5,253 results match your criteria foxp3+ tregs


Induction of CD4 regulatory T cells by stimulation with Staphylococcal Enterotoxin C2 through different signaling pathways.

Biomed Pharmacother 2021 Sep 21;143:112204. Epub 2021 Sep 21.

Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang, China; Key Laboratory of Superantigen Research, Shenyang Bureau of Science and Technology, Shenyang, China.

As a member of superantigens, Staphylococcal Enterotoxin C2 (SEC2) can potently activate T cells expressing specific Vβ repertoires and has been applied in clinic for tumor immunotherapy in China for more than 20 years. However, excessive activation of T cells by over-stimulation with superantigen are always followed by eliciting regulatory T cells (Tregs) induction and functional immunosuppression, which brings uncertainties to SEC2 application in tumor immunotherapy. In this study, we found that SEC2 could induce CD4CD25Foxp3 Tregs from the murine splenocytes in dose and time related manners. Read More

View Article and Full-Text PDF
September 2021

Cannabinoids induce functional Tregs by promoting tolerogenic DCs via autophagy and metabolic reprograming.

Mucosal Immunol 2021 Sep 21. Epub 2021 Sep 21.

Department of Biochemistry and Molecular Biology, School of Chemistry, Complutense University of Madrid, Madrid, Spain.

The generation of functional regulatory T cells (Tregs) is essential to keep tissue homeostasis and restore healthy immune responses in many biological and inflammatory contexts. Cannabinoids have been pointed out as potential therapeutic tools for several diseases. Dendritic cells (DCs) express the endocannabinoid system, including the cannabinoid receptors CB1 and CB2. Read More

View Article and Full-Text PDF
September 2021

Are circulating immune cells a determinant of pancreatic cancer risk? A prospective study using epigenetic cell count measures.

Cancer Epidemiol Biomarkers Prev 2021 Sep 20. Epub 2021 Sep 20.

Nutrition and Metabolism Branch, International Agency For Research On Cancer.

Background: Evidence is accumulating that immune cells play a prominent role in pancreatic cancer aetiology but prospective investigations are missing.

Methods: We conducted a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) study with 502 pairs of incident pancreatic cancer cases and matched controls. Relative counts of circulating immune cells (neutrophils and lymphocyte sub-lineages: total CD3+, CD8+, CD4+, and FOXP3+ regulatory T cells (Tregs) relative to nucleated cells, (white blood cells) were measured by qRT-PCR. Read More

View Article and Full-Text PDF
September 2021

Augmented Expansion of Treg Cells From Healthy and Autoimmune Subjects Adult Progenitor Cell Co-Culture.

Front Immunol 2021 1;12:716606. Epub 2021 Sep 1.

Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom.

Recent clinical experience has demonstrated that adoptive regulatory T (Treg) cell therapy is a safe and feasible strategy to suppress immunopathology induction of host tolerance to allo- and autoantigens. However, clinical trials continue to be compromised due to an inability to manufacture a sufficient Treg cell dose. Multipotent adult progenitor cells (MAPC) promote Treg cell differentiation , suggesting they may be repurposed to enhance expansion of Tregs for adoptive cellular therapy. Read More

View Article and Full-Text PDF
September 2021

Upregulation of Cytotoxic T-Lymphocyte-Associated Protein 4 and Forkhead Box P3 Transcripts in Peripheral Blood of Patients with Bladder Cancer.

Iran J Med Sci 2021 Sep;46(5):339-346

Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Regulatory T cells (Tregs) play a key role in the progression of tumors. These cells express forkhead box P3 (FOXP3) and cytotoxic T-lymphocyte-associated protein 4 (CTLA4), which are the potential targets for cancer immunotherapy. The present study aimed to evaluate and transcripts in patients with bladder cancer (BC) compared with healthy individuals. Read More

View Article and Full-Text PDF
September 2021

Effects of enzymatic hydrolysis on the allergenicity of natural cow milk based on a BALB/c mouse model.

J Dairy Sci 2021 Sep 15. Epub 2021 Sep 15.

College of Food Science, Shenyang Agricultural University, Shenyang 100866, P. R. China. Electronic address:

Cow milk allergy is one of the most prevalent food allergies worldwide, particularly in infants and children. To the best of our knowledge, minimal research exists concerning the antigenicity of cow milk (CM). This study was performed to evaluate the allergenicity of enzymatically hydrolyzed cow milk (HM) in a BALB/c mouse model. Read More

View Article and Full-Text PDF
September 2021

The semaphorin 4A-neuropilin 1 axis alleviates kidney ischemia reperfusion injury by promoting the stability and function of regulatory T cells.

