12,847 results match your criteria fracture induced

Expression of angiogenesis-related proteins in bone marrow mesenchymal stem cells induced by osteoprotegerin during osteogenic differentiation in rats.

Wei Wang Bo Wang

Int Immunopharmacol 2021 Jun 9;98:107821. Epub 2021 Jun 9.

Department of Orthopaedic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China. Electronic address:

This study aimed to discuss the expression of angiogenesis-related proteins in bone marrow mesenchymal stem cells (BMSCs) induced by osteoprotegerin (OGP) during osteogenic differentiation in rats, and to analyze the effect of fracture healing inflammatory factor TNF-ɑ on the osteogenic differentiation of BMSCs of rats. BMSCs isolated and cultured from the third generation rats were taken as the research object. According to the addition amount of OGP, BMSCs were divided into control group, OGP (10 mol/L) group, OGP (10 mol/L) group, and OGP (10 mol/L) group. Read More

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WNT7B overexpression rescues bone loss caused by glucocorticoids in mice.

FASEB J 2021 Jul;35(7):e21683

Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO, USA.

Glucocorticoids, widely prescribed for anti-inflammatory and immunosuppressive purposes, are the most common secondary cause for osteoporosis and related fractures. Current anti-resorptive and anabolic therapies are insufficient for treating glucocorticoid-induced osteoporosis due to contraindications or concerns of side effects. Glucocorticoids have been shown to disrupt Wnt signaling in osteoblast-lineage cells, but the efficacy for Wnt proteins to restore bone mass after glucocorticoid therapy has not been examined. Read More

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Potential Role of Perilacunar Remodeling in the Progression of Osteoporosis and Implications on Age-Related Decline in Fracture Resistance of Bone.

Curr Osteoporos Rep 2021 Jun 12. Epub 2021 Jun 12.

Faculty of Dentistry, McGill University, Strathcona Anatomy and Dentistry Building, 3640 Rue University, Montreal, Canada.

Purpose Of Review: We took an interdisciplinary view to examine the potential contribution of perilacunar/canalicular remodeling to declines in bone fracture resistance related to age or progression of osteoporosis.

Recent Findings: Perilacunar remodeling is most prominent as a result of lactation; recent advances further elucidate the molecular players involved and their effect on bone material properties. Of these, vitamin D and calcitonin could be active during aging or osteoporosis. Read More

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Vitamin B12 status is a risk factor for bone fractures among vegans.

Roman Pawlak

Med Hypotheses 2021 Jun 5;153:110625. Epub 2021 Jun 5.

Department of Nutrition Science, East Carolina University, Greenville, NC 27858, United States. Electronic address:

Several studies consistently showed vegans having a higher risk of bone fractures compared to individuals from other diet groups. While researchers have focused on several factors as possible explanation of these findings, both dietary (e.g. Read More

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Bone healing around titanium implants in a preclinical model of bile duct ligation-induced liver injury.

Clin Oral Implants Res 2021 Jun 11. Epub 2021 Jun 11.

Department of Oral Biology, University Clinic of Dentistry, Medical University of Vienna, Vienna, Austria.

Objectives: Chronic liver disease increases the risk for periodontal disease and osteoporotic fractures, but its impacts on bone regeneration remain unknown. Herein we studied the impact of liver cirrhosis on peri-implant bone formation.

Material And Methods: A total of 20 male Wistar rats were randomly divided into two groups; one with the common bile duct ligated (BDL) and the respective sham-treated control group (SHAM). Read More

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Short-term glucocorticoid excess blunts abaloparatide-induced increase in femoral bone mass and strength in mice.

Sci Rep 2021 Jun 10;11(1):12258. Epub 2021 Jun 10.

Department of Biomedicine, Health, Aarhus University, Wilhelm Meyers Allé 3, 8000, Aarhus C, Denmark.

Glucocorticoids (GCs), such as prednisolone, are widely used to treat inflammatory diseases. Continuously long-term or high dose treatment with GCs is one of the most common causes of secondary osteoporosis and is associated with sarcopenia and increased risk of debilitating osteoporotic fragility fractures. Abaloparatide (ABL) is a potent parathyroid hormone-related peptide analog, which can increase bone mineral density (aBMD), improve trabecular microarchitecture, and increase bone strength. Read More

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Exogenous parathyroid hormone attenuates ovariectomy-induced skeletal muscle weakness in vivo.

