9 results match your criteria frα

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[Neural network: A future in pathology?]

Ann Pathol 2019 Apr 14;39(2):119-129. Epub 2019 Feb 14.

ENSMM, CNR, FEMTO-ST institute, université de Bourgogne Franche-Comté, 25000 Besançon, France. Electronic address:

Artificial Intelligence, in particular deep neural networks are the most used machine learning technics in the biomedical field. Artificial neural networks are inspired by the biological neurons; they are interconnected and follow mathematical models. Two phases are required: a learning and a using phase. Read More

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High prevalence of serum folate receptor autoantibodies in children with autism spectrum disorders.

Biomarkers 2018 Nov 6;23(7):622-624. Epub 2018 Sep 6.

i Shanghai Key Laboratory of Birth Defects , Xiamen Branch of Children's Hospital of Fudan University (Xiamen Children's Hospital), Children's Hospital of Fudan University , Shanghai , China.

Background: Supplementation of folic acid by pregnant mothers is thought to lower the risk of autism spectrum disorders (ASDs) in the offspring. Folic acid is taken up by cells via receptors with high affinity for folate and reduced folic acid derivatives. However, this is blocked by the presence of folate receptor autoantibodies (FRAA). Read More

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November 2018

Salmonella FraE, an Asparaginase Homolog, Contributes to Fructose-Asparagine but Not Asparagine Utilization.

J Bacteriol 2017 Nov 17;199(22). Epub 2017 Oct 17.

Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA

can utilize fructose-asparagine (F-Asn) as a source of carbon and nitrogen. This capability has been attributed to five genes in the locus. Previously, we determined that mutations in (deglycase), (kinase), or (transporter) eliminated the ability of to grow on F-Asn, while a mutation in allowed partial growth. Read More

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November 2017

[Prediction of round window visibility in cochlear implantation with temporal bone high resolution computed tomography].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Aug;52(8):561-565

Division of Otology, Otorhinolaryngology Hospital, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

To discuss the prediction of round window(RW) visibility in cochlear implantation(CI) with temporal bone high resolution computed tomography(HRCT). From January 2013 to January 2017, 130 cases underwent both HRCT and CI in our hospital were analyzed. The distance from facial nerve to posterior canal wall(FWD), the angle between facial nerve and inner margin of round window(FRA), and the angle between facial nerve and tympanic anulus to inner margin of round window(FRAA) were detected at the level of round window on axial temporal bone HRCT. Read More

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Thyroid dysfunction in children with autism spectrum disorder is associated with folate receptor α autoimmune disorder.

J Neuroendocrinol 2017 03;29(3)

Department of Medicine, State University of New York - Downstate Medical Center, Brooklyn, NY, USA.

Folate receptor α (FRα) autoantibodies (FRAAs) are prevalent in autism spectrum disorder (ASD). FRAAs disrupt folate transport across the blood-brain barrier by binding to the FRα. Thyroid dysfunction is frequently found in children with ASD. Read More

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Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial.

Mol Psychiatry 2018 02 18;23(2):247-256. Epub 2016 Oct 18.

Department of Medicine, State University of New York - Downstate Medical Center, Brooklyn, NY, USA.

We sought to determine whether high-dose folinic acid improves verbal communication in children with non-syndromic autism spectrum disorder (ASD) and language impairment in a double-blind placebo control setting. Forty-eight children (mean age 7 years 4  months; 82% male) with ASD and language impairment were randomized to receive 12 weeks of high-dose folinic acid (2 mg kg per day, maximum 50 mg per day; n=23) or placebo (n=25). Children were subtyped by glutathione and folate receptor-α autoantibody (FRAA) status. Read More

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February 2018

Blocking and Binding Folate Receptor Alpha Autoantibodies Identify Novel Autism Spectrum Disorder Subgroups.

Front Neurosci 2016 9;10:80. Epub 2016 Mar 9.

Department of Medicine, State University of New York-Downstate Medical Center Brooklyn, NY, USA.

Folate receptor α (FRα) autoantibodies (FRAAs) are prevalent in autism spectrum disorder (ASD). They disrupt the transportation of folate across the blood-brain barrier by binding to the FRα. Children with ASD and FRAAs have been reported to respond well to treatment with a form of folate known as folinic acid, suggesting that they may be an important ASD subgroup to identify and treat. Read More

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Analysis of the immunoactivator sites of parotid protein isolated from bovine parotid glands.

Authors:
S Ishizaka T Tsujii

Int Immunol 1991 May;3(5):485-91

Third Department of Internal Medicine, Nara Medical University, Japan.

Parotid protein (parotin) was isolated from bovine parotid glands. To analyze the active site of parotid protein, the parotid subunit (PS) was digested by trypsin and then fractionated on a Sephadex G-25 column. Fraction A induced mainly polyclonal antibody responses and interleukin 1 (IL-1)-like activities. Read More

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Polyclonal antibody production induced by parotid protein and its active glycopeptide in mouse and human lymphocytes.

Immunopharmacology 1983 Aug;6(2):133-42

Parotid protein (extracted from bovine parotid gland), one parotid subunit, and the active fragment (FrAA-1) induced polyclonal IgM, IgG, and IgA antibody production in murine spleen cells in vivo and in vitro. The parotid subunit also elicited polyclonal IgM antibody responses in immune defective CBA/N and LPS nonresponder C3H/HeJ mouse. When one carbohydrate residue in the subunit was removed by treatment with mixed galactosidase, the ability to generate nonspecific responses was markedly reduced. Read More

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