Kidney Int 2021 Sep 14. Epub 2021 Sep 14.

Department of Urology, The 3(rd) Medical Center of Chinese PLA General Hospital, Beijing, China; Department of Urology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address:

Previous studies have suggested the role of CD4Foxp3 regulatory T cells (Tregs) in protection against kidney ischemia reperfusion injury via their immunosuppressive properties. Unfortunately, the associated mechanisms of Tregs in kidney ischemia reperfusion injury have not been fully elucidated. Semaphorin 4A (Sema4A) is essential for maintaining the immunosuppressive capacity of Tregs in tumors. Read More

View Article and Full-Text PDF
September 2021

The characteristics and novel clinical implications of CD4+CXCR5+Foxp3+ follicular regulatory T cells in breast cancer.

Ann Transl Med 2021 Aug;9(16):1332

Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Hangzhou, China.

Background: Follicular regulatory T cells (Tfr) are a subset of regulatory T cells (Tregs) that suppress the humoral immune response in the germinal center. They are associated with increased rates of disease stabilization and decreased autoantibody levels in a variety of tumor and autoimmune diseases. The binding of T-cell immunoglobulin mucin 3 (TIM-3) and its ligand on the surface of Tfr cells could result in the depletion of T lymphocytes and the termination of the immune response mediated by helper T cell 1. Read More

View Article and Full-Text PDF

Glucose Metabolism Reprogramming of Regulatory T Cells in Concanavalin A-Induced Hepatitis.

Front Pharmacol 2021 31;12:726128. Epub 2021 Aug 31.

Department of Gastroenterology and Hepatology, Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.

Autoimmune hepatitis (AIH) is an inflammatory liver disease caused by a dysregulated immune response. Although the pathogenesis of AIH remains unclear, impaired regulatory T cells (Tregs) have been considered a driver of AIH development. Unlike autoreactive T cells, Tregs mainly utilize oxidative phosphorylation (OXPHOS) as their energy supply. Read More

View Article and Full-Text PDF

Decoding the Pro-regenerative Competence of Regulatory T cells (Treg) through Complex Tissue Regeneration in Zebrafish.

Clin Exp Immunol 2021 Sep 16. Epub 2021 Sep 16.

S. N. Pradhan Centre for Neurosciences, University of Calcutta, 35, Ballygunge Circular Road, Kolkata, 700019, India.

Regulatory T (Treg) cells are specific subtypes of T cells that play a central role in sustaining self-antigen tolerance and restricting inflammatory tissue damage. More recently, additional direct functions of Tregs in mammalian tissue repair have emerged, but the regenerative potential of Tregs in non-mammalian vertebrates has not been explored despite the latter possessing a highly developed adaptive immune system. Why do complex organs such as the caudal fin, heart, brain, spinal cord, and retina regenerate in certain non-mammalian vertebrates, but not in mammals, is an interesting but unresolved question in the field of regenerative biology. Read More

View Article and Full-Text PDF
September 2021

Harnessing Treg Homeostasis to Optimize Posttransplant Immunity: Current Concepts and Future Perspectives.

Front Immunol 2021 30;12:713358. Epub 2021 Aug 30.

Department of Hematology and Oncology, Okayama University, Okayama, Japan.

CD4CD25Foxp3 regulatory T cells (Tregs) are functionally distinct subsets of mature T cells with broad suppressive activity and have been shown to play an important role in the establishment of immune tolerance after allogeneic hematopoietic stem cell transplantation (HSCT). Tregs exhibit an activated phenotype from the stage of emigration from the thymus and maintain continuous proliferation in the periphery. The distinctive feature in homeostasis enables Tregs to respond sensitively to small environmental changes and exert necessary and sufficient immune suppression; however, on the other hand, it also predisposes Tregs to be susceptible to apoptosis in the inflammatory condition post-transplant. Read More

View Article and Full-Text PDF

Regulatory T cells protect against brain damage by alleviating inflammatory response in neuromyelitis optica spectrum disorder.

J Neuroinflammation 2021 Sep 15;18(1):201. Epub 2021 Sep 15.

Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.