Bone 2021 Jun 7:116029. Epub 2021 Jun 7.

Department of Orthopaedic Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan, Department of Orthopaedic Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.

Osteoporosis commonly affects the elderly and is associated with significant morbidity and mortality. Loss of bone mineral density induces muscle atrophy and increases fracture risk. However, muscle lipid content and droplet size are increased by aging and mobility impairments, inversely correlated with muscle function, and a cause of reduced motor function. Read More

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Extended Whole-body Ga-68 DOTATATE PET-CT in evaluating Tumour-Induced Osteomalacia: Case report and review of literature.

Nucl Med Mol Imaging 2021 Jun 19;55(3):130-135. Epub 2021 Apr 19.

Internal Medicine & Endocrinology, Internal Medicine, Sunway Medical Centre, No. 5 Jalan Lagoon Selatan, Bandar Sunway, 47500 Petaling Jaya, Selangor Darul Ehsan Malaysia.

Tumour-induced osteomalacia is a rare paraneoplastic syndrome that manifests as chronic hypophosphataemia, non-specific bone pain and muscle weakness. It is generally caused by phosphaturic mesenchymal tumour (PMT), which is uncommonly associated with synchronous tumours. However, diagnosis is often delayed for several years due to the rarity, indolent growing nature and non-specific symptoms of the disease, often resulting in an overlook by clinicians during assessments. Read More

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Understanding porosity and temperature induced variabilities in interface, mechanical characteristics and thermal conductivity of borophene membranes.

Sci Rep 2021 Jun 9;11(1):12123. Epub 2021 Jun 9.

Department of Mechanical Engineering, National Kaohsiung University of Science and Technology, Kaohsiung, 807, Taiwan.

Evaluating the effect of porosity and ambient temperature on mechanical characteristics and thermal conductivity is vital for practical application and fundamental material property. Here we report that ambient temperature and porosity greatly influence fracture behavior and material properties. With the existence of the pore, the most significant stresses will be concentrated around the pore position during the uniaxial and biaxial processes, making fracture easier to occur than when tensing the perfect sheet. Read More

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Update on Glucocorticoid Induced Osteoporosis.

Endocrinol Metab (Seoul) 2021 Jun 1. Epub 2021 Jun 1.

Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.

Glucocorticoids are used to treat many autoimmune and inflammatory diseases. However, an adverse systemic effect is a deleterious effect on bone, which may lead to glucocorticoid-induced osteoporosis, characterized by a rapid and transient increase in bone resorption and fracture risk, which may increase rapidly within 3 months of commencing oral glucocorticoids. Therefore, early risk assessment and intervention are crucial for preventing fractures in patients receiving glucocorticoids. Read More

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Percutaneous Fixation of Unstable Proximal Phalanx Fractures: A Biomechanical Study.

Hand (N Y) 2021 Jun 9:15589447211017224. Epub 2021 Jun 9.

Columbia University Irving Medical Center, New York, NY, USA.

Background: Unstable extra-articular proximal phalanx fractures are common injuries to the hand that are often treated by closed reduction and percutaneous pinning. Fracture-induced shortening of the proximal phalanx leads to an extensor lag at the proximal interphalangeal joint. We describe a biomechanical study in cadaver hands to compare the ability of each of three different pin configurations to resist shortening in unstable fractures. Read More

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Cluster phenomenon of vertebral refractures after posterior pedicle screw fixation in a patient with glucocorticosteroid-induced Kümmell's disease: a treatment dilemma.

Arch Osteoporos 2021 Jun 8;16(1):93. Epub 2021 Jun 8.

Department of Orthopaedic Surgery, The Sixth Medical Center, General Hospital of PLA, 6# Fucheng Road, Haidian District, Beijing, 100048, China.

Introduction: Surgical treatments are usually preferred in patients with Kümmell's disease since it represents a failure of conservative treatment for osteoporotic vertebral compression fracture without evidence of spontaneous healing. However, the risk of postoperative refractures is much higher in patients with glucocorticosteroid-induced osteoporosis (GIOP) than in those with primary osteoporosis, possessing a therapeutic challenge and dilemma to orthopaedic surgeons.

