function before the age of 40 years, is a life-changing diagnosis that has numerous long-term consequences. Musculoskeletal complications, including osteoporosis and fractures, are a key concern for women with POI. The risk of bone loss is influenced by the underlying etiology of POI, and the degree and duration of estrogen deficiency. Read More

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Premature ovarian insufficiency: the need for evidence on the effectiveness of hormonal therapy.

Climacteric 2021 Apr 30:1-6. Epub 2021 Apr 30.

Reproductive Medicine Unit, University College London Hospitals, London, UK.

Premature ovarian insufficiency (POI) - the loss of ovarian function before the age of 40 years, a decade before natural menopause - is a life-changing diagnosis for women. POI causes significant short-term and long-term morbidity related to estrogen deficiency. The condition is managed by providing exogenous estrogen replacement, usually as the oral contraceptive pill or hormone therapy. Read More

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Utility of adjuvant whole abdominal radiation therapy in ovarian clear cell cancer (OCCC): a pragmatic cohort study of women with classic immuno-phenotypic signature.

Radiat Oncol 2021 Feb 6;16(1):29. Epub 2021 Feb 6.

Department of Radiation Oncology, Northern Sydney Cancer Centre, Royal North Shore Hospital, Level 1 ASB Building, St Leonards, NSW, 2065, Australia.

Background: To evaluate the initial experience and clinical utility of first-line adjuvant intensity-modulated whole abdominal radiation therapy (WART) in women with ovarian clear cell cancer (OCCC) referred to an academic center.

Methods: Progression-free and overall survival was analyzed in a pragmatic observational cohort study of histologically pure OCCC patients over-expressing HNF-1ß treated between 2013 and end-December 2018. An in-house intensity-modulated WART program was developed from a published pre-clinical model. Read More

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February 2021

Network pharmacology-based investigation on the mechanisms of action of Morinda officinalis How. in the treatment of osteoporosis.

Comput Biol Med 2020 12 22;127:104074. Epub 2020 Oct 22.

Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, Guangdong, China. Electronic address:

Background: Osteoporosis is a systemic skeletal disease that leads to a high risk for bone fractures. Morinda officinalis How. has been used as osteoporosis treatment in China. Read More

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December 2020

Sarcopenia and adverse health-related outcomes: An umbrella review of meta-analyses of observational studies.

Cancer Med 2020 11 13;9(21):7964-7978. Epub 2020 Sep 13.

Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China.

Objective: The purpose of this umbrella review was to assess the associations between sarcopenia and adverse health-related outcomes.

Design: An umbrella review of meta-analyses of observational studies.

Setting And Participants: Patients with sarcopenia and controls without sarcopenia were included. Read More

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November 2020

Vitamin D, Calcium, Parathyroid Hormone, and Sex Steroids in Bone Health and Effects of Aging.

J Osteoporos 2020 17;2020:9324505. Epub 2020 Jun 17.

Department of Biotechnology, Kathmandu University, Dhulikhel, Nepal.

Bone health of the elderly is a major global health concern, since about 1 in 3 women and 1 in 5 men suffer from bone loss and fractures, often called osteoporosis, in old age. Bone health is a complex issue affected by multiple hormones and minerals. Among all the hormones involved in bone health, calcitriol (also vitamin D), parathyroid, and sex hormones (especially estrogen) have been discussed in this review paper. Read More

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The midlife transition and the risk of cardiovascular disease and cancer Part II: strategies to maximize quality of life and limit dysfunction and disease.

Am J Obstet Gynecol 2020 12 10;223(6):834-847.e2. Epub 2020 Jun 10.

Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, NY.

Chronic dysfunction, disabilities, and complex diseases such as cardiovascular disease, diabetes mellitus type 2, osteoporosis and certain cancers, among other burdens, emerge and accelerate in midlife women. Previously in part l, we described the clinical and laboratory research findings that more readily explain and clarify the underlying pathogenetic mechanisms driving these clinical burdens, including new findings on how in particular visceral obesity and the emergence and acceleration of various components of metabolic syndrome-glucotoxicity and lipotoxicity-and a chronic systemic inflammatory state abetted by the loss of ovarian production of estradiol and the inevitable inroads of aging generate this spectrum of clinical problems. These research insights translate into opportunities for effective care strategies leading to prevention, amelioration, possible correction, and enhanced quality of life. Read More

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December 2020

Estrogen and bones after menopause: a reappraisal of data and future perspectives.