Background And Purpose: Neuromyelitis optica spectrum disorder (NMOSD) is mainly an anti-aquaporin 4 (anti-AQP4) autoantibodies-mediated idiopathic inflammatory demyelinating disease of the central nervous system. Systemic and local inflammatory responses play a key role in the pathophysiology of NMOSD. However, the role of the crucial immunomodulators CD4CD25 forkhead box P3 (Foxp3) regulatory T cells (Tregs) has not been investigated in NMOSD. Read More

View Article and Full-Text PDF
September 2021

RORγt Promotes Foxp3 Expression by Antagonizing the Effector Program in Colonic Regulatory T Cells.

J Immunol 2021 Sep 13. Epub 2021 Sep 13.

Department of Pathology, University of Alabama at Birmingham, Birmingham, AL;

RORγt is the master transcription factor for the Th17 cells. Paradoxically, in the intestine, RORγt is coexpressed in peripherally induced regulatory T cells (pTregs) together with Foxp3, the master transcription factor for Tregs. Unexpectedly, by an unknown mechanism, colonic RORγt Tregs show an enhanced suppressor function and prevent intestinal inflammation more efficiently than RORγt-nonexpressing pTregs. Read More

View Article and Full-Text PDF
September 2021

Infants Younger Than 90 Days Admitted for Late-Onset Sepsis Display a Reduced Abundance of Regulatory T Cells.

Front Immunol 2021 27;12:666447. Epub 2021 Aug 27.

Department of Pediatrics, University Hospital of Würzburg, Würzburg, Germany.

Objective: To provide epidemiological data of infants < 90 days of age with suspected late-onset sepsis (LOS) and evaluate distinct immunological specificities. We hypothesized that previously healthy infants < 3 months of age with sepsis have a yet undefined immunological predisposition; e.g. Read More

View Article and Full-Text PDF

CD4 T-Cell Plasticity in Non-Infectious Retinal Inflammatory Disease.

Int J Mol Sci 2021 Sep 3;22(17). Epub 2021 Sep 3.

UCL Institute of Ophthalmology, University College London, London EC1V 9EL, UK.

Non-infectious uveitis (NIU) is a potentially sight-threatening disease. Effector CD4 T cells, especially interferon-γ-(IFNγ) producing Th1 cells and interleukin-17-(IL-17) producing Th17 cells, are the major immunopathogenic cells, as demonstrated by adoptive transfer of disease in a model of experimental autoimmune uveitis (EAU). CD4FoxP3CD25 regulatory T cells (Tregs) were known to suppress function of effector CD4 T cells and contribute to resolution of disease. Read More

View Article and Full-Text PDF
September 2021

The Defect in Regulatory T Cells in Psoriasis and Therapeutic Approaches.

J Clin Med 2021 Aug 29;10(17). Epub 2021 Aug 29.

Department of Dermatology, Nippon Medical School, Tokyo 113-8602, Japan.

Psoriasis is a chronic inflammatory skin disease characterized by accelerated tumor necrosis factor-α/interleukin (IL)-23/IL-17 axis. Patients with psoriasis manifest functional defects in CD4CD25 forkhead box protein 3 (Foxp3) regulatory T cells (Tregs), which suppress the excess immune response and mediate homeostasis. Defects in Tregs contribute to the pathogenesis of psoriasis and may attribute to enhanced inhibition and/or impaired stimulation of Tregs. Read More

View Article and Full-Text PDF

Dynamics and epigenetic signature of regulatory T-cells following antiretroviral therapy initiation in acute HIV infection.

EBioMedicine 2021 Sep 6;71:103570. Epub 2021 Sep 6.

Department of Biological Sciences and CERMO-FC Research Centre, Université du Québec à Montréal (UQAM), Montreal, QC, Canada; Department of Microbiology, Infectiology and Immunology, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada; Department of Microbiology & Immunology, McGill University, Montreal, QC, Canada. Electronic address:

Background: HIV infection promotes the expansion of immunosuppressive regulatory T-cells (Tregs), contributing to immune dysfunction, tissue fibrosis and disease progression. Early antiretroviral treatment (ART) upon HIV infection improves CD4 count and decreases immune activation. However, Treg dynamics and their epigenetic regulation following early ART initiation remain understudied. Read More

View Article and Full-Text PDF
September 2021

Differential role of TNFR1 and TNFR2 in the development of imiquimod-induced mouse psoriasis.

J Leukoc Biol 2021 Sep 8. Epub 2021 Sep 8.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China.