Case Report: We described a rare cluster phenomenon of vertebral refractures in a patient with GIOP subsequent to segmental internal fixation for the initial management of glucocorticosteroid-induced Kümmell's disease, and a review of the literature. Read More

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Fracture of the Dens Axis Due to Spinal Manifestation of Sarcoidosis: Treatment Option and Review of the Literature.

Spine (Phila Pa 1976) 2021 Jul;46(13):E743-E749

Department of Orthopedics, Trauma Surgery and Hand Unit, Helios Klinikum Krefeld, Krefeld, Germany.

Study Design: Case report and literature review.

Objective: We present a case of a pathologic unstable fracture of the odontoid process due to vertebral osseous sarcoidosis. The surgical management of this unreported pathology is described and a review of the literature is given. Read More

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Targeting angiogenesis for fracture nonunion treatment in inflammatory disease.

Bone Res 2021 Jun 7;9(1):29. Epub 2021 Jun 7.

Department of Orthopaedic Surgery, School of Medicine, Washington University, St. Louis, MO, USA.

Atrophic fracture nonunion poses a significant clinical problem with limited therapeutic interventions. In this study, we developed a unique nonunion model with high clinical relevance using serum transfer-induced rheumatoid arthritis (RA). Arthritic mice displayed fracture nonunion with the absence of fracture callus, diminished angiogenesis and fibrotic scar tissue formation leading to the failure of biomechanical properties, representing the major manifestations of atrophic nonunion in the clinic. Read More

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Using first-principles calculations to predict the mechanical properties of transmuting tungsten under first wall fusion power-plant conditions.

J Phys Condens Matter 2021 Jun 7. Epub 2021 Jun 7.

Mechanical Engineering, Villanova University, 800 Lancaster Ave, Villanova, Pennsylvania, 19085-1603, UNITED STATES.

Tungsten and tungsten alloys are being considered as leading candidates for structural and functional materials in future fusion energy devices. The most attractive properties of tungsten for the design of magnetic and inertial fusion energy reactors are its high melting point, high thermal conductivity, low sputtering yield and low long-term disposal radioactive footprint. Yet, despite these relevant features, tungsten also presents a very low fracture toughness, mostly associated with inter-granular failure and bulk plasticity, that limits its applications. Read More

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Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate/GPR109A signaling pathway.

J Nanobiotechnology 2021 Jun 6;19(1):170. Epub 2021 Jun 6.

Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, No. 188 Shizi Street, Suzhou, 215006, Jiangsu, China.

Background: Inflammatory osteolysis after total joint replacement (TJR) may cause implant failure, periprosthetic fractures, and be a severe threat to global public health. Our previous studies demonstrated that melatonin had a therapeutic effect on wear-particles induced osteolysis. Gut microbiota is closely related to bone homeostasis, and has been proven to be affected by melatonin. Read More

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Extremity trauma exacerbates acute kidney injury following prolonged hemorrhagic hypotension.

J Trauma Acute Care Surg 2021 Jun 4. Epub 2021 Jun 4.

US Army Institute of Surgical Research, JBSA-Fort Sam Houston, TX Uniformed Services University, Bethesda, MD.

Background: The incidence of and mortality due to acute kidney injury (AKI) is high in patients with traumatic shock. However, it is unclear how hemorrhage and trauma synergistically affect renal function, especially when timely volume resuscitation is not available.

Method: We hypothesized that trauma impairs renal tolerance to prolonged hemorrhagic hypotension. Read More

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Diffuse adverse cutaneous reactions induced by zoledronic acid administration: a case report : Eruptions cutanées diffuses induites par l'administration de l'acide zolédronique.

Osteoporos Int 2021 Jun 3. Epub 2021 Jun 3.

Rheumatology department, Ibn Rochd University Hospital, Hassan II University of Medecine and Pharmacy, Casablanca, Morocco.