Hormones (Athens) 2021 Mar 9;20(1):13-21. Epub 2020 Jun 9.

2nd Department of Obstetrics and Gynecology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Menopausal hormone therapy (MHT) is effective in preventing menopause-related bone loss and decreasing vertebral, non-vertebral and hip fracture risk. MHT contains estrogens that exert both antiosteoclastic and osteoanabolic effects. These effects are dose-dependent, as even ultra-low doses preserve or increase bone mineral density. Read More

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Common incidental findings on sacroiliac joint MRI in children clinically suspected of juvenile spondyloarthritis.

Eur J Radiol Open 2020 4;7:100225. Epub 2020 Mar 4.

Department of Radiology and Medical Imaging, Ghent University Hospital, Corneel Heymanslaan 10, 9000, Gent, Belgium.

Purpose: To determine the prevalence of incidental findings on sacroiliac (SI) joint MRI in children clinically suspected of Juvenile Spondyloarthritis (JSpA).

Methods: In this retrospective multi-center study of 540 children clinically suspected of JSpA who underwent MRI of SI joints from February 2012 to May 2018, the prevalence of sacroiliitis and other incidental findings was recorded.

Results: In 106/540 (20 %) children MRI features of sacroiliitis were present. Read More

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Natural history of Ollier disease and Maffucci syndrome: Patient survey and review of clinical literature.

Am J Med Genet A 2020 05 7;182(5):1093-1103. Epub 2020 Mar 7.

McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Ollier disease (OD) and Maffucci syndrome (MS) are characterized by multiple enchondromas. Patients with MS also have benign vascular overgrowths that become malignant in 8.5% of cases. Read More

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"Falling down": a retroperitoneal catastropheC.

G Chir 2019 Nov-Dec;40(6):535-5380

Hemoperitoneum due to ruptured retroperitoneal varices is an extremely rare condition and a poor prognostic sign with a catastrophic and life-threatening situation. Early recognition affords appropriate management and urgent surgical intervention in order to favor the survival rate. In this case report we accurately describe the complex clinical course of a 56-year old woman with retroperitoneal varices, who few months earlier had a chest trauma with multiple left lower rib fractures and 10 years earlier she underwent to ovarian hyperstimulation for an ovulation induction. Read More

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Turner syndrome and osteoporosis.

Maturitas 2019 Dec 25;130:41-49. Epub 2019 Sep 25.

Menopause Clinic, 2ndDepartment of Obstetrics and Gynecology, Medical School, National and Kapodistrian University of Athens, Athens, Greece. Electronic address:

Turner syndrome is one of the most common sex chromosomal anomalies, characterized by the complete or partial loss of one X chromosome. Females with Turner syndrome are characterized by skeletal abnormalities, short stature and primary ovarian insufficiency. The aim of this narrative review was to identify the underlying mechanisms of osteoporosis in Turner syndrome, summarize its clinical manifestations and provide suggestions regarding the management of osteoporosis. Read More

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December 2019

Fracture rate in women with oestrogen deficiency - Comparison of Turner syndrome and premature ovarian insufficiency.

Clin Endocrinol (Oxf) 2019 12 6;91(6):743-749. Epub 2019 Nov 6.

Reproductive Medicine Unit, University College London Hospitals, London, UK.

Objective: Women with early-onset oestrogen deficiency are at risk of reduced bone mineral density (BMD). We sought to assess fracture history and BMD in women with Turner syndrome (TS) and premature ovarian insufficiency (POI).

Design: A cross-sectional observational study. Read More

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December 2019

Autosomal-Recessive Mutations in MESD Cause Osteogenesis Imperfecta.

Am J Hum Genet 2019 10 26;105(4):836-843. Epub 2019 Sep 26.

Orthopaedic Research Laboratories, Department of Orthopaedic Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.

Osteogenesis imperfecta (OI) comprises a genetically heterogeneous group of skeletal fragility diseases. Here, we report on five independent families with a progressively deforming type of OI, in whom we identified four homozygous truncation or frameshift mutations in MESD. Affected individuals had recurrent fractures and at least one had oligodontia. Read More

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October 2019

McCune-Albright Syndrome With Unremitting Hyperthyroidism at Early Age: Management Perspective for Early Thyroidectomy.