Tumor necrosis factor alpha (TNF) has been implicated in the pathogenesis of psoriasis and anti-TNF therapeutics are used in the treatment of psoriasis in the clinic. However, considerable proportion of patients fail to respond to anti-TNF treatment. Furthermore, anti-TNF therapy induces de novo development of psoriasis in some patients with other type of autoimmune disorders. Read More

View Article and Full-Text PDF
September 2021

Dendritic cells matured with recombinant human sperm associated antigen 9 (rhSPAG9) induce CD4, CD8 T cells and activate NK cells: a potential candidate molecule for immunotherapy in cervical cancer.

Cancer Cell Int 2021 Sep 7;21(1):473. Epub 2021 Sep 7.

Department of Molecular Oncology, Cancer Institute (WIA), Dr. Krishnamurthi Campus, 38, SardarPatel Road, Chennai, 600036, India.

Background: Dendritic cell (DC)-based immunotherapy is capable of activating the immune system and in particular tumor-specific cytotoxic T lymphocytes (CTLs) to eradicate the tumor. However, major limitations are the availability of autologous tumor cells as antigenic source and the selection of antigen that may have potential to activate both CD4 and CD8 T cells in immune-specific manner. Recently, we reported the expression of sperm associated antigen 9 (SPAG9) that is associated with various types of malignancies including cervical cancer. Read More

View Article and Full-Text PDF
September 2021

Mesenchymal stem cells enhance Treg immunosuppressive function at the fetal-maternal interface.

J Reprod Immunol 2021 Aug 24;148:103366. Epub 2021 Aug 24.

Laboratory for Reproductive Immunology, NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, China; Department of Obstetrics and Gynecology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China. Electronic address:

Well-regulated maternal-fetal immune tolerance is a prerequisite for normal pregnancy. Hyperactivated immune cells and overwhelming inflammatory responses trigger adverse gestation outcome, such as recurrent spontaneous abortion (RSA). Local exacerbation of immunomodulatory cells in maternal decidua is a critical event, tightly linked with fetus acceptance. Read More

View Article and Full-Text PDF

Tissue Tregs and Maintenance of Tissue Homeostasis.

Front Cell Dev Biol 2021 18;9:717903. Epub 2021 Aug 18.

Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Regulatory T cells (Tregs) specifically expressing Forkhead box P3 (Foxp3) play roles in suppressing the immune response and maintaining immune homeostasis. After maturation in the thymus, Tregs leave the thymus and migrate to lymphoid tissues or non-lymphoid tissues. Increasing evidence indicates that Tregs with unique characteristics also have significant effects on non-lymphoid peripheral tissues. Read More

View Article and Full-Text PDF

The Role of Regulatory T Cells in Pulmonary Arterial Hypertension.

Front Immunol 2021 19;12:684657. Epub 2021 Aug 19.

Department of Medicine, VA Palo Alto Health Care System, Palo Alto, CA, United States.

Pulmonary arterial hypertension (PAH) is a chronic, incurable condition characterized by pulmonary vascular remodeling, perivascular inflammation, and right heart failure. Regulatory T cells (Tregs) stave off autoimmunity, and there is increasing evidence for their compromised activity in the inflammatory milieu of PAH. Abnormal Treg function is strongly correlated with a predisposition to PAH in animals and patients. Read More

View Article and Full-Text PDF

Modulation of Peripheral CD4CD25Foxp3 Regulatory T Cells Ameliorates Surgical Stress-Induced Atherosclerotic Plaque Progression in ApoE-Deficient Mice.

Front Cardiovasc Med 2021 12;8:682458. Epub 2021 Aug 12.

Department of Anesthesiology, Heidelberg University Hospital, Heidelberg, Germany.

Systemic inflammation associated with major surgery rapidly accelerates atherosclerotic plaque progression in mice. Regulatory T cells (Tregs) have emerged as important modulators of atherogenesis. In coronary artery disease patients, low frequency of Tregs constitutes an independent risk factor for cardiovascular complications after non-cardiac surgery. Read More

View Article and Full-Text PDF

CD8 Regulatory T Cell - A Mystery to Be Revealed.

Front Immunol 2021 18;12:708874. Epub 2021 Aug 18.

Department of Microbiology, Immunology and Molecular Genetics, The Joe R. and Teresa Lozano Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States.