Zoledronic acid, an amino-bisphosphonate, is an antiresorptive drug given intravenously. It is commonly used for the treatment of severe postmenopausal osteoporosis, and it is also used for other types of osteoporosis, management of bone metastasis, multiple myeloma, hypercalcemia, and Paget's disease. The use varies according to these diseases. Read More

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Micro-mechanical insights into the dynamics of crack propagation in snow fracture experiments.

Sci Rep 2021 Jun 3;11(1):11711. Epub 2021 Jun 3.

WSL Institute for Snow and Avalanche Research SLF, Davos, Switzerland.

Dry-snow slab avalanches result from crack propagation in a highly porous weak layer buried within a stratified and metastable snowpack. While our understanding of slab avalanche mechanisms improved with recent experimental and numerical advances, fundamental micro-mechanical processes remain poorly understood due to a lack of non-invasive monitoring techniques. Using a novel discrete micro-mechanical model, we reproduced crack propagation dynamics observed in field experiments, which employ the propagation saw test. Read More

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Cerium oxide nanoparticles protect against irradiation-induced cellular damage while augmenting osteogenesis.

Mater Sci Eng C Mater Biol Appl 2021 Jul 29;126:112145. Epub 2021 Apr 29.

Biionix Cluster, Department of Internal Medicine, College of Medicine, University of Central Florida, Orlando, FL, United States. Electronic address:

Increased bone loss and risk of fracture are two of the main challenges for cancer patients who undergo ionizing radiation (IR) therapy. This decline in bone quality is in part, caused by the excessive and sustained release of reactive oxygen species (ROS). Cerium oxide nanoparticles (CeONPs) have proven antioxidant and regenerative properties and the purpose of this study was to investigate the effect of CeONPs in reducing IR-induced functional damage in human bone marrow-derived mesenchymal stromal cells (hBMSCs). Read More

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Optimal time-dependent levels of weight-bearing for bone fracture healing under Ilizarov circular fixators.

J Mech Behav Biomed Mater 2021 May 28;121:104611. Epub 2021 May 28.

Department of Infrastructure Engineering, The University of Melbourne, Parkville, Australia. Electronic address:

It is known that weight-bearing exercises under Ilizarov circular fixators (ICF) could enhance bone fracture healing by mechano-regulation. However, interfragmentary movements at the fracture site induced by weight-bearing may inhibit angiogenesis and ultimately delay the healing process. To tackle this challenge, a computational model is presented in this study which considers the spatial and temporal changes in mechanical properties of fracture callus to predict optimal levels of weight-bearing during fracture healing under ICF. Read More

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Fracture-induced pain-like behaviours in a femoral fracture mouse model.

Osteoporos Int 2021 Jun 2. Epub 2021 Jun 2.

Skeletal Biology Group, Department of Comparative Biomedical Sciences, Royal Veterinary College, 4 Royal College Street, London, NW1 0TU, UK.

This study is the first comprehensive characterisation of the pain phenotype after fracture using both evoked and naturalistic behaviours in adult male and ovariectomised female mice. It also shows that an anti-nerve growth factor (NGF) therapy could be considered to reduce pain after fracture surgery.

Introduction: Bone fractures are common due to the ageing population and very painful even after healing. Read More

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Novel testing method to evaluate the mechanical strength of self-adhesive resin cements with reflection of cement thickness.

Dent Mater J 2021 Jun 1. Epub 2021 Jun 1.

Department of Biomaterials Science, Osaka University Graduate School of Dentistry.

This study aimed to propose an evaluation method for testing the mechanical strength of film-formed self-adhesive resin cements (SARCs) while reflecting cement layer thickness. Three commercially available dual-cure type SARCs were used for tensile and shear tests using specimens with varying thicknesses (0.05, 0. Read More

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Prevalence of Musculoskeletal Manifestations in Adult Kidney Transplant's Recipients: A Systematic Review.

Medicina (Kaunas) 2021 May 23;57(6). Epub 2021 May 23.

College of Medicine and Medical Sciences, Arabian Gulf University (AGU), 323 Manama, Bahrain.

: The musculoskeletal (MSK) manifestations in the kidney transplant recipient (KTxR) could lead to decreased quality of life and increased morbidity and mortality. However, the prevalence of these MSK manifestations is still not well-recognized. This review aimed to investigate the prevalence and outcomes of MSK manifestations in KTxR in the last two decades. Read More

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Interface Modification, Water Absorption Behaviour and Mechanical Properties of Injection Moulded Short Hemp Fiber-Reinforced Thermoplastic Composites.