Glob Pediatr Health 2019 9;6:2333794X19875153. Epub 2019 Sep 9.

Baylor College of Medicine, Houston, TX, USA.

. McCune-Albright syndrome (MAS) is characterized by hyperpigmented macules, endocrinopathies, and fibrous dysplasia. Hyperthyroidism is the second most common endocrinopathy in MAS and its management is challenging, particularly among infants and toddlers. Read More

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September 2019

[Bone effects of bisphosphonates and denosumab treatments in breast or prostate cancer].

Authors:
Emmanuel Biver

Rev Med Suisse 2019 Apr;15(647):824-830

Service des maladies osseuses, Département de médecine, HUG et Faculté de médecine, 1211 Genève 14.

Two types of bone diseases can be observed in patients with breast or prostate cancer: fragility fractures related to osteoporosis, and skeletal related events (SRE) complicating bone metastases. Aromatase inhibitors, ovarian function suppression and tamoxifen use in pre-menopausal women, and androgen deprivation therapy, induce a decrease of bone mineral density and an increase of the incidence of fractures, which can be prevented by inhibitors of bone resorption at low doses. In addition, adjuvant bisphosphonates may be associated with benefits on disease free survival, especially regarding bone recurrences, in postmenopausal women with non-metastatic breast cancer. Read More

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The effects of adjuvant endocrine therapy on bone health in women with breast cancer.

J Endocrinol 2019 06;241(3):R111-R124

Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia.

In women with oestrogen receptor (ER)-positive early breast cancer, oestradiol is important for breast cancer development and progression. Endocrine therapy prevents the deleterious effects of oestradiol in breast tissue by systemically depleting oestradiol concentration (aromatase inhibitors) or preventing its local action in breast tissue (selective oestrogen receptor modulators i.e. Read More

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Osteoprotective Effects of Tribulus terrestris L.: Relationship Between Dehydroepiandrosterone Levels and Ca-Sparing Effect.

J Med Food 2019 Mar;22(3):241-247

1 Laboratory of Pre-Clinical Research of Natural Products, Paranaense University, Umuarama, PR, Brazil.

Osteoporosis is a systemic bone disease that is characterized by impairments in bone strength that predispose an individual to a higher risk of fractures. Despite the various etiologies, undoubtedly the most important factors are aging of the population and hypogonadism. Although several therapeutic options are available, pharmacological treatments have some risks. Read More

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Mechanical Thrombectomy for Trousseau Syndrome in a Terminally Ill Cancer Patient.

J Pain Symptom Manage 2019 03 19;57(3):688-694. Epub 2018 Dec 19.

Department of Neurosurgery, Seirei Hamamatsu General Hospital, Hamamatsu, Japan; Department of Neurosurgery, Hamamatsu University School of Medicine, Hamamatsu, Japan; Palliative Care Team, Seirei Mikatahara General Hospital, Hamamatsu, Japan.

Trousseau syndrome was first described by Armand Trousseau in 1865 and is characterized by hypercoagulation resulting from malignant tumors. This complication can markedly impact quality of life (QOL). This is the first report of a terminally ill patient who developed large-vessel occlusion stroke from Trousseau syndrome and underwent mechanical thrombectomy. Read More

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Pregnancy outcomes following nonobstetric surgery during gestation: a nationwide population-based case-control study in Taiwan.

BMC Pregnancy Childbirth 2018 Nov 26;18(1):460. Epub 2018 Nov 26.

Division of Women's and Children's Anesthesia, Department of Anesthesiology, Chi Mei Medical Center, 901 Zhonghua Road, Yongkang District, Tainan City, 710, Taiwan.

Background: Whether nonobstetric surgery during gestation is associated with a higher risk of spontaneous abortion or adverse delivery outcomes is still unclear.

Methods: We performed a retrospective case-control study using a Longitudinal Health Insurance Database (LHID 2000) containing claim-data of 1 million randomly selected beneficiaries. We compared the incidences and estimated the adjusted odds ratios (aOR) with 95% confidence interval (95% CI) for spontaneous abortion, adverse delivery outcomes, cesarean delivery, and prolonged hospital stay to determine the risk of adverse outcomes in women who had nonobstetric surgery during gestation as compared to those who did not have any surgery during gestation. Read More

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November 2018

Association between age at menopause and fracture risk: a systematic review and meta-analysis.