Regulatory T cells (Treg) are essential to maintain immune homeostasis and prevent autoimmune disorders. While the function and molecular regulation of Foxp3CD4 Tregs are well established, much of CD8 Treg biology remains to be revealed. Here, we will review the heterogenous subsets of CD8 T cells have been named "CD8 Treg" and mainly focus on CD122Ly49CD8 Tregs present in naïve mice. Read More

View Article and Full-Text PDF

RNA sequencing of blood in coronary artery disease: involvement of regulatory T cell imbalance.

BMC Med Genomics 2021 09 3;14(1):216. Epub 2021 Sep 3.

The St. Laurent Institute, Vancouver, WA, USA.

Background: Cardiovascular disease had a global prevalence of 523 million cases and 18.6 million deaths in 2019. The current standard for diagnosing coronary artery disease (CAD) is coronary angiography. Read More

View Article and Full-Text PDF
September 2021

FOXP3 Predicts Response to Treatment in Mycosis Fungoides.

Acta Dermatovenerol Croat 2021 Jul;29(2):67-71

Ilan Goldberg, MD, Department of Dermatology, Sourasky Medical Center, 6 Weizmann St., Tel-Aviv, Israel;

Background: The role of the T-regulatory cells (Tregs) marker forkhead box Protein 3 (FOXP3) in mycoses fungoides (MF) pathogenesis is unclear and the results of previous studies are inconclusive.

Objective: We aimed at ascertaining the possibility that FOXP3 expression may serve to predict MF stage and response to therapy.

Patients And Methods: Immunohistochemistry staining for FOXP3 was performed on 30 skin biopsies from patients with MF, and FOXP3 expression level was quantitatively graded. Read More

View Article and Full-Text PDF

Blood transfusion practices affect CD4 CD25 FOXP3 regulatory T cells/T helper-17 cells and the clinical outcome of geriatric patients with hip fracture.

Aging (Albany NY) 2021 09 1;13(17):21408-21420. Epub 2021 Sep 1.

Department of Orthopedic Research Center, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, PR China.

Hip fracture (HF) is common among older individuals and associated with high mortality, poor vitality and functional impairment. HF patients suffer whole body immunological changes and that lead to severe consequences, including immobilization, physical impairment and a high risk of complications. The objective of this study was to decipher the pattern of dynamic immunological changes, especially in two major T cell subsets, CD4 CD25 FOXP3 regulatory T (Treg) cells and T helper-17 (Th17) cells, and their balance, during the hospital stay and to observe whether blood transfusion could influence these cells and clinical patietns' prognosis. Read More

View Article and Full-Text PDF
September 2021

Pre-incubation of corneal donor tissue with sCD83 improves graft survival via the induction of alternatively activated macrophages and tolerogenic dendritic cells.

Am J Transplant 2021 Sep 1. Epub 2021 Sep 1.

Department of Experimental Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Immune responses reflect a complex interplay of cellular and extracellular components which define the microenvironment of a tissue. Therefore, factors that locally influence the microenvironment and re-establish tolerance might be beneficial to mitigate immune-mediated reactions, including the rejection of a transplant. In this study, we demonstrate that pre-incubation of donor tissue with the immune modulator soluble CD83 (sCD83) significantly improves graft survival using a high-risk corneal transplantation model. Read More

View Article and Full-Text PDF
September 2021

Aiduqing formula inhibits breast cancer metastasis by suppressing TAM/CXCL1-induced Treg differentiation and infiltration.

Cell Commun Signal 2021 Aug 30;19(1):89. Epub 2021 Aug 30.

The Research Center of Integrative Cancer Medicine, Discipline of Integrated Chinese and Western Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.

Background: Metastasis represents the leading cause of death in patients with breast cancer. Traditional Chinese medicine is particularly appreciated for metastatic diseases in Asian countries due to its benefits for survival period prolongation and immune balance modulation. However, the underlying molecular mechanisms remain largely unknown. Read More

View Article and Full-Text PDF

Gold nanorods enhance different immune cells and allow for efficient targeting of CD4+ Foxp3+ Tregulatory cells.

PLoS One 2021 30;16(8):e0241882. Epub 2021 Aug 30.

Center for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock, Little Rock, AR, United States of America.

Gold nanoparticles (AuNPs) hold great promise in nanomedicine, yet their successful clinical translation has not been realized. Some challenges include effective AuNP targeting and delivery to improve modulation of immune cells of interest while limiting potential adverse effects. In order to overcome these challenges, we must fully understand how AuNPs impact different immune cell subsets, particularly within the dendritic cell and T cell compartments. Read More

View Article and Full-Text PDF