Polymers (Basel) 2021 May 18;13(10). Epub 2021 May 18.

Laboratory for Wear, Testing & Materials (LED&MAT), Instituto Pedro Nunes, Rua Pedro Nunes, 3030-199 Coimbra, Portugal.

The effects of maleic anhydride, stearic acid and water absorption on the physical and flexural properties of injection moulded short hemp fiber-reinforced thermoplastic composites were investigated, in order to understand the suitability of these materials for outdoor applications. The water absorption, diffusion mechanisms and kinetics of composites were evaluated by immersing the specimens in distilled water at 23 °C. Flexural fracture surface morphologies were investigated in order to compare the results of flexural tests with qualitative morphological observations. Read More

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Electric Shock-Induced Vertebral Fracture: A Case Report and Literature Review with Special Emphasis on Fracture Morphology.

JBJS Case Connect 2020 Oct-Dec;10(4):e2000143

1Department of Orthopaedic Surgery, Maulana Azad Medical College & Associated Lok Nayak Hospital, New Delhi, India 2Department of Radiodiagnosis, Maulana Azad Medical College & Associated Lok Nayak Hospital, New Delhi, India.

Case: A 35-year-old man suffered electric injury with 220 V alternating current when he was connecting electric wires at approximately 5 feet height and accidentally touched a live wire. He was diagnosed to have fracture involving superior and inferior endplates of L2 vertebral body without involvement of posterior elements. He, subsequently, underwent spinal stabilization with percutaneous pedicle screws fixation. Read More

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Guidelines for the acute care of severe limb trauma patients.

Anaesth Crit Care Pain Med 2021 May 28:100862. Epub 2021 May 28.

Soins Intensifs, Hôpitaux Universitaires de Genève, Genève, Suisse.

Goal: To provide healthcare professionals with comprehensive multidisciplinary expert recommendations for the acute care of severe limb trauma patients, both during the prehospital phase and after admission to a Trauma Centre.

Design: A consensus committee of 21 experts was formed. A formal conflict-of-interest (COI) policy was developed at the onset of the process and enforced throughout. Read More

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Cervical spine injury after virtual reality gaming: a case report.

J Med Case Rep 2021 May 31;15(1):312. Epub 2021 May 31.

University hospital, 04103, Leipzig, Germany.

Background: We report a patient who fractured the seventh cervical vertebra while playing a virtual reality (VR) game, without any other trauma. This case report aims to describe the spinal trauma incurred during the use of a VR headset in a video game.

Case Presentation: The Caucasian patient presented with pain and swelling in the lower cervical spine at our clinic after playing a video game involving a combination of shoulder, arm and head movements while wearing a VR headset. Read More

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Glycolipid toxicity induces osteogenic dysfunction via the TLR4/S100B pathway.

Int Immunopharmacol 2021 May 26;97:107792. Epub 2021 May 26.

Department of Endocrinology, M.D. Candidate, The First Affiliated Hospital of Fujian Medical University, China; Diabetes Research Institute of Fujian Province, Fuzhou, Fujian, China. Electronic address:

Diabetes can cause bone metabolism disorders and osteoporosis. The occurrence of both diabetes mellitus and osteoporosis increases the disability and mortality of elderly individuals due to pathological fracture. Abnormal metabolism of nutrientsis considered to be one of the important mechanisms of diabetes mellitus-induced osteoporosis. Read More

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Bone-modifying Agents (BMAs) in Breast Cancer.

Clin Breast Cancer 2021 Apr 26. Epub 2021 Apr 26.

Icahn School of Medicine at Mt Sinai, New York, NY. Electronic address:

Bone-modifying agents (BMAs) are mainstays in breast cancer and prevent and treat osteoporosis in early-stage disease and reduce skeletal metastases complications in advanced disease. There is some evidence to support that BMA also prevents skeletal metastases and improves overall survival. Bone loss occurs with chemotherapy-induced ovarian failure, gonadotrophin-releasing hormone (GnRH) agonists, and aromatase inhibitors. Read More

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