Endocrine 2019 02 10;63(2):213-224. Epub 2018 Sep 10.

Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Purpose: Early menopause (EM, age at menopause < 45 years) and premature ovarian insufficiency (POI, age at menopause < 40 years) are associated with an increased risk of osteoporosis. However, their association with increased fracture risk has not been established, with studies yielding conflicting results. The primary aim of this systematic review and meta-analysis was to synthesize studies evaluating the association between age at menopause and fracture risk. Read More

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February 2019

Osteoporosis and musculoskeletal complications related to therapy of breast cancer.

Gland Surg 2018 Aug;7(4):411-423

Icahn School of Medicine at Mt Sinai, New York, NY, USA.

Aromatase inhibitors (AIs) are the treatment of choice for the majority of postmenopausal women with estrogen receptor (ER) positive breast cancers in early and advanced stage settings. One of most frequent side effects of AIs is bone loss that is of sufficient magnitude to increase risk of osteoporotic fractures. Osteoporosis is primarily a complex genetic disease with few modifiable risk factors. Read More

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Conservative management of reproductive cancers. Ovarian protection during treatment.

Best Pract Res Clin Obstet Gynaecol 2019 Feb 28;55:49-58. Epub 2018 Jun 28.

Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia; Sir Peter MacCallum Dept of Oncology, The University of Melbourne, Parkville, Victoria, Australia. Electronic address:

Globally, breast cancer is the most common female reproductive cancer. Although alkylating chemotherapy is not part of initial curative-intent treatment in women with other reproductive cancers, it is often used to treat women with curable breast cancer. Chemotherapy-associated ovarian failure (COF) is a potential consequence of this treatment and can cause infertility and increase the risk of cognitive impairment, cardiovascular disease and fractures from reduced bone mineral density. Read More

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February 2019

Clinical efficacy of PVP and PKP in the treatment of OVCFs after bilateral resection of ovarian cancer.

Oncol Lett 2018 Jul 7;16(1):151-156. Epub 2018 May 7.

Department of Micro-Orthopaedics, The Second People's Hospital of Hefei, Hefei, Anhui 230011, P.R. China.

The clinical efficacy of percutaneous vertebroplasty (PVP) and percutaneous kyphoplasty (PKP) in the treatment of osteoporotic vertebral compression fractures after bilateral resection of ovarian cancer was investigated. Eighty-six patients with osteoporotic vertebral compression fractures after bilateral resection of ovarian cancer admitted to the Second People's Hospital of Hefei from September, 2015 to August, 2016 were selected and randomly divided into control group (n=43) and observation group (n=43). The control group was treated with PVP, while the observation group received PKP. Read More

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Soy protein improves tibial whole-bone and tissue-level biomechanical properties in ovariectomized and ovary-intact, low-fit female rats.

Bone Rep 2018 Jun 18;8:244-254. Epub 2018 May 18.

Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA.

Background: Osteoporosis and related fractures, decreased physical activity, and metabolic dysfunction are serious health concerns for postmenopausal women. Soy protein might counter the negative effects of menopause on bone and metabolic health due to the additive or synergistic effects of its bioactive components.

Objective: To evaluate the effects of ovariectomy (OVX) and a soy-protein diet (SOY) on bone outcomes in female, low-capacity running (LCR) rats selectively bred for low aerobic fitness as a model of menopause. Read More

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Risk of hysterectomy and salpingectomy or oophorectomy compared to repair after pelvic gynecologic trauma.

Eur J Trauma Emerg Surg 2019 Jun 6;45(3):403-410. Epub 2018 Mar 6.

Division of Trauma, Burns and Surgical Critical Care, Department of Surgery, University of California, Irvine, 333 The City Blvd West, Suite 1600, Orange, CA, 92868-3298, USA.

Purpose: Pelvic gynecologic trauma (PGT) includes injury to the uterus, ovaries or fallopian tubes. We hypothesized Injury Severity Score (ISS) ≥ 25, hypotension on admission and age ≥ 51 (average age for menopause) would be independent risk factors for resection compared to repair.

Methods: A retrospective analysis of the National Trauma Data Bank was performed between 2007 and 2015. Read More

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