4 results match your criteria frα high

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High prevalence of serum folate receptor autoantibodies in children with autism spectrum disorders.

Biomarkers 2018 Nov 6;23(7):622-624. Epub 2018 Sep 6.

i Shanghai Key Laboratory of Birth Defects , Xiamen Branch of Children's Hospital of Fudan University (Xiamen Children's Hospital), Children's Hospital of Fudan University , Shanghai , China.

Background: Supplementation of folic acid by pregnant mothers is thought to lower the risk of autism spectrum disorders (ASDs) in the offspring. Folic acid is taken up by cells via receptors with high affinity for folate and reduced folic acid derivatives. However, this is blocked by the presence of folate receptor autoantibodies (FRAA). Read More

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November 2018

[Prediction of round window visibility in cochlear implantation with temporal bone high resolution computed tomography].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Aug;52(8):561-565

Division of Otology, Otorhinolaryngology Hospital, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

To discuss the prediction of round window(RW) visibility in cochlear implantation(CI) with temporal bone high resolution computed tomography(HRCT). From January 2013 to January 2017, 130 cases underwent both HRCT and CI in our hospital were analyzed. The distance from facial nerve to posterior canal wall(FWD), the angle between facial nerve and inner margin of round window(FRA), and the angle between facial nerve and tympanic anulus to inner margin of round window(FRAA) were detected at the level of round window on axial temporal bone HRCT. Read More

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Thyroid dysfunction in children with autism spectrum disorder is associated with folate receptor α autoimmune disorder.

J Neuroendocrinol 2017 03;29(3)

Department of Medicine, State University of New York - Downstate Medical Center, Brooklyn, NY, USA.

Folate receptor α (FRα) autoantibodies (FRAAs) are prevalent in autism spectrum disorder (ASD). FRAAs disrupt folate transport across the blood-brain barrier by binding to the FRα. Thyroid dysfunction is frequently found in children with ASD. Read More

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Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial.

Mol Psychiatry 2018 02 18;23(2):247-256. Epub 2016 Oct 18.

Department of Medicine, State University of New York - Downstate Medical Center, Brooklyn, NY, USA.

We sought to determine whether high-dose folinic acid improves verbal communication in children with non-syndromic autism spectrum disorder (ASD) and language impairment in a double-blind placebo control setting. Forty-eight children (mean age 7 years 4  months; 82% male) with ASD and language impairment were randomized to receive 12 weeks of high-dose folinic acid (2 mg kg per day, maximum 50 mg per day; n=23) or placebo (n=25). Children were subtyped by glutathione and folate receptor-α autoantibody (FRAA) status. Read More

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February 2018
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